1. The document discusses intracranial pressure (ICP), cerebrospinal fluid (CSF) circulation and compensation mechanisms when ICP increases. It defines normal ICP and the factors that affect it, including the Monro-Kellie doctrine.
2. Symptoms of increased ICP are described, from early signs like headache to late signs like herniation and changes in vital signs. Different types of herniation are explained.
3. Methods for monitoring ICP are summarized, including invasive techniques like intraventricular and subdural monitors and non-invasive options. Indications for ICP monitoring include severe head injuries with abnormal CT scans or certain risk factors.
Intracerebral hemorhage Diagnosis and managementRamesh Babu
About ICH - Diagnosis and management, Discussed the clinical presentation, evaluation, radiological features and management including recent guidelines
Intracerebral hemorhage Diagnosis and managementRamesh Babu
About ICH - Diagnosis and management, Discussed the clinical presentation, evaluation, radiological features and management including recent guidelines
Craniotomy
A craniotomy involves making an incision in the scalp and creating a hole known as a bone flap in the skull. The hole and incision are made near the area of the brain being treated.
During open brain surgery, it is done to remove tumors, clip off an aneurysm, drain blood or fluid from an infection & remove abnormal brain tissue
Decompressive craniectomy
It is a neurosurgical procedure in which part of the skull is removed to allow a swelling brain room to expand without being squeezed. It is performed on victims of traumatic brain injury, stroke and other conditions associated with raised intracranial pressure.
Increased intracranial pressure is defined as cerebrospinal fluid pressure greater than 15 mm Hg.
Infections
Tumors
Stroke
Aneurysm
Epilepsy
Seizures
Hydrocephalus
Hypertensive brain injury
Hypoxemia
Meningitis
Due to etiological factors
Components of ICP is disturbed- brain tissue, CSF, blood volume
An increase in the volume of ANY ONE component must be accompanied by a reciprocal decrease in one of the other components.
When this volume-pressure relationship becomes unbalanced, ICP increases.
Craniotomy
A craniotomy involves making an incision in the scalp and creating a hole known as a bone flap in the skull. The hole and incision are made near the area of the brain being treated.
During open brain surgery, it is done to remove tumors, clip off an aneurysm, drain blood or fluid from an infection & remove abnormal brain tissue
Decompressive craniectomy
It is a neurosurgical procedure in which part of the skull is removed to allow a swelling brain room to expand without being squeezed. It is performed on victims of traumatic brain injury, stroke and other conditions associated with raised intracranial pressure.
Increased intracranial pressure is defined as cerebrospinal fluid pressure greater than 15 mm Hg.
Infections
Tumors
Stroke
Aneurysm
Epilepsy
Seizures
Hydrocephalus
Hypertensive brain injury
Hypoxemia
Meningitis
Due to etiological factors
Components of ICP is disturbed- brain tissue, CSF, blood volume
An increase in the volume of ANY ONE component must be accompanied by a reciprocal decrease in one of the other components.
When this volume-pressure relationship becomes unbalanced, ICP increases.
hydrocephalus, clinical features in various age groups, investigations, treatment options to create a basic understanding of the underlying pathology and management
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2.
Def: CSF is a clear, colorless body fluid found in the
brain and spine.
Secretion Absorption
Any obstruction to the flow will lead to increase ICP
2
Anatomy
6. 1. Sum of the intracranial volumes of blood, brain, CSF, and other
components (for example, tumour, haematoma) is constant.
2. The skull is considered as an enclosed and inelastic container.
An increase in the volume of any one of the intracranial
contents must be offset by a decrease in one or more of the
others or be associated with a rise in ICP.
3. Intracranial blood (especially in the venous compartment)
and CSF are the two components whose volume can adapt most
easily to accommodate an increase in the volume
of intracranial contents.2
6
Monro-Kellie doctrine
8.
Pressure Normally 0-140 mm CSF (0-10 mm Hg
N.B: (Children 3-7 ,Term infants 1.5-6)
There are normal regular waves due to pulse and
respiration
With increased pressure “pressure waves” appear
volume : Average intracranial volume = 1700 ml
1. Brain (80%) = 1400 ml
2. Blood (10%) = 150 ml
3. CSF (10%) = 150 ml
8
Normal ICP
10.
