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Indian
APIs (Active Pharmaceutical Ingredients)
Analysis
By Sunil Kumar (sunilzon@gmail.com)
WORLD OF APIs
• Globally there are over 7000 APIs are active in 2013
• Altogether APIs creates USD 120 billion world market
• Which is 12% of world pharmaceuticals market
• That is around USD 1000 billion
• World market of APIs is growing at the rate of 8%
• US is biggest market with around 45% share of the world
market
INDIAN APIs INDUSTRY
• India has around 2300 APIs manufacturing units
•Which produces around 1500 APIs
•For domestic and International market
•Indian APIs Industry is worth USD 9 billion in 2013
•Out of which USD 5 billion exported across the world
•Rest USD 4 billion goes for formulation
•Out of which USD 2 billion goes for the formulation for
export
•Rest USD 2 billion goes for domestic formulation
manufacturing
INDIAN APIs INDUSTRY: ASSUMPTIONS
• The basis of the study is export data of APIs and
formulations and articles published in different journals
for the year 2012-13
• The export data suggest USD 5 billion worth APIs goes
for export we assume the domestic consumption (for
domestic and export formulation) is USD 4 billion or
80% of the export business
• It must be noted that while USD 2 billion APIs results in
USD 10 billion export of formulation while the same
value of APIs creates USD 18-20 billion Indian domestic
formulation markets
INDIAN APIs INDUSTRY
• Out of 1500 APIs produced in India around 1000 goes
for export
• Top 50 APIs contributes 50% of the industry
• Top 100 APIs accounts for 70% of the industry
• Top 200 APIs constitutes 85 % of the industry
• Top 500 APIs represents 95% of the industry
The TOP 500 APIs
• Top 500 APIs accounts for 95% of business
• But the study leaves some APIs which does more than USD
5 million in export of formulation like ---
DIDANOSINE, MUPIROCIN, CYCLOSERINE,
IPRATROPIUM, ZIPRASIDOE, WARFARINSODIUM,
GENTAMICIN,BECLOMETHASONE, IRINOTECAN,
ZONISAMIDE, MISOPROSTOL, INDAPAMIDE,
AMYLMETACRESOL, LEVODOPA, ATRACURIUM,
RILUZOLE, PROPOFOL, ISOTRETINOIN,
OXALIPLATIN, LEVONORGESTREL, ZAFIRLUKAST,
ALPRAZOLAM, TROSPIUMCHLORIDE, AZELASTINE,
DOXORUBICIN, VECURONIUM, ESTRADIOL,
NORETHINDRONE, FONDAPARINUX, ETOMIDATE,
CEVIMELINE, OCTREOTIDE, ETHINYLESTRADIOL,
RITUXIMAB, TIAGABINE, and NORGESTIMATE and
THE MILLION DOLLAR CLUB
• There are 430 APIs whose export is above USD 1 Million
• The club represents 93% of the Industry
• We further filter the list and leave APIs whose average price
is below USD 25/kg and that leaves few major products
whose export is considerable like----
NAPROXEN, SALICYLIC ACID, TRICLOSAN, ERYTHROMYCIN,
RANITIDINE, POVIDONE IODINE, COTRIMOXAZOLE,
CAFFEINE, DICLOFENAC, METRONIDAZOLE, PERMETHRIN,
GUAIFENESIN, SULFAMETHOXAZOLE, NICOTINAMIDE,
CHLORHEXIDINE, ACETAMINOPHEN, METFORMIN, NIACIN,
GLYCINE, BENZYL CHLORIDE, CLOXACILLIN, ZINCOXIDE,
AMPICILLIN, CALCIUM CARBONATE and ALUMINIUM
HYDROXIDE
THE MILLION DOLLAR CLUB…
• Now we are left with 355 APIs for our analysis
• Which represents around 75% of the industry
• Further we eliminate the APIs whose export is less than
500 Kg
• And that leaves some valued products like
ROCURONIUM, TACROLIMUS, FIDAXOMICIN,
ADAPALENE and SIROLIMUS
• Now we are have left with 320 APIs which represents
70% of the industry
• AND THAT IS THE BASIS OF INDIAN APIs
ANALYSIS
THERAUPEUTICAREAS/CATEGOREIS
• ANTI-INFECTIVES
• CARDIOVASCULAR & HEMATOPOIETIC SYSTEM
• CENTRAL NERVOUS SYSTEM
• ENDOCRINE & METABOLIC SYSTEM
• GASTROINTESTINAL & HEPATOBILIARY SYSTEM
• GENITO-URINARY SYSTEM
• MUSCULO-SKELETAL SYSTEM
• ONCOLOGY
• RESPIRATORY SYSTEM
• OTHERS: DERMATOLOGICALS, ALLERGY & AMMUNE SYSTEM, EAR &
MOUTH/THROAT, EYE, HORMONES, NUTRITION, VITAMINS &
MINERALS, ANAESTHETICS - LOCAL & GENERAL,VETERINARY
DRUGS
THERAPEUTIC SEGMENTS SHARE
Therapeutica Areas Industry
Share in %
ANTI-INFECTIVES 32.65
CARDIOVASCULAR & HEMATOPOIETIC SYSTEM 23.48
CENTRAL NERVOUS SYSTEM 15.89
RESPIRATORY SYSTEM 8.53
GASTROINTESTINAL & HEPATOBILIARY SYSTEM 7.84
MUSCULO-SKELETAL SYSTEM 2.43
ONCOLOGY 2.14
GENITO-URINARY SYSTEM 1.8
ENDOCRINE & METABOLIC SYSTEM 1.65
OTHERS 3.59
CONTINUE…
TOP 10 APIs
Value in USD
APIs
Therapeutic
Areas
Export
Indian
Market
Total
Lowest
Price/Kg
CLOPIDOGREL
CARDIOVASCULAR & HEMATOPOIETIC
SYSTEM 113,127,772.16 90,502,217.73 203,629,989.89 61.83
ATORVASTATIN
CARDIOVASCULAR & HEMATOPOIETIC
SYSTEM 96,548,251.42 77,238,601.14 173,786,852.56 253.59
AMOXYCILLIN ANTI-INFECTIVES (SYSTEMIC) 91,257,244.93 73,005,795.94 164,263,040.87 24.13
CEFUROXIME ANTI-INFECTIVES (SYSTEMIC) 90,505,803.00 72,404,642.40 162,910,445.40 115.87
OMEPRAZOLE
GASTROINTESTINAL & HEPATOBILIARY
SYSTEM 89,885,147.35 71,908,117.88 161,793,265.23 60.00
CLARITHROMYCIN ANTI-INFECTIVES (SYSTEMIC) 79,722,899.15 63,778,319.32 143,501,218.47 123.43
DEXTROMETHORPHAN RESPIRATORY SYSTEM 78,454,335.24 62,763,468.19 141,217,803.43 148.67
CITALOPRAM CENTRAL NERVOUS SYSTEM 66,944,118.69 53,555,294.95 120,499,413.64 200.07
VALSARTAN
CARDIOVASCULAR & HEMATOPOIETIC
SYSTEM 63,634,936.37 50,907,949.10 114,542,885.47 142.05
CEFIXIME ANTI-INFECTIVES (SYSTEMIC) 61,014,383.99 48,811,507.19 109,825,891.18 126.53
TOP 10 APIs: ANTI-INFECTIVES
Value in USD
APIs
Sub-Therapeutic
Areas
Export
Indian
Market
Total
Lowest
Price/Kg
AMOXYCILLIN PENICILLINS 91,257,244.93 73,005,795.94 164,263,040.87 24.13
CEFUROXIME CEPHALOSPORINS 90,505,803.00 72,404,642.40 162,910,445.40 115.87
CLARITHROMYCIN MACROLIDES 79,722,899.15 63,778,319.32 143,501,218.47 123.43
CEFIXIME CEPHALOSPORINS 61,014,383.99 48,811,507.19 109,825,891.18 126.53
CEFACLOR CEPHALOSPORINS 53,948,395.96 43,158,716.77 97,107,112.73 166.12
TENOFOVIR ANTIVIRALS 53,807,425.50 43,045,940.40 96,853,365.90 332.19
CIPROFLOXACIN
EAT ANTI-INFECTIVES & ANTISEPTICS,
QUINOLONES, ANTIBACTERIAL
COMBINATINS, ANTIDIARRHEALS 49,292,536.59 39,434,029.27 88,726,565.86 26.11
ACYCLOVIR ANTIVIRALS 48,339,569.79 38,671,655.83 87,011,225.62 41.41
CEFALEXIN CEPHALOSPORINS 37,070,819.21 29,656,655.37 66,727,474.58 44.23
VALACYCLOVIR ANTIVIRALS 36,327,195.31 29,061,756.25 65,388,951.56 192.21
TOP 10 APIs: CARDIOVASCULAR &
HEMATOPOIETIC SYSTEM
Value in USD
APIs
Sub-Therapeutic
Areas
Export
Indian
Market
Total
Lowest
Price/Kg
CLOPIDOGREL
ANTICOAGULANTS, ANTIPLATELETS & FIBRINOLYTICS
(THROMBOLYTICS) 113,127,772.16 90,502,217.73 203,629,989.89 61.83
ATORVASTATIN DYSLIPIDAEMIC AGENTS 96,548,251.42 77,238,601.14 173,786,852.56 253.59
VALSARTAN ANGIOTENSIN II ANTAGONISTS 63,634,936.37 50,907,949.10 114,542,885.47 142.05
ROSUVASTATIN DYSLIPIDAEMIC AGENTS 56,931,747.75 45,545,398.20 102,477,145.95 949.16
LOSARTAN ANGIOTENSIN II ANTAGONISTS, 39,860,199.59 31,888,159.67 71,748,359.26 63.23
IRBESARTAN ANGIOTENSIN II ANTAGONISTS 37,130,963.40 29,704,770.72 66,835,734.12 156.25
LISINOPRIL ACE INHIBITORS/DIRECT RENIN INHIBITORS 30,279,107.60 24,223,286.08 54,502,393.68 249.48
AMLODIPINE
CALCIUM ANTAGONISTS, ANTI-ANGINAL DRUGS, BETA-
BLOCKERS, CALCIUM ANTAGONISTS, ACE
INHIBITORS/DIRECT RENIN INHIBITORS 28,318,215.10 22,654,572.08 50,972,787.18 40.18
SIMVASTATIN DYSLIPIDAEMIC AGENTS 26,653,749.16 21,322,999.33 47,976,748.49 224.32
HEPARIN
ANTICOAGULANTS, ANTIPLATELETS & FIBRINOLYTICS
(THROMBOLYTICS) 23,381,921.67 18,705,537.34 42,087,459.01 1,547.23
TOP 10 APIs: CENTRAL NERVOUS SYSTEM
Value in USD
APIs
Sub-Therapeutic
Areas
Export
Indian
Market
Total
Lowest
Price/Kg
CITALOPRAM ANTIDEPRESSANTS 66,944,118.69 53,555,294.95 120,499,413.64 200.07
GABAPENTIN
ANTICONVULSANTS, DRUGS FOR
NEUROPATHIC PAIN 54,993,418.08 43,994,734.46 98,988,152.54 45.45
ESCITALOPRAM ANTIDEPRESSANTS 39,828,029.90 31,862,423.92 71,690,453.82 343.52
LEVETIRACETAM ANTICONVULSANTS 28,187,827.22 22,550,261.78 50,738,089.00 92.71
PAROXETINE ANTIDEPRESSANTS 27,170,240.25 21,736,192.20 48,906,432.45 405.00
SERTRALINE ANTIDEPRESSANTS 25,670,868.48 20,536,694.78 46,207,563.26 106.59
VENLAFAXINE ANXIOLYTICS,ANTIDEPRESSANTS 24,385,914.56 19,508,731.65 43,894,646.21 83.21
NABUMETONE
NONSTEROIDAL ANTI-INFLAMMATORY
DRUGS (NSAIDs) 22,697,951.63 18,158,361.30 40,856,312.93 54.11
TRAMADOL ANALGESICS (OPIOID) 20,228,926.97 16,183,141.58 36,412,068.55 32.78
OXCARBAZEPINE ANTICONVULSANTS 18,982,106.90 15,185,685.52 34,167,792.42 99.00
TOP 10 APIs: RESPIRATORY SYSTEM
Value in USD
APIs
Sub-Therapeutic
Areas
Export
Indian
Market
Total
Lowest
Price/Kg
DEXTROMETHORPHAN
COUGH & COLD
PREPARATIONS 78,454,335.24 62,763,468.19 141,217,803.43 148.67
MONTELUKAST
