Immunomodulators can stimulate or suppress the immune system. There are several classes of immunomodulators including glucocorticoids, calcineurin inhibitors, antiproliferatives, and biologicals. Glucocorticoids have broad anti-inflammatory effects and work by binding to receptors that regulate gene transcription. Calcineurin inhibitors like tacrolimus and cyclosporine inhibit T cell activation. Antiproliferatives such as azathioprine, mycophenolate mofetil, and methotrexate inhibit lymphocyte proliferation. Biologicals include monoclonal antibodies that target specific molecules. Immunomodulators are used to prevent transplant rejection and treat autoimmune disorders but can have side
Immunostimulators are prescribed to enhance the immune response against infectious diseases, tumours, primary or secondary immunodeficiency, and alterations in antibody transfer, among others .
Immunosupressants and Immunostimulants their pharmacology, uses etc. Basics of immunology, innate immune response, acquired immune response, role of complement in innate immune response. Major histocompatibility complex, antibody structure. classification of immunosupressants, their mechanism of action, uses and adverse effects.
Immunostimulators are prescribed to enhance the immune response against infectious diseases, tumours, primary or secondary immunodeficiency, and alterations in antibody transfer, among others .
Immunosupressants and Immunostimulants their pharmacology, uses etc. Basics of immunology, innate immune response, acquired immune response, role of complement in innate immune response. Major histocompatibility complex, antibody structure. classification of immunosupressants, their mechanism of action, uses and adverse effects.
immunostimulants
Immunomodulators are natural or synthetic materials that regulate the immune system and induce innate and adaptive defense mechanisms. These substances are classified into two types, immunostimulants and immunosuppressants.
Immunostimulants can enhance body's resistance against various infections through increasing the basal levels of immune response.
Immunosuppressants are drugs which inhibit cellular/humoral or both types of immune responses and have their major use in organ transplantation and autoimmune diseases.
Immunopharmacology : Defination, components of immunity, classification of immunity and its explanation.
Drugs used in immune disorder : Immunosuppressants and Immunostimulants.
Pharmacology of antimalarial drugs with treatment of malaria. mechanism of action, uses, adverse effects of antimalarial drugs like chloroquine, quinine, artemisinin compounds.
Immunomodulators modern and ayuvedic conceptsJAYAKRISHNAN K
A MINOR SIMPLE PROJECT ON IMMUNOMODULATORS. It explains types of immunity, hyper sensitivity, allergy, immunostimulants, immunoadjuvants, immunosuppressants etc. with relevant ayurvedic portions.
immunostimulants
Immunomodulators are natural or synthetic materials that regulate the immune system and induce innate and adaptive defense mechanisms. These substances are classified into two types, immunostimulants and immunosuppressants.
Immunostimulants can enhance body's resistance against various infections through increasing the basal levels of immune response.
Immunosuppressants are drugs which inhibit cellular/humoral or both types of immune responses and have their major use in organ transplantation and autoimmune diseases.
Immunopharmacology : Defination, components of immunity, classification of immunity and its explanation.
Drugs used in immune disorder : Immunosuppressants and Immunostimulants.
Pharmacology of antimalarial drugs with treatment of malaria. mechanism of action, uses, adverse effects of antimalarial drugs like chloroquine, quinine, artemisinin compounds.
Immunomodulators modern and ayuvedic conceptsJAYAKRISHNAN K
A MINOR SIMPLE PROJECT ON IMMUNOMODULATORS. It explains types of immunity, hyper sensitivity, allergy, immunostimulants, immunoadjuvants, immunosuppressants etc. with relevant ayurvedic portions.
Download Cancer immunomodulators market & pipeline insight 2020KuicK Research
\"Cancer Immunomodulators Market & Pipeline Insight 2020\" Report Highlights:
Introduction & Need of Cancer Immunomodulators
Cancer Immunomodulators Mechanism
Cancer Immunomodulators Clinical Pipeline By Company, Indication & Phase
Cancer Immunomodulators Clinical Pipeline: 747 Cancer Immunomodulators Drugs
Majority Cancer Immunomodulators in Preclinical Phase: 300 Marketed Cancer Immunomodulators Clinical Insight
Marketed Cancer Immunomodulators: 47
Cancer Immunomodulators Drug Patent Analysis
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
7. Glucocorticoids have broad anti-inflammatory effects on multiple components of cellular
immunity.
MOA –
To effect longer-term responses, steroids bind to receptors inside cells; either these
receptors, glucocorticoid-induced proteins, or interacting proteins regulate the
transcription of numerous other genes
Glucocorticoids lyse and induce the redistribution of lymphocytes,
Curtail activation of NF-КB, which increases apoptosis of activated cells, key pro-
inflammatory cytokines such as IL-1 and IL-6 are downregulated.
