Short introduction to Citizen Science and Crowdsourcing, and the new Edinburgh University network to promote uptake and quality co-production of scholarly research
Digital Democracy Commission - a #Notwestminster Lightning TalkLocal Democracy Bytes
Lightning Talk by Edward Wood (UK Parliament) at the We're Not In Westminster Any More event held at The Media Centre in Huddersfield on Saturday 7th February 2015. This event was for everyone who has something positive to say about local democracy and for anyone who is up for a challenge.
This project presentation was presented in the D-CENT launch event Democracy reboot: re-imagining democracy and currency in Europe held @Nesta, London.
Presentation given at Digital Humanities in Practice Seminar, Open University, UK. 24th January 2013.
More info at http://ww1.discovery.ac.uk/digital-humanities-and-the-first-world-war/
On Wednesday 29th January, the Doctoral Training Partnerships and Centres for Doctoral Training were launched at a conference at the University of Nottingham.
Biljana Kosanovic - Open Access National Repository of EU Funded Project: Ser...Metamorphosis
Biljana Kosanovic's presentation on the International Conference e-Society.mk 2012, held annually in Skopje, Macedonia, entitled "Open Education for an Open Society – Let’s Share the Knowledge!"
Digital Democracy Commission - a #Notwestminster Lightning TalkLocal Democracy Bytes
Lightning Talk by Edward Wood (UK Parliament) at the We're Not In Westminster Any More event held at The Media Centre in Huddersfield on Saturday 7th February 2015. This event was for everyone who has something positive to say about local democracy and for anyone who is up for a challenge.
This project presentation was presented in the D-CENT launch event Democracy reboot: re-imagining democracy and currency in Europe held @Nesta, London.
Presentation given at Digital Humanities in Practice Seminar, Open University, UK. 24th January 2013.
More info at http://ww1.discovery.ac.uk/digital-humanities-and-the-first-world-war/
On Wednesday 29th January, the Doctoral Training Partnerships and Centres for Doctoral Training were launched at a conference at the University of Nottingham.
Biljana Kosanovic - Open Access National Repository of EU Funded Project: Ser...Metamorphosis
Biljana Kosanovic's presentation on the International Conference e-Society.mk 2012, held annually in Skopje, Macedonia, entitled "Open Education for an Open Society – Let’s Share the Knowledge!"
Extending the University 'community': Integrating Research, Learning and Comm...David McGillivray
In this seminar I explore the challenges facing universities when trying to live up to their commitments towards community engagement and the transformation of the social, cultural and economic environment in the regions they serve. I focus on how the University needs to extend beyond the confines of its campuses and the importance of the curriculum being adaptable to respond to external drivers. I draw on two participatory arts and media projects that I led on behalf of UWS to highlight the opportunities and threats that exist when the University takes its research and learning activities outside the lecture theatre or seminar room - physically and virtually. I will stress that whilst universities rightly focus on the delivery of formal, accredited learning they can also make a significant contribution to their constituencies through the realm of informal learning and the production (and circulation) of open educational resources. I will talk about two externally funded practice-research projects that included significant internal stakeholder involvement across UWS. The first of these is citizenrelay, a project that made an impact on the practices of the University by recruiting students as producers of content, providing them with opportunities for volunteering and other paid employment and that brought about discussion of curriculum changes as a result. Second, I will focus on an ongoing project, Digital Commonwealth, which takes UWS staff and students outside the boundaries of their traditional practice by working with community groups and organisations in the regions around our four campuses and beyond to deliver formal and informal learning in the fields of creative practice (songwriting, filmmaking, creative writing), journalism and community development.
TEL4Health research at University College Cork (UCC)Hendrik Drachsler
Invited talk given at Application of Science to Simulation, Education and Research on Training for Health Professionals Centre (ASSERT for Health Care)
http://portal.ou.nl/documents/363049/e42710d3-255b-46df-bcba-169f7a5e0341
http://creativecommons.org/licenses/by-nc-sa/3.0/
Drachsler, H., (May, 2013). TEL4Health research at University College Cork (UCC). Invited talk given at Application of Science to Simulation, Education and Research on Training for Health Professionals Centre (ASSERT for Health Care). Cork, Ireland.
