INHALATION PREPARATIONS ( AEROSOLS )
Defination :
Inahalation Preparation are liquid or solid dosage forms intended for administration as vapours or aerosols to the lung in order to obtain a local or systemic effect. They contain solution or dispersion of one or more active ingredients which may be dissolved or dispersed in a suitable vehicleThere are two types of Pressurized Metered Dose Inhalers :
1. Two phase system consisting of gas and liquid
2. Three phase system consisting of gas, liquid and solid or liquids.
STANDARD TESTS OR EVALUATION :
Pressurised Metered – Dose Preparation –
1) Description : It should comply with Specification of Products.
2) Content of active ingredient delivered per actuation : Shall Comply with the specification.
3) Uniformity of delivered dose : The preparation complies with the test if 9 out of 10 results lie between 75 to 125 % of the average value and all lie between 65 to 135 % . If 2 or 3 values lies out side the limits of 75 – 125 %. Repeat the tests for two more inhalers. Not more than 3 of 30 values lie out side the limits of 65 – 135 %.
4) Particle size :
The number of pariticles longer than 20 micron meter dosent exceed 50 and no particles exceeds 100 micron meter in length.
5) Number of deliveries per containers : The number of deliveries so discharged in the test for particles size is not less than the number stated on label.
6) Deposition of emitted dose : as per IP or the specification.
7) Leak Test :
A average leakage rate of the 12 containers should not more than 3.5 % of the net fill weigh per container and none of the containers leaks more than 5 % of the net fill weight per yearPOWDER FOR INHALATION :
Powder for Inhalation are presented as single dose powders or multi dose powders. For pre- metered inhaler, the inhaler is loaded with powders pre- dispensed in capsules or other suitable pharmaceutical dosage form.
1) Description : It should comply with Specification of products.
2) Uniformity of delivered dose : The Preparation complies with the test if 9 out of 10 results lies between 75 – 125 % of the average value and all lie between 65 - 135 % . If 2 or 3 value lies out side the limits of 75 -125 % . repeat the test for two more inhalers. Not more than 3 of the 30 values lies out side the limits of 65 – 135 %,
3) Uniformity of content : As given in capsules.
4) Number of deliveries per container : The number of deliveries so discharged in the test for particles size is not less than the number started on label
Parenterals are the sterile preparation that is directly administered into the circulatory system avoiding the enteral route. And these preparation provide rapid onset of action that is why the administered preparation must be safe.
Stability problem arise from microbial contamination of these products so sterility and stability must be ensured for these preparations.
To ensure their sterility and stability, regulations regarding to quality control through pharmacopeial specifications has great importance.
Pharmaceutical aerosols have been playing a crucial role in the health and wellbeing of millions of people throughout the world for many years. These products include pressurized metered dose inhalers (MDIs), dry powder inhalers (DPIs), nebulizers, sublingual’s, skin sprays (coolants, anaesthetics, etc.) and dental sprays. The technology’s continual advancement, the ease of use, and the more desirable pulmonary-rather-than-needle delivery for systemic drugs has increased the attraction for the pharmaceutical aerosol in recent years.
Many of the tests required for the evaluation of MDIs are similar to those used for other dosage forms. These include description, identification, and assay of the active ingredient; microbial limits; moisture content; net weight, degradation products and impurities (if any); extractable; and any other tests deemed appropriate for the active ingredient.
Parenterals are the sterile preparation that is directly administered into the circulatory system avoiding the enteral route. And these preparation provide rapid onset of action that is why the administered preparation must be safe.
Stability problem arise from microbial contamination of these products so sterility and stability must be ensured for these preparations.
To ensure their sterility and stability, regulations regarding to quality control through pharmacopeial specifications has great importance.
Pharmaceutical aerosols have been playing a crucial role in the health and wellbeing of millions of people throughout the world for many years. These products include pressurized metered dose inhalers (MDIs), dry powder inhalers (DPIs), nebulizers, sublingual’s, skin sprays (coolants, anaesthetics, etc.) and dental sprays. The technology’s continual advancement, the ease of use, and the more desirable pulmonary-rather-than-needle delivery for systemic drugs has increased the attraction for the pharmaceutical aerosol in recent years.
Many of the tests required for the evaluation of MDIs are similar to those used for other dosage forms. These include description, identification, and assay of the active ingredient; microbial limits; moisture content; net weight, degradation products and impurities (if any); extractable; and any other tests deemed appropriate for the active ingredient.
University Institute of Pharmaceutical Sciences is a flag bearer of excellence in Pharmaceutical education and research in the country. Here is another initiative to make study material available to everyone worldwide. Based on the new PCI guidelines and syllabus here we have a presentation dealing with the types of containers and closure systems which are up to par with all the parameters defined by pharmacopoeias for parenterals.
Thank you for reading.