COMPENSATORY MECHANISMS FOR
EXPANDING MASSES:
Immediate
Decrease in CSF volume by movement of fluid to the lumbar
area.
Decrease in the blood volume by squeezing blood out of sinuses
Delayed
Decrease in the extra-cellular fluid.
10
COMPENSATORY
MECHANISMS
11.
WHEN COMPENSATORY MECHANISMS FAIL;
Pathology OCCURS:
Brain Oedema
Brain Herniation
Ischemia if CPP (< 30-40 mm Hg)
N.B: After head injury cerebral blood flow depends on SYSTOLIC BP
(Stress)
N.B: The ICP finally rises to the level of arterial pressure which it self begins
to increase, accompanied by bradycardia or other disturbances of heart rhythm
(Cushing response).
COMPENSATORY
MECHANISMS FAIL
11
13. 13
Localised
mass lesions
Traumatic
haematomas
Neoplasms
Abscess
Focal oedema secondary to
trauma, infarction, tumour
Disturbance of
CSF
circulation
Obstructive
hydrocephalus
Communicating
hydrocephalus
Obstruction to
major venous
sinuses
Depressed
fractures
overlying major
venous sinuses
Cerebral venous
thrombosis
Diffuse brain
oedema or
swelling
Encephalitis,
meningitis, diffuse
head injury,
subarachnoid
haemorrhage, Reye’s
syndrome, lead
encephalopathy, water
intoxication, near
drowning
Idiopathic
Benign
intracranial
hypertension
14. There is no consistent relation between the severity of symptoms
and the degree of hypertension.
A) Headache : (Traction on vessels + Compression on dura)
characteristics:
1. Throbbing or bursting .
2. Worse in the morning
3. Exacerbated by any factors that further increase ICP (ex:
coughing, sneezing, or exertion)
4. Relived by vomiting & analgesia.
B)Visual Disturbance
C) Projectile vomiting
Clinical Presentation
16.
16
Herniation of
intracerebral contents
•Uncal: most frequently noted herniation
Results in ipsilateral pupil dilatation, decreased level of consciousness, changes in
respiratory patterns, respiratory arrest, and contralateral hemiplegia
•Subfalcine which results in affection of the ACA leading to contralateral leg weakness
Supratentorial herniation
•Results in loss of consciousness, small reactive pupils advancing to fixed/dilated
pupils, respiratory changes leading to respiratory arrest and decorticate posturing
advancing to flacidity
Central/Transtentorial herniation
•Tonsillar: As a result of a downward herniation the medula oblongata is compressed
and displaced causing respiratory and cardiac arrest
Infratentorial herniation
17. Early signs Late signs
A) Headache : : increasing
with projectile vomiting
A) Headache : increasing
with projectile vomiting
B) LOC: restlessness,
agitation, lethargy
B) LOC: difficult to arouse,
decreasing Glasgow Coma
Scale
C)Papilloedema:delayed or
sluggish reaction, unilateral
changes in size
C)Papilloedema: Loss of
vision if severe and
prolonged.
D) MOTOR: pronator drift,
weakened hand grasp
D) MOTOR: posturing,
flaccid muscles
E) MEMORY: mildly
impaired
E) VITAL SIGNS:
CUSHING’S TRIAD
F) SPEECH: slowed or
slurred
F) SPEECH: decreasing, or
with groans or moaning
19.
1. HTN, high pulse pressure,
2. Cheynes-Stoke respiration,
3. Cushing’s response, in 1/3 of cases of tonsillar
herniation.
4. Hematoma.
N.B: The most common anatomical locations affected by
herniation syndromes include subfalcine, central
transtentorial, uncal transtentorial, upward cerebellar,
cerebellar tonsillar/foramen magnum, and transcalvarial .
Signs of Herniation:
19
20.
Early:
Headache, projectile vomiting and papilloedema.
Late:
Change in the level of consciousness,
Loss of motor and sensory functions, pupillary changes
(compression of Cranial Nerve III)
Vital sign changes, bradycardia and irregular
respirations,
Posturing: decorticate(flexion), decerebrate (extension)
or mixed (intermittent)
Coma
20
Herniation CP
22.
