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Running head. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 1
HOMELAND SECURITY MANAGEMENT INSTITUTE
LONG ISLAND UNIVERSITY - RIVERHEAD
THESIS PROPOSAL
03 February 2015
From: Philip S. Bucci
To: Director, Homeland Security Management Institute
Via: (1) Dr. Vincent E. Henry, Thesis Advisor
(2) Dr. Steven Bucci, Second Reader
(3) Prof. Neal Anderson, Third Reader
SUBJECT: THESIS FOR THE DEGREE OF MASTER OF SCIENCE IN HOMELAND
SECURITY MANAGEMENT
Please find the attached thesis proposal, entitled “First Responders in a Biothreat Environment”.
My anticipated graduation date is January 2015. For your information and appropriate attention.
______________________________
Philip S. Bucci
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 2
Table of Contents
Table of Contents 2
Abstract 3
Introduction: First Responders in a Biothreat Environment 4
Significance of Research 6
Literature Review 14
Methodology 18
Types of Biological Warfare Agents 20
Biological Warfare Agent Production by Agent 32
Biological Warfare Agent Production Equipment 35
Policy Options and Recommendations 45
Conclusion 54
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 3
Abstract
The threat of extremists attacking major American population centers with weapons of
mass destruction has increased since the September 11th
Terror attacks. Consequently, the need
for the Nation’s First Responders, police, fire, and Emergency Medical Service (EMS)
personnel, to be trained to recognize and respond to this unconventional threat has grown as
well. While many technologies exist to detect chemical or biological threats, along with nuclear
and radiological, the primary method of detection is Detect to Treat, which relies on the ability of
medical personnel to recognize the symptoms of infected patients. While this paper will focus
on biological, chemical weapons will be discussed for reference purposes. Many biological
agents have the ability to rapidly spread, and if the detection process is slow, these agents can
overtake the ability of a community to treat the illness. The best way to ensure the community is
prepared for a biological agent outbreak is to give First Responders the knowledge to identify
threats before they spread. While technology is useful, having the knowledge to identify
ingredients, tools, and symptoms of biological agent production will decrease the likelihood of
secondary contamination and response time. Training First Responders can be costly, but
utilizing Reserve Soldiers will not commit additional resources and will develop the relationships
necessary for ensuring success in securing the homeland. The US Army Reserves has the
capability and manpower to ensure proper training and support for all State and Local agencies
to ensure the nation has a strong defense against biological agent outbreaks - whether natural or
intentional.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 4
Introduction: First Responders in a Biothreat Environment
The threat of extremists attacking major American population centers with chemical or
biological weapons has increased since the September 11th
Terrorist attacks on the Pentagon and
the World Trade Center. The US Congress’s Commission on the Prevention of Weapons of
Mass Destruction Proliferation and Terrorism, which Congress established in fulfillment of a
recommendation of the Final Report of the National Commission on Terrorist Attacks Upon the
United States (the 9/11 Commission Report), declared “biological weapons are the most
dangerous threat the United States is facing,” making it clear the threat of biological attack is
taken seriously. (Bucci, 2013, pg. 11) Consequently, the need for our Nation’s First Responders,
police, fire, and Emergency Medical Service (EMS) personnel to be trained to recognize this
unconventional threat and respond to it accordingly has grown as well.
Because it may become the responsibility of State and Local health agencies to discover
these threats after they occur, and because such discovery is unlikely to occur until a substantial
number of individuals become infected, it is reasonable to question whether American First
Responders have the knowledge and the organizational capacity to recognize threats such as
biological weapons in a diverse, dispersed, and highly populated area. First Responders such as
police, firefighters and emergency medical services personnel can play a critical role in
identifying a potential outbreak since they are the most likely to encounter and be exposed to a
patient before he or she arrives to a hospital, and they are also at high risk because they will
likely not be wearing appropriate protective gear. If first responders have the knowledge to
recognize symptoms and alert medical personnel of the need for further diagnosis and
appropriate laboratory processes, they can speed up the detection process significantly. This
paper will focus on police, fire, and EMS personnel, who are likely to arrive at a small-scale
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 5
biological attack conducted in a manner similar to the Aum Shinrikyo incident in Japan, before
creation of an Incident Command post at the incident site.
Using the latest policy options, and with a basic understanding of biological warfare
agent production methods, materials, and equipment, a simple low cost solution to enabling and
enhancing the knowledge of First Responders can be accomplished. Using the Military and its
vast array of personnel and material, as well as online self-paced learning, First Responders can
keep up to date on the latest threats and methods of detection and production. Based on the gaps
in the literature and the lack of understanding of the threat seen in the media during the 2014
Ebola outbreaks, there is not enough solid expertise to deal with a large outbreak of biological
agents, whether the attack be natural or manmade.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 6
Significance of Research
Cities have turned to technology to fill the current gap in training exists for first
responders. While many technologies exist to detect these threats, the primary method of
detection is Detect to Treat (DTT) which relies on “local doctors and nurses to serve as the initial
‘detection’ screen”. (Bucci, 2013, pg. 11) This means once an outbreak or attack occurs the
threat will be analyzed by medical centers and then the appropriate treatments will be
administered. DTT is an effective method of dealing with biological attacks yet DTT still has
immense risks for the population. Many biological agents have the ability to rapidly spread, and
if the detection process is slow, these agents can overtake the ability of a community to treat the
illness. Perhaps the best known example of an illness outbreak overwhelming a community’s
ability to identify and treat the victim’s condition is the Spanish Flu pandemic of 1918.
Originating at Fort Riley KS, the movement of infected troops to New York and then to Europe
in support of World War I allowed the flu to spread and infect over 500 million people ultimately
resulting in around 50 million deaths worldwide or about 3% of the world’s population at the
time. (Tauberger, 2006) Although medical facilities and diagnostics have changed dramatically
since this time, this event serves as lesson on the dangers of transmission prior to detection.
Another technology being used to help protect populated areas is the BioShield system.
Unfortunately about 90% of the $3.3 Billion earmarked for spending on protection against
threats such as Ebola was spent on only three biological warfare agents: anthrax, small pox, and
botulism. (Quinn, 2014) While these represent a much higher likelihood of occurrence it shows
how the system has been weakened toward certain threats and is not the catch-all system needed.
Additionally, the BioShield systems use filters which need to be manually collected and then
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 7
analyzed for the presence of agents. While cost effective, significant gaps of time may exist
between collections and testing.
Given the advances in global transportation since 1918 one can easily comprehend the
impact which slow detection can have on the world’s population. Fortunately along with
advances in transportation, significant advances in medicine and hygiene have been achieved
around the world since the Spanish Flu epidemic of 1918. These advances in medicine, in
hygiene, and in health organizations’ knowledge of the dynamics of epidemiology have served to
counter or mitigate (but not eliminate) the potential for the rapid spread of infectious diseases. In
2009 when the H1N1 Flu virus was thought to be on the brink of epidemic outbreak the world’s
health organizations rapidly offered measures to help slow the spread by infected persons,
especially those traveling by air. While these measures did not entirely halt the spread of the
virus, they helped limit the spread and keep H1N1 at a more manageable level.
While the frightening examples above are not the result of attacks, a coordinated effort to
infect a large population and cause widespread panic is the stuff of nightmares. With the world’s
intelligence apparatus primarily focused on the threats of more ‘traditional’ terrorist activities
such as bombings or targeted killings taking place overseas, many domestic events such as small
and highly focused attacks using non-nuclear WMDs in the homeland may be left up to state and
local responders both to detect and to address after the event occurs. This is not to say the
Federal Bureau of Investigation (FBI) or other Federal Agencies, such as the Centers for Disease
Control and Prevention (CDC), and the National Biosurveilliance Integration Center (NBIC) are
not focused on preventing or interdicting threats before they occur, but they do not play a
substantial role in DTT until a significant number of patients begin to develop and seek treatment
for their illness.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 8
The 1994 and 1995 Sarin gas attacks in Japan by the religious cult Aum Shinrikyo killed
dozens of people and injured about 5000 others. (Seto, 2001, pg. 1) Sarin Gas is a colorless,
tasteless, odorless nerve agent created in 1938 as a pesticide. Once air, water, food, or clothing
is contaminated people can get exposed to the agent’s effects, which include nausea, vomiting,
confusion, paralysis, and respiratory failure leading to death. While treatable, the antidotes to
Sarin must be administered quickly in order to be effective. According to the Organization for
the Prohibition of Chemical Weapons’ Yasuo Seto (2001), these attacks introduced the Japanese
police to “a new type of crime.” (pg. 1)
The Nagano Prefectural Police officers assigned to the Matsumoto Police Station
received a call from an ambulance team alerting them of injuries and patients needing help.
Patients were suffering from ocular pain and numbness in the hands. For the next two days
further casualties were brought into the hospital with an unknown cause of death. Investigations
discovered plants and animals had died all in a 150 meter radius of a local pond and people near
open windows, air conditioned rooms and moving near the pond all had serious symptoms. In
all, 274 people were treated with symptoms including “darkened vision, ocular pain, nausea,
myosis, and a decrease in serum cholinesterase (ChE) activities” and “autopsy findings showed
intense post-mortem lividity [bruising], myosis [severe pupil constriction], pulmonary edema
[swelling], increased bronchial secretion, and congestion of the parenchymatous [functional
tissue] organs.” (Seto, 2001, pg. 1) The local police assumed the source of the toxic gas must
have been the pond and began testing to determine the cause. Eventually the Sarin was detected
and samples were sent to a laboratory for confirmation. The attack occurred 50 minutes before
the police were alerted and a number of changes occurred to agent. When mixed with water, the
agent will hydrolyze into a compound unique to each carrier. On plants the agent will synthesize
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 9
and become an acid, killing the plants. These indictors and the patient symptoms should have
tipped off the responders to the presence of an agent. However, since Sarin is banned under
international treaty, and the likelihood of a Sarin attack is low, it took several days to get a
presumptive analysis and samples to send to the laboratory. As it turned out, the lessons of this
attack would greatly help the Tokyo Metropolitan police the next year.
On March 20th
, 1995 Aum Shinrikyo cult members released Sarin gas on five subway
cars at approximately 8:00 AM. The number of victims began to overwhelm local hospital’s
capacity and the symptoms reported were the same as those reported in the attack at Matsumoto
in Nagano Prefecture. Armed with this knowledge, Tokyo Metropolitan Police officers donned
protective suits to continue rescue efforts and conduct their investigations. Soon after this
realization, the Japanese Ministry of Defense, equivalent to the US Department of Defense,
arrived on scene with military support to aid in the inspections of the site and conduct
decontamination of the area. (Seto, 2001, pg. 1)
This incident is taught at the US Army Chemical, Biological, Radiological, and Nuclear
(CBRN) Center and School at FT Leonard Wood, MO to all officers in the Chemical Branch as
the model for non-state attacks. The lessons learned from this event are used to demonstrate the
ease of production by non-state actors of, as well as the dangers faced if the chemical weapons
are released in a populated area. Had Japan not been prepared, or had its responders not
recognized the signs of an attack, the outcome would have been far worse. This level of
recognition and understanding by first responders is required to quickly and decisively undercut
the effects of biological attacks on the homeland. In this attack, the gas was released by
puncturing plastic bags with the tips of umbrellas. This allowed the members of Aum Shinrikyo
to surreptitiously attack the subway system. People normally look for men in masks unlocking
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 10
pelican cases with green mist in glass vials as the sign of a gas attack. While surgical masks are
popular in Japan, the culprits were average looking people with umbrellas, which are also
popular in counties utilizing outdoor public transportation.
On February 2004 Senator Bill Frist’s mail room at the Dirksen Senate Office Building in
Washington DC received a letter containing a white powdery substance later confirmed to be
Ricin. This event shut down other Senate buildings and required several staffers to be
decontaminated. This event came on the heels of a November 2003 ricin-laced letter sent to the
White House demanding changes to trucking regulations. The 2003 letter was not made public
until February 2004 and to date no connection has been made between the two. The Centers for
Disease Control and Prevention (CDC) advised “Clinicians and public health officials should be
vigilant for illnesses suggestive of ricin exposure.” (Gibson, 2013, pg. 1129) The 2004 ricin
attack was similar to the 1994 and 1995 Sarin attack in Japan, insofar as it involved the use of a
public vector, (i.e. mail in 2004 and public transportation in 1994 and 1995), providing attackers
the opportunity to increase dissemination due to the fact, contaminated mail comes in contact
with sorting machines and other mail.
In late September 2014 Thomas Eric Duncan was diagnosed with Ebola in Dallas, Texas.
(Darcy, 2014) Ebola is an extremely contagious hemorrhagic fever believed to be spread by
animals to humans. The disease is native to the African Continent and was first discovered in
1976. Hemorrhagic fevers are transmitted by body fluid and cause headache, muscle pain,
diarrhea, vomiting, and bleeding. (CDC, 2014) Duncan lied on his entrance documents from
Liberia, stating he did not care for sick patients from the region’s Ebola epidemic. (Darcy, 2014)
Duncan apparently contracted the disease in Liberia from helping carry a sick pregnant woman.
Duncan flew to the United States a few days later to stay with relatives. After becoming sick,
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 11
Duncan went to the local hospital where he was seen and discharged with antibiotics. When he
returned a few days later, Duncan was admitted for Ebola. (Darcy, 2014)
This is a classic example of how the Detect to Treat (DTT) process operates in the real
world, and it illustrates how the process can fail to operate efficiently: An infected individual
becomes ill following a latency period, and upon presenting his or her symptoms to medical
personnel the individual patient is misdiagnosed. Due to the misdiagnosis, the contagious
individual is not quarantined and he or she may continue to serve as a vector spreading the
illness to others. There is no perfect solution for patients lying to care providers, or human error,
but education for the public about the threats and who may be at risk can be helpful. This case
also illustrates how easily a suicide terrorist willing to be infected with Ebola could conduct a
biological terrorism attack on a US population center. Commencing the attack at the end of
September, when the flu season is starting, might cause local hospitals to misdiagnose the
symptoms of nausea and fever as influenza rather than Ebola. If a terrorist infected with Ebola
(or another highly communicable and deadly virus) circulated among the population, he or she
could potentially infect a substantial number of individuals. These individuals infected with
Ebola virus, who had no recent travel history to West Africa, might not be suspected of having
anything more than the flu until it was too late. Only when the number of fatal cases (the
number of Ebola cases misdiagnosed and treated as the far less deadly influenza virus and
ultimately result in death) reached a critical mass might the proper laboratory tests and screening
algorithms be applied to those presenting themselves with flu-like symptoms. The situation
might be further confused and complicated once the Ebola outbreak becomes public knowledge
and patients with influenza believe they may have Ebola.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 12
If first responders know to recognize the symptoms of biological agents, they would give
the medical system an additional “sensor” to identify and speed up the process of DTT. In other
words, first responders who are alert to the possibility of biological terrorism and are trained to
distinguish indicators of biological terrorism from ‘ordinary’ illnesses and infections can serve as
an early warning system bringing these events to the attention of medical personnel capable of
accurately screening for and diagnosing infections from a deadly biological agent. In Duncan’s
case, the hospital did not relay his travel from Liberia to the administrative personnel who made
the decision to send him home. This decision increased the number of people he may have
infected, including the sick people in the waiting and pharmacy areas of the hospital.
While four of the 24 weeks of the Chemical, Biological, Radiological, and Nuclear
(CBRN) Center and School are devoted to operating in a simulated contaminated environment,
all Chemical Corps officers spend at least a day in the Chemical Defense Training Facility
(CDTF) which boasts live CBRN agent and source training. This live training is conducted in
protective equipment ranging from the lowest level of protection known as Mission Oriented
Protective Posture (MOPP) Zero, which provides no splash or vapor protection, all the way up to
Level A, fully encapsulated self-contained breathing apparatus (SCBA) with splash protection.
MOPP equipment levels start at carrying the entire suit, MOPP 1has protective pants and top,
MOPP 2 adds protective overboots, MOPP 3 adds the mask, and MOPP 4 finalizes with gloves.