Hope it was of help to you.
UIPS,PU team
These defects can cause serious injury and harm. When this occurs, you should speak with our product liability attorneys in Denver. You may have a viable claim to file a product liability lawsuit against the negligent manufacturer.Capsules are solid dosage forms in which the drug substance is enclosed within either a hard or soft soluble shell. Generally the shells are formed from gelatin. The capsule may be regarded as “container” drug delivery system, which provides a tasteless/odorless dosage form without the need of a secondary coating step, as may be required for tablets.Capsules are one of the essential components of the pharmaceutical sector. They are mainly used to hold dry powder or little pellets of medication and are made using specific machinery and techniques. The capsule's production method entails pharmaceutically active ingredients, additives, and a cover. Every pharmaceutical business understands capsule manufacturing takes time, and the reason is the critical measures.
I Omkar B. Tipugade , M-Pharm, Sem 4th , Department of Pharmaceutics , Shree Santkrupa College Of Pharmacy, Ghogaon. Today I published the hard gelatin & Soft Gelatin Capsule in brief .
Expt. 5 Bioassay of oxytocin using rat uterine horn by interpolation methodVISHALJADHAV100
Objective
Principle
Requirements
Experimental specifications (conditions)
Preparation of oxytocin standard solution
Preparation of De Jalon solution (PSS)
Procedure
Kymograph recording of contractions
Observation table
Graphical presentation of DRC
Calculation
Result and interpretation
University Institute of Pharmaceutical Sciences is a flag bearer of excellence in Pharmaceutical education and research in the country. Here is another initiative to make study material available to everyone worldwide. Based on the new PCI guidelines and syllabus here we have a presentation dealing with the types of parenteral formulation including the types of parenteral route for administration along withcomponents of parenteral formulation.
Thank you for reading.
Hope it was of help to you.
UIPS,PU team
These are the sterile preparation intended to administered other than intestinal route to bypass first pass metabolism and directly goes to systemic circulation.
These preparation give quick onset of action and site specific activity.
Suitable for drugs which are inactive in GIT environment.
Can be given unconscious or vomiting or diarrheal patient.
These are the sterile preparation intended to administered other than intestinal route to bypass first pass metabolism and directly goes to systemic circulation.
These preparation give quick onset of action and site specific activity.
Suitable for drugs which are inactive in GIT environment.
Can be given unconscious or vomiting or diarrheal patient.
University Institute of Pharmaceutical Sciences is a flag bearer of excellence in Pharmaceutical education and research in the country. Here is another initiative to make study material available to everyone worldwide. Based on the new PCI guidelines and syllabus here we have a presentation dealing with the types of containers and closure systems which are up to par with all the parameters defined by pharmacopoeias for parenterals.
Thank you for reading.
Hope it was of help to you.
UIPS,PU team
These defects can cause serious injury and harm. When this occurs, you should speak with our product liability attorneys in Denver. You may have a viable claim to file a product liability lawsuit against the negligent manufacturer.Capsules are solid dosage forms in which the drug substance is enclosed within either a hard or soft soluble shell. Generally the shells are formed from gelatin. The capsule may be regarded as “container” drug delivery system, which provides a tasteless/odorless dosage form without the need of a secondary coating step, as may be required for tablets.Capsules are one of the essential components of the pharmaceutical sector. They are mainly used to hold dry powder or little pellets of medication and are made using specific machinery and techniques. The capsule's production method entails pharmaceutically active ingredients, additives, and a cover. Every pharmaceutical business understands capsule manufacturing takes time, and the reason is the critical measures.
I Omkar B. Tipugade , M-Pharm, Sem 4th , Department of Pharmaceutics , Shree Santkrupa College Of Pharmacy, Ghogaon. Today I published the hard gelatin & Soft Gelatin Capsule in brief .
Expt. 5 Bioassay of oxytocin using rat uterine horn by interpolation methodVISHALJADHAV100
Objective
Principle
Requirements
Experimental specifications (conditions)
Preparation of oxytocin standard solution
Preparation of De Jalon solution (PSS)
Procedure
Kymograph recording of contractions
Observation table
Graphical presentation of DRC
Calculation
Result and interpretation
University Institute of Pharmaceutical Sciences is a flag bearer of excellence in Pharmaceutical education and research in the country. Here is another initiative to make study material available to everyone worldwide. Based on the new PCI guidelines and syllabus here we have a presentation dealing with the types of parenteral formulation including the types of parenteral route for administration along withcomponents of parenteral formulation.
Thank you for reading.
Hope it was of help to you.
UIPS,PU team
These are the sterile preparation intended to administered other than intestinal route to bypass first pass metabolism and directly goes to systemic circulation.
These preparation give quick onset of action and site specific activity.
Suitable for drugs which are inactive in GIT environment.