General Management
Resuscitation : A.B.C, Head elevation
IV:
Fluid management.
mannitol (Osmotic diuretics)
Glucocorticoids
Propofol
Hypertonic saline bolus (may lower ICP)
Treat the Cause (The best therapy for (ICH))
Sedation : Keeping patients appropriately sedated can decrease ICP by reducing
metabolic demand,
Bp control : maintain CPP >60 mmHg.
Position : positioned to maximize venous outflow from the head
23. INTRACRANIAL PRESSURE MONIRORING .
Control Fever (as it increases brain )
Antiepileptic therapy (if needed)
Barbiturates : ( reduce brain metabolism and cerebral blood flow)
Removal of CSF (ventriculostomy )
Rapid aspiration of CSF should be avoided because it may lead to
obstruction of the catheter opening by brain tissue.
Decompressive craniectomy
General Management
29.
•1)Simple, Spinal fluid doesn’t reflect the ICP if there is
no communication.
•2)May cause acute brain stem compression.
Lumber
puncture
•The "gold standard" of ICP monitoring catheters.
•placed into the ventricular system and affixed to a
drainage bag and pressure transducer with a three-way
stopcock.
•Advantages :
•accuracy, simplicity of measurement, and the unique
characteristic of allowing for treatment of some causes
of elevated ICP via drainage of CSF.
•Disadvantages: Infections
Intraventricular
Invasive Systems ICP
Monitoring
30.
•consist of a thin cable with an electronic or fiberoptic transducer at
the tip.
•The most widely used device is the fiberoptic Camino system.
These monitors can be inserted directly into the brain parenchyma
via a small hole drilled in the skull.
•Advantages :
•Ease of placement.
•A lower risk of infection .
•Disadvantages:
•inability to drain CSF for diagnostic or therapeutic purposes.
•mechanical failure due to the complex design of these monitors.
Intraparenchymal :
•Epidural monitors contain optical transducers that rest against the
dura after passing through the skull.
•Inaccurate, as the dura damps the pressure transmitted to the
epidural space.
•They are of limited clinical utility.
•Used in the management of coagulopathic patients with hepatic
encephalopathy complicated by cerebral edema.
Epidural
31.
Subarachnoid
•Subarachnoid bolts are fluid-coupled systems within a hollow screw that
can be placed through the skull adjacent to the dura. The dura is then
punctured, which allows the CSF to communicate with the fluid column
and transducer.
•The most commonly used subarachnoid monitor is the Richmond (or
Becker) bolt; other types include the Philly bolt, the Leeds screw, and the
Landy screw.
•Advantages:
•Low risk of infection and haemorrhage.
•Disadvantages:
•Often unreliable; therefore, they are rarely used.
31
32.
Non-invasive systems
• an ultrasound-based method, has shown some
promise.
Tissue resonance
analysis (TRA)
• can provide a noninvasive measure of optic
nerve sheath diameter, which has been found to
correlate with intracranial pressure.
Ocular sonography
• measures the velocity of blood flow in the
proximal cerebral circulation.
Transcranial
Doppler (TCD)
• can be assessed noninvasively using an
ultrasonic handheld optic tonometer.
Intraocular
pressure
• (measured using an impedance audiometer).
Tympanic
membrane
displacement
34.
34
ICP monitoring
Indication
Bullock and colleagues:
There was sufficient class II and III evidence to support the following
recommendations (no class I) :
ICP monitoring is appropriate in patients with severe head injury (GCS 3-8 after
CPR) and an abnormal (CT) scan (haematomas, contusions, oedema or compressed
basal cisterns)
ICP monitoring is appropriate in patients with severe head injury and a normal CT
scan if ≥ 2 of the following features are noted on admission: age > 40 years,
unilateral or bilateral motor posturing, systolic blood pressure < 90 mm Hg
ICP monitoring is not routinely indicated in patients with mild or moderate head
injury; however, a clinician may choose to monitor ICP in certain conscious patients
with traumatic mass lesions.
35.