A significant amount of class time is devoted to identifying the symptoms, visual description,
and methods of delivery of conventional CBRN agents as well as many of the next-generation
CBRN warfare agents. Despite the length of this training, the course does not address how to
conduct operations in a populated environment with armed threats, or live casualties, who might,
like a drowning person, try to tear a first responder out of the protective suit to save themselves.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 13
Select US Army Special Forces teams receive training on operating in MOPP 4 or Level B,
splash protection with SCBA, in a threat environment.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 14
Literature Review
There is a plethora of material on the internet pertaining to biological warfare agents.
From hefty tomes on the history of biological warfare to small journal entries expounding on the
need for more resources to ensure protection from the same, there is no shortage of reading
materials. Knowing this it takes a significant amount of time to sift through the dross and find
the sources with both accurate information and the clarity to explain the importance of the threat.
The Center for Disease Control (CDC) is a great source for anything biological as the CDC’s
mission is protecting from infectious disease. The CDC produces a number of journals relating
to various causes and factors of infection. The Department of Defense has a significant amount
of information classified Official Use Only or higher on all subjects related to all warfare agents
including next generation agents available to the appropriate personnel. With the outbreak of
Ebola in the United States, the CDC and other government agencies have published guidelines
and information designed to minimize the fear and myths surrounding this hemorrhagic fever.
Medical associations have published a significant number of articles supporting or refuting the
CDC’s and some State’s measures regarding Ebola as well. As the government and Medical
communities expand public awareness of biological events, the media also weighs in, pointing
out faults and successes. Since the public tends to believe what is presented on the news, the
desire for greater security due to the now visible threat or Ebola, and by extension biological
warfare agents, Security organizations are beginning to discuss how to protect assets from
biological threats.
Centers for Disease Control (CDC) has published a significant amount of information
about diseases and publishes a weekly report focusing on Morbidity and Mortality across the
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 15
spectrum. This is a short document containing many authors and opinions and represents a great
place to starting research.
In 1999 the CDC released an issue of the Morbidity and Mortality Weekly Report
focusing on anthrax attacks around the nation along with guidelines to prepare for attacks and
how to cope afterward. The report focuses on “letters alleged to contain anthrax sent to health
clinics on October 30, 1998, in Indiana, Kentucky, and Tennessee. During December 17-23 in
California, a letter alleged to contain anthrax was sent to a private business…” (Bioterrorism,
1999) After giving a synopsis of the events, the CDC provides guidelines for response planning
and post-exposure protection. The crux of the guidance is “public health response to
bioterrorism requires communication and coordination with first responders and law enforcement
officials…” (Bioterrorism, 1999)
In 2003 the CDC published a short review of the events surrounding a possible ricin
contamination of the Greenville, SC mail distribution center. After a suspicious package was
identified and quarantined, the plant was reopened when “all workers who had worked at the
facility since the package was discovered had been contacted and confirmed to be well and
environmental samples for ricin were negative.” (Gibson, 2003) This event shows how easily an
attack could occur and how quickly one could be thwarted by alert people in the field.
In Science Magazine Dr. Henderson writes about biological weapons and how they have
garnered attention. Dr. Henderson writes “Discerning the nature of the threat of bioweapons as
well as appropriate responses to them requires greater attention to the biological characteristics
of these instruments of war and terror.” (Henderson, 1999) Dr. Henderson writes his work
before the attacks of September 11, 2001 however he argues “the paradigm of a weapon as a
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 16
nuclear device that explodes or a chemical cloud that is set adrift leaves us ill-equipped… to
assess and thus to prevent the potentially devastating effects of bioterrorism.” (Henderson, 1999)
Dr. Christopher Richards points out in the Annals of Emergency Medicine in 1999 “only
the military has some capability to actually detect a bioagent in the field.” (Richards, 1999)
Since the attacks on September 11, 2001, this has changed but his policy focus is more on the
necessary steps taken once a patient enters a hospital system as opposed to detection before
infection. Another author who writes before the September 11, 2001 attacks is Keim, who
discusses how to respond to bioterrorism. Keim also focuses on “Emergency physicians, first
responders, and hazardous materials response teams need[ing] a standardized approach to the
management of patients who may have been exposed to biological threat agents.” (Keim, 1999)
However, he maintains “Currently recommended hospital infection control procedures seem
appropriate for the level of risk involved…” (Keim, 1999) Given the more appropriate level of
attention bioterrorism has garnered this may no longer be accurate.
Dr. Yasuo Seto of the Organization for the Prohibition of Chemical Weapons discussed
the Sarin gas attacks in Japan by Aum Shinrikyo. If the Japanese police had not been able to
determine Sarin had been used in a test run earlier, the subway attack would have been much
more effective. Kaplan and Marshall also provide exhaustive details about the history and
background of this cult in their work The Cult at the End of the World. The authors also describe
how the cult was planning to obtain Russian nuclear weapons and even attack and overthrow the
Japanese parliament.
Organizations such as the Heritage Foundation can be great sources of data on any
number of subjects. However, one must always read what is published with an understanding of
the bias the organization has. Mayer and Erickson write for the Heritage Foundation about Law
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 17
Enforcement Education “The education obtained throughout the academy, directed through
POST [Peace Officer Standards and Training] mandates, helped to form the functioning law
enforcement officer’s working character.” (Mayer, 2011) If First Responders can be taught the
signs and symptoms associated with bioterrorism, correct responses can then be expected.
Risk is always involved when using media sources. During the Ebola outbreaks in 2014
almost all news outlets carried stories about the various patients infected and how some were
improperly diagnosed or quarantined. Depending on the news outlet, President Obama’s
handling of the possible Ebola pandemic was either spot on or moving the nation closer to the
edge of chaos. The Blaze and the Heritage Foundations’ Daily Signal both carried articles on the
Ebola outbreak of 2014, specifically the death of Eric Duncan. The primary crux of the articles
is Duncan walked into a hospital and was sent home despite his symptoms and his travel history.
The lack of proper care he received is directly related to his death.
In the end, there is a gap in current literature. This gap has grown since September 11,
2001 and the realization the homeland is no longer secure. While technology and awareness
have grown to help combat emerging threats, most medical research and defensive techniques
are decades old. Lastly, as the policy section of this paper will show, the advent of new
Department of the Army policies combined with US Army Reserve Command re-alignments
provide a new tool in the fight against biological warfare agent attack.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 18
Methodology
This Thesis will attempt to fill the training gap identified earlier by presenting a policy
option enabling State and Local organizations to receive training on any Chemical, Biological,
Radiological, and Nuclear (CBRN) threat, without incurring significant additional costs. First,
an outline of the current system for detection and treatment of biological attack, and how they
are lacking in the light of the recent Ebola cases will be presented. The method for increasing
the knowledge base for First Responders will be discussed based on the unique mission sets and
threats faced. Included in this discussion will be the effect of pay and hours available.
Breakdowns of what type of training and when in a responder’s career the training should be
applied will be covered. A proposed solution to the training gap will be laid out, showing how
this training supports National Goals as well as State and Local needs. This solution will allow
for greater interoperability and standardization of methods and techniques across the spectrum of
emergency response.
A catalog of biological warfare agents, production methods, materials, and equipment
will be laid out to demonstrate the ease of production and identification. This section will
include history and signs and symptoms of the major warfare agents along with treatment options
currently available. Images for the agents will be included to demonstrate the terrible nature of
these threats. The equipment required for agent production will also be discussed with pictures
for general identification. The recipes for these agents will be presented in an abbreviated format
due to classification issues and the desire to not enable threat production.
In the end, this thesis will answer the question “Do American First Responders have the
knowledge to recognize threats such as biological weapons in a populated area?” This answer
must meet certain criteria in order to be valid. Given the austere financial times the solution
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 19
must be fiscally responsible, as well as feasible and suitable to the issue at hand. The solution
put forth in this Thesis will cost little to no money not already being paid out to employees of the
federal government. Additionally, all training conducted will support overall national level
needs nesting all training objectives with higher level’s strategic goals.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 20
Types of Biological Warfare Agents
The CDC divides Biological Threat Agents into three nominal categories - the A, B, and
C categories. Category A agents are characterized by the ease with which they can be
disseminated or transmitted, they have high mortality rates, and widespread infection might
cause public panic. Category B agents have easy to moderate transmission, and they involve
moderate morbidity (rate of sickness) and low mortality. Category C agents are emerging or
future threats based on availability, are relatively easy to produce and disseminate, and have the
potential for high morbidity and mortality. For this paper, Category C agents will not be
discussed due to classification rules.
Category A Agents are further broken down in three subsidiary categories: bacteria,
toxins, and viruses. Common Bacteria agents are Anthrax, Plague, and Tularemia. The common
Toxin agent is Botulism or Botox. Common Virus agents are Smallpox, and Hemorrhagic Fever
(Ebola). While not all of these agents can be made in clandestine labs, this paper will familiarize
the reader will the major agents.
Bacillus Anthracis or Anthrax is a naturally occurring spore forming soil based bacteria
which is very stable in the environment and is easily disseminated. The three main forms of the
disease are cutaneous, ingestion, and inhalation. Treatment for Anthrax is Doxycycline,
Ciprofloxin, and Penicillin, usually intravenously. Cutaneous infection occurs via breaks in the
skin or from biting flies. The symptoms include rapid necrosis, and black necrotic lesions with a
20% untreated mortality rate and a near 1% for treated persons. Gastrointestinal Anthrax results
from ingestion of contaminated food, usually meat, or water. The symptoms include sore throat,
fever, swollen lymph nodes, nausea, bloody diarrhea, toxemia, shock, and death. This form of
the disease has a greater than 50% mortality rate. Inhalation Anthrax results from the inhalation
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 21
of spores into the lungs. While the incubation period is 1-6 days persons will see mild symptoms
it may be hard to diagnose (Henry, 2001). These include abrupt onset of fever, non-productive
cough, chest pain, and sweats. Shock and death occur 24-36 hours after abrupt onset with a
100% mortality rate. What make anthrax so dangerous is the ability of the bacteria to grow
spores. Usually found in long “string like” formations the bacteria can last for centuries when
placed in less than ideal conditions. When the bacteria detects the environment around it is
dangerous, the strings begin to break apart and form “seeds” which grow a protective shell. This
shell, or spore, allows the bacteria to remain safe and dormant for extremely long periods. Once
the spore is placed into warm, moist conditions, such as lungs, the spores dissolve and the seeds
begin to reform strings.
Anthrax under Microscope (CDC, 2014)
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 22
Yersinia pestis or Plague, commonly known as the Black Death, is a historically deadly
bacteria. Famously known for killing millions of people starting in China and spreading to
Europe in the middle ages. (History, 2012) Plague is passed from person to person or through
fleas and is relatively stable in the environment. The three primary forms of the disease are.
Bubonic, Septicemic, and Pneumonic. Plague is usually treated with Tetracline and
Streptomycin. Bubonic Plague symptoms are swollen lymph nodes, fever, chills, and weakness
and has a greater than 50% mortality rate if untreated and 10% if treated. Septicemic Plague
adds abdominal pain, shock, and bleeding underneath the skin or organs and has a 100%
untreated mortality rate. Pneumonic Plague presents with severe pneumonia and shortness of
breath, necrosis of the small blood vessels (hence the “black death”) and productive cough and
also has a 100% untreated mortality rate. Pneumonic Plague is also the most likely to cause a
contagious epidemic.
Plague Signs (CDC, 2014)
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 23
Francisella Tularensis or Tularemia commonly known as Rabbit Fever is highly prevalent
in the US in the Arkansas, Oklahoma, Missouri, and Kansas areas but can be found throughout
the country. Tularemia is spread by direct contact, inhalation or ingestion and can remain viable
in soil or water for weeks. The most common form of the disease is Ulcerograndular at 75% and
Typhoidal-Systemic at 25%. The standard treatment is Tetracycline or Streptomycin. Tularemia
is contracted through contact or arthropod bites. It shows with ulcer development, lymph node
enlargement, back pain, fever, chills, exhaustion, non-productive cough, and nausea.
Ulcerograndular has a 5% untreated mortality rate while Typhoidal has a 50% rate.
Tularemia Outbreak (CDC, 2014)
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 24
Clostridium Botulinum Toxin or Botox is the most potent biotoxin currently known and
effects the nervous system. The most common forms are Food Born, Wound, and Infant. The
route of infection is ingestion or direct inoculation (purposefully injected) with symptoms
showing 12-36 hours after ingestion. Symptoms include Weakness, dizziness, weariness,
constipation, difficulty speaking, descending paralysis, and respiratory paralysis. Botox has a
significant mortality rate.
Wound Botulism of Right Arm (CDC, 2014)
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 25
Variola Virus, known as smallpox is known only to humans and is passed among
unvaccinated populations. Route of infection includes contract with pulsates, whether direct or
indirect, or through respiration. The symptoms include high fever headache, chills, back pain,
exhaustion, body rash blistered lesions leading to scabs with a fatality rate of 30%.
Man with Smallpox (CDC, 2014)
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 26
Hemorrhagic Fevers include Marburg, Junin, Lassa, and Ebola viruses, usually having a
low infections dose. While passed from person to person, inhalation is also a risk. Symptoms
include high fever, internal bleeding and hemorrhaging (bleeding profusely) from orifices with
various mortality rates.
Isolated Female Patient Diagnosed with Crimean-Congo Hemorrhagic Fever (CDC, 2014)
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 27
Category B Agents are broken down in two categories, bacteria and toxin. Common
Bacteria agents are Cholera, Typhoid Fever, and Typhus Fever. The common Toxin agents are
Ricin and Staphylococcus Aureus. While not all of these agents can be made in clandestine labs,
this paper will familiarize the reader will the major agents.
The Category B Bacteria Agents are not normally used for biological weapons. Vibrio
Cholerae or Cholera is transmitted through food or water contamination with symptoms water
diarrhea, vomiting, low blood pressure, thirst, restlessness, and dry mucous membranes. Cholera
is easily treatable with antibiotics. Salmonella Typhi or Typhoid Fever lives only in humans and
is transmitted through food contamination. Typhoid symptoms include fever, weakness, stomach
pains, and flat rose colored spots and is treated with antibiotics. Rickettsia Prowazekii or Typhus
Fever is spread by body lice, and flying squirrel ectoparasites. Typhus symptoms include fever,
headache, malaise, vomiting and rashes. Typhus can be deadly in 20%-60% of untreated cases.
Loss of Skin Elasticity seen is Cholera (CDC, 2014)
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 28
Ricinus Communis or Ricin is made from Castor Bean plants. Ricin is transmitted
through inhalation, injection, or ingestion. The Castor plant is easily available and the process of
production is not difficult to find. Ricin symptoms include fever, weakness, non-productive
cough, pulmonary edema, respiratory distress, vascular collapse, and death within 36-72 hours.
Mortality is dependent on dose and there is no known antitoxin.
Castor Beans (CDC, 2014)
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 29
Staphylococcus Aureus or SEB Toxin is usually inhaled or ingested and is stable and
water soluble. Ingestion symptoms include intense nausea, vomiting, abdominal pain, and
diarrhea. In this form the disease is debilitating rather than deadly. If inhaled, a sign of
intentional poisoning, SEB Toxin symptoms include fever, headache, nonproductive cough,
chills, shortness of breath, and chest pain. Symptoms will lead to respiratory failure.
Effects of SEB Toxin (CDC, 2014)
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 30
As stated above, Category C agents are under specific classification, however this
category includes specific forms of: Influenza, SARS, Encephalitis, and Tick-borne Hemorrhagic
Fevers. This category will also include hybrid agents which will either evolve naturally or as the
result of specific experimentation.
Biological weapons are not difficult to create. Some of the procedures below will be
described in abbreviated detail because the source of the information is For Official Use Only or
Law Enforcement Sensitive. The point of this section is not to be a primer for weapons
production but rather provide the reader an understanding of the ease of production on the non-
state level.
Bacterial production requires either liquid or solid cultures to grow the agent. As the
agent grows, it can be transferred to larger vessels as needed. Obviously the larger the vessel the
more ingredients are required as well as risk of detection. Bacterial growth follows a predictable
pattern starting with the inoculation of the growth media, and then an exponential growth phase,
leading to death of the bacteria. The growth phase can be sustained as long as the bacteria is
given sufficient space and food. When sufficient bacteria has been grown it is harvested in
centrifuges and then dried for dissemination. Once dried the bacteria is milled to the correct size
and prepped into the dissemination method.