ANTIASTHMATIC & COPD
PREPARATIONS 57,727,967.21 46,182,373.77 103,910,340.98 854.27
LORATADINE
NASAL DECONGESTANTS &
OTHER NASAL PREPARATIONS 34,789,681.10 27,831,744.88 62,621,425.98 173.36
EPHEDRINE ANTI-OBESITY AGENTS 28,241,693.22 22,593,354.58 50,835,047.80 43.17
PSEUDOEPHEDRINE HCL
COUGH & COLD
PREPARATIONS 22,501,033.75 18,000,827.00 40,501,860.75 32.61
CODEINE
COUGH & COLD
PREPARATIONS 21,576,582.54 17,261,266.03 38,837,848.57 25.23
PHENIRAMINE
ANTIHISTAMINES &
ANTIALLERGICS 9,190,574.19 7,352,459.35 16,543,033.54 16.36
SALBUTAMOL 6,971,400.06 5,577,120.05 12,548,520.11 57.00
CHLORPHENIRAMINE 6,932,754.38 5,546,203.50 12,478,957.88 16.00
PHENYLEPHRINE 6,478,375.66 5,182,700.53 11,661,076.19 136.00
TOP 10 APIs: GASTROINTESTINAL &
HEPATOBILIARY SYSTEM
Value in USD
APIs
Sub-Therapeutic
Areas
Export
Indian
Market
Total
Lowest
Price/Kg
OMEPRAZOLE
ANTACIDS, ANTIREFLUX
AGENTS & ANTIULCERANTS 89,885,147.35 71,908,117.88 161,793,265.23 60.00
PANTOPRAZOLE
ANTACIDS, ANTIREFLUX
AGENTS & ANTIULCERANTS 52,392,370.87 41,913,896.70 94,306,267.57 80.80
ESOMEPRAZOLE
ANTACIDS, ANTIREFLUX
AGENTS & ANTIULCERANTS 44,642,855.04 35,714,284.03 80,357,139.07 107.00
RABEPRAZOLE
ANTACIDS, ANTIREFLUX
AGENTS & ANTIULCERANTS 17,775,512.56 14,220,410.05 31,995,922.61 132.32
LANSOPRAZOLE
ANTACIDS, ANTIREFLUX
AGENTS & ANTIULCERANTS 17,028,016.31 13,622,413.05 30,650,429.36 17.15
RIFAXIMIN ANTIDIARRHEALS 11,994,127.81 9,595,302.25 21,589,430.06 298.18
HYOSCINE BUTYL BROMIDE ANTISPASMODICS 11,207,584.39 8,966,067.51 20,173,651.90 1,345.12
FAMOTIDINE 6,990,584.68 5,592,467.74 12,583,052.42 42.00
URSODIL 4,812,759.21 3,850,207.37 8,662,966.58 353.00
MEBEVERINE 3,739,520.53 2,991,616.42 6,731,136.95 60.00
TOP 10 APIs: MUSCULO-SKELETAL
SYSTEM
Value in USD
APIs
Sub-Therapeutic
Areas
Export
Indian
Market
Total
Lowest
Price/Kg
THIOCOLCHICOSIDE MUSCLE RELAXANTS 21,028,203.84 16,822,563.07 37,850,766.91 6,783.67
ALLOPURINOL
HYPERURICEMIA & GOUT
PREPARATIONS 17,897,980.90 14,318,384.72 32,216,365.62 28.80
CARISOPRODOL MUSCLE RELAXANTS 11,290,349.93 9,032,279.94 20,322,629.87 23.49
IBANDRONATE 6,311,155.45 5,048,924.36 11,360,079.81 715.00
PHENYRAMIDOL 5,438,490.36 4,350,792.29 9,789,282.65 93.00
COLCHICINE 3,677,652.58 2,942,122.06 6,619,774.64 893.00
ALENDRONATE 3,320,521.22 2,656,416.98 5,976,938.20 38.00
DIACEREIN 3,201,306.61 2,561,045.29 5,762,351.90 295.00
CHLORZOXAZONE 2,538,904.74 2,031,123.79 4,570,028.53 14.00
TIZANIDINE 2,326,605.64 1,861,284.51 4,187,890.15 1,393.00
TOP 5 APIs: ONCOLOGY
Value in USD
APIs
Sub-Therapeutic
Areas
Export
Indian
Market
Total
Lowest
Price/Kg
GEMCITABINE
CYTOTOXIC
CHEMOTHERAPY 40,404,865.35 32,323,892.28 72,728,757.63 6,121.79
IMATINIB
TARGETED CANCER
THERAPY 23,389,730.10 18,711,784.08 42,101,514.18 1,455.35
CAPECITABINE 4,456,115.62 3,564,892.50 8,021,008.12 426.00
BICALUTAMIDE 4,239,622.78 3,391,698.22 7,631,321.00 738.00
MELOXICAM 3,306,640.18 2,645,312.14 5,951,952.32 73.00
TOP 10 APIs: GENITO-URINARY SYSTEM
Value in USD
APIs
Sub-Therapeutic
Areas
Export
Indian
Market
Total
Lowest
Price/Kg
MASULOSIN
DRUGS FOR BLADDER &
PROSTATE DISORDERS 11,190,244.56 8,952,195.65 20,142,440.21 1,169.32
TAMSULOSIN
ACE INHIBITORS/DIRECT RENIN
INHIBITORS 11,190,244.56 8,952,195.65 20,142,440.21 49.27
TRIMETHOPRIM URINARY TRACT INFECTIONS 10,594,664.06 8,475,731.25 19,070,395.31 22.65
SILDENAFIL 8,081,910.88 6,465,528.70 14,547,439.58 36.00
FINASTERIDE 7,480,116.68 5,984,093.34 13,464,210.02 2,986.00
PHENAZOPYRIDINE 3,614,695.29 2,891,756.23 6,506,451.52 32.00
PROBENECID 2,743,350.90 2,194,680.72 4,938,031.62 38.00
TOLTERODINE 2,643,803.47 2,115,042.78 4,758,846.25 494.00
CEFDITOREN 2,541,756.59 2,033,405.27 4,575,161.86 1,023.00
PENICILLAMINE 1,491,748.52 1,193,398.82 2,685,147.34 1,444.00
TOP 10 APIs: ENDOCRINE & METABOLIC
SYSTEM
Value in USD
APIs
Sub-Therapeutic
Areas
Export
Indian
Market
Total
Lowest
Price/Kg
PIOGLITAZONE ANTIDIABETIC AGENTS 14,538,744.26 11,630,995.41 26,169,739.67 95.03
ORLISTAT ANTI-OBESITY AGENTS 11,925,939.75 9,540,751.80 21,466,691.55 740.00
GLIMEPIRIDE 6,605,904.37 5,284,723.50 11,890,627.87 335.00
GLICLAZIDE 4,369,257.44 3,495,405.95 7,864,663.39 131.00
REPAGLINIDE 4,009,591.01 3,207,672.81 7,217,263.82 2,728.00
NATEGLINIDE 3,828,042.01 3,062,433.61 6,890,475.62 435.00
GLIPIZIDE 3,200,115.21 2,560,092.17 5,760,207.38 187.00
SITAGLIPTIN 3,109,199.99 2,487,359.99 5,596,559.98 766.00
GLYBURIDE OR
GLIBENCLAMIDE 3,103,533.66 2,482,826.93 5,586,360.59 31.00
RISEDRONATE SODIUM 1,979,262.61 1,583,410.09 3,562,672.70 643.00
TOP 10 APIs: OTHERS
Value in USD
APIs
Sub-Therapeutic
Areas
Export
Indian
Market
Total
Lowest
Price/Kg
TRICLABENDAZOLE VETERINARY DRUGS 10,569,294.98 8,455,435.98 19,024,730.96 59.98
DESLORATADINE ALLERGY & AMMUNE SYSTEM 8,374,530.38 6,699,624.30 15,074,154.68 311.56
BENZETHONIUM CHLORIDE DERMATOLOGICALS 8,174,060.42 6,539,248.34 14,713,308.76 30.00
DORZOLAMIDE EYE 7,612,650.70 6,090,120.56 13,702,771.26 3,974.00
HYDROCORTISONE HORMONES 6,676,926.25 5,341,541.00 12,018,467.25 820.00
RACTOPAMINE VETERINARY DRUGS 6,561,142.75 5,248,914.20 11,810,056.95 322.00
CLOBETASOL EYE 6,419,728.18 5,135,782.54 11,555,510.72 1,927.00
BETAMETHASONE EAR & MOUTH/THROAT 6,081,371.83 4,865,097.46 10,946,469.29 1,668.00
HYDROCORTISONE SODIUM
SUCCINATE HORMONES 6,064,140.25 4,851,312.20 10,915,452.45 854.00
ARTICAINE
ANAESTHETICS - LOCAL &
GENERAL 5,906,888.76 4,725,511.01 10,632,399.77 182.00
TOP 10 APIs: EXPORT> USD5 Mn,
VLUE: USD 500 -1000/Kg
Value in USD
APIs
Sub-Therapeutic
Areas
Export
Indian
Market
Total
Lowest
Price/Kg
MONTELUKAST RESPIRATORY SYSTEM 57,727,967.21 46,182,373.77 103,910,340.98 854.27
ROSUVASTATIN
CARDIOVASCULAR &
HEMATOPOIETIC SYSTEM 56,931,747.75 45,545,398.20 102,477,145.95 949.16
SUMATRIPTAN CENTRAL NERVOUS SYSTEM 15,899,307.92 12,719,446.34 28,618,754.26 779.37
FLUVASTATIN
CARDIOVASCULAR &
HEMATOPOIETIC SYSTEM 13,547,955.56 10,838,364.45 24,386,320.01 741.84
ORLISTAT
ENDOCRINE & METABOLIC
SYSTEM 11,925,939.75 9,540,751.80 21,466,691.55 740.00
LERCANIDIPINE
CARDIOVASCULAR &
HEMATOPOIETIC SYSTEM 11,387,619.57 9,110,095.66 20,497,715.23 952.57
LOPINAVIR ANTI-INFECTIVES (SYSTEMIC) 7,002,709.04 5,602,167.23 12,604,876.27 696.00
HYDROCORTISONE HORMONES 6,676,926.25 5,341,541.00 12,018,467.25 820.00
IBANDRONATE MUSCULO-SKELETAL SYSTEM 6,311,155.45 5,048,924.36 11,360,079.81 715.00
HYDROCORTISONE SODIUM
SUCCINATE HORMONES 6,064,140.25 4,851,312.20 10,915,452.45 854.00
TOP 10 APIs: Export > USD 5 Mn,
VALUE: USD100-500/Kg
Value in USD
APIs
Sub-Therapeutic
Areas
Export
Indian
Market
Total
Lowest
Price/Kg
ATORVASTATIN
CARDIOVASCULAR &
HEMATOPOIETIC SYSTEM 96,548,251.42 77,238,601.14 173,786,852.56 253.59
TENOFOVIR ANTI-INFECTIVES (SYSTEMIC) 53,807,425.50 43,045,940.40 96,853,365.90 332.19
ESCITALOPRAM CENTRAL NERVOUS SYSTEM 39,828,029.90 31,862,423.92 71,690,453.82 343.52
LISINOPRIL
CARDIOVASCULAR &
HEMATOPOIETIC SYSTEM 30,279,107.60 24,223,286.08 54,502,393.68 249.48
PAROXETINE CENTRAL NERVOUS SYSTEM 27,170,240.25 21,736,192.20 48,906,432.45 405.00
CEFDINIR ANTI-INFECTIVES (SYSTEMIC) 23,664,993.08 18,931,994.46 42,596,987.54 286.87
RAMIPRIL
CARDIOVASCULAR &
HEMATOPOIETIC SYSTEM 16,801,622.49 13,441,297.99 30,242,920.48 327.94
CEFPROZIL ANTI-INFECTIVES (SYSTEMIC) 14,618,836.07 11,695,068.86 26,313,904.93 401.82
RIFAXIMIN
GASTROINTESTINAL &
HEPATOBILIARY SYSTEM 11,994,127.81 9,595,302.25 21,589,430.06 298.18
ARTEMETHER ANTI-INFECTIVES (SYSTEMIC) 11,382,428.56 9,105,942.85 20,488,371.41 495.00
TOP 10 APIs: BY VOLUME
Value in USD
APIs
Therapeutic
Areas
Export
Indian
Market
Total
Lowest
Price/Kg
Export
in MTS
AMOXYCILLIN
ANTI-INFECTIVES
(SYSTEMIC) 91,257,244.93 73,005,795.94 164,263,040.87 24.13 3,140.774
OMEPRAZOLE
GASTROINTESTINAL &
HEPATOBILIARY
SYSTEM 89,885,147.35 71,908,117.88 161,793,265.23 60.00 2,673.176
CIPROFLOXACIN
ANTI-INFECTIVES
(SYSTEMIC) 49,292,536.59 39,434,029.27 88,726,565.86 26.11 1,434.307
GABAPENTIN
CENTRAL NERVOUS
SYSTEM 54,993,418.08 43,994,734.46 98,988,152.54 45.45 1,023.985
AMLODIPINE
CARDIOVASCULAR &
HEMATOPOIETIC
SYSTEM 28,318,215.10 22,654,572.08 50,972,787.18 40.18 763.721
CEFALEXIN
ANTI-INFECTIVES
(SYSTEMIC) 37,070,819.21 29,656,655.37 66,727,474.58 44.23 749.841
CODEINE RESPIRATORY SYSTEM 21,576,582.54 17,261,266.03 38,837,848.57 25.23 611.706
ATENOLOL
CARDIOVASCULAR &
HEMATOPOIETIC
SYSTEM 15,481,607.22 12,385,285.78 27,866,893.00 17.92 587.789
TRAMADOL
CENTRAL NERVOUS
SYSTEM 20,228,926.97 16,183,141.58 36,412,068.55 32.78 524.087
