The document outlines the process U.S. agencies take to screen immigrants for communicable diseases and study disease outbreaks. It discusses two classes of diseases that can deny visa applications and notes illegal immigrants are not screened. It then describes four steps agencies like the CDC take: 1) identifying the infection and pathogenesis, 2) determining the pathogen's distribution, 3) identifying its properties, and 4) finding infectious and lethal doses to determine threat level and safety measures. The overall goal is to understand diseases at a molecular level to stop epidemics from spreading.