Viral production requires hosts to grow, usually live chicken eggs. The viral source is
inoculated in live tissue such as animals or eggs and allowed to incubate. Once the virus is
sufficiently developed, it is harvested from the live subject and can be immediately used for wet
dissemination. If a dry dissemination is desired then the virus is dried and milled to the
necessary size.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 31
Toxins are harvested from their source and prepared for distribution through
fermentation. Once isolated the toxin is extracted, purified, and dried for dissemination. The
fermentation process allows the toxin to be separated from other impurities present in the source
plant, animal, or bacteria. Once dried the toxin is milled to the necessary size.
Once a First Responder understands the symptom and the nature of the illness that he or
she is encountering, further confirmation must be sought on scene if possible based on
production methods. The symptoms and production methods are two significant indicators for
initial analysis, and can be useful to determining that protective equipment is required on the
scene.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 32
Biological Warfare Agent Production by Agent
This section will cover the production processes for various compounds and the inherent
dangers. While the focus of this paper is risk and dangers posed by biological agents, many of
the precursors for these agents are shared with illegal narcotics as well. This section does not
contain the exact recipes for biological warfare agent production, but does provide sufficient
representation of the required processes. The information below is available on the internet;
please do not attempt to make any of these substances at home.
Ricin
Ricin attacks the vascular system of the body and has no anti-toxin. Ricin can be
extracted from castor seeds, a plant which can be bought from local plant stores and is used as a
decoration. Ricin is extracted from the castor seeds much like the meat of a sunflower. Once the
seeds are soaked they can be broken open, and the meat can then be ground and dried into
powder. Pure ricin powder is white, if discolored then the process is either incomplete or
rudimentary. One Castor bean plant yields approximately 1300 seeds or roughly 2.75 cups of
seeds. One cup of seeds, roughly 500 seeds, weighs 130 grams and can yield up to three grams
of pure ricin. Lab processes require some easily-obtained ingredients such as vinegar, acetone,
bleach, and Epsom salts, as well as some more difficult to obtain ingredients, such as DEA List
II regulated chemicals hydrochloric acid and sulfuric acid. Responders can easily identify a
location where ricin is being produced by the presence of Castor Seeds, coffee filters, and
blenders. Dead animals in the vicinity are also a good indicator of the agent.
Botulinum Toxin
Clostridium Botulinum Toxin or Botox is the most potent biotoxin currently known and it
effects the nervous system. While primarily used to fix wrinkles and signs of aging, if given in
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 33
sufficient doses the toxin can shut down the body’s ability to use the nervous system to function.
Botulinum bacteria can be extracted from soil where it grows naturally, or the bacteria can be
grown in fatty beef without oxygen and is stable is tap water. The bacteria can be placed into
beef, placed into an airtight container such as a mason jar, and allowed to grow. Once the
bacteria has consumed the beef it can be purified and then given to the target. As it is grown in
rotting meat the toxin will have a putrid odor and can be part of a slurry or dried to a refined
powder. Responders can identify the botulinum toxin process by the presence of jars, pressure
cookers, raw and rotting meat, and the DEA List II regulated chemical hydrochloric acid.
Anthrax
Bacillus Anthracis is a naturally occurring spore forming soil based bacteria. What
makes anthrax so dangerous is the ability of the bacteria to grow spores. Usually found in long
“string like” formations the bacteria can last for centuries when placed in less than ideal
conditions. When the bacteria detects the environment around it is dangerous, the strings begin
to break apart and form “seeds” which grow a protective shell. This shell, or spore, allows the
bacteria to remain safe and dormant for extremely long periods. Once the spore is placed into
warm, moist conditions, such as lungs, the spores dissolve and the seeds begin to reform strings.
Once a sample of anthrax is obtained, it is placed into an incubation media, easily purchased
from laboratory supply companies, and allowed to grow. Once a sufficient amount is grown the
bacteria is introduced to less than ideal conditions so the spores will form. The spores are the
best way to disseminate the agent across a large area in any environment. The most deadly way
to contract the bacteria is through the lungs with death occurring 24 to 36 hour after symptom
onset at a 100% mortality rate. The most common route of infection is though food, usually
meat, which can lead to toxemia and death if untreated. Anthrax spores are usually white to gray
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 34
in color and look like a powder. Responders can identify this process because of the hazardous
material items such as incubators, growth media, storage units, and glove boxes. The DEA List
II regulated chemical, hydrochloric acid will also be found on site along with bleach and acetone.
Nicotine
Nicotine is a poison commonly inhaled, usually in cigarettes, or readily absorbed through
the skin and mucous membranes. Nicotine Sulfate is usually sold under the trade names Black
leaf 40 or Tender Leaf Insect Spray. Nicotine can also be extracted from tobacco products if
required. In this process tobacco is heated and filtered, with the extract containing the poison.
Responders can identify this process through the trade labels, large quantities of tobacco
products, and the DEA List II regulated chemical, ethyl ether, along with calcium hydroxide
(lime water) and isopropyl alcohol.
Once a First Responder understands the processes for the biological warfare agent that he
or she is encountering, further confirmation can be found by analyzing the equipment on scene.
The production process and equipment on scene are important for initial analysis, and can be
useful to confirming that a biological warfare agent is or was present.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 35
Biological Warfare Agent Production Equipment
As a first responder entering a location the ability to identify glassware and clandestine
laboratory processes, including precursors, is vital to determining the nature of the hazard one
may be facing. This section will cover the basic lab glassware and equipment most commonly
found in clandestine laboratories. All of the items listed below are available for purchase from
reputable sellers on the internet and ownership of these devices does not represent a crime.
SHEL LAB Economy Lab Incubator with Digital Controller, 1 Cu. Ft. (28 L) (Shel Lab, 2014)
Incubators: Incubators allow for the control and regulation of temperature, humidity, and
other environmental factors effecting the growth and development of biological agents. While
the presence of an incubator is not a definite sign of biological agent production, it is a red flag
and an indicator of the type of agent may be present. Anthrax, Botox, and Plague are among the
agents requiring incubation.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 36
Celestron Advanced Biological Microscope 1000 (Celestron, 2014)
Microscopes: Microscopes are used to see very small things. In biological agent
production, being able to see the development of the agent as different environmental factors
change, or ensuring the host media is properly infected with the agent before dissemination are a
few uses for this piece of equipment. The existence of microscopes is not a defining indicator of
wrong doing but when added to other laboratory equipment it can paint a clearer picture.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 37
BioRad Centrifuge (BioRad, 2014)
Centrifuges: Centrifuges are devices designed to separate items, usually by size or
weight. Agents with impurities can be subjected to centrifuge processes allowing the production
of more pure substances. This item is also found in drug labs. Additionally, depending on the
type of centrifuge, separation of the agent from an existing host’s body fluids, like blood, can be
done allowing for a cleaner, more pure agent.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 38
Magnetic Mini-Stirrers with Speedsafe (Magnetic, 2014)
Magnetic Stir Plates: Magnetic Stir Plates are used to mix ingredients for agent
production. Whether mixing two liquids or a liquid and a powdery substance the magnetic stir
plate allows for a constant speed for the solution. Additionally, magnetic stir plates have very
few moving parts, allowing them to run constantly with little to no maintenance, meaning this
stage of agent production can be performed simultaneously with other stages if necessary. There
are not many at home uses for magnetic stir plates, so this is a major indicator of wrong doing,
however this item is not a definite weapons only item.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 39
Bio Fermentation Tank (BioFermentation, 2014)
Fermenters: Fermenters are used to allow bacteria and other organic substances to grow
in non-oxygen environments. They can be used for food production, but are rarely seen in
private homes. Fermenters allow the agent to grow at accelerated rates by regulating the oxygen
content and providing temperature control throughout the growth media. This allows the agent
production process to advance rapidly once a suitable agent is produced and introduced to the
fermentation process. This apparatus is a strong indicator of biological agent production but the
other laboratory items must be present to confirm the substances existence without sampling.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 40
Tuttnauer 2340M Manual Autoclave (Tuttnauer, 2014)
Autoclave: In order to maintain a sterilized environment autoclaves are used to subject
instruments and tools to steam at extreme pressure. While many models are not stable at high
temperature, such as rubber gloves, most biological agent production items are made of glass or
metals. Many hospitals and research facilities are beginning to employ one time use materials
such as injector kits for medicines, and surgical tools, reducing the need to use autoclaves for
sterilizations. Despite this, a clandestine laboratory with limited funds would benefit from the
ability to use materials several times. While autoclaves are not common household items, they
are found in tattoo and piecing shops, and barber and hair salons. If found in the presence of
other laboratory equipment this device is a good indicator of nefarious or illegal activities.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 41
Thermo Scientific HERAtherm General Protocol Ovens (HERAtherm, 2014)
Drying Systems: The proper and rapid drying of biological agent production glassware
and tools is vital to maintaining a sterilized environment. If the glassware or tools are
improperly dried or left out to dry in the elements, impurities and other contaminates could be
introduced into the agent production process damaging or rendering useless the agent being
produced. Additionally, dirt and dust can be introduced to the agent production systems
mentioned above and can cause significant damage causing delays and high replacement costs.
This device is not widely used in homes and when seen with other laboratory equipment is not
illegal but is an indicator of medical level activities.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 42
Ceramill Motion 2 Milling Machine from AmannGirrbach GmbH (Ceramill, 2014)
Milling Systems: Milling systems are used to grind solids used in biological agent
production to the correct size. This allows for the agent to be manufactured to combat the
specifications of any protective equipment and detectors. While not many homes have this level
of mill, certain cultures mill food stuffs such as corn to make certain dietary items. Knowing
this, first responders should know the difference between a laboratory mill and a home mill, and
taken with other laboratory equipment this can be a signal of criminal activity. As with other
equipment listed here, mills can be used for drug as well as biological agent production.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 43
The lists below are for High School laboratory equipment. While not a complete list of
what can be purchased online, the list is representative of what can be bought and how much it
could cost. Seeing many of these items outside of a designated laboratory location such as a
school, would be a serious indicator of wrong doing, but as with the above items does not
represent a crime. First Responders should know and be able to recognize the items listed below
are not normally for cooking food and could be used to make drugs as well as biological warfare
agents. The presence of these items should indicate further sampling and testing maybe required
and follow on agencies should be called on scene to determine the product being made.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 44
Frey Scientific Lab Lists, 2013
First Responders who understand the symptoms, processes, and equipment for biological
warfare agents can aid in decreasing the recognition time for all elements of emergency
management. How to train a First Responder to be aware and ready is vital to the success of the
emergency management enterprise.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 45
Policy Options and Recommendations
Emergency room personnel need not be the only human indicator of biological attacks.
In order to function effectively to inhibit or prevent the deaths and illnesses resulting from a
biological attack, and to ensure the prompt and effective operation of the DTT process, the
Nation’s First Responders must be able to identify the signs a CBRN attack has occurred and
recognize the laboratory processes and precursors necessary to conduct these attacks. The
capacity to identify these indicators at the earliest stages of a biological attack or outbreak is
essential so follow on entities such as hospital personnel, healthcare professionals and crime
scene investigators can take the appropriate steps to protect themselves or others from secondary
contamination. In the end suspects, bystanders, and responders can be cleared of contamination
and placed back into general population. Secondary contamination will increase the burden on
the response system as the contamination spreads to greater areas and population counts. If the
type of contaminate is extremely contagious, the risk of widespread panic increases dramatically.
Training first responders to recognize and identify biological agents as well as their
precursors and symptoms is relatively simple and can be implemented at relatively low cost.
Training can be accomplished in two phases across a responders’ career. The first could be basic
awareness-level training taking place at during the first responders’ initial entry-level training,
such as the police or fire academy. This training might consist of one or more modules of
training on CBRN agent symptoms and precursors, laboratory process recognition, and high risk
entry training using a protective mask. The second phase could be provided in annual in-service
refresher, followed by a written exam on symptoms, precursors, dissemination methods, and
visual identification of laboratory processes. Finally, all in-service responders would have to
demonstrate they have maintained the ability to operate in a protective mask.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 46
The high risk training would be significantly different for different categories and roles of
First Responders, and the specific elements of this training should vary depending upon the first
responders’ task environment. Police, for example, are likely to encounter the indicators of a
biological weapon under different conditions and circumstances than firefighters, simply because
their roles and operating environments are so different. To be effective and relevant, the training
provided to different first responder occupational groups should align with the realities of the
work they do.
For Police the high risk entry training would include training on tactics to enter and clear
a structure with both threat and non-threat targets while wearing a protective mask, and might
include tactical training concerning the rescue of a downed officer. For Firefighters, who already
wear SCBA into high risk situations, the training might focus on firefighting operations in areas
with dangerous chemicals and biological hazards. For EMS personnel, the training might focus
on entry into a location with victims who are panicking as well as on treating patients while
wearing a protective mask and the safe evacuation of casualties to avoid secondary
contamination. Many state and local agencies do not have sufficient training dollars to give this
threat the proper amount of time and man power necessary to ensure minimum risk is achieved
by a potential attack. According to Long Island University’s Dr. Vincent Henry, “Particularly in
an era of fiscal austerity, one of the critical issues municipal public safety agencies have to deal
with is justifying the need and expense of training." Because biological events are very low risk,
very high consequence events, municipal agencies may not give high priority to training for
these events. Agencies must recognize the effects of an attack in an American city would be
devastating, despite the actual rate of incidence of biological attacks being low. State and local
agencies must maintain a requisite level of manpower “on the streets” to maintain law and order
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 47
and perform other public safety functions while still providing sufficient time for First
Responders to receive proper training. Cognizant of these constraints and requirements, the
Department of Defense (DOD) typically maintains a 10% overage of Commissioned Officers in
order to keep duty positions filled and maintain professional military education. For many state
and local agencies this number can drop to one third of the force in school with no overages.
The issue of maintaining sufficient ‘minimum manning’ can be complicated and made more
expensive by the rotating shifts many first responders work and the seven day, 24-hour
operations first responder agencies conduct. As a result, First Responders working the overnight
shift, for example, may have to work a double shift (perhaps incurring overtime) to get daytime
only training. While budget shortfalls may lead to departments cutting unnecessary training to
levels that meet, rather than exceed, their liability requirements, effective biological threat
training can be accomplished at relatively low expense. By giving the basics of this training in
the academy, or even through Internet-based training modules First Responders can complete on
their own, only refreshers would be needed annually.
Defense Support to Civil Authorities is a newly revamped doctrine in the Department of
the Army (DOA) under Army Doctrine Publication (ADP) 3-28 placing federal soldiers into the
Incident Command System after a major incident occurs. While Federal Troops and support
have been used for years to reinforce State and Local events such as hurricanes and forest fires,
the DOA has finally put Defense Support to Civil Authorities (DSCA) on the same level as
Offensive and Stability Operations. Under the terms of DSCA doctrine and policy as well as the
legislation enabling its conduct, states can request an appropriately-trained National Guard or a
local Reserve Training Support Battalion to deliver a standardized training program to local
agencies. Because the DOD has already paid the costs of training development for its own
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 48
Soldiers, local agencies would realize substantial savings, at the same time helping to build the
relationships required to conduct Civil Support operations in the event a disaster or attack does
occur. Army Reserve Training Support Battalions have various skill sets geared toward
providing relevant effective training for Soldiers preparing for and going into combat. These
Battalions like all Reserve units must provide their Soldiers with 24 days of Battle Training
Assemblies (BTA) and 14 days of Annual Training (AT). This is the one weekend a month and
two weeks a year mantra from the commercials. This is in addition to the regular work schedule
the Reservists have in their non-military careers. A First Responding agency could request the
local Training Support Battalion come for a given length of time to give classes and training
without adding cost to the military by simply having Soldiers conduct their monthly BTA or AT
during this same period. An argument can be made for using these Soldiers for current mission
requirements, but with the drawdown in Afghanistan and the lack of mobilizations for Reserve
Soldiers opens a great amount of personnel for other missions.
