In this presentation we will discuss about Immunotherapeutics and their types with uses.

1. TOPIC
IMMUNOTHERAPEUTICS
PRESENTED BY :-REHAN UMAR
M-PHARM 1YR (PHARMACOLOGY)
department OF PHARMACY

2. CONTENTS
INTRODUCTION
TYPES OF IMMUNOTHERAPEUTICS
HUMANISATION ANTIBODY THERAPY

3. IMMUNOTHERAPEUTICS :-
 IT IS ALSO SOMETIMES CALLED BIOLOGIC THERAPY OR BIOTHERAPY.
 IT IS A TREATMENT THAT USES CERTAIN PARTS OF THE IMMUNE SYSTEM TO FIGHT DISEASE
SUCH AS CANCER.
 IMMUNOTHERAPY IS THE TREATMENT OF DISEASE BY ACTIVATING OR SUPPRESSING THE
IMMUNE SYSTEM.
 IT AIMS TO ACTIVATE THE BODY’S OWN DEFENCE MECHANISMS BY TRIGGERING OR MIMICKING
IMMUNE RESPONSES.
 Immunotherapy can treat many different types of cancer.

4. How It Works ?
 Immunotherapy includes a wide variety of treatments that work in different ways.
 By boosting the body's immune system in a very general way.
 Helps to train the immune system to attack cancer cells specifically.
 Giving immune system components, such as man-made immune system proteins.

5. TYPES OF IMMUNOTHERAPY :-
 The main types of immunotherapy now being used to treat cancer are:-
 Monoclonal Antibodies.
 Cancer Vaccines.
 Non-Specific Immunotherapies.
 Engineered Antibodies

6. MONOCLONAL ANTIBODIES :-
 Monoclonal antibodies are man-made proteins that act like human antibodies.
 These Antibodies can be useful in fighting diseases because they can designed specifically to only target a
certain antigen, such as one that is found on cancer cells.
 Many copies of a specific Antibody can be made in the lab. These are known as Monoclonal Antibodies.

7. Cancer vaccines :-
 Cancer vaccines are made up from -
 Dead cancer cells
 Proteins from cancer cells
 Immune system cells
 These use your immune system to prevent cancer and or treat cancer.

8. Non-specific immunotherapies :-
 Most non-specific immunotherapies also help the immune system destroy cancer cells and given after or
at the same time as other cancer treatments.
 Two common non-specific immunotherapies are Interferon and Interleukins.
 interferon help the immune system fight cancer and may slow the growth of cancer cells.
 interleukin help the immune system produce cells that destr0y cancer.
 interleukin made in the laboratory is called Interleuukin-2 or aldesleukin.

9. HUMANIZATION ANTIBODY THERAPY:-
 Humanization is now a well-established technique for reducing the immunogenicity of monoclonal
antibody from xenogeneic sources and for their activation of the human immune system.
 Humanized antibodies are antibodies from non-human species whose protein sequences have been
modified to increase their similarity to antibody variants produced naturally in humans.
 The process of humanization is usually applied to monoclonal antibodies developed for administration to
humans e.g. Antibodies developed as anti- cancer drugs.

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