CEFUROXIME
ANTI-INFECTIVES
(SYSTEMIC) 90,505,803.00 72,404,642.40 162,910,445.40 115.87 513.861
TOP 10 APIs: BY VALUE
Value in USD
APIs
Therapeutic
Areas
Export
Indian
Market
Total
Lowest
Price/Kg
CILAZAPRIL
CARDIOVASCULAR &
HEMATOPOIETIC SYSTEM 7,103,329.50 5,682,663.60 12,785,993.10 6,983.00
THIOCOLCHICOSIDE MUSCULO-SKELETAL SYSTEM 21,028,203.84 16,822,563.07 37,850,766.91 6,783.67
GEMCITABINE ONCOLOGY 40,404,865.35 32,323,892.28 72,728,757.63 6,121.79
VORICONAZOLE ANTI-INFECTIVES (SYSTEMIC) 6,869,564.74 5,495,651.79 12,365,216.53 4,393.00
DORZOLAMIDE EYE 7,612,650.70 6,090,120.56 13,702,771.26 3,974.00
DARUNAVIR ANTI-INFECTIVES (SYSTEMIC) 3,471,649.79 2,777,319.83 6,248,969.62 3,892.00
VALGANCICLOVIR ANTI-INFECTIVES (SYSTEMIC) 1,154,667.73 923,734.18 2,078,401.91 3,707.00
NEBIVOLOL
CARDIOVASCULAR &
HEMATOPOIETIC SYSTEM 22,545,134.58 18,036,107.66 40,581,242.24 3,686.07
RIVASTIGMINE CENTRAL NERVOUS SYSTEM 7,524,671.06 6,019,736.85 13,544,407.91 3,369.00
FINASTERIDE GENITO-URINARY SYSTEM 7,480,116.68 5,984,093.34 13,464,210.02 2,986.00
CLOPIDOGREL, METFORMIN, ATORVASTATIN, AMOXYCILLIN, CEFUROXIME, OMEPRAZOLE, CLARITHROMYCIN, DEXTROMETHORPHAN, PARACETAMOL, CITALOPRAM, VALSARTAN, IBUPROFEN, CEFIXIME, MONTELUKAST, ROSUVASTATIN, GABAPENTIN, CEFACLOR, TENOFOVIR, PANTOPRAZOLE, CIPROFLOXACIN, ACYCLOVI,
ESOMEPRAZOLE, RANITIDINE, PERMETHRIN, GEMCITABINE, LOSARTAN, ESCITALOPRAM, SULFAMETHOXAZOLE, IRBESARTAN, CEFALEXIN, VALACYCLOVIR, CLOXACILLIN, LORATADINE, ERYTHROMYCIN, AZITHROMYCIN, EFAVIRENZ, LISINOPRIL, AMLODIPINE, EPHEDRINE, LEVETIRACETAM, PAROXETINE, SIMVASTATIN,
CEFPODOXIME, SERTRALINE, NAPROXEN, VENLAFAXINE, CEFDINIR, IMATINIB, ZIDOVUDINE, NABUMETONE, NEBIVOLOL, PSEUDOEPHEDRINE, DICLOFENAC, AMPICILLIN, THIOCOLCHICOSIDE, LAMIVUDINE, TRAMADOL, ACETAMINOPHEN, NICOTINAMIDE, NIACINAMIDE, EPROSARTAN, OXCARBAZEPINE, PREGABALIN,
ALLOPURINOL, RABEPRAZOLE, PENTOXIFYLLINE, LANSOPRAZOLE, TRICLOSAN, RAMIPRIL, LEVOFLOXACIN, METOPROLOL, SUMATRIPTAN, CARVEDILOL, ROCURONIUM, METRONIDAZOLE, ATENOLOL, CEFTRIAXONE, CEFPROZIL, PIOGLITAZONE, TACROLIMUS, ETHAMBUTOL, QUETIAPINE, PERINDOPRIL, FLUVASTATIN,
COTRIMOXAZOLE, TOPIRAMATE, ITRACONAZOLE, CHLOROQUINE, RIFAXIMIN, ORLISTAT, LAMOTRIGINE,
MINOCYCLINE, GUAIFENESIN, CHLORHEXIDINE, MEROPENEM, LERCANIDIPINE, ARTEMETHER, MOXIFLOXACIN, CARISOPRODOL, KETOCONAZOLE, FLUCLOXACILLIN, TAMSULOSIN, FLUCONAZOLE, TRIMETHOPRIM, TRICLABENDAZOLE, FUROSEMIDE, TERBINAFINE, SALICYLIC ACID, DONEPEZIL, NIZATIDINE,
GLUCOSAMINE, PHENIRAMINE, CHLOROTHIAZIDE, HYDROCHLOROTHIAZIDE, FLURBIPROFEN, FOSINOPRIL, CLINDAMYCIN, OXYCLOZANIDE, OLANZAPINE, DESLORATADINE, PRAZIQUANTEL, BENZETHONIUM, SILDENAFIL, CARBAMAZEPINE, DICLOXACILLIN, CARBIDOPA, DORZOLAMIDE, MIRTAZAPINE, RIVASTIGMINE,
FINASTERIDE, HYDROXYCHLOROQUINE, LUMEFANTRINE, ALBENDAZOLE, KETOPROFEN, CILAZAPRIL, LOPINAVIR, FAMOTIDINE, SALBUTAMOL, RITONAVIR, MYCOPHENOLATE, CHLORPHENIRAMINE, VORICONAZOLE, RIZATRIPTAN, FRUSEMIDE, HYDROCORTISONE, LOVASTATIN, GLIMEPIRIDE, RACTOPAMINE,
PHENYLEPHRINE, CLOBETASOL, IBANDRONATE, ATOVAQUONE, QUININE SULPHATE, CEFADROXIL, NEVIRAPINE, BETAMETHASONE, EMTRICITABINE, CEFTIOFUR, IOPAMIDOL, DILTIAZEM, ARTICAINE, FAMCICLOVIR, CHOLINE, FLECAINIDE, LINEZOLID, CILOSTAZOL, ZOLPIDEM, TRIMETAZIDINE, ANTHRANILIC, BISOPROLOL,
AMITRIPTYLINE, PHENYRAMIDOL, GEMFIBROZIL, ENROFLOXACIN, OLMESARTAN, RISPERIDONE, BILASTINE, LABETALOL, MECLIZINE, MEBENDAZOLE, URSODIL, FLUOXETINE, RIBOFLAVIN, CHLORAMPHENICOL, RIFAMPICIN, AMBROXOL, AMIODARONE, FLUVOXAMINE, CAPECITABINE, AMODIAQUINE, GLICLAZIDE,
DULOXETINE, BICALUTAMIDE, CEFOTAXIME, CETRIMIDE, TELMISARTAN, CEFEPIME, SALMETEROL, REPAGLINIDE, NORFLOXACIN, SULPHADIAZINE, PIPERACILLIN, BUTYLAMINE, NATEGLINIDE, ENALAPRIL, ADAPALENE, ONDANSETRON, NORTRIPTYLINE, ROXITHROMYCIN, SULTAMICILLIN, MEBEVERINE, COLCHICINE,
CINNARIZINE, PHENAZOPYRIDINE, NIMESULIDE, VERAPAMIL, APREPITANT, CELECOXIB, DIMINAZENE, DARUNAVIR, METHOCARBAMOL, OXACILLIN, EBASTINE, PYRAZINAMIDE, DIVALPROEX, ALENDRONATE, MELOXICAM, MIDAZOLAM, EZETIMIB, THEOPHYLLINE, ETORICOXIB, DIACEREIN, GLIPIZIDE, MALATHION,
MESALAZINE, SITAGLIPTIN, GLYBURIDE, GLIBENCLAMIDE, LIDOCAINE, GLIBENCLAMIDE, CLOMIPRAMINE, PACLITAXEL, ABACAVIR, CEFTIBUTEN, FIDAXOMICIN, ROPINIROLE, NITROXYNIL, SIROLIMUS, LEVOCETIRIZINE, NARATRIPTAN, PIPERAZINE, NITAZOXANIDE, CLOZAPIN, IMIQUIMOD, SULINDAC, OFLOXACIN, ASPIRIN,
CEFAZOLIN, ZOLMITRIPTAN, TINIDAZOLE, PRAMIPEXOLE, DOXAZOSIN, ISOFLURANE, PROBENECID, ORPHENADRINE, LETROZOLE, ARTESUNATE, CHLORPHENESIN, DOXOFYLLINE, TOLTERODINE, BRINZOLAMIDE, DILOXANIDE, PROPRANOLOL, CEFDITOREN, CHLORZOXAZONE, CLORSULON, IRON SUCROSE, NICOTINE,
TAZOBACTAM, ACETAZOLAMIDE, METOCLOPRAMIDE, SOTALOL, CEFTAZIDIME, DANAZOL, BROMHEXINE, CHOLECALCIFEROL, IMIPENEM, TRIPROLIDINE, TIZANIDINE, ZALTOPROFEN, ZOPICLONE, FOLIC ACID, ALCAFTADINE, BOSENTAN, ENTACAPONE, MESALAMINE, ACECLOFENAC, STAVUDINE, BIPERIDEN, FLUTICASONE,
TERBUTALINE, DIPHENHYDRAMINE, ETHOPABATE, NALIDIXIC, ITOPRIDE, CEPHRADINE, RISEDRONATE, PHENAZONE, SULFADOXINE, CLONAZEPAM, DEXAMETHASONE, PROPYPHENAZONE, LOPERAMIDE, PINAVERIUM, MICONAZOLE, CILASTATIN, RAFOXANIDE, CYCLOBENZAPRINE, MODAFINIL, SULBACTAM, QUINFAMIDE,
CARBOPLATIN, MOMETASONE, LOMUSTINE, PITOFENONE, ISONIAZID, METHYLPREDNISOLONE, PHENOBARBITAL, RALOXIFENE, KETAMINE, RESERPINE, PHENYTOIN, PROPAFENONE, MEMANTINE, PYRIMETHAMINE, BENAZEPRIL, BENZALKONIUM, ASENAPINE, HALOPERIDOL, ATAZANAVIR, BUPROPION, PROGUANIL,
PENICILLAMINE, DEXCHLORPHENIRAMINE, DAPSONE, FENOFIBRATE, DEXLANSOPRAZOLE, MEFENAMIC, CYPROHEPTADINE, ISOSORBIDE MONONITRATE, PITAVASTATIN, TESTOSTERONE, AMPHOTERICIN, MEPHENESIN, SOLIFENACIN, PEMETREXED, TIMOLOL, PALIPERIDONE, IMIPRAMINE, TICLOPIDINE, CINACALCET,
DORIPENEM, LEFLUNOMIDE, DIOXANE, GEMIFLOXACIN, ARIPIPRAZOLE, SEVELAMER, ENOXAPARIN, BUPARVAQUONE, ANASTROZOLE, TRIAMTERENE, TERPINEOL, BUDESONIDE, DEXKETOPROFEN, QUINAPRIL, YOHIMBINE, BENZBROMARONE, DIFLUNISAL, VALGANCICLOVIR, BISACODYL, LOXAPINE, CETRIZINE, TADALAFIL,
DOXYCYCLINE, BACITRACIN, SAQUINAVIR, PROMETHAZINE, TRIAMCINOLONE, TOLPERISONE, NICLOSAMIDE, TERNIDAZOLE, ENTECAVIR, DUTASTERIDE, INDINAVIR, EPLERENONE, FELODIPINE, ROPIVACAINE, TORSEMIDE, TRAZODONE, BACLOFEN, OSELTAMIVIR, ETODOLAC, NALTREXON, GLYCOPYRROLATE, ZOLEDRONIC,
NIFEDIPINE, BENZATHINE, CLOTRIMAZOLE, CLOSANTEL, MALEIC ACID, BACAMPICILLIN, AMILORIDE, FELBAMATE, BRIMONIDINE, HYDROXYZINE, PERAZINE, ATROPINE, DEFERIPRONE, OXYTOCIN, NEOMYCIN, MEPROBAMATE, BROMPHENIRAMINE, GLATIRAMER, CYANOCOBALAMIN, MORANTEL, CEFRADINE, PRIMIDONE,
HOMATROPINE, BENZARONE, NICORANDIL, STRONTIUM, FENPIVERINIUM, VALPROIC ACID, BROMAZEPAM, AMOXAPINE, ASCORBIC ACID, FEBANTEL, PRAVASTATIN, DOTHIEPIN, FLUNARIZINE, SECNIDAZOLE, TOLDIMFOS, TRIMIPRAMINE, ISOMETAMEDIUM, ERTAPENEM, FENBENDAZOLE, FOSAPREPITANT, AMYLASE,
RUFINAMIDE, TOLNAFTATE, PHENYLPROPANOLAMINE, MONOSULFIRAM, MOSAPRIDE, ATOMOXETINE, BETAXOLOL, CISAPRIDE, DROTAVERINE, CYCLOSPORINE, URSODEOXYCHOLIC, GALANTAMINE, ORNIDAZOLE, HYDROGEN PEROXIDE, NORPSEUDOEPHEDRINE, VANCOMYCIN, PREDNISOLONE, MENATETRENONE,
DOCETAXEL, FORMOTEROL, OXANTEL, HYDRALAZINE, LEVOBUNOLOL, FLUORESCEIN, DIDANOSINE, PRILOCAINE, TIOCONAZOLE, CEFALONIUM, NAFCILLIN, PIROXICAM, ECABET, MYCOPHENOLIC ACID, FLUMEQUINE, METHADONE, CLOBAZAM, LEVALBUTEROL, BUCLIZINE, DOBUTAMINE, FEBUXOSTAT, BUPRENORPHINE,
LANTHANUM, ERLOTINIB, OXFENDAZOLE, PYRANTEL, ALLYLESTRENOL, RAMELTEON, FOSPHENYTOIN, LORAZEPAM, METHYLPHENIDATE, DIGOXIN, RANOLAZINE, CLOMIPHENE, TRANDOLAPRIL, ESMOLOL, ACEFYLLINE, MUPIROCIN, BENDROFLUMETHIAZIDE, ACEBROPHYLLINE, NANDROLONE, AMISULPRIDE, BENZOCAINE,
PRASUGREL, TOLBUTAMIDE, FLUOCINONIDE, FLAVOXATE, SPARFLOXACIN, TETRABENAZINE, CLOFAZIMINE, METHOXSALEN, GRISEOFULVIN, VILDAGLIPTIN, CLORPHENESIN, ISOXSUPRINE, CAMYLOFIN, DIMEGLUMINE, MEGLUMINE, PYRILAMINE, CYCLOSERINE, PRIMAQUINE, ADENINE, IPRATROPIUM, THIOPENTAL,
CEFTIZOXIME, BAMBUTEROL, RESIDRONATE, MELITRACEN, TRIMETHOBENZAMIDE, PAMABROM, ALFUZOSIN, ZIPRASIDONE, DAPOXETINE, RICOBENDAZOLE, WARFARIN, MESNA, QUINAPYRAMINE, CEFPIROME, FROVATRIPTAN, GRANISETRON, PYRIDOXINE, ACETYLSALICYLIC, ELETRIPTAN, FESOTERODINE, FEXOFENADINE,
GENTAMICIN, BESIFLOXACIN, OXYBUTYNIN, SILODOSIN, BUPIVACAINE, MEFLOQUINE, ARMODAFINIL, DRONEDARONE, OXAZEPAM, BENZYDAMINE, BRONOPOL, PICOSULPHATE, BECLOMETHASONE, DIMENHYDRINATE, MAGALDRATE, LENALIDOMIDE, BROMELAIN, ESZOPICLONE, OLOPATADINE, PHENYLBUTAZONE,