The Reserve Battalion is required to conduct annual Chemical, Biological, Radiological,
and Nuclear (CBRN) training and can request the requisite materials to accomplish this training.
If the Reserve Battalion aligned its CBRN training with the First Responders training both could
use the materials at nominal to no additional costs. Furthermore, as stated above, the DSCA
Doctrine requires Local, State, and Federal organizations work together during emergencies.
Using this requirement, States could fund additional materials and pay using Federal money for
Emergency Preparedness. All of these steps would meet the Federal goal of well trained and
coordinated emergency responses, the State goal of better training with less waste and the local
goal of better training with less cost. Furthermore, these units could train first responders on all
aspects of CBRN threats not just biological.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 49
Little to no biological threat training is conducted for the majority of First Responders
based on discussions with Dr. Vincent Henry, retired New York Police Department, Katrina
Morgan of the Richland County, SC Sheriff’s Office, and Benjamin Hann of the Charlotte NC
Police Department. For most agencies this is born out of the lack of tangible threat and for
others it is born out of time and budget constraints. Both are understandable and given the
budget crisis facing most municipalities’ citizens prefer agencies do not waste resources for low
or non-existent threats. Even the United States Army is downsizing the amount of CBRN
Soldiers contained within the ranks as well as cutting training money for national level
Emergency Scenarios. Organizations make up for these adjustments through the use of computer
based training events allowing organizations spread across large geographical areas to come
together and train without spending thousands of dollars on travel, maintenance, and lodging.
The current policy options for dealing with natural or intentional biological agent
outbreaks lack the depth to ensure preparedness for the future and rely on the hospital system to
detect the threat and develop treatment plans. While this system does work, and given the right
amount of time can solve the problem, Detect to Treat is not effective if any one piece of the
system fails as seen in the Duncan Ebola case. While the Duncan case was not a failure on the
part of first responders, it is an example of how a Detect to Treat failure can leave civilians open
to threats. First Responders need the tools to identify threats before a crisis develops while being
able to defend themselves from the same threats.
Other options for solving this problem include Responders paying for training on their
own time, private organizations teaching classes at cost to the agency, or providing training only
at the academy and relying on internet based training to maintain the knowledge. Responders
paying for their own training puts a double burden on the Responder. First the Responder will
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 50
not be at work, or if off shift, will not be at home with the family. For many Responders, Union
rules come into play when doing work related training on personal time. The second impact felt
by Responders will be from their personal bank account unless they can receive reimbursement
from the agency. Private training organizations are a great resource to provide specialize
training, but they cost significant amounts of money, and still require Responders to be available
when the organization can provide the training. Relying on internet based training to maintain
knowledge and skill sets is dangerous because Responders can find ways to ensure success
without significant work or study, the online training costs money to build and maintain, and
agencies will likely have to pay for Responders’ time spent online.
A new paradigm in national level training must be established to keep the nation’s
defenses firmly rooted in current threats without incurring significant cost increases. Currently
individual agencies must either pay to send their people to schools or pay to have experts come
teach at the local agency school house. This means the local Police department would have to
pay to have a Deputy fly to a training site, pay for hotels, food, and training aids in order to
receive training which will make the nation as whole more secure. The military uses this model
as well even though the money all comes from the same place.
The new training model should look more seamless and allow for more continuity of
training. As discussed above the use of Reserve Training Support Battalions would reduce the
costs and aid in maintaining a high level of training readiness. Rather than having the local
Police have to scrounge up the money to send a Deputy to the New York Police Department’s
Biological Agent Protection course for a long weekend, a Reserve Unit could schedule their
mandatory two week Annual Training or a weekend Battle Training Assembly at the local Police
Office and conduct training. Using a US Army Reserve Soldier at the rank of Sergeant First
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 51
Class, or E7, with 10 years of service is costs $499.60 plus food and around $35-$40 for lodging
for a Battle Training Assemble. If this same Soldier was tasked to train a local Responder
organization during this same time period, the cost would be exactly the same. Active Duty
Soldiers may require Temporary Duty funds to cover the cost of living away from home.
Reserve Soldiers receive this pay simply by attending the BTA regardless of where it is held. No
additional cost would have to be spent on the Soldier to conduct this training so the US Army
Reserves budget would remain the same. Normally State and Local organizations would have to
reimburse Federal or out of State organizations for their work under the Stafford Act. Since
State and Local organizations receive money to support training, either this money could be
used, or since the money is going to be spent on the Soldier anyway an amendment could be
made to exempt this type of activity. This would ensure all organizations who need or want
training will receive the training using the same materials, tests, and procedures across the
nation. Unity of method will allow different organizations to seamlessly integrate during time of
national emergency. To ensure this training is correct and based in the most accurate science the
Center for Disease Control should be the lead effort to design and build the courses.
The Center for Disease Control (CDC) is the primary organization for the US
Government’s efforts to “protect America from health, safety and security threats, both foreign
and in the U.S.” from diseases which “start at home or abroad, are chronic or acute, curable or
preventable, human error or deliberate attack.” (CDC, 2014) This means the CDC is the primary
federal organization for the protection of the American people against illness whether natural or
intentional. Based in Atlanta, GA, the CDC has departments for Global Health, Occupational
Safety, Infectious Disease, Noncommunicable Disease, Health Preparedness, and Health Science
among others, and it publishes various health related reports and research studies as well as the
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 52
Morbidity and Mortality Weekly Report (MMWR). This weekly report touches on current
events and important topics facing the health community as it relates to disease. The MMWR of
October 21, 2014 featured data on the epidemiological spread and the casualty and fatality rates
of Ebola in Africa.
The course of action that will allow State and Local agencies to prepare for biological
warfare agent outbreaks while ensuring minimum cost and maximum effect starts with the CDC
developing a national response standard for domestic outbreak. This should include
identification of symptoms, ingredients, laboratory processes and equipment, and likely method
of infection for the First Responder. Once the First Responder has identified a possible event,
the CDC guidelines should provide a clear step by step process for reporting the data that led to
the suspicion to the medical facility responding to an event so proper testing, evaluation, and
quarantine can begin. The CDC should also develop a training curriculum supporting these
procedures for all agencies so any responding organization in the country has the same
knowledge and operating procedures. The Department of the Army, and the primary CBRN
response force for the Federal Government in Civil Support operations should conduct the
training for all agencies utilizing the Army Reserve Training Support Battalions across the
country. Using these Battalions will not only keep costs low, as discussed above, this training
will also strengthen Civil Support relationships and ensure preparedness for other National
Emergency Scenario events. The CDC should revise the training every three years, as well as
support development of new techniques and procedures for outbreak response alongside the
Federal Emergency Management Agency, and the Department of Homeland Security.
Other Options for providing training to State and Local First Responders exist but have
drawbacks that would limit their use. The State National Guard Units could be used given their
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 53
prominence in disaster events for states, but as they are primarily combat focused the cost to
adjust missions and create a competent cadre of DSCA trainers would be unnecessary given the
Army Reserves current adaptation to the mission. FEMA could offer grants to local
organizations to send Responders to schools, but this plan does not address the lack of unified
curriculum, the limited number of responders being trained, and time available to receive the
training in a given period. The DoD has developed the CBRN Response Enterprise on which all
Federal Forces operate, however Local and State elements that are not military rarely get access
to this network and system. The Army Reserve Training Support Battalion is designed and
tasked to teach and instruct students on any military mission including CBRN operations and
DSCA making it the most appropriate choice. This is accomplished through AT and BTAs all
across the country supporting Active Duty, National Guard, and other Reserve organizations.
Adding Local and State organizations to the list, meeting the requirements for Total Force
Integration, is the best way to increase education without significant disruption in operations
given that the Reserves have lost many of the significant missions it held over the last ten years
including Bosnia and Kosovo support, the Sini mission, and mobilization for combat
deployments. While the approval of the Secretary of Defense is usually required to send Reserve
Soldiers on missions (meaning longer than the two week Annual Training) or to Federalize a
Reserve Solider this type of training would not require approval due to the short duration and the
already existing relationships required under the DSCA doctrine.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 54
Conclusion
Biological attack whether from a state level adversary or from a non-state actor is one of
the greatest, yet least protected against, threats our Nation faces. As this paper has shown a
determined group of non-states actors could easily produce biological warfare agents in the
privacy of a kitchen in much the same way criminals make methamphetamines. With the
internet, and various dark networks, offering a near endless stream of information a determined
person could find the appropriate recipes for various biological warfare agents and the restricted
materials needed to make them. While cities have the BioShield systems to protect against
significant attack, BioShield has significant limitations and, as with all government programs, is
effected by budgets and training.
The more recently published literature on the subject of biological warfare agent attack is
usually focused on the threat and how it will effect society. Older literature tends to focus on
how hospitals can prepare for the influx of patients will accompany an outbreak. Even movies
such as Outbreak or World War Z which show the rapid spread of disease reveal the gap in
knowledge of rapid identification and response by first responders. Unfortunately, old literature
and movies are the basis for most thought processes on health protection. Rather than allowing
the Center for Disease Control or Health and Human Services develop and support health
protection standards, citizens will attempt to emplace whatever they saw on TV or read in a book
to protect themselves.
This paper has proposed a low cost high payoff method to ensure at least the First
Responders who stand between the sheep and wolves can be as prepared as possible for
biological threats. By providing First Responders with current and useful training the gap
between recognition of a threat and the threat’s spread are dramatically reduced. The
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 55
Department of the Army has significant resources and responsibility in supporting Civil
Authorities before, during, and after an event or attack. Using these resources State and Local
responders can become better prepared and trained allowing for a more rapid response. As
demonstrated above the US Army Reserve is the most cost effective, appropriate, and capable
organization to support local Responders with training.
While other options are available to State and Local agencies to fill the gaps in
knowledge and skills discussed above, very few have the low cost and require long hours and
dedication from the individual responder on his or her own time. Using resources for which the
federal or state government already pays, such as pay for attending a Battle Training Assembly,
allows for responders to maximize their efforts without undue burden to the taxpayer, or at the
expense of more common and likely threats. The best system to combat the threat of attack no
matter what kind it may be, is between the ears of every citizen in the nation. A well-educated
populace dramatically increases the likelihood nefarious activities will be identified in the early
stages and stopped before the danger becomes lethal. Just as citizens are trained to look for the
signs of sickness to avoid spreading colds and the flu, people should be trained to notice the
signs of more significant illness. Additionally, a populous with more knowledge about illness
will be less likely to emplace useless health protection measures or panic when an outbreak
occurs.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 56
References
2340M - Manual Autoclave. (2014, November 19). Retrieved November 19, 2014, from
http://www.tuttnauerusa.com/products/office-based-practices/manual-autoclaves/2340m
About Ebola Virus Disease. (2014, October 3). Retrieved October 20, 2014, from
http://www.cdc.gov/vhf/ebola/about.html
Advanced Biological Microscope 1000. (2014, November 17). Retrieved November 17, 2014,
from http://www.celestron.com/browse-shop/microscopes/biological-
microscopes/advanced-biological-microscope-1000
Bio Fermentation Tank - Buy Bio Fermentation Tank, Fermenter Tank, Fermenting Tank
Product on Alibaba.com. (2014, November 17). Retrieved November 17, 2014, from
http://www.alibaba.com/product-detail/Bio-Fermentation-tank_1100864834.html?s=p
Bioterrorism Alleging Use of Anthrax and Interim Guidelines for Management. (1999, February
5). Retrieved October 22, 2014, from
http://www.cdc.gov/mmwr/preview/mmwrhtml/00056353.htm
Bucci, S., & Corrente-Bucci, J. (2013). Needed: More Biothreat Training for First Responders.
DomPrep Journal, 9(11), 11-12. Retrieved October 22, 2014, from
http://www.domesticpreparedness.com/pub/docs/DPJNov13.pdf
Centrifuges. (2014, November 17). Retrieved November 17, 2014, from http://www.bio-
rad.com/en-us/product/general-lab-equipment/centrifuges
Ceramill Motion 2 Milling Machine from AmannGirrbach GmbH. (2014, November 19).
Retrieved November 19, 2014, from http://www.dentalcompare.com/24988-Dental-Lab-
Milling-Units/4459994-Ceramill-Motion-2-Milling-
Machine/?ncatid=24988&ppim=4459994_1_0
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 57
Cholera - Vibrio Cholerae Infection. (2013, October 18). Retrieved October 22, 2014, from
http://www.cdc.gov/cholera/index.html
Darcy, O. (2014, October 1). The 'Mistake' Hospital Treating Ebola Patient Made That
'Hopefully...Will Never Happen Again' Retrieved October 22, 2014, from
http://www.theblaze.com/stories/2014/10/01/the-mistake-hospital-treating-ebola-patient-
made-that-hopefullywill-never-happen-again/
Darcy, O. (2014, October 2). Here’s Everything We Know About the Texas Patient Diagnosed
with Ebola. Retrieved October 22, 2014, from
http://www.theblaze.com/stories/2014/10/02/heres-everything-we-know-about-the-
texas-patient-diagnosed-with-ebola/
Facts About Sarin. (2013, May 20). Retrieved October 19, 2014, from
http://www.bt.cdc.gov/agent/sarin/basics/facts.asp
Frey Scientific Lab Lists. (2014, November 23). Retrieved November 23, 2014, from
http://www.freyscientific.com/Resources/2013LabLists/tabid/427/Default.aspx
Gibson, J. (2003). Investigation of a Ricin-Containing Envelope at a Postal Facility — South
Carolina, 2003. Morbidity and Mortality Weekly Report, 52(46), 1129-1129. Retrieved
October 22, 2014, from
http://www.cdc.gov/nceh/hsb/chemicals/pdfs/mmwr5246p1129.pdf
Henderson, D. (1999). The Looming Threat of Bioterrorism. Science, 283(5046), 1279-1282.
Henry, L. (2001). Inhalational Anthrax: Threat, Clinical Presentation, and Treatment. Journal of
the American Academy of Nurse Practitioners, 13(4), 164-168.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 58
HERAtherm™ General Protocol Ovens. (2014, November 19). Retrieved November 19, 2014,
from http://www.thermoscientific.com/en/product/heratherm-general-protocol-
ovens.html
History of the Plague. (2012, June 13). Retrieved October 20, 2014, from
http://www.cdc.gov/plague/history/index.html
Johnson, O. (2013, January 1). The Journal of Law Enforcement. Retrieved October 22, 2014,
from http://www.jghcs.info/index.php/l/article/view/235
Kaplan, D., & Marshall, A. (1996). The cult at the end of the world: The terrifying story of the
Aum doomsday cult, from the subways of Tokyo to the nuclear arsenals of Russia =
[Oumu]. New York: Crown.
Keim, M. (1999). Principles For Emergency Response To Bioterrorism. Annals of Emergency
Medicine, 34(2), 177-182.
Magnetic Mini-Stirrers with Speedsafe. (2014, November 17). Retrieved November 17, 2014,
from http://www.labdepotinc.com/Product_Details~id~593~pid~59108.aspx
Mayer, M., & Erickson, S. (2011, June 23). Heritage.org. Retrieved December 8, 2014, from
http://www.heritage.org/research/reports/2011/06/changing-todays-law-enforcement-
culture-to-face-21st-century-threats
Meselson, M. (1994). The Sverdlovsk Anthrax Outbreak of 1979. Science, 266, 1202-1208.
Mission, Role and Pledge. (2014, April 14). Retrieved October 21, 2014, from
http://www.cdc.gov/about/organization/mission.htm
Osterholm, M. (1999). The Medical Impact of a Bioterrorist Attack: Is It All Media Hype or
Clearly a Potential Nightmare. Postgraduate Medicine, 106(2), 121-130.
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 59
Peskin, N. (1999). Do US Emergency Medicine Residency Programs Provide Adequate Training
For Bioterrorism? Annals of Emergency Medicine, 34(2), 173-176.
Quinn, M. (2014, November 3). BioShield: Obama Diverted Its Funds From Fighting Ebola.
