This document provides an overview of microbiology concepts including: 1) It lists common human pathogens and notes that 61% are zoonotic. 2) It discusses the office hours, labs, and lectures for a microbiology course. 3) It summarizes key discoveries and advances in microbiology, infectious disease, and molecular biology from the 18th century to present.

1. MICROBIOLOGY FALL 2011

2. Office Hrs. MW 11-12; STC 239 Tue 10-1; NEWDL 312 Independence Rd. Laboratory M/W 12-3 Lecture MW 3-4:15

3. Syllabus

5. Dasek et al. 2000

7. Wild Animals Involved in MPXV Transmission (USA, 2003) Gambian Giant Rat (Crycetomys sp.) Prairie Dog (Cynomis sp.)

8. Ghana TX WI IL * IA 15/4 09/04 Entry and Distribution Route of Crycetomys sp . and Cynomys sp. Involved in MPXV Outbreak (USA, 2003) Source: MMWR 52 (23), CDC, 2003. 15/4

9. Index case in Marshfield, 26 May 2003: Disseminated lesions.

10. Distribution of MPXV Cases in the USA WI IL IN OH KS MO Number of cases = 87 WI = 38 IN = 24 IL = 19 OH = 4 KS = 1 MO = 1 Source: MMWR 52 (23), CDC, 2003.

13. Microbiology

14. Microbiology

23. DISEASE Occurrence of Disease

33. Toxins – Exo and Endotoxins

52. Prokaryotes / Eukaryotes Size of cell 1-10 u m diameter 10-100 u m diameter Nucleus No nuclear membrane True nucleus Membrane bound organelles absent present Flagella 2 protein building blocks complex

53. Prokaryotes / Eukaryotes Glycocalyx Slime layer Absent Cell Wall Usually present Complex When present, simple Plasma membrane No CHO and lack sterols Sterols and CHO present Cytoplasm No cytoskeleton cytoskeleton

54. Prokaryotes / Eukaryotes Ribosomes Small size 70s Large 80s; small 70s Chromosome Circular, lacks histones Linear, with histones Cell division Binary fission mitosis Sexual reproduction No meiosis meiosis

98. E.M Pili on E. coli – N. gonorrhea

151. COMPARISON OF GRM+VE /GRM-VE CELL WALLS

160. FLUID MOSAIC MEMBRANE Davison & Danelli

166. Bacterial Chromosome