CITICOLINE, ADENOSINE, DIPHENOXYLATE, LACIDIPINE, FLORFENICOL, TETRACAINE, CEFOXITIN, ROTIGOTINE, EPINASTINE, LACOSAMIDE, DARIFENACIN, TERAZOSIN, LATANOPROST, CHROMIUM, NITROUS, ZALEPLON, PROPANTHELINE, CINITAPRIDE, PEFLOXACIN, BENDAMUSTINE, EFLORNITHINE, LORNOXICAM,
ROXARSONE, IRINOTECAN, XIPAMIDE, ZONISAMIDE, PENTOSAN, MISOPROSTOL, AMINOPHYLLINE, PENTAZOCINE, OXYMETAZOLINE, IVABRADINE, INDAPAMIDE, TROPICAMIDE, DESOXIMETASONE, ACARBOSE, AMOROLFINE, FOMEPIZOLE, DIOSMIN, AMYLMETA, CHLORDIAZEPOXIDE, TIOTROPIUM, ZILEUTON, LEVODOPA,
BEPOTASTINE, PROCHLORPERAZINE, TRIHEXYPHENIDYL, MEPYRAMINE, ILAPRAZOLE, SORAFENIB, ADRENALINE, FLUTAMIDE, CLIDINIUM, METHYLDOPA, ARTEMISININ, CAPSAICIN, UDENAFIL, ALMOTRIPTAN, LOMEFLOXACIN, FLUPHENAZINE, IMIDAPRIL, DEFERASIROX, LYNESTRENOL, ACRIFLAVINE, NORETHISTERONE,
METHYLEPHEDRINE, AZATHIOPRINE, IFOSFAMIDE, ACENOCOUMAROL, DIPYRIDAMOLE, CARPROFEN, FENTICONAZOLE, NYSTATIN, OXATOMIDE, CABERGOLINE, TAMOXIFEN, BUTAPHOSPHAN, CROTAMITON, CARBAMAZINE, TOLFENAMIC, DITHRANOL, DEFLAZACORT, VARDENAFIL, ETHACRYNIC, RACECADOTRIL, FENOFIBRIC,
CLORAMPHENICOL, ATRACURIUM, SIBUTRAMINE, NITROSCANATE, LEVOMEPROMAZINE, CEPHALOTHIN, NITRAZEPAM, PARGEVERINE, TELAPREVIR, DIFLORASONE, ECONAZOLE, PIVMECILLINAM, CARBINOXAMINE, NITROFURANTOIN, PIPERAQUINE, TOLMETIN, ZOFENOPRIL, FLUPIRTINE, STREPTOKINASE, RASAGILINE,
MIZOLASTINE, TIGECYCLINE, TEMOZOLOMIDE, METHYLCOBALAMINE, PROCYCLIDINE, RILUZOLE, LEVOSALBUTAMOL, ETHACRYNATE, TRIFLUOPERAZINE, LUBIPROSTONE, FAROPENEM, CHLORPROMAZINE, BITHIONOL, CARBIMAZOLE, OXANDROLONE, RESPERIDONE, TAPENTADOL, CARBOCISTEINE, CHLORPROPAMIDE,
PROPOFOL, TIBOLONE, TAZAROTENE, PIMOZIDE, PIRFENIDONE, DABIGATRAN, OXETACAINE, SERTACONAZOLE, CLORAZEPATE, FLUNITRAZEPAM, ALISKIREN, DIAZEPAM, BEVANTOLOL, GUAIACOL, SELEGILINE, DEXTROPROPOXYPHENE, ISOTRETINOIN, MILNACIPRAN, DOXEPIN, CALAMINE, EXEMESTANE, INDOMETHACIN,
AZACITIDINE, DEXIBUPROFEN, TRIAZOLAM, NILUTAMIDE, CYCLOPENTOLATE, ROFLUMILAST, BUTENAFINE, DOXAPRAM, CEFOPERZONE, DESMOPRESSIN, DEXTROSE, OXALIPLATIN, DEXTRAN, CHLORTALIDONE, FLURAZEPAM, TENOXICAM, RITODRINE, POSACONAZOLE, TERFENADINE, MEXILETINE, ETAMSYLATE,
GALACTOSIDASE, BORTEZOMIB, RIVAROXABAN, DROSPIRENONE, LYMECYCLINE, CHYMOTRYPSIN, HYDROTALCITE, AGOMELATINE, OPIPRAMOL, NEPAFENAC, ETOFYLLINE, PENICILLIN, SPIRONOLACTONE, DISULFIRAM, BENSERAZIDE, ISOCONAZOLE, CEFQUINOME, LEVONORGESTREL, TRIMEBUTINE, ZAFIRLUKAST,
POLICOSANOL, TICAGRELOR, DEXBROMPHENIRAMINE, NORMETHADONE, XYLOMETAZOLINE, NAPHAZOLINE, PROPIVERINE, KETEROLAC, SEVOFLURANE, BUFLOMEDIL, ETHYLESTRENOL, DIFLOXACIN, AZELNIDIPINE, ANALGIN, BROMFENAC, METOPIMAZINE, BOLDENONE, OXYPHENONIUM, ADEFOVIR, CEPHAPIRIN,
METAXALONE, CICLESONIDE, LEVOBUPIVACAINE, ETOPOSIDE, METHYLROSANILINIUM, DOBESILATE, DESVENLAFEXIN, FENOPROFEN, TERCONAZOLE, NEOSTIGMINE, BENZOINE, PHYTOMENADIONE, LOTEPREDNOL, TOBRAMYCIN, PRALIDOXIME, BIPYRIDINE, SUCRALFATE, CLOTIAZEPAM, PRAZOSIN, CLOBETASONE,
RILPIVIRINE, MOCLOBEMIDE, CARMOTEROL, FOSAMPRENAVIR, AZILSARTAN, GATIFLOXACINE, PAMIDRONATE, VARENICLINE, ALPRAZOLAM, DICYCLOVERINE, HPMCP, HEXETIDINE, ACAMPROSATE, MIFEPRISTONE, NAFTOPIDIL, ERDOSTEINE, TROSPIUM, PROGESTERONE, LEVOLEUCOVORIN, PAMIDRONIC, COLESEVELAM,
MECETRONIUM, PRANLUKAST, AZELASTINE, MOEXIPRIL, STEVIA, LURASIDONE, LAPATINIB, DOXORUBICIN, AMIKACIN, PALONOSETRON, DICYCLOMINE, PENTETRAZOL, CYPROTERONE, FENOXAZOLINE, GLUTARALDEHYDE, DALFAMPRIDINE, THALIDOMIDE, TETRAZEPAM, VIGABATRIN, VECURONIUM, ACEBUTOLOL, GLYCERYL
TRINITRATE, SULFASALAZINE, PROCARBAZINE, ILOPERIDONE, ESTRADIOL, CLOXAZOLAM, EZOGABINE, ETAFEDRINE, RALTEGRAVIR, DOPAMINE, MEPHENTERMINE, PAZOPANIB, METHENAMINE, EVEROLIMUS, PINAZEPAM, NORDAZEPAM, CYCLOPHOSPHAMIDE, NALOXONE, MARAVIROC, GEFITINIB, BENZTROPINE,
VINORELBINE, MERCAPTOPURINE, VOGLIBOSE, TEMSIROLIMUS, BIFONAZOLE, CLENBUTEROL, PIMECROLIMUS, BELLADONA, MIRABEGRON, ETIZOLAM, PRAZEPAM, DEXRABEPRAZOLE, NORETHINDRONE, PHENOBARBITONE, VILAZODONE, LOPRAZOLAM, CLONIDINE, LEUPROLIDE, LEUPRORELIN, HYDROXYUREA,
SILYMARIN, FLUCINOLONE, BUSPIRONE, PRULIFLOXACIN, CHLOROZOXAZONE, DIBUCAINE, ALOSETRON, PHLOROGLUCINOL, DESONIDE, XANTHINOL, ALMAGATE, ANIDULAFUNGIN, ALOGLIPTIN, EPIRUBICIN, FONDAPARINUX, OCTREOTIDE, ETHINYLESTRADIOL, ETOMIDATE, CEVIMELINE, RITUXIMAB, CISPLATIN, TIAGABINE,
NORGESTIMATE, CYTARABINE, METHOTREXATE, CISATRACURIUM, BLEOMYCIN, RIBAVIRIN, FLOROURACIL, FLUOROURACIL, TOPOTECAN, ARTEETHER, CASPOFUNGIN, PROCAINE, TETANUS, CALCIPOTRIENE, POLYGELINE, RIFABUTIN, ALFACALCIDOL, EPOPROSTENOL, LEVOTHYROXINE, GONADOTROPIN, SOMATOSTATIN,
NADOLOL, CARMUSTINE, ARGATROBAN, TRASTUZUMAB, DESOGESTREL, CEPHALOSPORINS, FILGRASTIM, TRAVOPROST, ECOTRIN, MITOMYCIN, BIMATOPROST, ERGOMETRINE, VINCRISTINE, DAUNORUBICIN, VINBLASTINE, FLUMAZENIL, STREPTOMYCIN, MITOXANTRONE, ACEMETACIN, PYRIDOSTIGMINE, BIAPENEM,
MELPHALAN, FENTANYL, FLUDARABINE, MEDROXYPROGESTERONE, ROFECOXIB, DACTINOMYCIN, DACARBAZINE, KETOTIFEN, CLADRIBINE, TEICOPLANIN, MORPHINE, BROMOCRIPTINE, LEVODROPROPIZINE, BOMHEXINE, CALCIPOTRIOL, CLOFARABINE, DEXMEDETOMIDINE, HYDROXYPROGESTERONE, TICARCILLIN,
CETUXIMAB, LOPAMIDOL, DIPYRONE, SUNITINIB, INTERFERON, NELFINAVIR, HYDROXOCOBALAMIN, TUBERCULIN, CHLORAMBUCIL, IDARUBICIN, CALCITONIN, AZTREONAM, EPERISONE, DECITABINE, PILOCARPINE, ERGOTAMINE, TERLIPRESSIN, DOMEPERIDONE, BUSULFAN, BENZPHETAMINE, LIOTHYRONINE,
ACTINOMYCIN, DOXERCALCIFEROL, MEGESTROL, OXAPROZIN, FINGOLIMOD, PANCURONIUM, FLUOROMETHOLONE, TRIPTORELIN, IXABEPILONE, GONADORELIN, LEVOSULPIRIDE, DASATINIB, ACITRETIN, DECARBAZINE, LIRAGLUTIDE, NICERGOLINE, BUSERELIN, CANDISARTAN, GADOPENTETIC ACID,, FULVESTRANT,
BALSALAZIDE, FORTIFIED PROCAINE, FLUDROCORTISONE, GOSERELIN, ESLICARBAZEPINE, LINAGLIPTIN, DINOPROSTONE, GLUCAGON, ETANERCEPT, SULPHACETAMIDE SODIUM, FRAMYCETIN, CETRORELIX, UROKINASE, ALCLOMETASONE, XYLAZINE, EPTIFIBATIDE, CEFTAROLINE, EXENATIDE, TOLVAPTAN, PHOLCODINE,
ABIRATERONE, FLUNISOLIDE, FLUCYTOSINE, NEFAZODONE, MOXONIDINE, MIGLITOL, COTININE, DAPTOMYCIN, BENFOTIAMINE, FELBINAC, BIVALIRUDIN, DIFLUPREDNATE, PLERIXAFOR, BENTHIAZIDE, ARFORMOTEROL, PRALATREXATE, REGADENOSON, TERIPARATIDE, QUINOLONE, PRAMOXINE, CANRENONE,
ACEPROMAZINE, ALITRETINOIN, ALPISARIN, ALVIMOPAN, AMCINONIDE, AMEZINIUM, AMINEPTINE, AMLEXANOX, AMTOLMETIN, ANDROSTANOLONE, APIXABAN, ATOSIBAN, AUREOFUNGIN, AVAFINIL, AXITINIB, BALOFLOXACIN, BAZEDOXIFENE, BENTAZEPAM, BENZIODARONE, BETALACTAMS, BEXAROTENE, BICIFADINE,
BICLOFEN, BIOLIMUS, BIRODONE, BIRONE, BISOXATIN, BLONASERIN, BOCEPREVIR, BOSVELIA, BTORPHANOL, BUTABARBITAL, BUTAFOSFAN, BUTALBITAL, BUTAMBEN, BUTORPHANOL, BUTRIPTYLINE, CABAZITAXEL, CALCITRIOL, CARBAPENEM, CEFCAPENE, CEFETAMET, CEFOTETAN, CEFOTIAM, CEFOZOPRAN,
CHLOROPYRAMINE, CIGLITAZONE, CILNIDIPINE, CINCHONINE, CLEBOPRIDE, CLEVIDIPINE, CLOFIBRATE, COCARBOXYLASE, CONIVAPTAN, DEFEROXAMINE, DEPRODONE, DESOXYCORTONE, DEXMETHYLPHENIDATE, DEXPRAMIPEXOLE, DIHYDROARTEMISININ, DIHYDROCODEINE, DIHYDROERGOCRISTINE,
DIHYDROERGOTAMINE, DIHYDROTESTOSTERONE, DIMETINDINE, DIPROFYLLINE, DOLASETRON, DROXIDOPA, EDARAVONE, EFONIDIPINE, ELVITEGRAVIR, EMBRAMINE, EMEDASTINE, ENFLURANE, ETHYLMORPHINE, ETHYNODIOL, ETIDRONATE, ETRAVIRINE, FENSPIRIDE, FENSPIRIDE, FLUINDIONE, FLUMETASONE, FLUNIXIN,
FUDOSTEINE, GADOBENATE, GLUFOSFAMIDE, HYDROCODONE, HYDROMORPHONE, HYDROXYAMPHETAMINE, IBUDILAST, ILOPROST, IMIDOCARB, INDACATEROL, ISRADIPINE, LAFUTIDINE, LEVAMLODIPINE, LEVOBETAXOLOL, LEVOCLOPERASTINE, LEVOMETHADONE, LEVOMETHAMPHETAMINE, LEVOSIMENDAN,
LEVOTHYROXINE SODIUM, LICOFELONE, LISDEXAMFETAMINE, LIXIVAPTAN, LORMETAZEPAM, MANIDIPINE, MAXACALCITOL, MECLIZINE HCL, MEPHENOXALONE, METHAMPHETAMINE, METHOHEXITAL, MILBEMYCIN, MITIGLINIDE, MIVACURIUM, MORNIFLUMATE, NAFTIFINE, NALFURAFINE, NAPROXCINOD, NIFEKALANT,
NISOLDIPINE, NOOTROPIC, NORELGESTROMIN, OLSALAZINE, ORMELOXIFENE, OSPEMIFENE, OTILONIUM, OXBUTYNIN, OXIRACETAM, OXOLINIC, OXOMEMAZINE, OXYCODONE, OXYTETRACYCLINE, PARAMETHASONE, PARECOXIB, PEMIROLAST, PENTAMIDINE, PERGOLIDE, PERPHENAZINE, PHTHALYLSULFATHIAZOLE,
PIDOTIMOD, PIRFENODINE, PREDNICARBATE, PROCAINAMIDE, PROPYLIODONE, PROTRIPTYLINE, PYRONARIDINE, RAMOSETRON, REBOXETINE, RETIGABINE, ROMIDEPSIN, ROSIGLITAZONE, SAFINAMIDE, SERATRODAST, SITAFLOXACIN, SPIRAPRIL, STANOLONE, SUGAMMADEX, TEBIPENEM, TEGAFUR, TEGASEROD,
TERIFLUNOMIDE, THEODRENALINE, THIOPROPERAZINE, THIOTEPA, TIAPROFENIC, TOFACITINIB, TOFISOPAM, TRANILAST, TREPROSTINIL, TRIFLUSAL , TROXERUTIN, TROXIPIDE, VALDECOXIB,
DETAILED ANALYSES of below APIs are
AVAILABLE
Thank
You
sunilzon@gmail.com

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Indian APIs (Active Pharmaceuticals Ingredients) Analysis