Retrieved November 23, 2014, from http://dailysignal.com/2014/11/03/bioshield-obama-
diverted-funds-from-its-fight-against-ebola-other-
threats/?utm_source=heritagefoundation&utm_medium=email&utm_campaign=mornin
gbell&mkt_tok=3RkMMJWWfF9wsRokuKTBZKXonjHpfsX56+QtWqC0lMI/0ER3fO
vrPUfGjI4CSM
Richards, C. (1999). Emergency Physicians and Biological Terrorism. Annals of Emergency
Medicine, 34(2), 183-190.
SMI1EM SHEL LAB Economy Laboratory Incubator with Digital Controller, 1 Cu. Ft. (28 L).
(2014, November 17). Retrieved November 17, 2014, from
http://www.shellab.com/store/SMI1EM-Lab-Laboratory-general-purpose-economy-
incubator-120V-also-model-E1500M.html
Science Department / Chemistry Safety Guidelines. (2011, November 8). Retrieved October 23,
2014, from http://www.portnet.k12.ny.us/Page/5592
Seto, Y. (2001, June 1). The Sarin Gas Attack in Japan and the Related Forensic Investigation.
Retrieved October 21, 2014, from http://www.opcw.org/news/article/the-sarin-gas-
attack-in-japan-and-the-related-forensic-investigation/
Siegrist, D. (1999, August 1). The Threat of Biological Attack: Why Concern Now? - Volume 5,
Number 4-August 1999 - Emerging Infectious Disease journal - CDC. Retrieved
October 22, 2014, from http://wwwnc.cdc.gov/eid/article/5/4/99-0407_article
FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 60
Tauberger, J., & Morens, D. (2006, January 1). 1918 Influenza: The Mother of All Pandemics -
Volume 12, Number 1-January 2006 - Emerging Infectious Disease journal - CDC.
Retrieved October 21, 2014, from http://wwwnc.cdc.gov/eid/article/12/1/05-0979_article
Torok, T. (1997). A Large Community Outbreak of Salmonellosis Caused by Intentional
Contamination of Restaurant Salad Bars. JAMA, 278, 389-395.
Typhoid Fever. (2013, May 14). Retrieved October 22, 2014, from
http://www.cdc.gov/nczved/divisions/dfbmd/diseases/typhoid_fever/
Unknown. (2012). Indicators and Warning of Improvised Chemical and Biological Agent
Production. Arlington: Technical Support Working Group.
Wendell, W. (2012). Chemical Biological Advanced Warfighter Training. Dugway Proving
Grounds: Special Programs Division.

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Bucci_LIU_Thesis

  • 1. Running head. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 1 HOMELAND SECURITY MANAGEMENT INSTITUTE LONG ISLAND UNIVERSITY - RIVERHEAD THESIS PROPOSAL 03 February 2015 From: Philip S. Bucci To: Director, Homeland Security Management Institute Via: (1) Dr. Vincent E. Henry, Thesis Advisor (2) Dr. Steven Bucci, Second Reader (3) Prof. Neal Anderson, Third Reader SUBJECT: THESIS FOR THE DEGREE OF MASTER OF SCIENCE IN HOMELAND SECURITY MANAGEMENT Please find the attached thesis proposal, entitled “First Responders in a Biothreat Environment”. My anticipated graduation date is January 2015. For your information and appropriate attention. ______________________________ Philip S. Bucci
  • 2. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 2 Table of Contents Table of Contents 2 Abstract 3 Introduction: First Responders in a Biothreat Environment 4 Significance of Research 6 Literature Review 14 Methodology 18 Types of Biological Warfare Agents 20 Biological Warfare Agent Production by Agent 32 Biological Warfare Agent Production Equipment 35 Policy Options and Recommendations 45 Conclusion 54
  • 3. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 3 Abstract The threat of extremists attacking major American population centers with weapons of mass destruction has increased since the September 11th Terror attacks. Consequently, the need for the Nation’s First Responders, police, fire, and Emergency Medical Service (EMS) personnel, to be trained to recognize and respond to this unconventional threat has grown as well. While many technologies exist to detect chemical or biological threats, along with nuclear and radiological, the primary method of detection is Detect to Treat, which relies on the ability of medical personnel to recognize the symptoms of infected patients. While this paper will focus on biological, chemical weapons will be discussed for reference purposes. Many biological agents have the ability to rapidly spread, and if the detection process is slow, these agents can overtake the ability of a community to treat the illness. The best way to ensure the community is prepared for a biological agent outbreak is to give First Responders the knowledge to identify threats before they spread. While technology is useful, having the knowledge to identify ingredients, tools, and symptoms of biological agent production will decrease the likelihood of secondary contamination and response time. Training First Responders can be costly, but utilizing Reserve Soldiers will not commit additional resources and will develop the relationships necessary for ensuring success in securing the homeland. The US Army Reserves has the capability and manpower to ensure proper training and support for all State and Local agencies to ensure the nation has a strong defense against biological agent outbreaks - whether natural or intentional.
  • 4. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 4 Introduction: First Responders in a Biothreat Environment The threat of extremists attacking major American population centers with chemical or biological weapons has increased since the September 11th Terrorist attacks on the Pentagon and the World Trade Center. The US Congress’s Commission on the Prevention of Weapons of Mass Destruction Proliferation and Terrorism, which Congress established in fulfillment of a recommendation of the Final Report of the National Commission on Terrorist Attacks Upon the United States (the 9/11 Commission Report), declared “biological weapons are the most dangerous threat the United States is facing,” making it clear the threat of biological attack is taken seriously. (Bucci, 2013, pg. 11) Consequently, the need for our Nation’s First Responders, police, fire, and Emergency Medical Service (EMS) personnel to be trained to recognize this unconventional threat and respond to it accordingly has grown as well. Because it may become the responsibility of State and Local health agencies to discover these threats after they occur, and because such discovery is unlikely to occur until a substantial number of individuals become infected, it is reasonable to question whether American First Responders have the knowledge and the organizational capacity to recognize threats such as biological weapons in a diverse, dispersed, and highly populated area. First Responders such as police, firefighters and emergency medical services personnel can play a critical role in identifying a potential outbreak since they are the most likely to encounter and be exposed to a patient before he or she arrives to a hospital, and they are also at high risk because they will likely not be wearing appropriate protective gear. If first responders have the knowledge to recognize symptoms and alert medical personnel of the need for further diagnosis and appropriate laboratory processes, they can speed up the detection process significantly. This paper will focus on police, fire, and EMS personnel, who are likely to arrive at a small-scale
  • 5. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 5 biological attack conducted in a manner similar to the Aum Shinrikyo incident in Japan, before creation of an Incident Command post at the incident site. Using the latest policy options, and with a basic understanding of biological warfare agent production methods, materials, and equipment, a simple low cost solution to enabling and enhancing the knowledge of First Responders can be accomplished. Using the Military and its vast array of personnel and material, as well as online self-paced learning, First Responders can keep up to date on the latest threats and methods of detection and production. Based on the gaps in the literature and the lack of understanding of the threat seen in the media during the 2014 Ebola outbreaks, there is not enough solid expertise to deal with a large outbreak of biological agents, whether the attack be natural or manmade.
  • 6. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 6 Significance of Research Cities have turned to technology to fill the current gap in training exists for first responders. While many technologies exist to detect these threats, the primary method of detection is Detect to Treat (DTT) which relies on “local doctors and nurses to serve as the initial ‘detection’ screen”. (Bucci, 2013, pg. 11) This means once an outbreak or attack occurs the threat will be analyzed by medical centers and then the appropriate treatments will be administered. DTT is an effective method of dealing with biological attacks yet DTT still has immense risks for the population. Many biological agents have the ability to rapidly spread, and if the detection process is slow, these agents can overtake the ability of a community to treat the illness. Perhaps the best known example of an illness outbreak overwhelming a community’s ability to identify and treat the victim’s condition is the Spanish Flu pandemic of 1918. Originating at Fort Riley KS, the movement of infected troops to New York and then to Europe in support of World War I allowed the flu to spread and infect over 500 million people ultimately resulting in around 50 million deaths worldwide or about 3% of the world’s population at the time. (Tauberger, 2006) Although medical facilities and diagnostics have changed dramatically since this time, this event serves as lesson on the dangers of transmission prior to detection. Another technology being used to help protect populated areas is the BioShield system. Unfortunately about 90% of the $3.3 Billion earmarked for spending on protection against threats such as Ebola was spent on only three biological warfare agents: anthrax, small pox, and botulism. (Quinn, 2014) While these represent a much higher likelihood of occurrence it shows how the system has been weakened toward certain threats and is not the catch-all system needed. Additionally, the BioShield systems use filters which need to be manually collected and then
  • 7. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 7 analyzed for the presence of agents. While cost effective, significant gaps of time may exist between collections and testing. Given the advances in global transportation since 1918 one can easily comprehend the impact which slow detection can have on the world’s population. Fortunately along with advances in transportation, significant advances in medicine and hygiene have been achieved around the world since the Spanish Flu epidemic of 1918. These advances in medicine, in hygiene, and in health organizations’ knowledge of the dynamics of epidemiology have served to counter or mitigate (but not eliminate) the potential for the rapid spread of infectious diseases. In 2009 when the H1N1 Flu virus was thought to be on the brink of epidemic outbreak the world’s health organizations rapidly offered measures to help slow the spread by infected persons, especially those traveling by air. While these measures did not entirely halt the spread of the virus, they helped limit the spread and keep H1N1 at a more manageable level. While the frightening examples above are not the result of attacks, a coordinated effort to infect a large population and cause widespread panic is the stuff of nightmares. With the world’s intelligence apparatus primarily focused on the threats of more ‘traditional’ terrorist activities such as bombings or targeted killings taking place overseas, many domestic events such as small and highly focused attacks using non-nuclear WMDs in the homeland may be left up to state and local responders both to detect and to address after the event occurs. This is not to say the Federal Bureau of Investigation (FBI) or other Federal Agencies, such as the Centers for Disease Control and Prevention (CDC), and the National Biosurveilliance Integration Center (NBIC) are not focused on preventing or interdicting threats before they occur, but they do not play a substantial role in DTT until a significant number of patients begin to develop and seek treatment for their illness.
  • 8. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 8 The 1994 and 1995 Sarin gas attacks in Japan by the religious cult Aum Shinrikyo killed dozens of people and injured about 5000 others. (Seto, 2001, pg. 1) Sarin Gas is a colorless, tasteless, odorless nerve agent created in 1938 as a pesticide. Once air, water, food, or clothing is contaminated people can get exposed to the agent’s effects, which include nausea, vomiting, confusion, paralysis, and respiratory failure leading to death. While treatable, the antidotes to Sarin must be administered quickly in order to be effective. According to the Organization for the Prohibition of Chemical Weapons’ Yasuo Seto (2001), these attacks introduced the Japanese police to “a new type of crime.” (pg. 1) The Nagano Prefectural Police officers assigned to the Matsumoto Police Station received a call from an ambulance team alerting them of injuries and patients needing help. Patients were suffering from ocular pain and numbness in the hands. For the next two days further casualties were brought into the hospital with an unknown cause of death. Investigations discovered plants and animals had died all in a 150 meter radius of a local pond and people near open windows, air conditioned rooms and moving near the pond all had serious symptoms. In all, 274 people were treated with symptoms including “darkened vision, ocular pain, nausea, myosis, and a decrease in serum cholinesterase (ChE) activities” and “autopsy findings showed intense post-mortem lividity [bruising], myosis [severe pupil constriction], pulmonary edema [swelling], increased bronchial secretion, and congestion of the parenchymatous [functional tissue] organs.” (Seto, 2001, pg. 1) The local police assumed the source of the toxic gas must have been the pond and began testing to determine the cause. Eventually the Sarin was detected and samples were sent to a laboratory for confirmation. The attack occurred 50 minutes before the police were alerted and a number of changes occurred to agent. When mixed with water, the agent will hydrolyze into a compound unique to each carrier. On plants the agent will synthesize
  • 9. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 9 and become an acid, killing the plants. These indictors and the patient symptoms should have tipped off the responders to the presence of an agent. However, since Sarin is banned under international treaty, and the likelihood of a Sarin attack is low, it took several days to get a presumptive analysis and samples to send to the laboratory. As it turned out, the lessons of this attack would greatly help the Tokyo Metropolitan police the next year. On March 20th , 1995 Aum Shinrikyo cult members released Sarin gas on five subway cars at approximately 8:00 AM. The number of victims began to overwhelm local hospital’s capacity and the symptoms reported were the same as those reported in the attack at Matsumoto in Nagano Prefecture. Armed with this knowledge, Tokyo Metropolitan Police officers donned protective suits to continue rescue efforts and conduct their investigations. Soon after this realization, the Japanese Ministry of Defense, equivalent to the US Department of Defense, arrived on scene with military support to aid in the inspections of the site and conduct decontamination of the area. (Seto, 2001, pg. 1) This incident is taught at the US Army Chemical, Biological, Radiological, and Nuclear (CBRN) Center and School at FT Leonard Wood, MO to all officers in the Chemical Branch as the model for non-state attacks. The lessons learned from this event are used to demonstrate the ease of production by non-state actors of, as well as the dangers faced if the chemical weapons are released in a populated area. Had Japan not been prepared, or had its responders not recognized the signs of an attack, the outcome would have been far worse. This level of recognition and understanding by first responders is required to quickly and decisively undercut the effects of biological attacks on the homeland. In this attack, the gas was released by puncturing plastic bags with the tips of umbrellas. This allowed the members of Aum Shinrikyo to surreptitiously attack the subway system. People normally look for men in masks unlocking
  • 10. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 10 pelican cases with green mist in glass vials as the sign of a gas attack. While surgical masks are popular in Japan, the culprits were average looking people with umbrellas, which are also popular in counties utilizing outdoor public transportation. On February 2004 Senator Bill Frist’s mail room at the Dirksen Senate Office Building in Washington DC received a letter containing a white powdery substance later confirmed to be Ricin. This event shut down other Senate buildings and required several staffers to be decontaminated. This event came on the heels of a November 2003 ricin-laced letter sent to the White House demanding changes to trucking regulations. The 2003 letter was not made public until February 2004 and to date no connection has been made between the two. The Centers for Disease Control and Prevention (CDC) advised “Clinicians and public health officials should be vigilant for illnesses suggestive of ricin exposure.” (Gibson, 2013, pg. 1129) The 2004 ricin attack was similar to the 1994 and 1995 Sarin attack in Japan, insofar as it involved the use of a public vector, (i.e. mail in 2004 and public transportation in 1994 and 1995), providing attackers the opportunity to increase dissemination due to the fact, contaminated mail comes in contact with sorting machines and other mail. In late September 2014 Thomas Eric Duncan was diagnosed with Ebola in Dallas, Texas. (Darcy, 2014) Ebola is an extremely contagious hemorrhagic fever believed to be spread by animals to humans. The disease is native to the African Continent and was first discovered in 1976. Hemorrhagic fevers are transmitted by body fluid and cause headache, muscle pain, diarrhea, vomiting, and bleeding. (CDC, 2014) Duncan lied on his entrance documents from Liberia, stating he did not care for sick patients from the region’s Ebola epidemic. (Darcy, 2014) Duncan apparently contracted the disease in Liberia from helping carry a sick pregnant woman. Duncan flew to the United States a few days later to stay with relatives. After becoming sick,
  • 11. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 11 Duncan went to the local hospital where he was seen and discharged with antibiotics. When he returned a few days later, Duncan was admitted for Ebola. (Darcy, 2014) This is a classic example of how the Detect to Treat (DTT) process operates in the real world, and it illustrates how the process can fail to operate efficiently: An infected individual becomes ill following a latency period, and upon presenting his or her symptoms to medical personnel the individual patient is misdiagnosed. Due to the misdiagnosis, the contagious individual is not quarantined and he or she may continue to serve as a vector spreading the illness to others. There is no perfect solution for patients lying to care providers, or human error, but education for the public about the threats and who may be at risk can be helpful. This case also illustrates how easily a suicide terrorist willing to be infected with Ebola could conduct a biological terrorism attack on a US population center. Commencing the attack at the end of September, when the flu season is starting, might cause local hospitals to misdiagnose the symptoms of nausea and fever as influenza rather than Ebola. If a terrorist infected with Ebola (or another highly communicable and deadly virus) circulated among the population, he or she could potentially infect a substantial number of individuals. These individuals infected with Ebola virus, who had no recent travel history to West Africa, might not be suspected of having anything more than the flu until it was too late. Only when the number of fatal cases (the number of Ebola cases misdiagnosed and treated as the far less deadly influenza virus and ultimately result in death) reached a critical mass might the proper laboratory tests and screening algorithms be applied to those presenting themselves with flu-like symptoms. The situation might be further confused and complicated once the Ebola outbreak becomes public knowledge and patients with influenza believe they may have Ebola.
