This document discusses various types and applications of immunotherapy. It defines immunotherapy as the treatment of disease by inducing, enhancing, or suppressing an immune response. The two main types are activation immunotherapy, which elicits an immune response, and suppression immunotherapy, which reduces an immune response. Activation immunotherapy includes techniques like cancer vaccines and adoptive T-cell transfer. Suppression immunotherapy uses drugs to dampen abnormal immune responses in diseases like autoimmunity and transplant rejection. The document also outlines specific immunotherapies for conditions like cancer, allergies, infertility, and more.
n overview of current immunotherapy therapies used to treat cancer. Also provides MOA of various medications, and updates on SITC guidelines for metastatice melanoma.
Therapeutic prospects in Cancer Immunotherapy.
Interleukins for Renal Cell Carcinoma.
BCG for Bladder Cancer.
Vaccination Strategies: Oncolytic virus for melanoma, Dendritic Cell therapy for CA Prostate.
Immune Checkpoint inhibitors. PD1 and PD L1 inhibitors.
Adoptive Cell Therpay. CAR T Cell Therapy
Clinical efficacy. Costs.
The presentation outlines aspects of immunity against cancer, evasion strategies by cells, immunotherapy in cancer, cancer vaccines etc. Download and view the slideshow for better experience.
Prepared in Sept 2014
Types of immunotherapy
Oncology
cancer vaccines
adoptive T cell transfer
oncolytic viruses
monoclonal antibodies
cytokine
treatment of cancer with immunotherapy
n overview of current immunotherapy therapies used to treat cancer. Also provides MOA of various medications, and updates on SITC guidelines for metastatice melanoma.
Therapeutic prospects in Cancer Immunotherapy.
Interleukins for Renal Cell Carcinoma.
BCG for Bladder Cancer.
Vaccination Strategies: Oncolytic virus for melanoma, Dendritic Cell therapy for CA Prostate.
Immune Checkpoint inhibitors. PD1 and PD L1 inhibitors.
Adoptive Cell Therpay. CAR T Cell Therapy
Clinical efficacy. Costs.
The presentation outlines aspects of immunity against cancer, evasion strategies by cells, immunotherapy in cancer, cancer vaccines etc. Download and view the slideshow for better experience.
Prepared in Sept 2014
Types of immunotherapy
Oncology
cancer vaccines
adoptive T cell transfer
oncolytic viruses
monoclonal antibodies
cytokine
treatment of cancer with immunotherapy
Présentation de toute l'équipe de la troupe Adama régie par Dan Zaoui, un passionné de culture et de musique juive.
Retrouvez toutes les informations sur la troupe dans cette présentation !
Design Process From Concept Sketch / Keywordsstout510
After extensive research you will create a set of actionable design keywords and a concept. These keywords and your concept are your communication goals for the project. These communication goals will drive your design.
This is how you create a visual language that corresponds to your concept and engages your viewers.
This presentation is part of MIU CE Pharmacy Program and is designed primarily for pharmacists with the following learning objectives:
1- Explain the mechanisms of action behind immune response to cancer and the application of immunotherapy in cancer treatment
2- Distinguish new and emerging immunotherapy classes and individual agents efficacy, safety to therapy in cancer treatment
3-Strategies to counsel and assist patients to overcome barriers to therapy, including Treatment side effects to improve adherence to therapy
Oncology Immunotherapy - Nivolumab and other PD-1/PD-L1 Targeted Agents (061213)Will Roettger
This is a short briefing on the oncology immunotherapy PD-1/PD-L1 targeted agents currently under development. In this briefing we look at the competitive landscape, PD-1/PD-L1 product profiles, positioning, strategy, as well as a development timeline and SWOT on the BMS PD-1 blocker nivolumab. Updates to this briefing will come as newer information is discovered.
A talk presented by Prof. Mohamed Labib Salem at Minofia University محاضرة للأستاذ الدكتور محمد لبيب سالم جامعة طنطا يوم الثلاثاء السادس عشر من فبراير بجامعة المنوفية
Tracxn Research — Immuno-Oncology Landscape, September 2016Tracxn
In 2015/16, five startups in this space — Stemcentrx, Gritstone Oncology, Hengrui Therapeutics, and Zai Lab secured big ticket funding rounds of $100 million and above.
Immunosuppressant are drugs or medicines that lower the body's ability to reject a transplanted organ. Another term for these drugs is anti-rejection drugs. There are 2 types of immunosuppressants: Induction drugs: Powerful antirejection medicine used at the time of transplant.