Can be given unconscious or vomiting or diarrheal patient.
These are the sterile preparation intended to administered other than intestinal route to bypass first pass metabolism and directly goes to systemic circulation.
These preparation give quick onset of action and site specific activity.
Suitable for drugs which are inactive in GIT environment.
Can be given unconscious or vomiting or diarrheal patient.
Ipqc tests for sterile formulations are as follows :
Leakage Test
Clarity Test
pH
Particulate Matter Injection
SterilityTest
Pyrogen Test
Content Uniformity & Weight
Volume Filled
The tests For Sterile products are as per IP, BP & USP
Sterility Testing is defined as a testing which confirms that products are free from the presence of viable microorganisms. Sterility testing is very important for medical devices, pharmaceuticals, preparations, tissue materials and other materials that claim to be sterile or free from viable microorganisms.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Honest Reviews of Tim Han LMA Course Program.pptxtimhan337
Personal development courses are widely available today, with each one promising life-changing outcomes. Tim Han’s Life Mastery Achievers (LMA) Course has drawn a lot of interest. In addition to offering my frank assessment of Success Insider’s LMA Course, this piece examines the course’s effects via a variety of Tim Han LMA course reviews and Success Insider comments.
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
Francesca Gottschalk - How can education support child empowerment.pptxEduSkills OECD
Francesca Gottschalk from the OECD’s Centre for Educational Research and Innovation presents at the Ask an Expert Webinar: How can education support child empowerment?
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
CLASS 11 CBSE B.St Project AIDS TO TRADE - INSURANCE
Inhalation preparation
1. Presented By :
Mr.Traymbak S. Shinde
M. Pharm ( second year )
INHALATION PREPARATIONS
( AEROSOLS )
&
POWDER FOR INHALATION :
1
2. 2
INHALATION PREPARATIONS ( AEROSOLS )
Defination :
Inahalation Preparation are liquid or solid dosage forms intended for administration as
vapours or aerosols to the lung in order to obtain a local or systemic effect. They contain
solution or dispersion of one or more active ingredients which may be dissolved or
dispersed in a suitable vehicle.
Inhalation preparation intended to be administered as aerosol ( dispersion of solid or
liquid particles of active ingredient in a gas ) are administered by pressurized metered –
dose inhaler or by powder inhalers.
Pressurised Metered Dose inhalers are dosage form containing therapeutically acitive
ingredients that are packed under pressure in a sealed container and are released as a fine
mist of spray up on actuation of a suitable valve system.
3. 3
There are two types of Pressurized Metered Dose Inhalers :
1. Two phase system consisting of gas and liquid
2. Three phase system consisting of gas, liquid and solid or liquids.
STANDARD TESTS OR EVALUATION :
Pressurised Metered – Dose Preparation –
1) Description : It should comply with Specification of Products.
2) Content of active ingredient delivered per actuation : Shall Comply with the
specification.
3) Uniformity of delivered dose : The preparation complies with the test if 9 out of 10
results lie between 75 to 125 % of the average value and all lie between 65 to 135 % . If
2 or 3 values lies out side the limits of 75 – 125 %. Repeat the tests for two more
inhalers. Not more than 3 of 30 values lie out side the limits of 65 – 135 %.
4. 4
4) Particle size :
The number of pariticles longer than 20 micron meter dosent exceed 50 and no particles
exceeds 100 micron meter in length.
5) Number of deliveries per containers :
The number of deliveries so discharged in the test for particles size is
not less than the number stated on label.
6) Deposition of emitted dose : as per IP or the specification.
7) Leak Test :
A average leakage rate of the 12 containers should not more than 3.5 % of the
net fill weigh per container and none of the containers leaks more than 5 % of the net
fill weight per year.
5. 5
POWDER FOR INHALATION :
Powder for Inhalation are presented as single dose powders or multi dose powders. For
pre- metered inhaler, the inhaler is loaded with powders pre- dispensed in capsules or
other suitable pharmaceutical dosage form.
1) Description : It should comply with Specification of products.
2) Uniformity of delivered dose : The Preparation complies with the test if 9 out of 10
results lies between 75 – 125 % of the average value and all lie between 65 - 135 % .
If 2 or 3 value lies out side the limits of 75 -125 % . repeat the test for two more
inhalers. Not more than 3 of the 30 values lies out side the limits of 65 – 135 %,
3) Uniformity of content : As given in capsules.
4) Number of deliveries per container : The number of deliveries so discharged in the
test for particles size is not less than the number started on label.
6. 6
5) Microbial contamination : Total viable aerobic bacterial count shall be not more
than 100 CFU per g of the powder.
E.coli – absent in 10 g of the powder.
Salmonella- absent in a 50 g of the powder.
S.Aereus – absent in 10g of the powder.
P. aeruginossa – absent in 10 g the powder.