  • 12. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 12 If first responders know to recognize the symptoms of biological agents, they would give the medical system an additional “sensor” to identify and speed up the process of DTT. In other words, first responders who are alert to the possibility of biological terrorism and are trained to distinguish indicators of biological terrorism from ‘ordinary’ illnesses and infections can serve as an early warning system bringing these events to the attention of medical personnel capable of accurately screening for and diagnosing infections from a deadly biological agent. In Duncan’s case, the hospital did not relay his travel from Liberia to the administrative personnel who made the decision to send him home. This decision increased the number of people he may have infected, including the sick people in the waiting and pharmacy areas of the hospital. While four of the 24 weeks of the Chemical, Biological, Radiological, and Nuclear (CBRN) Center and School are devoted to operating in a simulated contaminated environment, all Chemical Corps officers spend at least a day in the Chemical Defense Training Facility (CDTF) which boasts live CBRN agent and source training. This live training is conducted in protective equipment ranging from the lowest level of protection known as Mission Oriented Protective Posture (MOPP) Zero, which provides no splash or vapor protection, all the way up to Level A, fully encapsulated self-contained breathing apparatus (SCBA) with splash protection. MOPP equipment levels start at carrying the entire suit, MOPP 1has protective pants and top, MOPP 2 adds protective overboots, MOPP 3 adds the mask, and MOPP 4 finalizes with gloves. A significant amount of class time is devoted to identifying the symptoms, visual description, and methods of delivery of conventional CBRN agents as well as many of the next-generation CBRN warfare agents. Despite the length of this training, the course does not address how to conduct operations in a populated environment with armed threats, or live casualties, who might, like a drowning person, try to tear a first responder out of the protective suit to save themselves.
  • 13. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 13 Select US Army Special Forces teams receive training on operating in MOPP 4 or Level B, splash protection with SCBA, in a threat environment.
  • 14. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 14 Literature Review There is a plethora of material on the internet pertaining to biological warfare agents. From hefty tomes on the history of biological warfare to small journal entries expounding on the need for more resources to ensure protection from the same, there is no shortage of reading materials. Knowing this it takes a significant amount of time to sift through the dross and find the sources with both accurate information and the clarity to explain the importance of the threat. The Center for Disease Control (CDC) is a great source for anything biological as the CDC’s mission is protecting from infectious disease. The CDC produces a number of journals relating to various causes and factors of infection. The Department of Defense has a significant amount of information classified Official Use Only or higher on all subjects related to all warfare agents including next generation agents available to the appropriate personnel. With the outbreak of Ebola in the United States, the CDC and other government agencies have published guidelines and information designed to minimize the fear and myths surrounding this hemorrhagic fever. Medical associations have published a significant number of articles supporting or refuting the CDC’s and some State’s measures regarding Ebola as well. As the government and Medical communities expand public awareness of biological events, the media also weighs in, pointing out faults and successes. Since the public tends to believe what is presented on the news, the desire for greater security due to the now visible threat or Ebola, and by extension biological warfare agents, Security organizations are beginning to discuss how to protect assets from biological threats. Centers for Disease Control (CDC) has published a significant amount of information about diseases and publishes a weekly report focusing on Morbidity and Mortality across the
  • 15. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 15 spectrum. This is a short document containing many authors and opinions and represents a great place to starting research. In 1999 the CDC released an issue of the Morbidity and Mortality Weekly Report focusing on anthrax attacks around the nation along with guidelines to prepare for attacks and how to cope afterward. The report focuses on “letters alleged to contain anthrax sent to health clinics on October 30, 1998, in Indiana, Kentucky, and Tennessee. During December 17-23 in California, a letter alleged to contain anthrax was sent to a private business…” (Bioterrorism, 1999) After giving a synopsis of the events, the CDC provides guidelines for response planning and post-exposure protection. The crux of the guidance is “public health response to bioterrorism requires communication and coordination with first responders and law enforcement officials…” (Bioterrorism, 1999) In 2003 the CDC published a short review of the events surrounding a possible ricin contamination of the Greenville, SC mail distribution center. After a suspicious package was identified and quarantined, the plant was reopened when “all workers who had worked at the facility since the package was discovered had been contacted and confirmed to be well and environmental samples for ricin were negative.” (Gibson, 2003) This event shows how easily an attack could occur and how quickly one could be thwarted by alert people in the field. In Science Magazine Dr. Henderson writes about biological weapons and how they have garnered attention. Dr. Henderson writes “Discerning the nature of the threat of bioweapons as well as appropriate responses to them requires greater attention to the biological characteristics of these instruments of war and terror.” (Henderson, 1999) Dr. Henderson writes his work before the attacks of September 11, 2001 however he argues “the paradigm of a weapon as a
  • 16. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 16 nuclear device that explodes or a chemical cloud that is set adrift leaves us ill-equipped… to assess and thus to prevent the potentially devastating effects of bioterrorism.” (Henderson, 1999) Dr. Christopher Richards points out in the Annals of Emergency Medicine in 1999 “only the military has some capability to actually detect a bioagent in the field.” (Richards, 1999) Since the attacks on September 11, 2001, this has changed but his policy focus is more on the necessary steps taken once a patient enters a hospital system as opposed to detection before infection. Another author who writes before the September 11, 2001 attacks is Keim, who discusses how to respond to bioterrorism. Keim also focuses on “Emergency physicians, first responders, and hazardous materials response teams need[ing] a standardized approach to the management of patients who may have been exposed to biological threat agents.” (Keim, 1999) However, he maintains “Currently recommended hospital infection control procedures seem appropriate for the level of risk involved…” (Keim, 1999) Given the more appropriate level of attention bioterrorism has garnered this may no longer be accurate. Dr. Yasuo Seto of the Organization for the Prohibition of Chemical Weapons discussed the Sarin gas attacks in Japan by Aum Shinrikyo. If the Japanese police had not been able to determine Sarin had been used in a test run earlier, the subway attack would have been much more effective. Kaplan and Marshall also provide exhaustive details about the history and background of this cult in their work The Cult at the End of the World. The authors also describe how the cult was planning to obtain Russian nuclear weapons and even attack and overthrow the Japanese parliament. Organizations such as the Heritage Foundation can be great sources of data on any number of subjects. However, one must always read what is published with an understanding of the bias the organization has. Mayer and Erickson write for the Heritage Foundation about Law
  • 17. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 17 Enforcement Education “The education obtained throughout the academy, directed through POST [Peace Officer Standards and Training] mandates, helped to form the functioning law enforcement officer’s working character.” (Mayer, 2011) If First Responders can be taught the signs and symptoms associated with bioterrorism, correct responses can then be expected. Risk is always involved when using media sources. During the Ebola outbreaks in 2014 almost all news outlets carried stories about the various patients infected and how some were improperly diagnosed or quarantined. Depending on the news outlet, President Obama’s handling of the possible Ebola pandemic was either spot on or moving the nation closer to the edge of chaos. The Blaze and the Heritage Foundations’ Daily Signal both carried articles on the Ebola outbreak of 2014, specifically the death of Eric Duncan. The primary crux of the articles is Duncan walked into a hospital and was sent home despite his symptoms and his travel history. The lack of proper care he received is directly related to his death. In the end, there is a gap in current literature. This gap has grown since September 11, 2001 and the realization the homeland is no longer secure. While technology and awareness have grown to help combat emerging threats, most medical research and defensive techniques are decades old. Lastly, as the policy section of this paper will show, the advent of new Department of the Army policies combined with US Army Reserve Command re-alignments provide a new tool in the fight against biological warfare agent attack.
  • 18. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 18 Methodology This Thesis will attempt to fill the training gap identified earlier by presenting a policy option enabling State and Local organizations to receive training on any Chemical, Biological, Radiological, and Nuclear (CBRN) threat, without incurring significant additional costs. First, an outline of the current system for detection and treatment of biological attack, and how they are lacking in the light of the recent Ebola cases will be presented. The method for increasing the knowledge base for First Responders will be discussed based on the unique mission sets and threats faced. Included in this discussion will be the effect of pay and hours available. Breakdowns of what type of training and when in a responder’s career the training should be applied will be covered. A proposed solution to the training gap will be laid out, showing how this training supports National Goals as well as State and Local needs. This solution will allow for greater interoperability and standardization of methods and techniques across the spectrum of emergency response. A catalog of biological warfare agents, production methods, materials, and equipment will be laid out to demonstrate the ease of production and identification. This section will include history and signs and symptoms of the major warfare agents along with treatment options currently available. Images for the agents will be included to demonstrate the terrible nature of these threats. The equipment required for agent production will also be discussed with pictures for general identification. The recipes for these agents will be presented in an abbreviated format due to classification issues and the desire to not enable threat production. In the end, this thesis will answer the question “Do American First Responders have the knowledge to recognize threats such as biological weapons in a populated area?” This answer must meet certain criteria in order to be valid. Given the austere financial times the solution
  • 19. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 19 must be fiscally responsible, as well as feasible and suitable to the issue at hand. The solution put forth in this Thesis will cost little to no money not already being paid out to employees of the federal government. Additionally, all training conducted will support overall national level needs nesting all training objectives with higher level’s strategic goals.
  • 20. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 20 Types of Biological Warfare Agents The CDC divides Biological Threat Agents into three nominal categories - the A, B, and C categories. Category A agents are characterized by the ease with which they can be disseminated or transmitted, they have high mortality rates, and widespread infection might cause public panic. Category B agents have easy to moderate transmission, and they involve moderate morbidity (rate of sickness) and low mortality. Category C agents are emerging or future threats based on availability, are relatively easy to produce and disseminate, and have the potential for high morbidity and mortality. For this paper, Category C agents will not be discussed due to classification rules. Category A Agents are further broken down in three subsidiary categories: bacteria, toxins, and viruses. Common Bacteria agents are Anthrax, Plague, and Tularemia. The common Toxin agent is Botulism or Botox. Common Virus agents are Smallpox, and Hemorrhagic Fever (Ebola). While not all of these agents can be made in clandestine labs, this paper will familiarize the reader will the major agents. Bacillus Anthracis or Anthrax is a naturally occurring spore forming soil based bacteria which is very stable in the environment and is easily disseminated. The three main forms of the disease are cutaneous, ingestion, and inhalation. Treatment for Anthrax is Doxycycline, Ciprofloxin, and Penicillin, usually intravenously. Cutaneous infection occurs via breaks in the skin or from biting flies. The symptoms include rapid necrosis, and black necrotic lesions with a 20% untreated mortality rate and a near 1% for treated persons. Gastrointestinal Anthrax results from ingestion of contaminated food, usually meat, or water. The symptoms include sore throat, fever, swollen lymph nodes, nausea, bloody diarrhea, toxemia, shock, and death. This form of the disease has a greater than 50% mortality rate. Inhalation Anthrax results from the inhalation
  • 21. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 21 of spores into the lungs. While the incubation period is 1-6 days persons will see mild symptoms it may be hard to diagnose (Henry, 2001). These include abrupt onset of fever, non-productive cough, chest pain, and sweats. Shock and death occur 24-36 hours after abrupt onset with a 100% mortality rate. What make anthrax so dangerous is the ability of the bacteria to grow spores. Usually found in long “string like” formations the bacteria can last for centuries when placed in less than ideal conditions. When the bacteria detects the environment around it is dangerous, the strings begin to break apart and form “seeds” which grow a protective shell. This shell, or spore, allows the bacteria to remain safe and dormant for extremely long periods. Once the spore is placed into warm, moist conditions, such as lungs, the spores dissolve and the seeds begin to reform strings. Anthrax under Microscope (CDC, 2014)
  • 22. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 22 Yersinia pestis or Plague, commonly known as the Black Death, is a historically deadly bacteria. Famously known for killing millions of people starting in China and spreading to Europe in the middle ages. (History, 2012) Plague is passed from person to person or through fleas and is relatively stable in the environment. The three primary forms of the disease are. Bubonic, Septicemic, and Pneumonic. Plague is usually treated with Tetracline and Streptomycin. Bubonic Plague symptoms are swollen lymph nodes, fever, chills, and weakness and has a greater than 50% mortality rate if untreated and 10% if treated. Septicemic Plague adds abdominal pain, shock, and bleeding underneath the skin or organs and has a 100% untreated mortality rate. Pneumonic Plague presents with severe pneumonia and shortness of breath, necrosis of the small blood vessels (hence the “black death”) and productive cough and also has a 100% untreated mortality rate. Pneumonic Plague is also the most likely to cause a contagious epidemic. Plague Signs (CDC, 2014)
  • 23. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 23 Francisella Tularensis or Tularemia commonly known as Rabbit Fever is highly prevalent in the US in the Arkansas, Oklahoma, Missouri, and Kansas areas but can be found throughout the country. Tularemia is spread by direct contact, inhalation or ingestion and can remain viable in soil or water for weeks. The most common form of the disease is Ulcerograndular at 75% and Typhoidal-Systemic at 25%. The standard treatment is Tetracycline or Streptomycin. Tularemia is contracted through contact or arthropod bites. It shows with ulcer development, lymph node enlargement, back pain, fever, chills, exhaustion, non-productive cough, and nausea. Ulcerograndular has a 5% untreated mortality rate while Typhoidal has a 50% rate. Tularemia Outbreak (CDC, 2014)
  • 24. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 24 Clostridium Botulinum Toxin or Botox is the most potent biotoxin currently known and effects the nervous system. The most common forms are Food Born, Wound, and Infant. The route of infection is ingestion or direct inoculation (purposefully injected) with symptoms showing 12-36 hours after ingestion. Symptoms include Weakness, dizziness, weariness, constipation, difficulty speaking, descending paralysis, and respiratory paralysis. Botox has a significant mortality rate. Wound Botulism of Right Arm (CDC, 2014)
  • 25. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 25 Variola Virus, known as smallpox is known only to humans and is passed among unvaccinated populations. Route of infection includes contract with pulsates, whether direct or indirect, or through respiration. The symptoms include high fever headache, chills, back pain, exhaustion, body rash blistered lesions leading to scabs with a fatality rate of 30%. Man with Smallpox (CDC, 2014)
  • 26. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 26 Hemorrhagic Fevers include Marburg, Junin, Lassa, and Ebola viruses, usually having a low infections dose. While passed from person to person, inhalation is also a risk. Symptoms include high fever, internal bleeding and hemorrhaging (bleeding profusely) from orifices with various mortality rates. Isolated Female Patient Diagnosed with Crimean-Congo Hemorrhagic Fever (CDC, 2014)
  • 27. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 27 Category B Agents are broken down in two categories, bacteria and toxin. Common Bacteria agents are Cholera, Typhoid Fever, and Typhus Fever. The common Toxin agents are Ricin and Staphylococcus Aureus. While not all of these agents can be made in clandestine labs, this paper will familiarize the reader will the major agents. The Category B Bacteria Agents are not normally used for biological weapons. Vibrio Cholerae or Cholera is transmitted through food or water contamination with symptoms water diarrhea, vomiting, low blood pressure, thirst, restlessness, and dry mucous membranes. Cholera is easily treatable with antibiotics. Salmonella Typhi or Typhoid Fever lives only in humans and is transmitted through food contamination. Typhoid symptoms include fever, weakness, stomach pains, and flat rose colored spots and is treated with antibiotics. Rickettsia Prowazekii or Typhus Fever is spread by body lice, and flying squirrel ectoparasites. Typhus symptoms include fever, headache, malaise, vomiting and rashes. Typhus can be deadly in 20%-60% of untreated cases. Loss of Skin Elasticity seen is Cholera (CDC, 2014)
  • 28. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 28 Ricinus Communis or Ricin is made from Castor Bean plants. Ricin is transmitted through inhalation, injection, or ingestion. The Castor plant is easily available and the process of production is not difficult to find. Ricin symptoms include fever, weakness, non-productive cough, pulmonary edema, respiratory distress, vascular collapse, and death within 36-72 hours. Mortality is dependent on dose and there is no known antitoxin. Castor Beans (CDC, 2014)
  • 29. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 29 Staphylococcus Aureus or SEB Toxin is usually inhaled or ingested and is stable and water soluble. Ingestion symptoms include intense nausea, vomiting, abdominal pain, and diarrhea. In this form the disease is debilitating rather than deadly. If inhaled, a sign of intentional poisoning, SEB Toxin symptoms include fever, headache, nonproductive cough, chills, shortness of breath, and chest pain. Symptoms will lead to respiratory failure. Effects of SEB Toxin (CDC, 2014)
  • 30. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 30 As stated above, Category C agents are under specific classification, however this category includes specific forms of: Influenza, SARS, Encephalitis, and Tick-borne Hemorrhagic Fevers. This category will also include hybrid agents which will either evolve naturally or as the result of specific experimentation. Biological weapons are not difficult to create. Some of the procedures below will be described in abbreviated detail because the source of the information is For Official Use Only or Law Enforcement Sensitive. The point of this section is not to be a primer for weapons production but rather provide the reader an understanding of the ease of production on the non- state level. Bacterial production requires either liquid or solid cultures to grow the agent. As the agent grows, it can be transferred to larger vessels as needed. Obviously the larger the vessel the more ingredients are required as well as risk of detection. Bacterial growth follows a predictable pattern starting with the inoculation of the growth media, and then an exponential growth phase, leading to death of the bacteria. The growth phase can be sustained as long as the bacteria is given sufficient space and food. When sufficient bacteria has been grown it is harvested in centrifuges and then dried for dissemination. Once dried the bacteria is milled to the correct size and prepped into the dissemination method. Viral production requires hosts to grow, usually live chicken eggs. The viral source is inoculated in live tissue such as animals or eggs and allowed to incubate. Once the virus is sufficiently developed, it is harvested from the live subject and can be immediately used for wet dissemination. If a dry dissemination is desired then the virus is dried and milled to the necessary size.