Vaccines (Immunotherapy) along with COVID-19 Overview, Types of Vaccines, Adjuvants, Antigen Uptake Mechanism, COVID-19 Mechanism Of Action, and much more.
Immunotherapeutics (Types of immunotherapeutics, humanisation antibody therap...NikitaBankoti2
Immunotherapy
➢ Treatment to stimulate or restore the ability of the immune (defence) system to fight
against infection or disease.
➢ It is also sometimes called Biologic therapy or Biotherapy.
➢ Biological therapy is thus any form of treatment that uses the body’s natural abilities
that constitute the immune system to fight infection and disease or to protect the body
from some of the side effects of treatment e.g. – cancer.
Types of Immunotherapeutics
1. Monoclonal antibody
2. Cancer vaccines therapy
3. Immune checkpoint inhibitors
4. Non-specific Immunotherapies
5. Chimeric antigen receptor (CAR) T-cell therapy
Humanized Antibody- They are antibodies from non-human species whose protein sequences have
been modified to increase their similarity to antibody variants produced naturally in humans.
➢The process of humanization is usually applied to monoclonal antibodies developed for administration
to humans. (e.g- antibodies developed as anti-cancer drugs)
Largest dengue outbreak of the decade with high fatality may be due to reemer...Dr.Arifa Akram
T. Shirin1, A. K. M. Muraduzzaman1, A. N. Alam1, S. Sultana1,M. Siddiqua4, M. H. Khan1, A. Akram1, A. R. Sharif2,S. Hossain2and M. S. Flora31) Department of Virology, 2) Department ofEpidemiology, 3) IEDCR and 4) Department of Microbiology, IbnSina MedicalCollege, Dhaka, Bangladesh.
Event based surveillance of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Bangladesh among pilgrims and travelers from the Middle East: An update for the period 2013-2016
Akram et al-2018-journal_of_viral_hepatitisDr.Arifa Akram
Detection of Hepatitis B Virus DNA among Chronic and potential Occult HBV patients in resource‐limited settings by Loop‐Mediated Isothermal Amplification assay
If the many beneficial effects of the chemokines can be preserved, such efforts hold great promise for uncovering new therapies for inflammatory and immunologic disease
OBI is a complex entity that comprises many conditions and different situations. Patients who have recovered from acute hepatitis B can carry HBV genomes for a long time,
and the virus might aggravate the course of their liver disease, when other causes of liver damage are present.The availability of highly sensitive molecular methods
has made it possible to unveil several virological features of OBI, to show its worldwide diffusion, and to reveal its possible involvement in different clinical settings. Relevant evidence indicates that HBV persistence as an OBI represents an important risk factor for HCC development.
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
1. ~Immuno Therapy~
Dr. Arifa Akram
MD Student
Virology Department
Bangabandhu Sheikh Mujib Medical University, Dhaka
2. Immunotherapy
Immunotherapy is a medical term defined as the
"treatment of disease by inducing, enhancing, or
suppressing an immune response".
Immunotherapies designed to elicit or amplify an
immune response are classified as activation
immunotherapies, while immunotherapies that
reduce or suppress are classified as
suppression immunotherapies.
3. `Types of Immunotherapy1. Active immunotherapy
The basic idea is to give the proper mission
objectives to the T helper cells of the immune system
so that they attack the cancer and continue to attack
it until it is completely destroyed. This is called active
immunotherapy, because the treatment given to the
patient has a direct interaction with the body's
immune system. Active immunotherapy can be
achieved by administering cytokines, such as
interferons (IFNs) and interleukins (IL-2), which
triggers non-specific stimulation of numerous
immune cells. It divides into:
Non-Specific Active Immunotherapy:
Specific Active Immunotherapy.
4. 2. Passive immunotherapy
The other method of immunotherapy is to
develop new ways to "create" antibodies and
other types of cells that mimic the immune
system of the human body. These synthesized
cells are usually designed to attack cancer
cells directly through the use of toxins and
radioactive materials without interacting with
the body's natural immune system. Due to its
lack of interaction with the immune system,
this is referred to as passive
immunotherapy.Administering monoclonal
antibodies (mAbs) is a form of passive
immunotherapy.
5. 3. Non-Specific ImmunotherapiesThere are other forms of immunotherapies that
do not attack a specific antigen or tumor cell.
Instead, a non-specific immunotherapy is
designed to boost the performance of the
immune system to make the cells that travel
throughout the body more powerful and efficient.
