Security is a major concern in computer networking which faces increasing threats as the commercial Internet and related economies continue to grow. Virtualization technologies enabling scalable Cloud services pose further challenges to the security of computer infrastructures, demanding novel mechanisms combining the best-of-breed to counter certain types of attacks . Our work aims to explore advances in Cyber Threat Intelligence (CTI) in the context of Software Defined Networking (SDN) architectures. While CTI represents a recent approach to combat threats based on reliable sources, by sharing information and knowledge about computer criminal activities, SDN is a recent trend in architecting computer networks based on modularization and programmability principles. In this dissertation, we propose IntelFlow, an intelligent detection system for SDN that follows a proactive approach using OpenFlow to deploy countermeasures to the threats learned through a distributed intelligent plane. We show through a proof of concept implementation that the proposed system is capable of delivering a number of benefits in terms of effectiveness, altogether contributing to the security of modern computer network designs.