MW18 Presentation: Development, Supply, Deployment, Demand: Balancing The Mus...MuseWeb Foundation
By Ross Parry, University of Leicester, UK, Doris Ruth Eikhof, CAMEo Research Institute, University of Leicester, United Kingdom , Sally-Anne Barnes, Institute for Employment Research, University of Warwick, UK, Erika Kispeter, University of Warwick, United KIngdom
Skills matter. The digital literacy of the workforce remains one of the key challenges for the adoption of technology within museums (NMC, 2015; 2016). According to Nesta, the AHRC and ACE (2014; 2015), over a third of museums in England still feel that they do not have the in-house skills to meet their digital aspirations, and rather than improving, some digital skills areas have decreased. The latest findings (Nesta and ACE, 2017) report a "lack of confidence" as a barrier—more so than the cultural sector as a whole.
Addressing this pressing issue, the aim of the UK’s "One by One" national project, is to work over the next two years to understand how to deliver a transformative framework for museum workforce digital literacy. This paper is the first sharing, internationally, of the emerging findings of the initial phase of the "One by One" research.
Combining museology with leading-edge employment studies, the paper attempts to evidence the development, supply, demand, and deployment of digital skills in the UK museum sector, identifying key actors and mapping typical employment patterns and skills policies. The paper shares how digital skills are currently developed and recruited, how demand is articulated, what skills gaps exist, and what challenges impede skill development and deployment.
Furthermore, it explores the shift from "technical skills" to "digital literacies" — what this shift represents, and the facilitators and inhibitors related to this shift that are recognized within the sector.
AERA 2015 - Virtual Learning in New Zealand: Examples of Networked SchoolsMichael Barbour
Barbour, M. K., Wenmoth, D., & Davis, N. (2015, April). Virtual learning in New Zealand: Examples of networked schools. A paper presentation at the annual meeting of the American Educational Research Association, Chicago, IL.
Bringing together digital practices, learning resources and librariesJisc
A presentation at Connect More in Scotland, 4 June 2019.
Speaker: Chris Thomson: subject specialist: digital practice (lead communication and collaboration), Jisc.
If your college or university is looking to create a more digitally-enabled organisation, your library or learning resources service should be a key asset.
If you work in a library or learning resources service, you’ll know that your digital capability – whether it’s delivering online content, engaging users or facilitating digital literacy - is essential for helping students and academics succeed. But how can we maximize the potential of the library or learning resources service in digital practice? We will look at questions such as:
What technologies for learning and teaching do libraries need to have their eye on?
How might the shape and role of the library/learning resources service evolve amid rapid digital change?
How can staff collaborate across different roles in the digitally-enabled organisation?
The presentation looks at some of the key capabilities that are required, whether at a campus-wide, regional or national level to make sure that digitisation happens effectively, as rapidly as possible and offers value for money in the medium and long term.
A presentation in Wrekenton Library on March 18th 2010 in a workshop to encourage social reporting in local groups. The session a was arranged by David Wilcox http://socialreporter.com and Nial Smith http://idea.gov.uk
Radical Digital Citizenship - What's Digital Sociology's contributionHuw Davies
My slides for this event:
https://www.eventbrite.com/e/towards-a-radical-digital-citizenship-in-digital-education-tickets-32496084664
I outline my interpretation of digital sociology. I argue it needs to become mainstream & it can enable a more ethical interventionist citizenship.
This is a snapshot of how social media is being used at NC State University as of March 2010. It was presented in ENG 583a Social Media and Technical Communication, a course in NC State's Master's of Science in Technical Communication curriculum.
Digital Age Evidence and the Living Lab: Keynote for SICSA MadnessJames Stewart
These slides introduce the concept of evidence to counterbalance too much talk about 'data'. It focuses on the socially constructed nature of Evidence, and how it needs to be in the right form at the right time and the right place to have impact on decision making. Evidence is expensive, and relies on legitimising agents. Intro digital world we have many new ways of creating evidence - from the original data sources to the final communication form. What tools and practices are needed to make the creation of evidence more effective and more easily accessible?