“Immunomodulators“
The active agents of immunotherapy are
collectively called immunomodulators. They are a
diverse array of recombinant, synthetic and
natural preparations, often cytokines.
Immunomodulatory regimens offer an attractive
approach as they often have fewer side effects
than existing drugs, including less potential for
7. `Activation immunotherapies`1)Cancer :
Cancer immunotherapy attempts to stimulate the
immune system to reject and destroy tumors. BCG
immunotherapy .Topical immunotherapy in skin
cancer & Injection immunotherapy uses mumps,
candida the HPV vaccine.
2)Autologous Immune Enhancement Therapy:
Autologous immune enhancement therapy (AIET)
is a treatment method in which immune cells are
taken out from the patient's body which are
cultured and processed to activate them until their
resistance to cancer is strengthened and then the
cells are put back in the body.
8. 3)T-cell adoptive transfer
This can be achieved by taking T cells that are
found with the tumor of the patient, which are
trained to attack the cancerous cells. These T
cells are referred to as tumor-infiltrating
lymphocytes (TIL) are then encouraged to
multiply in vitro using high concentrations of IL-2,
anti-CD3 and allo-reactive feeder cells. These T
cells are then transferred back into the patient
along with exogenous administration of IL-2 to
further boost their anti-cancer activity.
9. 4)Immune recoveryThe potential use of immunotherapy to restore
the immune system of patients with immune
deficiencies as result of infection or
chemotherapy. For example cytokines have
been tested in clinical trials interleukin-7 has
been in clinical trials for HIV and cancer
patients. In addition, interleukin-2 has also
been tested in HIV patients.
5)Vaccination /Immunization
Anti-microbial immunotherapy, which includes
vaccination, involves activating the immune
system to respond to an infectious agent.
Immunization may be active or passive.
10. `Suppression immunotherapies`
Immune suppression dampens an abnormal immune
response in autoimmune diseases or reduces a normal
immune response to prevent rejection of transplanted
organs or cells.
1)Immunosuppressive drugs
Immunosuppressive drugs are important tools in the
management of organ transplantation and autoimmune
disease. cytotoxic drugs are immunosuppressive.
2)Immune tolerance
Immune tolerance is the process by which the body
naturally does not launch an immune system attack on its
own tissues. Immune tolerance therapies seeks to reset
the immune system so that the body stops mistakenly
attacking its own organs or cells in autoimmune disease or
accepts foreign tissue in organ transplantation.
11. 3)Allergies
The Allergen immunotherapy is indicated for people who are
extremely allergic or who cannot avoid specific allergens. For
example, they may not be able to live a normal life and
completely avoid pollen, dust mites, mold spores, pet dander,
insect venom, and certain other common triggers of allergic
reactions. Immunotherapy is generally not indicated for food
or medicinal allergies. This therapy is particularly useful for
people with allergic rhinitis or asthma. Sublingual
immunotherapy involves putting drops or tablets of allergen
extracts under the tongue of a patient with allergic reactions
and then swallowing the extracts. It allows the organism to
become tolerant to the allergen by absorbing the allergen
through the stomach lining. Subcutaneous immunotherapy
is the historical route of administration and consists of
allergen extract injections. Subcutaneous immunotherapy
can only be performed with a medical observation. Although
efficacy of subcutaneous immunotherapy has been
demonstrated by several studies, subcutaneous
immunotherapy entails the risk of systemic anaphylactic
12. `Application of Immune Therapy`
1. Helminthic therapies in case of relapsing remitting
multiple sclerosis,Crohn’s, allergies and asthma.
2.Radioimmunotherapy in case of Lymphoma.
3. Immunotherapy to Attack Cancer( Monoclonal antibody
therapy).
Advantages over ordinary monoclonal antibodies:
Cancer immunotherapy with ordinary monoclonal
antibodies does not activate T-lymphocytes because this
type of cell does not possess Fc receptors, so the Fc
region cannot bind to them, and the Fab regions are
already used for binding the tumour cells. Bispecific
antibodies have a higher cytotoxic potential.
15. 4.Immune Therapies for Infertility.
5.In Allergic Rhinitis & Asthma .
6.Topical immunotherapy agents in skin cancer
7.Vaccination.
Conclusion:
Immunotherapy is a type of biological therapy that
utilizes a person's natural immune defense system to
fight disease.Today scientists are discovering ways in
which immunotherapy can be used as a stand-alone
treatment for cancer and a adjuvant (supplemental)
treatment to make current cancer treatments more
effective .