  • 1. Indian APIs (Active Pharmaceutical Ingredients) Analysis By Sunil Kumar (sunilzon@gmail.com)
  • 2. WORLD OF APIs • Globally there are over 7000 APIs are active in 2013 • Altogether APIs creates USD 120 billion world market • Which is 12% of world pharmaceuticals market • That is around USD 1000 billion • World market of APIs is growing at the rate of 8% • US is biggest market with around 45% share of the world market
  • 3. INDIAN APIs INDUSTRY • India has around 2300 APIs manufacturing units •Which produces around 1500 APIs •For domestic and International market •Indian APIs Industry is worth USD 9 billion in 2013 •Out of which USD 5 billion exported across the world •Rest USD 4 billion goes for formulation •Out of which USD 2 billion goes for the formulation for export •Rest USD 2 billion goes for domestic formulation manufacturing
  • 4. INDIAN APIs INDUSTRY: ASSUMPTIONS • The basis of the study is export data of APIs and formulations and articles published in different journals for the year 2012-13 • The export data suggest USD 5 billion worth APIs goes for export we assume the domestic consumption (for domestic and export formulation) is USD 4 billion or 80% of the export business • It must be noted that while USD 2 billion APIs results in USD 10 billion export of formulation while the same value of APIs creates USD 18-20 billion Indian domestic formulation markets
  • 5. INDIAN APIs INDUSTRY • Out of 1500 APIs produced in India around 1000 goes for export • Top 50 APIs contributes 50% of the industry • Top 100 APIs accounts for 70% of the industry • Top 200 APIs constitutes 85 % of the industry • Top 500 APIs represents 95% of the industry
  • 6. The TOP 500 APIs • Top 500 APIs accounts for 95% of business • But the study leaves some APIs which does more than USD 5 million in export of formulation like --- DIDANOSINE, MUPIROCIN, CYCLOSERINE, IPRATROPIUM, ZIPRASIDOE, WARFARINSODIUM, GENTAMICIN,BECLOMETHASONE, IRINOTECAN, ZONISAMIDE, MISOPROSTOL, INDAPAMIDE, AMYLMETACRESOL, LEVODOPA, ATRACURIUM, RILUZOLE, PROPOFOL, ISOTRETINOIN, OXALIPLATIN, LEVONORGESTREL, ZAFIRLUKAST, ALPRAZOLAM, TROSPIUMCHLORIDE, AZELASTINE, DOXORUBICIN, VECURONIUM, ESTRADIOL, NORETHINDRONE, FONDAPARINUX, ETOMIDATE, CEVIMELINE, OCTREOTIDE, ETHINYLESTRADIOL, RITUXIMAB, TIAGABINE, and NORGESTIMATE and
  • 7. THE MILLION DOLLAR CLUB • There are 430 APIs whose export is above USD 1 Million • The club represents 93% of the Industry • We further filter the list and leave APIs whose average price is below USD 25/kg and that leaves few major products whose export is considerable like---- NAPROXEN, SALICYLIC ACID, TRICLOSAN, ERYTHROMYCIN, RANITIDINE, POVIDONE IODINE, COTRIMOXAZOLE, CAFFEINE, DICLOFENAC, METRONIDAZOLE, PERMETHRIN, GUAIFENESIN, SULFAMETHOXAZOLE, NICOTINAMIDE, CHLORHEXIDINE, ACETAMINOPHEN, METFORMIN, NIACIN, GLYCINE, BENZYL CHLORIDE, CLOXACILLIN, ZINCOXIDE, AMPICILLIN, CALCIUM CARBONATE and ALUMINIUM HYDROXIDE
  • 8. THE MILLION DOLLAR CLUB… • Now we are left with 355 APIs for our analysis • Which represents around 75% of the industry • Further we eliminate the APIs whose export is less than 500 Kg • And that leaves some valued products like ROCURONIUM, TACROLIMUS, FIDAXOMICIN, ADAPALENE and SIROLIMUS • Now we are have left with 320 APIs which represents 70% of the industry • AND THAT IS THE BASIS OF INDIAN APIs ANALYSIS
  • 9. THERAUPEUTICAREAS/CATEGOREIS • ANTI-INFECTIVES • CARDIOVASCULAR & HEMATOPOIETIC SYSTEM • CENTRAL NERVOUS SYSTEM • ENDOCRINE & METABOLIC SYSTEM • GASTROINTESTINAL & HEPATOBILIARY SYSTEM • GENITO-URINARY SYSTEM • MUSCULO-SKELETAL SYSTEM • ONCOLOGY • RESPIRATORY SYSTEM • OTHERS: DERMATOLOGICALS, ALLERGY & AMMUNE SYSTEM, EAR & MOUTH/THROAT, EYE, HORMONES, NUTRITION, VITAMINS & MINERALS, ANAESTHETICS - LOCAL & GENERAL,VETERINARY DRUGS
  • 10. THERAPEUTIC SEGMENTS SHARE Therapeutica Areas Industry Share in % ANTI-INFECTIVES 32.65 CARDIOVASCULAR & HEMATOPOIETIC SYSTEM 23.48 CENTRAL NERVOUS SYSTEM 15.89 RESPIRATORY SYSTEM 8.53 GASTROINTESTINAL & HEPATOBILIARY SYSTEM 7.84 MUSCULO-SKELETAL SYSTEM 2.43 ONCOLOGY 2.14 GENITO-URINARY SYSTEM 1.8 ENDOCRINE & METABOLIC SYSTEM 1.65 OTHERS 3.59
  • 12. TOP 10 APIs Value in USD APIs Therapeutic Areas Export Indian Market Total Lowest Price/Kg CLOPIDOGREL CARDIOVASCULAR & HEMATOPOIETIC SYSTEM 113,127,772.16 90,502,217.73 203,629,989.89 61.83 ATORVASTATIN CARDIOVASCULAR & HEMATOPOIETIC SYSTEM 96,548,251.42 77,238,601.14 173,786,852.56 253.59 AMOXYCILLIN ANTI-INFECTIVES (SYSTEMIC) 91,257,244.93 73,005,795.94 164,263,040.87 24.13 CEFUROXIME ANTI-INFECTIVES (SYSTEMIC) 90,505,803.00 72,404,642.40 162,910,445.40 115.87 OMEPRAZOLE GASTROINTESTINAL & HEPATOBILIARY SYSTEM 89,885,147.35 71,908,117.88 161,793,265.23 60.00 CLARITHROMYCIN ANTI-INFECTIVES (SYSTEMIC) 79,722,899.15 63,778,319.32 143,501,218.47 123.43 DEXTROMETHORPHAN RESPIRATORY SYSTEM 78,454,335.24 62,763,468.19 141,217,803.43 148.67 CITALOPRAM CENTRAL NERVOUS SYSTEM 66,944,118.69 53,555,294.95 120,499,413.64 200.07 VALSARTAN CARDIOVASCULAR & HEMATOPOIETIC SYSTEM 63,634,936.37 50,907,949.10 114,542,885.47 142.05 CEFIXIME ANTI-INFECTIVES (SYSTEMIC) 61,014,383.99 48,811,507.19 109,825,891.18 126.53
  • 13. TOP 10 APIs: ANTI-INFECTIVES Value in USD APIs Sub-Therapeutic Areas Export Indian Market Total Lowest Price/Kg AMOXYCILLIN PENICILLINS 91,257,244.93 73,005,795.94 164,263,040.87 24.13 CEFUROXIME CEPHALOSPORINS 90,505,803.00 72,404,642.40 162,910,445.40 115.87 CLARITHROMYCIN MACROLIDES 79,722,899.15 63,778,319.32 143,501,218.47 123.43 CEFIXIME CEPHALOSPORINS 61,014,383.99 48,811,507.19 109,825,891.18 126.53 CEFACLOR CEPHALOSPORINS 53,948,395.96 43,158,716.77 97,107,112.73 166.12 TENOFOVIR ANTIVIRALS 53,807,425.50 43,045,940.40 96,853,365.90 332.19 CIPROFLOXACIN EAT ANTI-INFECTIVES & ANTISEPTICS, QUINOLONES, ANTIBACTERIAL COMBINATINS, ANTIDIARRHEALS 49,292,536.59 39,434,029.27 88,726,565.86 26.11 ACYCLOVIR ANTIVIRALS 48,339,569.79 38,671,655.83 87,011,225.62 41.41 CEFALEXIN CEPHALOSPORINS 37,070,819.21 29,656,655.37 66,727,474.58 44.23 VALACYCLOVIR ANTIVIRALS 36,327,195.31 29,061,756.25 65,388,951.56 192.21
  • 14. TOP 10 APIs: CARDIOVASCULAR & HEMATOPOIETIC SYSTEM Value in USD APIs Sub-Therapeutic Areas Export Indian Market Total Lowest Price/Kg CLOPIDOGREL ANTICOAGULANTS, ANTIPLATELETS & FIBRINOLYTICS (THROMBOLYTICS) 113,127,772.16 90,502,217.73 203,629,989.89 61.83 ATORVASTATIN DYSLIPIDAEMIC AGENTS 96,548,251.42 77,238,601.14 173,786,852.56 253.59 VALSARTAN ANGIOTENSIN II ANTAGONISTS 63,634,936.37 50,907,949.10 114,542,885.47 142.05 ROSUVASTATIN DYSLIPIDAEMIC AGENTS 56,931,747.75 45,545,398.20 102,477,145.95 949.16 LOSARTAN ANGIOTENSIN II ANTAGONISTS, 39,860,199.59 31,888,159.67 71,748,359.26 63.23 IRBESARTAN ANGIOTENSIN II ANTAGONISTS 37,130,963.40 29,704,770.72 66,835,734.12 156.25 LISINOPRIL ACE INHIBITORS/DIRECT RENIN INHIBITORS 30,279,107.60 24,223,286.08 54,502,393.68 249.48 AMLODIPINE CALCIUM ANTAGONISTS, ANTI-ANGINAL DRUGS, BETA- BLOCKERS, CALCIUM ANTAGONISTS, ACE INHIBITORS/DIRECT RENIN INHIBITORS 28,318,215.10 22,654,572.08 50,972,787.18 40.18 SIMVASTATIN DYSLIPIDAEMIC AGENTS 26,653,749.16 21,322,999.33 47,976,748.49 224.32 HEPARIN ANTICOAGULANTS, ANTIPLATELETS & FIBRINOLYTICS (THROMBOLYTICS) 23,381,921.67 18,705,537.34 42,087,459.01 1,547.23
  • 15. TOP 10 APIs: CENTRAL NERVOUS SYSTEM Value in USD APIs Sub-Therapeutic Areas Export Indian Market Total Lowest Price/Kg CITALOPRAM ANTIDEPRESSANTS 66,944,118.69 53,555,294.95 120,499,413.64 200.07 GABAPENTIN ANTICONVULSANTS, DRUGS FOR NEUROPATHIC PAIN 54,993,418.08 43,994,734.46 98,988,152.54 45.45 ESCITALOPRAM ANTIDEPRESSANTS 39,828,029.90 31,862,423.92 71,690,453.82 343.52 LEVETIRACETAM ANTICONVULSANTS 28,187,827.22 22,550,261.78 50,738,089.00 92.71 PAROXETINE ANTIDEPRESSANTS 27,170,240.25 21,736,192.20 48,906,432.45 405.00 SERTRALINE ANTIDEPRESSANTS 25,670,868.48 20,536,694.78 46,207,563.26 106.59 VENLAFAXINE ANXIOLYTICS,ANTIDEPRESSANTS 24,385,914.56 19,508,731.65 43,894,646.21 83.21 NABUMETONE NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) 22,697,951.63 18,158,361.30 40,856,312.93 54.11 TRAMADOL ANALGESICS (OPIOID) 20,228,926.97 16,183,141.58 36,412,068.55 32.78 OXCARBAZEPINE ANTICONVULSANTS 18,982,106.90 15,185,685.52 34,167,792.42 99.00