The slides outlines how a Living Lab and crowdsourcing could be used create new forms of evidence for science and policy
Digital Games for Empowerment & Inclusion (DGEI): Challenges and OpportunitiesJames Stewart
Keynote Presentation on the Digital GAmes for Social Inclusion and Empowerment report to the GALA serious games conference. Original report: http://is.jrc.ec.europa.eu/pages/EAP/eInclusion/games.html#publications
Extending the University 'community': Integrating Research, Learning and Comm...David McGillivray
In this seminar I explore the challenges facing universities when trying to live up to their commitments towards community engagement and the transformation of the social, cultural and economic environment in the regions they serve. I focus on how the University needs to extend beyond the confines of its campuses and the importance of the curriculum being adaptable to respond to external drivers. I draw on two participatory arts and media projects that I led on behalf of UWS to highlight the opportunities and threats that exist when the University takes its research and learning activities outside the lecture theatre or seminar room - physically and virtually. I will stress that whilst universities rightly focus on the delivery of formal, accredited learning they can also make a significant contribution to their constituencies through the realm of informal learning and the production (and circulation) of open educational resources. I will talk about two externally funded practice-research projects that included significant internal stakeholder involvement across UWS. The first of these is citizenrelay, a project that made an impact on the practices of the University by recruiting students as producers of content, providing them with opportunities for volunteering and other paid employment and that brought about discussion of curriculum changes as a result. Second, I will focus on an ongoing project, Digital Commonwealth, which takes UWS staff and students outside the boundaries of their traditional practice by working with community groups and organisations in the regions around our four campuses and beyond to deliver formal and informal learning in the fields of creative practice (songwriting, filmmaking, creative writing), journalism and community development.
TEL4Health research at University College Cork (UCC)Hendrik Drachsler
Invited talk given at Application of Science to Simulation, Education and Research on Training for Health Professionals Centre (ASSERT for Health Care)
http://portal.ou.nl/documents/363049/e42710d3-255b-46df-bcba-169f7a5e0341
http://creativecommons.org/licenses/by-nc-sa/3.0/
Drachsler, H., (May, 2013). TEL4Health research at University College Cork (UCC). Invited talk given at Application of Science to Simulation, Education and Research on Training for Health Professionals Centre (ASSERT for Health Care). Cork, Ireland.
MW18 Presentation: Development, Supply, Deployment, Demand: Balancing The Mus...MuseWeb Foundation
By Ross Parry, University of Leicester, UK, Doris Ruth Eikhof, CAMEo Research Institute, University of Leicester, United Kingdom , Sally-Anne Barnes, Institute for Employment Research, University of Warwick, UK, Erika Kispeter, University of Warwick, United KIngdom
Skills matter. The digital literacy of the workforce remains one of the key challenges for the adoption of technology within museums (NMC, 2015; 2016). According to Nesta, the AHRC and ACE (2014; 2015), over a third of museums in England still feel that they do not have the in-house skills to meet their digital aspirations, and rather than improving, some digital skills areas have decreased. The latest findings (Nesta and ACE, 2017) report a "lack of confidence" as a barrier—more so than the cultural sector as a whole.
Addressing this pressing issue, the aim of the UK’s "One by One" national project, is to work over the next two years to understand how to deliver a transformative framework for museum workforce digital literacy. This paper is the first sharing, internationally, of the emerging findings of the initial phase of the "One by One" research.
Combining museology with leading-edge employment studies, the paper attempts to evidence the development, supply, demand, and deployment of digital skills in the UK museum sector, identifying key actors and mapping typical employment patterns and skills policies. The paper shares how digital skills are currently developed and recruited, how demand is articulated, what skills gaps exist, and what challenges impede skill development and deployment.
Furthermore, it explores the shift from "technical skills" to "digital literacies" — what this shift represents, and the facilitators and inhibitors related to this shift that are recognized within the sector.
AERA 2015 - Virtual Learning in New Zealand: Examples of Networked SchoolsMichael Barbour
Barbour, M. K., Wenmoth, D., & Davis, N. (2015, April). Virtual learning in New Zealand: Examples of networked schools. A paper presentation at the annual meeting of the American Educational Research Association, Chicago, IL.
Bringing together digital practices, learning resources and librariesJisc
A presentation at Connect More in Scotland, 4 June 2019.
Speaker: Chris Thomson: subject specialist: digital practice (lead communication and collaboration), Jisc.
If your college or university is looking to create a more digitally-enabled organisation, your library or learning resources service should be a key asset.
If you work in a library or learning resources service, you’ll know that your digital capability – whether it’s delivering online content, engaging users or facilitating digital literacy - is essential for helping students and academics succeed. But how can we maximize the potential of the library or learning resources service in digital practice? We will look at questions such as:
What technologies for learning and teaching do libraries need to have their eye on?
