Plenary lecture of the XIV SBPMat Meeting, given by Prof. George Malliaras (École Nationale Supérieure des Mines de Saint-Étienne, France) on September 30, 2015, in Rio de Janeiro (Brazil).
3. Institut Mines‐Télécom
Outline
Introduction to neural interfacing
Why organics?
Conducting polymers yield new capabilities for neuroscience
• Recording single neurons without penetrating the brain
• Recording brain activity with high signal‐to‐noise ratio
• Stopping seizures (in vitro) with localized drug delivery
Ion transport in conducting polymers
Materials challenges ahead
Department of Bioelectronics – www.bel.emse.fr3
33. Institut Mines‐Télécom
Device model
Department of Bioelectronics – www.bel.emse.fr33
dx
V(x)
Vg
cd W dx
Rs
......
Q(x)
D.A. Bernards and G.G. Malliaras,
Adv. Funct. Mater. 17, 3538 (2008)
Ionic circuit
(electrochemistry)
Electronic circuit
(solid state physics)
-- -
-
-
+
+
-
+
- -
-
+
+
Gate Electrode
+
-
+
+
++
+ + +
+
+
SO3H SO3H SO3H SO3
H SO3
- SO3H SO3H SO3
H
S
O O
S
O O
S
O O
S
O O
S
O O
S
O O
S
O O
S
O O
+ *
48. Institut Mines‐Télécom Department of Bioelectronics – www.bel.emse.fr48
1 10 100 1000
0.01
0.1
1
10
e
(cm
2
/Vs)
C* (F/cm
3
)
+EG,GOPS
PEDOT:PSS
+EG,GOPS
P3HT‐SO
3‐
Recent New
High‐performer
(Iain McCulloch, Imperial)
0% EG
50% EG
5‐10% EG
μC* as the materials figure of merit
S
SO
O
O
* n
-
(C4H9)4N+
P3HT‐SO3
‐
(+EG +GOPS)
μC* = 7.2 F/cmVs
μ = 0.05 cm2/Vs
C* = 144 F/cm3
w/ M. Thelakkat,
U. Bayreuth
S. Inal, J. Rivnay, P. Leleux, M. Ferro, M. Ramuz, J.C. Brendel, M. Schmidt,
M. Thelakkat, and G.G. Malliaras, Adv. Mater. 26, 7450 (2014).
PEDOT:PSS
(+EG, +GOPS)
μC* = 128 F/cmVs
μ = 3.3 cm2/Vs
C* = 39 F/cm3
Such maps provide a way to
compare materials as potential
candidates in OECTs
56. Institut Mines‐Télécom
Acknowledgements
Neuroengineering team at BEL
Jonathan Rivnay, Sahika Inal, Mary Donahue, Marc Ferro,
Dimitris Koutsouras, Thomas Lonjaret, Ilke Uguz, Eloise
Bihar, Marcel Brändlein, Shahab Rezaei Mazinani, Jolien
Pas, Esma Ismailova
Colleagues @ BEL: Xenofon Strakosas, Roisin Owens
Institute of Systems Neuroscience
Animal research: Adam Williamson, Attila Kaszas,
Christophe Bernard
Clinical: Jean‐Michel Badier, Christian Benar
University of Linköping (Sweden)
Amanda Jonsson, Loig Kergoat, Daniel Simon, Magnus
Berggren
Microvitae Technologies
Pierre Leleux, Thierry Hervé
Other Collaborators
Dion Khodagholy, György Buzsáki (NYU), Michele Sessolo
(Valencia), Seiichi Takamatsu (AIST), Marc Ramuz (EMSE).
Department of Bioelectronics – www.bel.emse.fr56
For more information:
Department of Bioelectronics (BEL)