  • 16. TOP 10 APIs: RESPIRATORY SYSTEM Value in USD APIs Sub-Therapeutic Areas Export Indian Market Total Lowest Price/Kg DEXTROMETHORPHAN COUGH & COLD PREPARATIONS 78,454,335.24 62,763,468.19 141,217,803.43 148.67 MONTELUKAST ANTIASTHMATIC & COPD PREPARATIONS 57,727,967.21 46,182,373.77 103,910,340.98 854.27 LORATADINE NASAL DECONGESTANTS & OTHER NASAL PREPARATIONS 34,789,681.10 27,831,744.88 62,621,425.98 173.36 EPHEDRINE ANTI-OBESITY AGENTS 28,241,693.22 22,593,354.58 50,835,047.80 43.17 PSEUDOEPHEDRINE HCL COUGH & COLD PREPARATIONS 22,501,033.75 18,000,827.00 40,501,860.75 32.61 CODEINE COUGH & COLD PREPARATIONS 21,576,582.54 17,261,266.03 38,837,848.57 25.23 PHENIRAMINE ANTIHISTAMINES & ANTIALLERGICS 9,190,574.19 7,352,459.35 16,543,033.54 16.36 SALBUTAMOL 6,971,400.06 5,577,120.05 12,548,520.11 57.00 CHLORPHENIRAMINE 6,932,754.38 5,546,203.50 12,478,957.88 16.00 PHENYLEPHRINE 6,478,375.66 5,182,700.53 11,661,076.19 136.00
  • 17. TOP 10 APIs: GASTROINTESTINAL & HEPATOBILIARY SYSTEM Value in USD APIs Sub-Therapeutic Areas Export Indian Market Total Lowest Price/Kg OMEPRAZOLE ANTACIDS, ANTIREFLUX AGENTS & ANTIULCERANTS 89,885,147.35 71,908,117.88 161,793,265.23 60.00 PANTOPRAZOLE ANTACIDS, ANTIREFLUX AGENTS & ANTIULCERANTS 52,392,370.87 41,913,896.70 94,306,267.57 80.80 ESOMEPRAZOLE ANTACIDS, ANTIREFLUX AGENTS & ANTIULCERANTS 44,642,855.04 35,714,284.03 80,357,139.07 107.00 RABEPRAZOLE ANTACIDS, ANTIREFLUX AGENTS & ANTIULCERANTS 17,775,512.56 14,220,410.05 31,995,922.61 132.32 LANSOPRAZOLE ANTACIDS, ANTIREFLUX AGENTS & ANTIULCERANTS 17,028,016.31 13,622,413.05 30,650,429.36 17.15 RIFAXIMIN ANTIDIARRHEALS 11,994,127.81 9,595,302.25 21,589,430.06 298.18 HYOSCINE BUTYL BROMIDE ANTISPASMODICS 11,207,584.39 8,966,067.51 20,173,651.90 1,345.12 FAMOTIDINE 6,990,584.68 5,592,467.74 12,583,052.42 42.00 URSODIL 4,812,759.21 3,850,207.37 8,662,966.58 353.00 MEBEVERINE 3,739,520.53 2,991,616.42 6,731,136.95 60.00
  • 18. TOP 10 APIs: MUSCULO-SKELETAL SYSTEM Value in USD APIs Sub-Therapeutic Areas Export Indian Market Total Lowest Price/Kg THIOCOLCHICOSIDE MUSCLE RELAXANTS 21,028,203.84 16,822,563.07 37,850,766.91 6,783.67 ALLOPURINOL HYPERURICEMIA & GOUT PREPARATIONS 17,897,980.90 14,318,384.72 32,216,365.62 28.80 CARISOPRODOL MUSCLE RELAXANTS 11,290,349.93 9,032,279.94 20,322,629.87 23.49 IBANDRONATE 6,311,155.45 5,048,924.36 11,360,079.81 715.00 PHENYRAMIDOL 5,438,490.36 4,350,792.29 9,789,282.65 93.00 COLCHICINE 3,677,652.58 2,942,122.06 6,619,774.64 893.00 ALENDRONATE 3,320,521.22 2,656,416.98 5,976,938.20 38.00 DIACEREIN 3,201,306.61 2,561,045.29 5,762,351.90 295.00 CHLORZOXAZONE 2,538,904.74 2,031,123.79 4,570,028.53 14.00 TIZANIDINE 2,326,605.64 1,861,284.51 4,187,890.15 1,393.00
  • 19. TOP 5 APIs: ONCOLOGY Value in USD APIs Sub-Therapeutic Areas Export Indian Market Total Lowest Price/Kg GEMCITABINE CYTOTOXIC CHEMOTHERAPY 40,404,865.35 32,323,892.28 72,728,757.63 6,121.79 IMATINIB TARGETED CANCER THERAPY 23,389,730.10 18,711,784.08 42,101,514.18 1,455.35 CAPECITABINE 4,456,115.62 3,564,892.50 8,021,008.12 426.00 BICALUTAMIDE 4,239,622.78 3,391,698.22 7,631,321.00 738.00 MELOXICAM 3,306,640.18 2,645,312.14 5,951,952.32 73.00
  • 20. TOP 10 APIs: GENITO-URINARY SYSTEM Value in USD APIs Sub-Therapeutic Areas Export Indian Market Total Lowest Price/Kg MASULOSIN DRUGS FOR BLADDER & PROSTATE DISORDERS 11,190,244.56 8,952,195.65 20,142,440.21 1,169.32 TAMSULOSIN ACE INHIBITORS/DIRECT RENIN INHIBITORS 11,190,244.56 8,952,195.65 20,142,440.21 49.27 TRIMETHOPRIM URINARY TRACT INFECTIONS 10,594,664.06 8,475,731.25 19,070,395.31 22.65 SILDENAFIL 8,081,910.88 6,465,528.70 14,547,439.58 36.00 FINASTERIDE 7,480,116.68 5,984,093.34 13,464,210.02 2,986.00 PHENAZOPYRIDINE 3,614,695.29 2,891,756.23 6,506,451.52 32.00 PROBENECID 2,743,350.90 2,194,680.72 4,938,031.62 38.00 TOLTERODINE 2,643,803.47 2,115,042.78 4,758,846.25 494.00 CEFDITOREN 2,541,756.59 2,033,405.27 4,575,161.86 1,023.00 PENICILLAMINE 1,491,748.52 1,193,398.82 2,685,147.34 1,444.00
  • 21. TOP 10 APIs: ENDOCRINE & METABOLIC SYSTEM Value in USD APIs Sub-Therapeutic Areas Export Indian Market Total Lowest Price/Kg PIOGLITAZONE ANTIDIABETIC AGENTS 14,538,744.26 11,630,995.41 26,169,739.67 95.03 ORLISTAT ANTI-OBESITY AGENTS 11,925,939.75 9,540,751.80 21,466,691.55 740.00 GLIMEPIRIDE 6,605,904.37 5,284,723.50 11,890,627.87 335.00 GLICLAZIDE 4,369,257.44 3,495,405.95 7,864,663.39 131.00 REPAGLINIDE 4,009,591.01 3,207,672.81 7,217,263.82 2,728.00 NATEGLINIDE 3,828,042.01 3,062,433.61 6,890,475.62 435.00 GLIPIZIDE 3,200,115.21 2,560,092.17 5,760,207.38 187.00 SITAGLIPTIN 3,109,199.99 2,487,359.99 5,596,559.98 766.00 GLYBURIDE OR GLIBENCLAMIDE 3,103,533.66 2,482,826.93 5,586,360.59 31.00 RISEDRONATE SODIUM 1,979,262.61 1,583,410.09 3,562,672.70 643.00
  • 22. TOP 10 APIs: OTHERS Value in USD APIs Sub-Therapeutic Areas Export Indian Market Total Lowest Price/Kg TRICLABENDAZOLE VETERINARY DRUGS 10,569,294.98 8,455,435.98 19,024,730.96 59.98 DESLORATADINE ALLERGY & AMMUNE SYSTEM 8,374,530.38 6,699,624.30 15,074,154.68 311.56 BENZETHONIUM CHLORIDE DERMATOLOGICALS 8,174,060.42 6,539,248.34 14,713,308.76 30.00 DORZOLAMIDE EYE 7,612,650.70 6,090,120.56 13,702,771.26 3,974.00 HYDROCORTISONE HORMONES 6,676,926.25 5,341,541.00 12,018,467.25 820.00 RACTOPAMINE VETERINARY DRUGS 6,561,142.75 5,248,914.20 11,810,056.95 322.00 CLOBETASOL EYE 6,419,728.18 5,135,782.54 11,555,510.72 1,927.00 BETAMETHASONE EAR & MOUTH/THROAT 6,081,371.83 4,865,097.46 10,946,469.29 1,668.00 HYDROCORTISONE SODIUM SUCCINATE HORMONES 6,064,140.25 4,851,312.20 10,915,452.45 854.00 ARTICAINE ANAESTHETICS - LOCAL & GENERAL 5,906,888.76 4,725,511.01 10,632,399.77 182.00
  • 23. TOP 10 APIs: EXPORT> USD5 Mn, VLUE: USD 500 -1000/Kg Value in USD APIs Sub-Therapeutic Areas Export Indian Market Total Lowest Price/Kg MONTELUKAST RESPIRATORY SYSTEM 57,727,967.21 46,182,373.77 103,910,340.98 854.27 ROSUVASTATIN CARDIOVASCULAR & HEMATOPOIETIC SYSTEM 56,931,747.75 45,545,398.20 102,477,145.95 949.16 SUMATRIPTAN CENTRAL NERVOUS SYSTEM 15,899,307.92 12,719,446.34 28,618,754.26 779.37 FLUVASTATIN CARDIOVASCULAR & HEMATOPOIETIC SYSTEM 13,547,955.56 10,838,364.45 24,386,320.01 741.84 ORLISTAT ENDOCRINE & METABOLIC SYSTEM 11,925,939.75 9,540,751.80 21,466,691.55 740.00 LERCANIDIPINE CARDIOVASCULAR & HEMATOPOIETIC SYSTEM 11,387,619.57 9,110,095.66 20,497,715.23 952.57 LOPINAVIR ANTI-INFECTIVES (SYSTEMIC) 7,002,709.04 5,602,167.23 12,604,876.27 696.00 HYDROCORTISONE HORMONES 6,676,926.25 5,341,541.00 12,018,467.25 820.00 IBANDRONATE MUSCULO-SKELETAL SYSTEM 6,311,155.45 5,048,924.36 11,360,079.81 715.00 HYDROCORTISONE SODIUM SUCCINATE HORMONES 6,064,140.25 4,851,312.20 10,915,452.45 854.00
  • 24. TOP 10 APIs: Export > USD 5 Mn, VALUE: USD100-500/Kg Value in USD APIs Sub-Therapeutic Areas Export Indian Market Total Lowest Price/Kg ATORVASTATIN CARDIOVASCULAR & HEMATOPOIETIC SYSTEM 96,548,251.42 77,238,601.14 173,786,852.56 253.59 TENOFOVIR ANTI-INFECTIVES (SYSTEMIC) 53,807,425.50 43,045,940.40 96,853,365.90 332.19 ESCITALOPRAM CENTRAL NERVOUS SYSTEM 39,828,029.90 31,862,423.92 71,690,453.82 343.52 LISINOPRIL CARDIOVASCULAR & HEMATOPOIETIC SYSTEM 30,279,107.60 24,223,286.08 54,502,393.68 249.48 PAROXETINE CENTRAL NERVOUS SYSTEM 27,170,240.25 21,736,192.20 48,906,432.45 405.00 CEFDINIR ANTI-INFECTIVES (SYSTEMIC) 23,664,993.08 18,931,994.46 42,596,987.54 286.87 RAMIPRIL CARDIOVASCULAR & HEMATOPOIETIC SYSTEM 16,801,622.49 13,441,297.99 30,242,920.48 327.94 CEFPROZIL ANTI-INFECTIVES (SYSTEMIC) 14,618,836.07 11,695,068.86 26,313,904.93 401.82 RIFAXIMIN GASTROINTESTINAL & HEPATOBILIARY SYSTEM 11,994,127.81 9,595,302.25 21,589,430.06 298.18 ARTEMETHER ANTI-INFECTIVES (SYSTEMIC) 11,382,428.56 9,105,942.85 20,488,371.41 495.00
  • 25. TOP 10 APIs: BY VOLUME Value in USD APIs Therapeutic Areas Export Indian Market Total Lowest Price/Kg Export in MTS AMOXYCILLIN ANTI-INFECTIVES (SYSTEMIC) 91,257,244.93 73,005,795.94 164,263,040.87 24.13 3,140.774 OMEPRAZOLE GASTROINTESTINAL & HEPATOBILIARY SYSTEM 89,885,147.35 71,908,117.88 161,793,265.23 60.00 2,673.176 CIPROFLOXACIN ANTI-INFECTIVES (SYSTEMIC) 49,292,536.59 39,434,029.27 88,726,565.86 26.11 1,434.307 GABAPENTIN CENTRAL NERVOUS SYSTEM 54,993,418.08 43,994,734.46 98,988,152.54 45.45 1,023.985 AMLODIPINE CARDIOVASCULAR & HEMATOPOIETIC SYSTEM 28,318,215.10 22,654,572.08 50,972,787.18 40.18 763.721 CEFALEXIN ANTI-INFECTIVES (SYSTEMIC) 37,070,819.21 29,656,655.37 66,727,474.58 44.23 749.841 CODEINE RESPIRATORY SYSTEM 21,576,582.54 17,261,266.03 38,837,848.57 25.23 611.706 ATENOLOL CARDIOVASCULAR & HEMATOPOIETIC SYSTEM 15,481,607.22 12,385,285.78 27,866,893.00 17.92 587.789 TRAMADOL CENTRAL NERVOUS SYSTEM 20,228,926.97 16,183,141.58 36,412,068.55 32.78 524.087 CEFUROXIME ANTI-INFECTIVES (SYSTEMIC) 90,505,803.00 72,404,642.40 162,910,445.40 115.87 513.861
