Cancer immunotherapy uses the immune system to fight cancer. It stimulates the patient's immune system to attack and reject tumor cells. William Coley first observed in the late 1800s that some cancer patients who got infections after surgery saw their cancer improve. This led him to try treating patients by infecting them with bacteria, known as Coley toxins. Modern immunotherapy includes monoclonal antibody therapies like rituximab that target specific proteins on cancer cells, cancer vaccines, and cytokines to boost the immune system. Researchers are also exploring newer monoclonal antibodies and using cloned immune cells from patients to treat their cancer.

1. CANCER IMMUNOTHERAPY

2. • Immunotherapy is also sometimes called biologic
therapy or biotherapy. It is treatment that uses certain parts of the
immune system to fight diseases such as cancer
• Stimulating your own immune system
• Giving you immune system components
• Cancer immunotherapy is the use of the immune system to
reject cancer. The main premise is stimulating the patient's immune
system to attack the malignant tumor cells that are responsible for
the disease.

3. CANCER IMMUNOTHERAY
• In late 1800s Dr William
Coley first noted that
getting an infection after
surgery seemed to help
some cancer patients. he
began treating cancer
patients by infecting them
with certain kinds of
bacteria, which came to
be known as Coley toxins.

4. Types of immunotherapy
• Monoclonal antibodies
a) Naked mAbs
b) Conjugated mAbs
i. Radiolabelled
ii. Chemolabeled
iii. immunotoxin
• Cancer vaccines
• Non-specific immune
therapies
a) Cytokines
b) interleukin

5. DIFFERENT MONOCLONAL ANTIBODIES METHODS

6. Alemtuzumab + CD 52 against melanoma
Before After

7. Cancer immunotherapy:Monoclonal antibodies[2 ]
Brand
Antibody mab type Type Target Approved treatment(s)
name
humanize
Alemtuzum ab Campath Naked mAB CD52 Chronic lymphocytic leukemia
d
denileukin Chemolabeled humanize
(Ontak®) CD25 colorectal cancer
diftitox mAB d
Chemolabeled
Brentuximab Hodgkin lymphoma,Anaplastic large-
Adcetris chimeric CD30ss
vedotin cell lymphoma
mAB
Radiolabel led
Ibritumomab non-Hodgkin lymphoma(with yttrium-
Zevalin murine CD20
tiuxetan 90 or indium-111
mAB

8. Antibiotic based drugs

9. CANCER VACCINES
• Tumor cell vaccines
• Antigen vaccines
• Dendritic cell vaccines
• DNA vaccines
• Vector-based vaccines

10. VACATION STRATEGIES

12. LATEST RESEARCH
• Newer Monoclonal Antibodies
• In June 2008, it was announced that United States doctors from the
Clinical Research Division led by Cassian Yee at Fred Hutchinson
Cancer Research Centerin Seattle have for the first time successfully
treated a skin cancer patient by using immune cells cloned from his
own immune system which were then re-injected into him.
• Topical immunotherapy
• Imiquimod immune enhancement cream
• Natural product
• Agaricus subrufescens

13. LATEST
RESEARCH

14. CANCER IMMUNOTHERAPY A
NEW HOPE