According to The Department of Neurosurgery, Faculty of
Medicine, Jordan University Hospital, Amman, Jordan.
Objective: This retrospective study was done to evaluate the
Intracranial Pressure (ICP) monitoring and its effect on the
outcome of multi-trauma patients, including severe head
injury, in Jordan University, Hospital, as many studies were
published with controversies.
This study was done by Prof Dr. Walid Maani, Dr.Awni
Musharbash, Dr. Qussai Saleh, Dr. Ahmed Tamimi & Dr.
Moh'd Abu-Elrub.
Intracranial Pressure Monitoring,
Experience in Jordan
University Hospital
35
36.
Methods: A total of 67 patients were included in the study, and
in 42 patients ICP monitoring was used.
Results: It was found that the mortality rate increases with the
higher readings in the ICP, reaching up to 100% in patients with
an ICP of 60mmHg and above. Although the mortality rate was
less in the ICP monitored patients (35.7%), compared to the
Non- ICP monitored patients (52%).
Conclusion: The final outcome of severely head injured
patients is not truly known especially in multitrauma patients.
36
Intracranial Pressure Monitoring,
Experience in Jordan
University Hospital
37.
Role of CT
up to 1/3 of patients with initially normal scans developed CT scan
abnormalities within the first few days after closed head injury .
38. By Definition, the term ‘IIH’ describes patients with isolated raised (not
related to an intracranial disorder, a meningeal process or cerebral venous
thrombosi).
Typically affecting young obese women with menstrual irregularities or
taking OCPs, roduces a syndrome of increased intracranial pressure without
identifiable cause.
Pathophysiology:
remain unclear but those proposed classically include :
1. increased brain water content.
2. excess CSF production.
3. reduced CSF absorption and increased cerebral venous pressure.
Diagnosis : Modified Dandy criteria
Idiopathic intracranial
hypertension
39. Signs and symptoms : of increased ICP .
1. No localising focal neurological signs except unilateral or bilateral sixth nerve
paresis.
2. CSF opening pressure ≥25 cm H2O* but without cytological or chemical
abnormalities.
3. Normal neuroimaging adequate to exclude cerebral venous thrombosis—that is,
MRI of the brain, often with additional sequences (CT or MR venography).
TTT:
1. lumber puncture
2. weight loss
3. Medical treatment:
a) Carbonic anhydrase inhibitors, such as acetazolamide ,are the main medical
treatment classically prescribed for IIH. Acetazolamide decreases the
production of CSF in humans .
b) Topiramate particularly for the treatment of headaches.
c) Oral steroids
Idiopathic intracranial
hypertension
40. Surgery:
is required in patients with a fulminant onset of disease or when other
treatments have failed to prevent progressive visual loss.
In patients with papilloedema who have severe visual loss, but minimal or
no headache, optic nerve sheath fenestration (ONSF) is often advised, while
in those with visual loss, papilloedema and headache, a CSF diversion
procedure, such as ventriculo-peritoneal (VP) or lumbo-peritoneal (LP)
shunting, is preferred.
Aggressive management with CSF shunting is usually required to prevent
catastrophic visual loss in those with acute and rapidly progressive visual
loss.
These patients might benefit from a transient lumbar drain while awaiting a
more definite surgical procedure.
Idiopathic intracranial
hypertension
42.
Resolution of bilateral transverse sinus stenosis after lumbo-peritoneal shunt in
a young obese woman with idiopathic intracranial hypertension.
Biousse V et al. J Neurol Neurosurg Psychiatry
2012;83:488-494
Resolution of
bilateral
transverse sinus
stenosis after
lumbo-peritoneal
shunt in a young
obese woman
with idiopathic
intracranial
hypertension.
43.
Increased ICP is defined as a sustained elevation in pressure
above 20mm of Hg
An excess of brain water may occur:
1. Around lesions within the brain:
Tumor
Abscess
2. In relation to traumatic damage
3. In relation to ischemic brain insult
Types of edema:
1. Vasogenic (extra cellular): tumors
2. Cytotoxic (intra cellular): metabolic states
3. Interstitial (extra cellular): increased IVP
43
BRAIN OEDEMA