  • 26. TOP 10 APIs: BY VALUE Value in USD APIs Therapeutic Areas Export Indian Market Total Lowest Price/Kg CILAZAPRIL CARDIOVASCULAR & HEMATOPOIETIC SYSTEM 7,103,329.50 5,682,663.60 12,785,993.10 6,983.00 THIOCOLCHICOSIDE MUSCULO-SKELETAL SYSTEM 21,028,203.84 16,822,563.07 37,850,766.91 6,783.67 GEMCITABINE ONCOLOGY 40,404,865.35 32,323,892.28 72,728,757.63 6,121.79 VORICONAZOLE ANTI-INFECTIVES (SYSTEMIC) 6,869,564.74 5,495,651.79 12,365,216.53 4,393.00 DORZOLAMIDE EYE 7,612,650.70 6,090,120.56 13,702,771.26 3,974.00 DARUNAVIR ANTI-INFECTIVES (SYSTEMIC) 3,471,649.79 2,777,319.83 6,248,969.62 3,892.00 VALGANCICLOVIR ANTI-INFECTIVES (SYSTEMIC) 1,154,667.73 923,734.18 2,078,401.91 3,707.00 NEBIVOLOL CARDIOVASCULAR & HEMATOPOIETIC SYSTEM 22,545,134.58 18,036,107.66 40,581,242.24 3,686.07 RIVASTIGMINE CENTRAL NERVOUS SYSTEM 7,524,671.06 6,019,736.85 13,544,407.91 3,369.00 FINASTERIDE GENITO-URINARY SYSTEM 7,480,116.68 5,984,093.34 13,464,210.02 2,986.00
  • 27. CLOPIDOGREL, METFORMIN, ATORVASTATIN, AMOXYCILLIN, CEFUROXIME, OMEPRAZOLE, CLARITHROMYCIN, DEXTROMETHORPHAN, PARACETAMOL, CITALOPRAM, VALSARTAN, IBUPROFEN, CEFIXIME, MONTELUKAST, ROSUVASTATIN, GABAPENTIN, CEFACLOR, TENOFOVIR, PANTOPRAZOLE, CIPROFLOXACIN, ACYCLOVI, ESOMEPRAZOLE, RANITIDINE, PERMETHRIN, GEMCITABINE, LOSARTAN, ESCITALOPRAM, SULFAMETHOXAZOLE, IRBESARTAN, CEFALEXIN, VALACYCLOVIR, CLOXACILLIN, LORATADINE, ERYTHROMYCIN, AZITHROMYCIN, EFAVIRENZ, LISINOPRIL, AMLODIPINE, EPHEDRINE, LEVETIRACETAM, PAROXETINE, SIMVASTATIN, CEFPODOXIME, SERTRALINE, NAPROXEN, VENLAFAXINE, CEFDINIR, IMATINIB, ZIDOVUDINE, NABUMETONE, NEBIVOLOL, PSEUDOEPHEDRINE, DICLOFENAC, AMPICILLIN, THIOCOLCHICOSIDE, LAMIVUDINE, TRAMADOL, ACETAMINOPHEN, NICOTINAMIDE, NIACINAMIDE, EPROSARTAN, OXCARBAZEPINE, PREGABALIN, ALLOPURINOL, RABEPRAZOLE, PENTOXIFYLLINE, LANSOPRAZOLE, TRICLOSAN, RAMIPRIL, LEVOFLOXACIN, METOPROLOL, SUMATRIPTAN, CARVEDILOL, ROCURONIUM, METRONIDAZOLE, ATENOLOL, CEFTRIAXONE, CEFPROZIL, PIOGLITAZONE, TACROLIMUS, ETHAMBUTOL, QUETIAPINE, PERINDOPRIL, FLUVASTATIN, COTRIMOXAZOLE, TOPIRAMATE, ITRACONAZOLE, CHLOROQUINE, RIFAXIMIN, ORLISTAT, LAMOTRIGINE, MINOCYCLINE, GUAIFENESIN, CHLORHEXIDINE, MEROPENEM, LERCANIDIPINE, ARTEMETHER, MOXIFLOXACIN, CARISOPRODOL, KETOCONAZOLE, FLUCLOXACILLIN, TAMSULOSIN, FLUCONAZOLE, TRIMETHOPRIM, TRICLABENDAZOLE, FUROSEMIDE, TERBINAFINE, SALICYLIC ACID, DONEPEZIL, NIZATIDINE, GLUCOSAMINE, PHENIRAMINE, CHLOROTHIAZIDE, HYDROCHLOROTHIAZIDE, FLURBIPROFEN, FOSINOPRIL, CLINDAMYCIN, OXYCLOZANIDE, OLANZAPINE, DESLORATADINE, PRAZIQUANTEL, BENZETHONIUM, SILDENAFIL, CARBAMAZEPINE, DICLOXACILLIN, CARBIDOPA, DORZOLAMIDE, MIRTAZAPINE, RIVASTIGMINE, FINASTERIDE, HYDROXYCHLOROQUINE, LUMEFANTRINE, ALBENDAZOLE, KETOPROFEN, CILAZAPRIL, LOPINAVIR, FAMOTIDINE, SALBUTAMOL, RITONAVIR, MYCOPHENOLATE, CHLORPHENIRAMINE, VORICONAZOLE, RIZATRIPTAN, FRUSEMIDE, HYDROCORTISONE, LOVASTATIN, GLIMEPIRIDE, RACTOPAMINE, PHENYLEPHRINE, CLOBETASOL, IBANDRONATE, ATOVAQUONE, QUININE SULPHATE, CEFADROXIL, NEVIRAPINE, BETAMETHASONE, EMTRICITABINE, CEFTIOFUR, IOPAMIDOL, DILTIAZEM, ARTICAINE, FAMCICLOVIR, CHOLINE, FLECAINIDE, LINEZOLID, CILOSTAZOL, ZOLPIDEM, TRIMETAZIDINE, ANTHRANILIC, BISOPROLOL, AMITRIPTYLINE, PHENYRAMIDOL, GEMFIBROZIL, ENROFLOXACIN, OLMESARTAN, RISPERIDONE, BILASTINE, LABETALOL, MECLIZINE, MEBENDAZOLE, URSODIL, FLUOXETINE, RIBOFLAVIN, CHLORAMPHENICOL, RIFAMPICIN, AMBROXOL, AMIODARONE, FLUVOXAMINE, CAPECITABINE, AMODIAQUINE, GLICLAZIDE, DULOXETINE, BICALUTAMIDE, CEFOTAXIME, CETRIMIDE, TELMISARTAN, CEFEPIME, SALMETEROL, REPAGLINIDE, NORFLOXACIN, SULPHADIAZINE, PIPERACILLIN, BUTYLAMINE, NATEGLINIDE, ENALAPRIL, ADAPALENE, ONDANSETRON, NORTRIPTYLINE, ROXITHROMYCIN, SULTAMICILLIN, MEBEVERINE, COLCHICINE, CINNARIZINE, PHENAZOPYRIDINE, NIMESULIDE, VERAPAMIL, APREPITANT, CELECOXIB, DIMINAZENE, DARUNAVIR, METHOCARBAMOL, OXACILLIN, EBASTINE, PYRAZINAMIDE, DIVALPROEX, ALENDRONATE, MELOXICAM, MIDAZOLAM, EZETIMIB, THEOPHYLLINE, ETORICOXIB, DIACEREIN, GLIPIZIDE, MALATHION, MESALAZINE, SITAGLIPTIN, GLYBURIDE, GLIBENCLAMIDE, LIDOCAINE, GLIBENCLAMIDE, CLOMIPRAMINE, PACLITAXEL, ABACAVIR, CEFTIBUTEN, FIDAXOMICIN, ROPINIROLE, NITROXYNIL, SIROLIMUS, LEVOCETIRIZINE, NARATRIPTAN, PIPERAZINE, NITAZOXANIDE, CLOZAPIN, IMIQUIMOD, SULINDAC, OFLOXACIN, ASPIRIN, CEFAZOLIN, ZOLMITRIPTAN, TINIDAZOLE, PRAMIPEXOLE, DOXAZOSIN, ISOFLURANE, PROBENECID, ORPHENADRINE, LETROZOLE, ARTESUNATE, CHLORPHENESIN, DOXOFYLLINE, TOLTERODINE, BRINZOLAMIDE, DILOXANIDE, PROPRANOLOL, CEFDITOREN, CHLORZOXAZONE, CLORSULON, IRON SUCROSE, NICOTINE, TAZOBACTAM, ACETAZOLAMIDE, METOCLOPRAMIDE, SOTALOL, CEFTAZIDIME, DANAZOL, BROMHEXINE, CHOLECALCIFEROL, IMIPENEM, TRIPROLIDINE, TIZANIDINE, ZALTOPROFEN, ZOPICLONE, FOLIC ACID, ALCAFTADINE, BOSENTAN, ENTACAPONE, MESALAMINE, ACECLOFENAC, STAVUDINE, BIPERIDEN, FLUTICASONE, TERBUTALINE, DIPHENHYDRAMINE, ETHOPABATE, NALIDIXIC, ITOPRIDE, CEPHRADINE, RISEDRONATE, PHENAZONE, SULFADOXINE, CLONAZEPAM, DEXAMETHASONE, PROPYPHENAZONE, LOPERAMIDE, PINAVERIUM, MICONAZOLE, CILASTATIN, RAFOXANIDE, CYCLOBENZAPRINE, MODAFINIL, SULBACTAM, QUINFAMIDE, CARBOPLATIN, MOMETASONE, LOMUSTINE, PITOFENONE, ISONIAZID, METHYLPREDNISOLONE, PHENOBARBITAL, RALOXIFENE, KETAMINE, RESERPINE, PHENYTOIN, PROPAFENONE, MEMANTINE, PYRIMETHAMINE, BENAZEPRIL, BENZALKONIUM, ASENAPINE, HALOPERIDOL, ATAZANAVIR, BUPROPION, PROGUANIL, PENICILLAMINE, DEXCHLORPHENIRAMINE, DAPSONE, FENOFIBRATE, DEXLANSOPRAZOLE, MEFENAMIC, CYPROHEPTADINE, ISOSORBIDE MONONITRATE, PITAVASTATIN, TESTOSTERONE, AMPHOTERICIN, MEPHENESIN, SOLIFENACIN, PEMETREXED, TIMOLOL, PALIPERIDONE, IMIPRAMINE, TICLOPIDINE, CINACALCET, DORIPENEM, LEFLUNOMIDE, DIOXANE, GEMIFLOXACIN, ARIPIPRAZOLE, SEVELAMER, ENOXAPARIN, BUPARVAQUONE, ANASTROZOLE, TRIAMTERENE, TERPINEOL, BUDESONIDE, DEXKETOPROFEN, QUINAPRIL, YOHIMBINE, BENZBROMARONE, DIFLUNISAL, VALGANCICLOVIR, BISACODYL, LOXAPINE, CETRIZINE, TADALAFIL, DOXYCYCLINE, BACITRACIN, SAQUINAVIR, PROMETHAZINE, TRIAMCINOLONE, TOLPERISONE, NICLOSAMIDE, TERNIDAZOLE, ENTECAVIR, DUTASTERIDE, INDINAVIR, EPLERENONE, FELODIPINE, ROPIVACAINE, TORSEMIDE, TRAZODONE, BACLOFEN, OSELTAMIVIR, ETODOLAC, NALTREXON, GLYCOPYRROLATE, ZOLEDRONIC, NIFEDIPINE, BENZATHINE, CLOTRIMAZOLE, CLOSANTEL, MALEIC ACID, BACAMPICILLIN, AMILORIDE, FELBAMATE, BRIMONIDINE, HYDROXYZINE, PERAZINE, ATROPINE, DEFERIPRONE, OXYTOCIN, NEOMYCIN, MEPROBAMATE, BROMPHENIRAMINE, GLATIRAMER, CYANOCOBALAMIN, MORANTEL, CEFRADINE, PRIMIDONE, HOMATROPINE, BENZARONE, NICORANDIL, STRONTIUM, FENPIVERINIUM, VALPROIC ACID, BROMAZEPAM, AMOXAPINE, ASCORBIC ACID, FEBANTEL, PRAVASTATIN, DOTHIEPIN, FLUNARIZINE, SECNIDAZOLE, TOLDIMFOS, TRIMIPRAMINE, ISOMETAMEDIUM, ERTAPENEM, FENBENDAZOLE, FOSAPREPITANT, AMYLASE, RUFINAMIDE, TOLNAFTATE, PHENYLPROPANOLAMINE, MONOSULFIRAM, MOSAPRIDE, ATOMOXETINE, BETAXOLOL, CISAPRIDE, DROTAVERINE, CYCLOSPORINE, URSODEOXYCHOLIC, GALANTAMINE, ORNIDAZOLE, HYDROGEN PEROXIDE, NORPSEUDOEPHEDRINE, VANCOMYCIN, PREDNISOLONE, MENATETRENONE, DOCETAXEL, FORMOTEROL, OXANTEL, HYDRALAZINE, LEVOBUNOLOL, FLUORESCEIN, DIDANOSINE, PRILOCAINE, TIOCONAZOLE, CEFALONIUM, NAFCILLIN, PIROXICAM, ECABET, MYCOPHENOLIC