  • 31. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 31 Toxins are harvested from their source and prepared for distribution through fermentation. Once isolated the toxin is extracted, purified, and dried for dissemination. The fermentation process allows the toxin to be separated from other impurities present in the source plant, animal, or bacteria. Once dried the toxin is milled to the necessary size. Once a First Responder understands the symptom and the nature of the illness that he or she is encountering, further confirmation must be sought on scene if possible based on production methods. The symptoms and production methods are two significant indicators for initial analysis, and can be useful to determining that protective equipment is required on the scene.
  • 32. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 32 Biological Warfare Agent Production by Agent This section will cover the production processes for various compounds and the inherent dangers. While the focus of this paper is risk and dangers posed by biological agents, many of the precursors for these agents are shared with illegal narcotics as well. This section does not contain the exact recipes for biological warfare agent production, but does provide sufficient representation of the required processes. The information below is available on the internet; please do not attempt to make any of these substances at home. Ricin Ricin attacks the vascular system of the body and has no anti-toxin. Ricin can be extracted from castor seeds, a plant which can be bought from local plant stores and is used as a decoration. Ricin is extracted from the castor seeds much like the meat of a sunflower. Once the seeds are soaked they can be broken open, and the meat can then be ground and dried into powder. Pure ricin powder is white, if discolored then the process is either incomplete or rudimentary. One Castor bean plant yields approximately 1300 seeds or roughly 2.75 cups of seeds. One cup of seeds, roughly 500 seeds, weighs 130 grams and can yield up to three grams of pure ricin. Lab processes require some easily-obtained ingredients such as vinegar, acetone, bleach, and Epsom salts, as well as some more difficult to obtain ingredients, such as DEA List II regulated chemicals hydrochloric acid and sulfuric acid. Responders can easily identify a location where ricin is being produced by the presence of Castor Seeds, coffee filters, and blenders. Dead animals in the vicinity are also a good indicator of the agent. Botulinum Toxin Clostridium Botulinum Toxin or Botox is the most potent biotoxin currently known and it effects the nervous system. While primarily used to fix wrinkles and signs of aging, if given in
  • 33. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 33 sufficient doses the toxin can shut down the body’s ability to use the nervous system to function. Botulinum bacteria can be extracted from soil where it grows naturally, or the bacteria can be grown in fatty beef without oxygen and is stable is tap water. The bacteria can be placed into beef, placed into an airtight container such as a mason jar, and allowed to grow. Once the bacteria has consumed the beef it can be purified and then given to the target. As it is grown in rotting meat the toxin will have a putrid odor and can be part of a slurry or dried to a refined powder. Responders can identify the botulinum toxin process by the presence of jars, pressure cookers, raw and rotting meat, and the DEA List II regulated chemical hydrochloric acid. Anthrax Bacillus Anthracis is a naturally occurring spore forming soil based bacteria. What makes anthrax so dangerous is the ability of the bacteria to grow spores. Usually found in long “string like” formations the bacteria can last for centuries when placed in less than ideal conditions. When the bacteria detects the environment around it is dangerous, the strings begin to break apart and form “seeds” which grow a protective shell. This shell, or spore, allows the bacteria to remain safe and dormant for extremely long periods. Once the spore is placed into warm, moist conditions, such as lungs, the spores dissolve and the seeds begin to reform strings. Once a sample of anthrax is obtained, it is placed into an incubation media, easily purchased from laboratory supply companies, and allowed to grow. Once a sufficient amount is grown the bacteria is introduced to less than ideal conditions so the spores will form. The spores are the best way to disseminate the agent across a large area in any environment. The most deadly way to contract the bacteria is through the lungs with death occurring 24 to 36 hour after symptom onset at a 100% mortality rate. The most common route of infection is though food, usually meat, which can lead to toxemia and death if untreated. Anthrax spores are usually white to gray
  • 34. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 34 in color and look like a powder. Responders can identify this process because of the hazardous material items such as incubators, growth media, storage units, and glove boxes. The DEA List II regulated chemical, hydrochloric acid will also be found on site along with bleach and acetone. Nicotine Nicotine is a poison commonly inhaled, usually in cigarettes, or readily absorbed through the skin and mucous membranes. Nicotine Sulfate is usually sold under the trade names Black leaf 40 or Tender Leaf Insect Spray. Nicotine can also be extracted from tobacco products if required. In this process tobacco is heated and filtered, with the extract containing the poison. Responders can identify this process through the trade labels, large quantities of tobacco products, and the DEA List II regulated chemical, ethyl ether, along with calcium hydroxide (lime water) and isopropyl alcohol. Once a First Responder understands the processes for the biological warfare agent that he or she is encountering, further confirmation can be found by analyzing the equipment on scene. The production process and equipment on scene are important for initial analysis, and can be useful to confirming that a biological warfare agent is or was present.
  • 35. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 35 Biological Warfare Agent Production Equipment As a first responder entering a location the ability to identify glassware and clandestine laboratory processes, including precursors, is vital to determining the nature of the hazard one may be facing. This section will cover the basic lab glassware and equipment most commonly found in clandestine laboratories. All of the items listed below are available for purchase from reputable sellers on the internet and ownership of these devices does not represent a crime. SHEL LAB Economy Lab Incubator with Digital Controller, 1 Cu. Ft. (28 L) (Shel Lab, 2014) Incubators: Incubators allow for the control and regulation of temperature, humidity, and other environmental factors effecting the growth and development of biological agents. While the presence of an incubator is not a definite sign of biological agent production, it is a red flag and an indicator of the type of agent may be present. Anthrax, Botox, and Plague are among the agents requiring incubation.
  • 36. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 36 Celestron Advanced Biological Microscope 1000 (Celestron, 2014) Microscopes: Microscopes are used to see very small things. In biological agent production, being able to see the development of the agent as different environmental factors change, or ensuring the host media is properly infected with the agent before dissemination are a few uses for this piece of equipment. The existence of microscopes is not a defining indicator of wrong doing but when added to other laboratory equipment it can paint a clearer picture.
  • 37. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 37 BioRad Centrifuge (BioRad, 2014) Centrifuges: Centrifuges are devices designed to separate items, usually by size or weight. Agents with impurities can be subjected to centrifuge processes allowing the production of more pure substances. This item is also found in drug labs. Additionally, depending on the type of centrifuge, separation of the agent from an existing host’s body fluids, like blood, can be done allowing for a cleaner, more pure agent.
  • 38. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 38 Magnetic Mini-Stirrers with Speedsafe (Magnetic, 2014) Magnetic Stir Plates: Magnetic Stir Plates are used to mix ingredients for agent production. Whether mixing two liquids or a liquid and a powdery substance the magnetic stir plate allows for a constant speed for the solution. Additionally, magnetic stir plates have very few moving parts, allowing them to run constantly with little to no maintenance, meaning this stage of agent production can be performed simultaneously with other stages if necessary. There are not many at home uses for magnetic stir plates, so this is a major indicator of wrong doing, however this item is not a definite weapons only item.
  • 39. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 39 Bio Fermentation Tank (BioFermentation, 2014) Fermenters: Fermenters are used to allow bacteria and other organic substances to grow in non-oxygen environments. They can be used for food production, but are rarely seen in private homes. Fermenters allow the agent to grow at accelerated rates by regulating the oxygen content and providing temperature control throughout the growth media. This allows the agent production process to advance rapidly once a suitable agent is produced and introduced to the fermentation process. This apparatus is a strong indicator of biological agent production but the other laboratory items must be present to confirm the substances existence without sampling.
  • 40. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 40 Tuttnauer 2340M Manual Autoclave (Tuttnauer, 2014) Autoclave: In order to maintain a sterilized environment autoclaves are used to subject instruments and tools to steam at extreme pressure. While many models are not stable at high temperature, such as rubber gloves, most biological agent production items are made of glass or metals. Many hospitals and research facilities are beginning to employ one time use materials such as injector kits for medicines, and surgical tools, reducing the need to use autoclaves for sterilizations. Despite this, a clandestine laboratory with limited funds would benefit from the ability to use materials several times. While autoclaves are not common household items, they are found in tattoo and piecing shops, and barber and hair salons. If found in the presence of other laboratory equipment this device is a good indicator of nefarious or illegal activities.
  • 41. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 41 Thermo Scientific HERAtherm General Protocol Ovens (HERAtherm, 2014) Drying Systems: The proper and rapid drying of biological agent production glassware and tools is vital to maintaining a sterilized environment. If the glassware or tools are improperly dried or left out to dry in the elements, impurities and other contaminates could be introduced into the agent production process damaging or rendering useless the agent being produced. Additionally, dirt and dust can be introduced to the agent production systems mentioned above and can cause significant damage causing delays and high replacement costs. This device is not widely used in homes and when seen with other laboratory equipment is not illegal but is an indicator of medical level activities.
  • 42. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 42 Ceramill Motion 2 Milling Machine from AmannGirrbach GmbH (Ceramill, 2014) Milling Systems: Milling systems are used to grind solids used in biological agent production to the correct size. This allows for the agent to be manufactured to combat the specifications of any protective equipment and detectors. While not many homes have this level of mill, certain cultures mill food stuffs such as corn to make certain dietary items. Knowing this, first responders should know the difference between a laboratory mill and a home mill, and taken with other laboratory equipment this can be a signal of criminal activity. As with other equipment listed here, mills can be used for drug as well as biological agent production.
  • 43. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 43 The lists below are for High School laboratory equipment. While not a complete list of what can be purchased online, the list is representative of what can be bought and how much it could cost. Seeing many of these items outside of a designated laboratory location such as a school, would be a serious indicator of wrong doing, but as with the above items does not represent a crime. First Responders should know and be able to recognize the items listed below are not normally for cooking food and could be used to make drugs as well as biological warfare agents. The presence of these items should indicate further sampling and testing maybe required and follow on agencies should be called on scene to determine the product being made.
  • 44. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 44 Frey Scientific Lab Lists, 2013 First Responders who understand the symptoms, processes, and equipment for biological warfare agents can aid in decreasing the recognition time for all elements of emergency management. How to train a First Responder to be aware and ready is vital to the success of the emergency management enterprise.
  • 45. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 45 Policy Options and Recommendations Emergency room personnel need not be the only human indicator of biological attacks. In order to function effectively to inhibit or prevent the deaths and illnesses resulting from a biological attack, and to ensure the prompt and effective operation of the DTT process, the Nation’s First Responders must be able to identify the signs a CBRN attack has occurred and recognize the laboratory processes and precursors necessary to conduct these attacks. The capacity to identify these indicators at the earliest stages of a biological attack or outbreak is essential so follow on entities such as hospital personnel, healthcare professionals and crime scene investigators can take the appropriate steps to protect themselves or others from secondary contamination. In the end suspects, bystanders, and responders can be cleared of contamination and placed back into general population. Secondary contamination will increase the burden on the response system as the contamination spreads to greater areas and population counts. If the type of contaminate is extremely contagious, the risk of widespread panic increases dramatically. Training first responders to recognize and identify biological agents as well as their precursors and symptoms is relatively simple and can be implemented at relatively low cost. Training can be accomplished in two phases across a responders’ career. The first could be basic awareness-level training taking place at during the first responders’ initial entry-level training, such as the police or fire academy. This training might consist of one or more modules of training on CBRN agent symptoms and precursors, laboratory process recognition, and high risk entry training using a protective mask. The second phase could be provided in annual in-service refresher, followed by a written exam on symptoms, precursors, dissemination methods, and visual identification of laboratory processes. Finally, all in-service responders would have to demonstrate they have maintained the ability to operate in a protective mask.
  • 46. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 46 The high risk training would be significantly different for different categories and roles of First Responders, and the specific elements of this training should vary depending upon the first responders’ task environment. Police, for example, are likely to encounter the indicators of a biological weapon under different conditions and circumstances than firefighters, simply because their roles and operating environments are so different. To be effective and relevant, the training provided to different first responder occupational groups should align with the realities of the work they do. For Police the high risk entry training would include training on tactics to enter and clear a structure with both threat and non-threat targets while wearing a protective mask, and might include tactical training concerning the rescue of a downed officer. For Firefighters, who already wear SCBA into high risk situations, the training might focus on firefighting operations in areas with dangerous chemicals and biological hazards. For EMS personnel, the training might focus on entry into a location with victims who are panicking as well as on treating patients while wearing a protective mask and the safe evacuation of casualties to avoid secondary contamination. Many state and local agencies do not have sufficient training dollars to give this threat the proper amount of time and man power necessary to ensure minimum risk is achieved by a potential attack. According to Long Island University’s Dr. Vincent Henry, “Particularly in an era of fiscal austerity, one of the critical issues municipal public safety agencies have to deal with is justifying the need and expense of training." Because biological events are very low risk, very high consequence events, municipal agencies may not give high priority to training for these events. Agencies must recognize the effects of an attack in an American city would be devastating, despite the actual rate of incidence of biological attacks being low. State and local agencies must maintain a requisite level of manpower “on the streets” to maintain law and order
  • 47. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 47 and perform other public safety functions while still providing sufficient time for First Responders to receive proper training. Cognizant of these constraints and requirements, the Department of Defense (DOD) typically maintains a 10% overage of Commissioned Officers in order to keep duty positions filled and maintain professional military education. For many state and local agencies this number can drop to one third of the force in school with no overages. The issue of maintaining sufficient ‘minimum manning’ can be complicated and made more expensive by the rotating shifts many first responders work and the seven day, 24-hour operations first responder agencies conduct. As a result, First Responders working the overnight shift, for example, may have to work a double shift (perhaps incurring overtime) to get daytime only training. While budget shortfalls may lead to departments cutting unnecessary training to levels that meet, rather than exceed, their liability requirements, effective biological threat training can be accomplished at relatively low expense. By giving the basics of this training in the academy, or even through Internet-based training modules First Responders can complete on their own, only refreshers would be needed annually. Defense Support to Civil Authorities is a newly revamped doctrine in the Department of the Army (DOA) under Army Doctrine Publication (ADP) 3-28 placing federal soldiers into the Incident Command System after a major incident occurs. While Federal Troops and support have been used for years to reinforce State and Local events such as hurricanes and forest fires, the DOA has finally put Defense Support to Civil Authorities (DSCA) on the same level as Offensive and Stability Operations. Under the terms of DSCA doctrine and policy as well as the legislation enabling its conduct, states can request an appropriately-trained National Guard or a local Reserve Training Support Battalion to deliver a standardized training program to local agencies. Because the DOD has already paid the costs of training development for its own
  • 48. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 48 Soldiers, local agencies would realize substantial savings, at the same time helping to build the relationships required to conduct Civil Support operations in the event a disaster or attack does occur. Army Reserve Training Support Battalions have various skill sets geared toward providing relevant effective training for Soldiers preparing for and going into combat. These Battalions like all Reserve units must provide their Soldiers with 24 days of Battle Training Assemblies (BTA) and 14 days of Annual Training (AT). This is the one weekend a month and two weeks a year mantra from the commercials. This is in addition to the regular work schedule the Reservists have in their non-military careers. A First Responding agency could request the local Training Support Battalion come for a given length of time to give classes and training without adding cost to the military by simply having Soldiers conduct their monthly BTA or AT during this same period. An argument can be made for using these Soldiers for current mission requirements, but with the drawdown in Afghanistan and the lack of mobilizations for Reserve Soldiers opens a great amount of personnel for other missions. The Reserve Battalion is required to conduct annual Chemical, Biological, Radiological, and Nuclear (CBRN) training and can request the requisite materials to accomplish this training. If the Reserve Battalion aligned its CBRN training with the First Responders training both could use the materials at nominal to no additional costs. Furthermore, as stated above, the DSCA Doctrine requires Local, State, and Federal organizations work together during emergencies. Using this requirement, States could fund additional materials and pay using Federal money for Emergency Preparedness. All of these steps would meet the Federal goal of well trained and coordinated emergency responses, the State goal of better training with less waste and the local goal of better training with less cost. Furthermore, these units could train first responders on all aspects of CBRN threats not just biological.
