API- active Pharmaceutical ingredient is an active part of pharmaceutical drug or pesticide. In most of drugs, there are usually two different kind of chemical ingredients, One is inert part of drug called excepient and another is active ingredient called API. For any disease, the remedy is chosen based upon the type of active ingredien.......

1. Introduction to Active Pharmaceutical Ingredients
API- active Pharmaceutical ingredient is an active part of pharmaceutical
drug or pesticide. In most of drugs, there are usually two different kind of
chemical ingredients, One is inert part of drug called excepient and another is
active ingredient called API.
For any disease, the remedy is chosen based upon the type of active
ingredient used in it.
Sometimes active pharmaceutical ingredients need cofactors in order to
achieve particular effects on body. In such cases, ingredients need to be
combined with other active ingredients as they are efficient only when
combined with some particular elements. Sometimes the mixing up of multiple
different APIs can create unwanted conflicts and side-effects on patients body
too.
In herbal medicines, Active Pharmaceutical Ingredients are made up by
combining several different substances which work as an API when mixed
perfectly together.
There are several different & standard methods for calculating relative strength
of various APIs inside the drug. These methods vary from manufacturer to
manufacturer. Unless & untill the proper amount of active pharmaceutical
ingredients in mixed up within medicine, it won't be as efficient as it was
supposed to be ideally.
Chlorhexidine digluconate solution, Cetylpyridinium chloride & cetrimide are
most popularly used Active Pharmaceutical Ingredients which you will know
about in the further portion of this document.
Cetrimides:
Cetrimides have great antiseptic properties which makes them widely used in
skin injuries like minor burns, cuts, grazes, nappy rash etc. Having effective
anti-fungal & anti bacterial characteristics, it is used in anti-infection creams &
powders.
However cetrimide doesn't produce side effects on patients, patients with
allergic nature can suffer from hypersensitivity reactions due to it.
Cetrimide is also used as an ingredient of shampoo and antiseptics to treat

2. psoriasis & seborrhoea. For sore gums, you can apply a very dilute solution of
cetrimide to soothe it.
Cetrimide is used in forms of sprays, creams, liquids etc and also used as
disinfectant solution to clean surgical instruments. It provides an efficient
antiseptic cover by destroying cellular structure of many microorganisms. In
comparison to other acidic agents, Cetrimide causes much less skin irritation
when topically applied.
Chlorhexidine digluconate solution:
Chlorhexidine digluconate solution is transparent, water-like liquid with odours
like menthol & peppermint. It can be used as active pharmaceutical ingredient
in combination with excipients like Hydrogenated Polyoxyl Castor Oil,
Ethanol(96%), Aspartame E951, Menthol, Peppermint oil & purified water.
Chlorhexidine digluconate solution is widely used in antiseptics & disinfectants.
It is effective against a wide range of bacteria, some fungi & some viruses too.
In commercial ophthalmic products, it is used as antibacterial agent as
replacement of thimerosal which is a mercury-containing bacteriostat.
In recent years, it has been replaced in ophthalmic preparations by methyl p-
hydroxybenzoate/ methyl paraben or other paraben esters due to sensitivity on
skin. Its use as a dental disinfectant has led to discoloration of teeth and gums.
Cetylpyridinium chloride:
Cetylpyridinium chloride is disinfectant or antiseptic agent . It is used widely in
dental care products like mouth fresheners, throat sprays, breath sprays, nosal
sprays, lozenges , mouth wash, toothpastes etc. It is clinically proven to
prevent plaques and reduce gingivitis . Due to its antibacterial properties , it is
also used in some pesticides
Tatva chintan pharma chem pvt ltd located at Ankleshwar, India is a leading
chemical and pharmaceutical company & ISO-9001 2000 accredited by BVQi .
The company is committed to the development and manufacture of bulk APIs
like Chlorhexidine digluconate 20% BP, cetrimide IP/BP/EP , cetrimide USP,
cetrimide 40% strong solution BP , Cetyl pyridinium chloride USP/BP along with
Cetrimide, Phase Transfer Catalysts (PTC), Quaternary Ammonium Compounds
(QUATS), Quaternary Phosphonium Compounds, Pyridinium Salts and Glymes.
For further details please visit the official website
http://www.tatvachintan.com or call at +91-2646-253593.