How might the shape and role of the library/learning resources service evolve amid rapid digital change?
How can staff collaborate across different roles in the digitally-enabled organisation?
The presentation looks at some of the key capabilities that are required, whether at a campus-wide, regional or national level to make sure that digitisation happens effectively, as rapidly as possible and offers value for money in the medium and long term.
A presentation in Wrekenton Library on March 18th 2010 in a workshop to encourage social reporting in local groups. The session a was arranged by David Wilcox http://socialreporter.com and Nial Smith http://idea.gov.uk
Radical Digital Citizenship - What's Digital Sociology's contributionHuw Davies
My slides for this event:
https://www.eventbrite.com/e/towards-a-radical-digital-citizenship-in-digital-education-tickets-32496084664
I outline my interpretation of digital sociology. I argue it needs to become mainstream & it can enable a more ethical interventionist citizenship.
This is a snapshot of how social media is being used at NC State University as of March 2010. It was presented in ENG 583a Social Media and Technical Communication, a course in NC State's Master's of Science in Technical Communication curriculum.
Digital Age Evidence and the Living Lab: Keynote for SICSA MadnessJames Stewart
These slides introduce the concept of evidence to counterbalance too much talk about 'data'. It focuses on the socially constructed nature of Evidence, and how it needs to be in the right form at the right time and the right place to have impact on decision making. Evidence is expensive, and relies on legitimising agents. Intro digital world we have many new ways of creating evidence - from the original data sources to the final communication form. What tools and practices are needed to make the creation of evidence more effective and more easily accessible?
The slides outlines how a Living Lab and crowdsourcing could be used create new forms of evidence for science and policy
Digital Games for Empowerment & Inclusion (DGEI): Challenges and OpportunitiesJames Stewart
Keynote Presentation on the Digital GAmes for Social Inclusion and Empowerment report to the GALA serious games conference. Original report: http://is.jrc.ec.europa.eu/pages/EAP/eInclusion/games.html#publications
The SlideShare 101 is a quick start guide if you want to walk through the main features that the platform offers. This will keep getting updated as new features are launched.
The SlideShare 101 replaces the earlier "SlideShare Quick Tour".
What is Extreme Citizen Science? Volunteerism & Publicly Initiated Scientific...Cindy Regalado
This presentation briefly illustrates the state of citizen science our approach in Extreme Citizen Science. We present two examples under this research group at University College London: Publicly Initiated Scientific Research and the Socio-demographics of Volunteerism
Kicking off the INCENTIVE project with an intro to the CS Principles and Char...Margaret Gold
-The Citizen Science Lab at Leiden University
- The core concept of the INCENTIVE project
- The ECSA 10 Principles of Citizen Science
- The ECSA Characteristics of Citizen Science
Introduction to the European Citizen Science AssociationMargaret Gold
Brief intro slides, shown at the COWM2018 Conference in Venice, which hosted the workshop “Citizen Science – New opportunities for research and innovation in the EU and the US” , in conjunction with the BILAT USA 4.0 project.
"Data Science" panel intro slides at Digital Research 2013, St Anne's, Oxford, September 2013 hosted by e-Research South and Oxford e-Research Centre - see http://digital-research.oerc.ox.ac.uk/
Presentation on how governments and the public sector can capture the value of networked individuals, given at the NETworked 2010 Conference in Oslo, Norway, 2010
ECSA and the 10 Principles of Citizen ScienceMargaret Gold
Citizen science is a flexible concept which can be adapted and applied within diverse situations and disciplines. The 10 Principles were developed by the ‘Sharing best practice and building capacity’ working group of the European Citizen Science Association, led by the Natural History Museum London with input from many members of the Association, to set out some of the key principles which as a community we believe underlie good practice in citizen science.
Big Data for the Social Sciences - David De Roure - Jisc Digital Festival 2014Jisc
The analysis of government data, data held by business, the web, social science survey data will support new research directions and findings. Big Data is one of David Willetts’ 8 great technologies, and in order to secure the UK’s competitive advantage new investments have been made by the Economic Social Science Research Council ( ESRC) in Big Data, for example the Business Datasafe and Understanding Populations investments. In this session the benefits of the use of Big Data in social science , and the ESRCs Big Data strategy will be explained by Professor David De Roure.of the Oxford e-Research Centre and advisor to the ESRC.