T cells are inhibited from making IL-2 and proliferating.
The activation of cytotoxic T lymphocytes is inhibited.
Neutrophils and monocytes display poor chemotaxis and decreased lysosomal enzyme
release.
8. combined with other immunosuppressive agents to prevent and treat
transplant rejection.
graft-versus-host disease in bone-marrow transplantation.
Glucocorticoids are routinely used to treat auto-immune disorders such
as
RA
SLE, psoriasis
Asthma and other allergic disorders,
inflammatory bowel disease
acute exacerbations of MS (see "Multiple Sclerosis").
to block first-dose cytokine storm caused by treatment with
muromonab-CD3 and to a lesser extent ATG
9. Growth retardation in children,
Avascular necrosis of bone, osteopenia
Increased risk of infection
Poor wound healing
Cataracts
Hyperglycemia
Hypertension
The advent of combined glucocorticoid + calcineurin inhibitor regimens
has allowed reduced doses or rapid withdrawal of steroids, resulting in
lower steroid-induced morbidities.
10. Perhaps the most effective immunosuppressive drugs
in routine use
They target intracellular signalling pathways induced as
a consequence of T cell–receptor activation
Tacrolimus Cyclosporine
11.
12. PK-
• Variable
• Trough level correlates better with clinical events
(100-200 ng/mL )
• The t 1/2 of tacrolimus is 12 hours
• CYP3A4
USE –
• prophylaxis of solid-organ allograft rejection
• GVHD
Tacrolimus (FK506) is a macrolide antibiotic produced by
Streptomyces tsukubaensis
13. Nephrotoxicity,
Neurotoxicity (e.g., tremor, headache, motor
disturbances, seizures),
GI complaints,
hypertension,
hyperkalemia,
Hyperglycemia and diabetes
14. PK-
• 20-50% bioavailability
• CYP3A4
USE –
• Clinical indications for cyclosporine are kidney, liver, heart,
and other organ transplantation
• Rheumatoid arthritis and psoriasis.
Cyclosporine, a cyclic polypeptide of 11 amino acids, is produced by
the fungus Beauveria nivea
16. PK-
• Systemic availability is 15%
• A loading dose of three times the
maintenance dose will provide
nearly steady-state
• CYP3A4
USE –
• Prophylaxis of organ transplant
rejection usually in combination
• At risk of calcineurin inhibitor–
associated nephrotoxicity
Sirolimus is a macrocyclic lactone produced by Streptomyces
hygroscopicus
MOA
17. dose-dependent increase in serum cholesterol
Lymphocele, a known surgical complication associated with renal
transplantation
cyclosporine and sirolimus interact, and their administration
should be separated by time
Everolimus
chemically and clinically related to sirolimus but has distinct
pharmacokinetics.
The main difference is a shorter t1/2 and thus a shorter time to
achieve steady-state concentrations of the drug.
18. It is an imidazolyl derivative of 6-mercaptopurine
MOA –
cleaved to 6-mercaptopurine (via Glutathione),
A fraudulent nucleotide, 6-thio-IMP, is converted to 6-
thio-GMP and finally to 6-thio-GTP, which is
incorporated into DNA.
converted to additional metabolites that inhibit de
novo purine synthesis
Cell proliferation thereby is inhibited, impairing a
variety of lymphocyte functions.
19. PK –
Well absorbed orally
T1/2 = 10 mins (active metabolites)
USE-
adjunct for prevention of organ transplant rejection
Severe RA
ADR –
The major side effect of azathioprine is bone marrow suppression
increased susceptibility to infections (HSV),
hepatotoxicity, alopecia, GI toxicity, pancreatitis,
20. It is an ester of mycophenolic acid (MPA).
MOA –
MMF is a prodrug that is rapidly
hydrolyzed to the active drug, MPA
MPA - a selective, noncompetitive,
reversible inhibitor of inosine
monophosphate dehydrogenase (IMPDH),
IMPDH is an enzyme @ de novo pathway
of guanine nucleotide synthesis
B and T lymphocytes are highly
dependent on this pathway for cell
proliferation (others- salvage pathway)
21. PK –
The parent drug - within a few minutes. The t1/2 of MPA is 16 hours.
T1/2 = 10 mins (active metabolites)
USE-
MMF is indicated for prophylaxis of transplant rejection, and it
typically is used in combination (Glucocorticoid/Calcineurin)
off label - SLE
ADR –
Gut -
Hematologic – PRCA, leucopenia
Congenital anomaly