ACID, FLUMEQUINE, METHADONE, CLOBAZAM, LEVALBUTEROL, BUCLIZINE, DOBUTAMINE, FEBUXOSTAT, BUPRENORPHINE, LANTHANUM, ERLOTINIB, OXFENDAZOLE, PYRANTEL, ALLYLESTRENOL, RAMELTEON, FOSPHENYTOIN, LORAZEPAM, METHYLPHENIDATE, DIGOXIN, RANOLAZINE, CLOMIPHENE, TRANDOLAPRIL, ESMOLOL, ACEFYLLINE, MUPIROCIN, BENDROFLUMETHIAZIDE, ACEBROPHYLLINE, NANDROLONE, AMISULPRIDE, BENZOCAINE, PRASUGREL, TOLBUTAMIDE, FLUOCINONIDE, FLAVOXATE, SPARFLOXACIN, TETRABENAZINE, CLOFAZIMINE, METHOXSALEN, GRISEOFULVIN, VILDAGLIPTIN, CLORPHENESIN, ISOXSUPRINE, CAMYLOFIN, DIMEGLUMINE, MEGLUMINE, PYRILAMINE, CYCLOSERINE, PRIMAQUINE, ADENINE, IPRATROPIUM, THIOPENTAL, CEFTIZOXIME, BAMBUTEROL, RESIDRONATE, MELITRACEN, TRIMETHOBENZAMIDE, PAMABROM, ALFUZOSIN, ZIPRASIDONE, DAPOXETINE, RICOBENDAZOLE, WARFARIN, MESNA, QUINAPYRAMINE, CEFPIROME, FROVATRIPTAN, GRANISETRON, PYRIDOXINE, ACETYLSALICYLIC, ELETRIPTAN, FESOTERODINE, FEXOFENADINE, GENTAMICIN, BESIFLOXACIN, OXYBUTYNIN, SILODOSIN, BUPIVACAINE, MEFLOQUINE, ARMODAFINIL, DRONEDARONE, OXAZEPAM, BENZYDAMINE, BRONOPOL, PICOSULPHATE, BECLOMETHASONE, DIMENHYDRINATE, MAGALDRATE, LENALIDOMIDE, BROMELAIN, ESZOPICLONE, OLOPATADINE, PHENYLBUTAZONE, CITICOLINE, ADENOSINE, DIPHENOXYLATE, LACIDIPINE, FLORFENICOL, TETRACAINE, CEFOXITIN, ROTIGOTINE, EPINASTINE, LACOSAMIDE, DARIFENACIN, TERAZOSIN, LATANOPROST, CHROMIUM, NITROUS, ZALEPLON, PROPANTHELINE, CINITAPRIDE, PEFLOXACIN, BENDAMUSTINE, EFLORNITHINE, LORNOXICAM, ROXARSONE, IRINOTECAN, XIPAMIDE, ZONISAMIDE, PENTOSAN, MISOPROSTOL, AMINOPHYLLINE, PENTAZOCINE, OXYMETAZOLINE, IVABRADINE, INDAPAMIDE, TROPICAMIDE, DESOXIMETASONE, ACARBOSE, AMOROLFINE, FOMEPIZOLE, DIOSMIN, AMYLMETA, CHLORDIAZEPOXIDE, TIOTROPIUM, ZILEUTON, LEVODOPA, BEPOTASTINE, PROCHLORPERAZINE, TRIHEXYPHENIDYL, MEPYRAMINE, ILAPRAZOLE, SORAFENIB, ADRENALINE, FLUTAMIDE, CLIDINIUM, METHYLDOPA, ARTEMISININ, CAPSAICIN, UDENAFIL, ALMOTRIPTAN, LOMEFLOXACIN, FLUPHENAZINE, IMIDAPRIL, DEFERASIROX, LYNESTRENOL, ACRIFLAVINE, NORETHISTERONE, METHYLEPHEDRINE, AZATHIOPRINE, IFOSFAMIDE, ACENOCOUMAROL, DIPYRIDAMOLE, CARPROFEN, FENTICONAZOLE, NYSTATIN, OXATOMIDE, CABERGOLINE, TAMOXIFEN, BUTAPHOSPHAN, CROTAMITON, CARBAMAZINE, TOLFENAMIC, DITHRANOL, DEFLAZACORT, VARDENAFIL, ETHACRYNIC, RACECADOTRIL, FENOFIBRIC, CLORAMPHENICOL, ATRACURIUM, SIBUTRAMINE, NITROSCANATE, LEVOMEPROMAZINE, CEPHALOTHIN, NITRAZEPAM, PARGEVERINE, TELAPREVIR, DIFLORASONE, ECONAZOLE, PIVMECILLINAM, CARBINOXAMINE, NITROFURANTOIN, PIPERAQUINE, TOLMETIN, ZOFENOPRIL, FLUPIRTINE, STREPTOKINASE, RASAGILINE, MIZOLASTINE, TIGECYCLINE, TEMOZOLOMIDE, METHYLCOBALAMINE, PROCYCLIDINE, RILUZOLE, LEVOSALBUTAMOL, ETHACRYNATE, TRIFLUOPERAZINE, LUBIPROSTONE, FAROPENEM, CHLORPROMAZINE, BITHIONOL, CARBIMAZOLE, OXANDROLONE, RESPERIDONE, TAPENTADOL, CARBOCISTEINE, CHLORPROPAMIDE, PROPOFOL, TIBOLONE, TAZAROTENE, PIMOZIDE, PIRFENIDONE, DABIGATRAN, OXETACAINE, SERTACONAZOLE, CLORAZEPATE, FLUNITRAZEPAM, ALISKIREN, DIAZEPAM, BEVANTOLOL, GUAIACOL, SELEGILINE, DEXTROPROPOXYPHENE, ISOTRETINOIN, MILNACIPRAN, DOXEPIN, CALAMINE, EXEMESTANE, INDOMETHACIN, AZACITIDINE, DEXIBUPROFEN, TRIAZOLAM, NILUTAMIDE, CYCLOPENTOLATE, ROFLUMILAST, BUTENAFINE, DOXAPRAM, CEFOPERZONE, DESMOPRESSIN, DEXTROSE, OXALIPLATIN, DEXTRAN, CHLORTALIDONE, FLURAZEPAM, TENOXICAM, RITODRINE, POSACONAZOLE, TERFENADINE, MEXILETINE, ETAMSYLATE, GALACTOSIDASE, BORTEZOMIB, RIVAROXABAN, DROSPIRENONE, LYMECYCLINE, CHYMOTRYPSIN, HYDROTALCITE, AGOMELATINE, OPIPRAMOL, NEPAFENAC, ETOFYLLINE, PENICILLIN, SPIRONOLACTONE, DISULFIRAM, BENSERAZIDE, ISOCONAZOLE, CEFQUINOME, LEVONORGESTREL, TRIMEBUTINE, ZAFIRLUKAST, POLICOSANOL, TICAGRELOR, DEXBROMPHENIRAMINE, NORMETHADONE, XYLOMETAZOLINE, NAPHAZOLINE, PROPIVERINE, KETEROLAC, SEVOFLURANE, BUFLOMEDIL, ETHYLESTRENOL, DIFLOXACIN, AZELNIDIPINE, ANALGIN, BROMFENAC, METOPIMAZINE, BOLDENONE, OXYPHENONIUM, ADEFOVIR, CEPHAPIRIN, METAXALONE, CICLESONIDE, LEVOBUPIVACAINE, ETOPOSIDE, METHYLROSANILINIUM, DOBESILATE, DESVENLAFEXIN, FENOPROFEN, TERCONAZOLE, NEOSTIGMINE, BENZOINE, PHYTOMENADIONE, LOTEPREDNOL, TOBRAMYCIN, PRALIDOXIME, BIPYRIDINE, SUCRALFATE, CLOTIAZEPAM, PRAZOSIN, CLOBETASONE, RILPIVIRINE, MOCLOBEMIDE, CARMOTEROL, FOSAMPRENAVIR, AZILSARTAN, GATIFLOXACINE, PAMIDRONATE, VARENICLINE, ALPRAZOLAM, DICYCLOVERINE, HPMCP, HEXETIDINE, ACAMPROSATE, MIFEPRISTONE, NAFTOPIDIL, ERDOSTEINE, TROSPIUM, PROGESTERONE, LEVOLEUCOVORIN, PAMIDRONIC, COLESEVELAM, MECETRONIUM, PRANLUKAST, AZELASTINE, MOEXIPRIL, STEVIA, LURASIDONE, LAPATINIB, DOXORUBICIN, AMIKACIN, PALONOSETRON, DICYCLOMINE, PENTETRAZOL, CYPROTERONE, FENOXAZOLINE, GLUTARALDEHYDE, DALFAMPRIDINE, THALIDOMIDE, TETRAZEPAM, VIGABATRIN, VECURONIUM, ACEBUTOLOL, GLYCERYL TRINITRATE, SULFASALAZINE, PROCARBAZINE, ILOPERIDONE, ESTRADIOL, CLOXAZOLAM, EZOGABINE, ETAFEDRINE, RALTEGRAVIR, DOPAMINE, MEPHENTERMINE, PAZOPANIB, METHENAMINE, EVEROLIMUS, PINAZEPAM, NORDAZEPAM, CYCLOPHOSPHAMIDE, NALOXONE, MARAVIROC, GEFITINIB, BENZTROPINE, VINORELBINE, MERCAPTOPURINE, VOGLIBOSE, TEMSIROLIMUS, BIFONAZOLE, CLENBUTEROL, PIMECROLIMUS, BELLADONA, MIRABEGRON, ETIZOLAM, PRAZEPAM, DEXRABEPRAZOLE, NORETHINDRONE, PHENOBARBITONE, VILAZODONE, LOPRAZOLAM, CLONIDINE, LEUPROLIDE, LEUPRORELIN, HYDROXYUREA, SILYMARIN, FLUCINOLONE, BUSPIRONE, PRULIFLOXACIN, CHLOROZOXAZONE, DIBUCAINE, ALOSETRON, PHLOROGLUCINOL, DESONIDE, XANTHINOL, ALMAGATE, ANIDULAFUNGIN, ALOGLIPTIN, EPIRUBICIN, FONDAPARINUX, OCTREOTIDE, ETHINYLESTRADIOL, ETOMIDATE, CEVIMELINE, RITUXIMAB, CISPLATIN, TIAGABINE, NORGESTIMATE, CYTARABINE, METHOTREXATE, CISATRACURIUM, BLEOMYCIN, RIBAVIRIN, FLOROURACIL, FLUOROURACIL, TOPOTECAN, ARTEETHER, CASPOFUNGIN, PROCAINE, TETANUS, CALCIPOTRIENE, POLYGELINE, RIFABUTIN, ALFACALCIDOL, EPOPROSTENOL, LEVOTHYROXINE, GONADOTROPIN, SOMATOSTATIN, NADOLOL, CARMUSTINE, ARGATROBAN, TRASTUZUMAB, DESOGESTREL, CEPHALOSPORINS, FILGRASTIM, TRAVOPROST, ECOTRIN, MITOMYCIN, BIMATOPROST, ERGOMETRINE, VINCRISTINE, DAUNORUBICIN, VINBLASTINE, FLUMAZENIL, STREPTOMYCIN, MITOXANTRONE, ACEMETACIN, PYRIDOSTIGMINE, BIAPENEM, MELPHALAN, FENTANYL, FLUDARABINE, MEDROXYPROGESTERONE, ROFECOXIB, DACTINOMYCIN, DACARBAZINE, KETOTIFEN, CLADRIBINE, TEICOPLANIN, MORPHINE, BROMOCRIPTINE, LEVODROPROPIZINE, BOMHEXINE, CALCIPOTRIOL, CLOFARABINE, DEXMEDETOMIDINE, HYDROXYPROGESTERONE, TICARCILLIN, CETUXIMAB, LOPAMIDOL, DIPYRONE, SUNITINIB, INTERFERON, NELFINAVIR, HYDROXOCOBALAMIN, TUBERCULIN, CHLORAMBUCIL, IDARUBICIN, CALCITONIN, AZTREONAM, EPERISONE, DECITABINE, PILOCARPINE, ERGOTAMINE, TERLIPRESSIN, DOMEPERIDONE, BUSULFAN, BENZPHETAMINE, LIOTHYRONINE, ACTINOMYCIN, DOXERCALCIFEROL, MEGESTROL, OXAPROZIN, FINGOLIMOD, PANCURONIUM, FLUOROMETHOLONE, TRIPTORELIN, IXABEPILONE, GONADORELIN, LEVOSULPIRIDE, DASATINIB, ACITRETIN, DECARBAZINE, LIRAGLUTIDE, NICERGOLINE, BUSERELIN, CANDISARTAN, GADOPENTETIC ACID,, FULVESTRANT, BALSALAZIDE, FORTIFIED PROCAINE, FLUDROCORTISONE, GOSERELIN, ESLICARBAZEPINE, LINAGLIPTIN, DINOPROSTONE, GLUCAGON, ETANERCEPT, SULPHACETAMIDE SODIUM, FRAMYCETIN, CETRORELIX, UROKINASE, ALCLOMETASONE, XYLAZINE, EPTIFIBATIDE, CEFTAROLINE, EXENATIDE, TOLVAPTAN, PHOLCODINE, ABIRATERONE, FLUNISOLIDE, FLUCYTOSINE, NEFAZODONE, MOXONIDINE, MIGLITOL, COTININE, DAPTOMYCIN, BENFOTIAMINE, FELBINAC, BIVALIRUDIN, DIFLUPREDNATE, PLERIXAFOR, BENTHIAZIDE, ARFORMOTEROL, PRALATREXATE, REGADENOSON, TERIPARATIDE, QUINOLONE, PRAMOXINE, CANRENONE, ACEPROMAZINE, ALITRETINOIN, ALPISARIN, ALVIMOPAN, AMCINONIDE, AMEZINIUM, AMINEPTINE, AMLEXANOX, AMTOLMETIN, ANDROSTANOLONE, APIXABAN, ATOSIBAN, AUREOFUNGIN, AVAFINIL, AXITINIB, BALOFLOXACIN, BAZEDOXIFENE, BENTAZEPAM, BENZIODARONE, BETALACTAMS, BEXAROTENE, BICIFADINE, BICLOFEN, BIOLIMUS, BIRODONE, BIRONE, BISOXATIN, BLONASERIN, BOCEPREVIR, BOSVELIA, BTORPHANOL, BUTABARBITAL, BUTAFOSFAN, BUTALBITAL, BUTAMBEN, BUTORPHANOL, BUTRIPTYLINE, CABAZITAXEL, CALCITRIOL, CARBAPENEM, CEFCAPENE, CEFETAMET, CEFOTETAN, CEFOTIAM, CEFOZOPRAN, CHLOROPYRAMINE, CIGLITAZONE, CILNIDIPINE, CINCHONINE, CLEBOPRIDE, CLEVIDIPINE, CLOFIBRATE, COCARBOXYLASE, CONIVAPTAN, DEFEROXAMINE, DEPRODONE, DESOXYCORTONE, DEXMETHYLPHENIDATE, DEXPRAMIPEXOLE, DIHYDROARTEMISININ, DIHYDROCODEINE, DIHYDROERGOCRISTINE, DIHYDROERGOTAMINE, DIHYDROTESTOSTERONE, DIMETINDINE, DIPROFYLLINE, DOLASETRON, DROXIDOPA, EDARAVONE, EFONIDIPINE, ELVITEGRAVIR, EMBRAMINE, EMEDASTINE, ENFLURANE, ETHYLMORPHINE, ETHYNODIOL, ETIDRONATE, ETRAVIRINE, FENSPIRIDE, FENSPIRIDE, FLUINDIONE, FLUMETASONE, FLUNIXIN, FUDOSTEINE, GADOBENATE, GLUFOSFAMIDE, HYDROCODONE, HYDROMORPHONE, HYDROXYAMPHETAMINE, IBUDILAST, ILOPROST, IMIDOCARB, INDACATEROL, ISRADIPINE, LAFUTIDINE, LEVAMLODIPINE, LEVOBETAXOLOL, LEVOCLOPERASTINE, LEVOMETHADONE, LEVOMETHAMPHETAMINE, LEVOSIMENDAN, LEVOTHYROXINE SODIUM, LICOFELONE, LISDEXAMFETAMINE, LIXIVAPTAN, LORMETAZEPAM, MANIDIPINE, MAXACALCITOL, MECLIZINE HCL, MEPHENOXALONE, METHAMPHETAMINE, METHOHEXITAL, MILBEMYCIN, MITIGLINIDE, MIVACURIUM, MORNIFLUMATE, NAFTIFINE, NALFURAFINE, NAPROXCINOD, NIFEKALANT, NISOLDIPINE, NOOTROPIC, NORELGESTROMIN, OLSALAZINE, ORMELOXIFENE, OSPEMIFENE, OTILONIUM, OXBUTYNIN, OXIRACETAM, OXOLINIC, OXOMEMAZINE, OXYCODONE, OXYTETRACYCLINE, PARAMETHASONE, PARECOXIB, PEMIROLAST, PENTAMIDINE, PERGOLIDE, PERPHENAZINE, PHTHALYLSULFATHIAZOLE, PIDOTIMOD, PIRFENODINE, PREDNICARBATE, PROCAINAMIDE, PROPYLIODONE, PROTRIPTYLINE, PYRONARIDINE, RAMOSETRON, REBOXETINE, RETIGABINE, ROMIDEPSIN, ROSIGLITAZONE, SAFINAMIDE, SERATRODAST, SITAFLOXACIN, SPIRAPRIL, STANOLONE, SUGAMMADEX, TEBIPENEM, TEGAFUR, TEGASEROD, TERIFLUNOMIDE, THEODRENALINE, THIOPROPERAZINE, THIOTEPA, TIAPROFENIC, TOFACITINIB, TOFISOPAM, TRANILAST, TREPROSTINIL, TRIFLUSAL , TROXERUTIN, TROXIPIDE, VALDECOXIB, DETAILED ANALYSES of below APIs are AVAILABLE