What's the promise of citizen science - overview or types and approaches with a few examples. Challenges & opportunities to consider plus some resources and possibilities for future, in opening up science.
Digital Divide, Social Exclusion, and inclusion policy and new harmsJames Stewart
A lecture on understanding concept of digital divide, sstatistica data on nternet use, theories of the digitial excluson, new hards, and policy responses and inituatives
Cloud to crowd talk to COST Virtual work Bucharest 2014James Stewart
The market place for work and work opportunities is changing, mediated by online markets and exchange. Here I present findings from an EC study on the trends, challenges and opportunities coming from crowdsourcing (crowd flower, AMT, Samasource etc), cloud work forces, and global freelance exchanges (ODesk, Elance etc). The presentation explores how these services have been developed, shaped, and used, and issues that policy makers should be aware of.
EC policy actions and priorities in employment, and the potential of online e...James Stewart
Talk to COST research meeting in Darmstadt about the policy rational for work on ICTs and employment and the JRC-IPTS work on crowdfunding, crowdsourcing, online volunteering and timebanks and their implcations for employment and employability policy
Making Web2.0 for science: Co-production of Web2.0 platforms and knowledgeJames Stewart
This paper examines how two contrasting scholarly publishers are responding to the opportunities and challenges of Web 2.0 to innovate their services. Our findings highlight the need to take seriously the role of publishers in the move towards a vision of more rapid and open scholarly communication and to understand the factors that shape their role as intermediaries in the innovation pathways that may be needed to achieve it.
ICT-enabled services for carers and care: pathways and actors in the developm...James Stewart
Presentation at the University of Edinburgh July 2012 of IPTS studies on ICT-enabled services to support informal care of the elderly,in the context of Long Term Care policy. The presentation reports on the empirical evidence and analysis of expereinces supporting informal carers for the elderly across Europe, and discussing challenges for policy: supporting innovation and knowledge transfer
The Memory Space - exploring future used of Web2.0 and mobile internet thoug...James Stewart
Presentation for COST 298 Action Conference, Copenhagen May 2009 on research done in Edinburgh on linking online and physical spaces, tags, tagging and the tagscape, and the memory space, specifically applied to 'The Conference'.
Internet and Society: Politics And Democracy 2009James Stewart
Lecture Slides for Internet and Society course and the University of Edinburgh on the topic of the the internet, mobiles, computing and practice and theorisation of politics and democracy
Lecture Slides for Internet and Society course at the University of Edinburgh on understanding the analysis of community and internet (amd mobile etc), using ideas from studies of CMC, social network studies, social capital etc https://www.wiki.ed.ac.uk/display/IandS/Internet+and+Society+Home
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Introduction to the Edinburgh University Citizen Science and Crowdsourcing Network Ppen.ed 9-3-2015
1. Crowdsourcing and
Citizen Science @ ed
Dr James Stewart j.k.stewart@ed.ac.uk @jamesks
Science Technology and Innovation Studies - Digital STIS
Edinburgh University Citizen Science and Crowdsourcing Interest group.
2.
3. What is citizen science and
crowdsourcing?
Citizen Science and crowdsourcing is a
set of processes through which citizens
take part in scientific, policy or design
research by undertaking research tasks
such as problem formulation, data
collection, data analysis, evidence
production, ideas generation and
communication.
11. 1. Raise the profile and understanding of issues
and potential of Citizen Science and
crowdsourcing within the research community.
2. Share knowledge and practice of existing
experiences to develop the practice of Citizen
Science.
3. Secure resources to develop Citizen Science
research and related activities by fostering
collaboration and proposal development,
including training for CPD, development of
methods, tools and infrastructure, and
building relationships with
external organisations.
Aims of the CSCS Network
12. Join Us
50 members so far, from most schools
• Add your name to the
Wiki:https://www.wiki.ed.ac.uk/display/CIT/
• Join the mailing list
• cit-sci-crowdsourcing-network@mlist.is.ed.ac.uk
• Introduce yourself, and suggest a talk you could
give, or a question you would like answered.
13. Questions
What could and or should the
university, schools and colleges be
providing to help develop quality
crowdsourcing and citizen science?
How can we improve quality and
availability of co-produced research
practices tools and evidence?