  • 49. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 49 Little to no biological threat training is conducted for the majority of First Responders based on discussions with Dr. Vincent Henry, retired New York Police Department, Katrina Morgan of the Richland County, SC Sheriff’s Office, and Benjamin Hann of the Charlotte NC Police Department. For most agencies this is born out of the lack of tangible threat and for others it is born out of time and budget constraints. Both are understandable and given the budget crisis facing most municipalities’ citizens prefer agencies do not waste resources for low or non-existent threats. Even the United States Army is downsizing the amount of CBRN Soldiers contained within the ranks as well as cutting training money for national level Emergency Scenarios. Organizations make up for these adjustments through the use of computer based training events allowing organizations spread across large geographical areas to come together and train without spending thousands of dollars on travel, maintenance, and lodging. The current policy options for dealing with natural or intentional biological agent outbreaks lack the depth to ensure preparedness for the future and rely on the hospital system to detect the threat and develop treatment plans. While this system does work, and given the right amount of time can solve the problem, Detect to Treat is not effective if any one piece of the system fails as seen in the Duncan Ebola case. While the Duncan case was not a failure on the part of first responders, it is an example of how a Detect to Treat failure can leave civilians open to threats. First Responders need the tools to identify threats before a crisis develops while being able to defend themselves from the same threats. Other options for solving this problem include Responders paying for training on their own time, private organizations teaching classes at cost to the agency, or providing training only at the academy and relying on internet based training to maintain the knowledge. Responders paying for their own training puts a double burden on the Responder. First the Responder will
  • 50. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 50 not be at work, or if off shift, will not be at home with the family. For many Responders, Union rules come into play when doing work related training on personal time. The second impact felt by Responders will be from their personal bank account unless they can receive reimbursement from the agency. Private training organizations are a great resource to provide specialize training, but they cost significant amounts of money, and still require Responders to be available when the organization can provide the training. Relying on internet based training to maintain knowledge and skill sets is dangerous because Responders can find ways to ensure success without significant work or study, the online training costs money to build and maintain, and agencies will likely have to pay for Responders’ time spent online. A new paradigm in national level training must be established to keep the nation’s defenses firmly rooted in current threats without incurring significant cost increases. Currently individual agencies must either pay to send their people to schools or pay to have experts come teach at the local agency school house. This means the local Police department would have to pay to have a Deputy fly to a training site, pay for hotels, food, and training aids in order to receive training which will make the nation as whole more secure. The military uses this model as well even though the money all comes from the same place. The new training model should look more seamless and allow for more continuity of training. As discussed above the use of Reserve Training Support Battalions would reduce the costs and aid in maintaining a high level of training readiness. Rather than having the local Police have to scrounge up the money to send a Deputy to the New York Police Department’s Biological Agent Protection course for a long weekend, a Reserve Unit could schedule their mandatory two week Annual Training or a weekend Battle Training Assembly at the local Police Office and conduct training. Using a US Army Reserve Soldier at the rank of Sergeant First
  • 51. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 51 Class, or E7, with 10 years of service is costs $499.60 plus food and around $35-$40 for lodging for a Battle Training Assemble. If this same Soldier was tasked to train a local Responder organization during this same time period, the cost would be exactly the same. Active Duty Soldiers may require Temporary Duty funds to cover the cost of living away from home. Reserve Soldiers receive this pay simply by attending the BTA regardless of where it is held. No additional cost would have to be spent on the Soldier to conduct this training so the US Army Reserves budget would remain the same. Normally State and Local organizations would have to reimburse Federal or out of State organizations for their work under the Stafford Act. Since State and Local organizations receive money to support training, either this money could be used, or since the money is going to be spent on the Soldier anyway an amendment could be made to exempt this type of activity. This would ensure all organizations who need or want training will receive the training using the same materials, tests, and procedures across the nation. Unity of method will allow different organizations to seamlessly integrate during time of national emergency. To ensure this training is correct and based in the most accurate science the Center for Disease Control should be the lead effort to design and build the courses. The Center for Disease Control (CDC) is the primary organization for the US Government’s efforts to “protect America from health, safety and security threats, both foreign and in the U.S.” from diseases which “start at home or abroad, are chronic or acute, curable or preventable, human error or deliberate attack.” (CDC, 2014) This means the CDC is the primary federal organization for the protection of the American people against illness whether natural or intentional. Based in Atlanta, GA, the CDC has departments for Global Health, Occupational Safety, Infectious Disease, Noncommunicable Disease, Health Preparedness, and Health Science among others, and it publishes various health related reports and research studies as well as the
  • 52. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 52 Morbidity and Mortality Weekly Report (MMWR). This weekly report touches on current events and important topics facing the health community as it relates to disease. The MMWR of October 21, 2014 featured data on the epidemiological spread and the casualty and fatality rates of Ebola in Africa. The course of action that will allow State and Local agencies to prepare for biological warfare agent outbreaks while ensuring minimum cost and maximum effect starts with the CDC developing a national response standard for domestic outbreak. This should include identification of symptoms, ingredients, laboratory processes and equipment, and likely method of infection for the First Responder. Once the First Responder has identified a possible event, the CDC guidelines should provide a clear step by step process for reporting the data that led to the suspicion to the medical facility responding to an event so proper testing, evaluation, and quarantine can begin. The CDC should also develop a training curriculum supporting these procedures for all agencies so any responding organization in the country has the same knowledge and operating procedures. The Department of the Army, and the primary CBRN response force for the Federal Government in Civil Support operations should conduct the training for all agencies utilizing the Army Reserve Training Support Battalions across the country. Using these Battalions will not only keep costs low, as discussed above, this training will also strengthen Civil Support relationships and ensure preparedness for other National Emergency Scenario events. The CDC should revise the training every three years, as well as support development of new techniques and procedures for outbreak response alongside the Federal Emergency Management Agency, and the Department of Homeland Security. Other Options for providing training to State and Local First Responders exist but have drawbacks that would limit their use. The State National Guard Units could be used given their
  • 53. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 53 prominence in disaster events for states, but as they are primarily combat focused the cost to adjust missions and create a competent cadre of DSCA trainers would be unnecessary given the Army Reserves current adaptation to the mission. FEMA could offer grants to local organizations to send Responders to schools, but this plan does not address the lack of unified curriculum, the limited number of responders being trained, and time available to receive the training in a given period. The DoD has developed the CBRN Response Enterprise on which all Federal Forces operate, however Local and State elements that are not military rarely get access to this network and system. The Army Reserve Training Support Battalion is designed and tasked to teach and instruct students on any military mission including CBRN operations and DSCA making it the most appropriate choice. This is accomplished through AT and BTAs all across the country supporting Active Duty, National Guard, and other Reserve organizations. Adding Local and State organizations to the list, meeting the requirements for Total Force Integration, is the best way to increase education without significant disruption in operations given that the Reserves have lost many of the significant missions it held over the last ten years including Bosnia and Kosovo support, the Sini mission, and mobilization for combat deployments. While the approval of the Secretary of Defense is usually required to send Reserve Soldiers on missions (meaning longer than the two week Annual Training) or to Federalize a Reserve Solider this type of training would not require approval due to the short duration and the already existing relationships required under the DSCA doctrine.
  • 54. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 54 Conclusion Biological attack whether from a state level adversary or from a non-state actor is one of the greatest, yet least protected against, threats our Nation faces. As this paper has shown a determined group of non-states actors could easily produce biological warfare agents in the privacy of a kitchen in much the same way criminals make methamphetamines. With the internet, and various dark networks, offering a near endless stream of information a determined person could find the appropriate recipes for various biological warfare agents and the restricted materials needed to make them. While cities have the BioShield systems to protect against significant attack, BioShield has significant limitations and, as with all government programs, is effected by budgets and training. The more recently published literature on the subject of biological warfare agent attack is usually focused on the threat and how it will effect society. Older literature tends to focus on how hospitals can prepare for the influx of patients will accompany an outbreak. Even movies such as Outbreak or World War Z which show the rapid spread of disease reveal the gap in knowledge of rapid identification and response by first responders. Unfortunately, old literature and movies are the basis for most thought processes on health protection. Rather than allowing the Center for Disease Control or Health and Human Services develop and support health protection standards, citizens will attempt to emplace whatever they saw on TV or read in a book to protect themselves. This paper has proposed a low cost high payoff method to ensure at least the First Responders who stand between the sheep and wolves can be as prepared as possible for biological threats. By providing First Responders with current and useful training the gap between recognition of a threat and the threat’s spread are dramatically reduced. The
  • 55. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 55 Department of the Army has significant resources and responsibility in supporting Civil Authorities before, during, and after an event or attack. Using these resources State and Local responders can become better prepared and trained allowing for a more rapid response. As demonstrated above the US Army Reserve is the most cost effective, appropriate, and capable organization to support local Responders with training. While other options are available to State and Local agencies to fill the gaps in knowledge and skills discussed above, very few have the low cost and require long hours and dedication from the individual responder on his or her own time. Using resources for which the federal or state government already pays, such as pay for attending a Battle Training Assembly, allows for responders to maximize their efforts without undue burden to the taxpayer, or at the expense of more common and likely threats. The best system to combat the threat of attack no matter what kind it may be, is between the ears of every citizen in the nation. A well-educated populace dramatically increases the likelihood nefarious activities will be identified in the early stages and stopped before the danger becomes lethal. Just as citizens are trained to look for the signs of sickness to avoid spreading colds and the flu, people should be trained to notice the signs of more significant illness. Additionally, a populous with more knowledge about illness will be less likely to emplace useless health protection measures or panic when an outbreak occurs.
  • 56. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 56 References 2340M - Manual Autoclave. (2014, November 19). Retrieved November 19, 2014, from http://www.tuttnauerusa.com/products/office-based-practices/manual-autoclaves/2340m About Ebola Virus Disease. (2014, October 3). Retrieved October 20, 2014, from http://www.cdc.gov/vhf/ebola/about.html Advanced Biological Microscope 1000. (2014, November 17). Retrieved November 17, 2014, from http://www.celestron.com/browse-shop/microscopes/biological- microscopes/advanced-biological-microscope-1000 Bio Fermentation Tank - Buy Bio Fermentation Tank, Fermenter Tank, Fermenting Tank Product on Alibaba.com. (2014, November 17). Retrieved November 17, 2014, from http://www.alibaba.com/product-detail/Bio-Fermentation-tank_1100864834.html?s=p Bioterrorism Alleging Use of Anthrax and Interim Guidelines for Management. (1999, February 5). Retrieved October 22, 2014, from http://www.cdc.gov/mmwr/preview/mmwrhtml/00056353.htm Bucci, S., & Corrente-Bucci, J. (2013). Needed: More Biothreat Training for First Responders. DomPrep Journal, 9(11), 11-12. Retrieved October 22, 2014, from http://www.domesticpreparedness.com/pub/docs/DPJNov13.pdf Centrifuges. (2014, November 17). Retrieved November 17, 2014, from http://www.bio- rad.com/en-us/product/general-lab-equipment/centrifuges Ceramill Motion 2 Milling Machine from AmannGirrbach GmbH. (2014, November 19). Retrieved November 19, 2014, from http://www.dentalcompare.com/24988-Dental-Lab- Milling-Units/4459994-Ceramill-Motion-2-Milling- Machine/?ncatid=24988&ppim=4459994_1_0
  • 57. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 57 Cholera - Vibrio Cholerae Infection. (2013, October 18). Retrieved October 22, 2014, from http://www.cdc.gov/cholera/index.html Darcy, O. (2014, October 1). The 'Mistake' Hospital Treating Ebola Patient Made That 'Hopefully...Will Never Happen Again' Retrieved October 22, 2014, from http://www.theblaze.com/stories/2014/10/01/the-mistake-hospital-treating-ebola-patient- made-that-hopefullywill-never-happen-again/ Darcy, O. (2014, October 2). Here’s Everything We Know About the Texas Patient Diagnosed with Ebola. Retrieved October 22, 2014, from http://www.theblaze.com/stories/2014/10/02/heres-everything-we-know-about-the- texas-patient-diagnosed-with-ebola/ Facts About Sarin. (2013, May 20). Retrieved October 19, 2014, from http://www.bt.cdc.gov/agent/sarin/basics/facts.asp Frey Scientific Lab Lists. (2014, November 23). Retrieved November 23, 2014, from http://www.freyscientific.com/Resources/2013LabLists/tabid/427/Default.aspx Gibson, J. (2003). Investigation of a Ricin-Containing Envelope at a Postal Facility — South Carolina, 2003. Morbidity and Mortality Weekly Report, 52(46), 1129-1129. Retrieved October 22, 2014, from http://www.cdc.gov/nceh/hsb/chemicals/pdfs/mmwr5246p1129.pdf Henderson, D. (1999). The Looming Threat of Bioterrorism. Science, 283(5046), 1279-1282. Henry, L. (2001). Inhalational Anthrax: Threat, Clinical Presentation, and Treatment. Journal of the American Academy of Nurse Practitioners, 13(4), 164-168.
  • 58. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 58 HERAtherm™ General Protocol Ovens. (2014, November 19). Retrieved November 19, 2014, from http://www.thermoscientific.com/en/product/heratherm-general-protocol- ovens.html History of the Plague. (2012, June 13). Retrieved October 20, 2014, from http://www.cdc.gov/plague/history/index.html Johnson, O. (2013, January 1). The Journal of Law Enforcement. Retrieved October 22, 2014, from http://www.jghcs.info/index.php/l/article/view/235 Kaplan, D., & Marshall, A. (1996). The cult at the end of the world: The terrifying story of the Aum doomsday cult, from the subways of Tokyo to the nuclear arsenals of Russia = [Oumu]. New York: Crown. Keim, M. (1999). Principles For Emergency Response To Bioterrorism. Annals of Emergency Medicine, 34(2), 177-182. Magnetic Mini-Stirrers with Speedsafe. (2014, November 17). Retrieved November 17, 2014, from http://www.labdepotinc.com/Product_Details~id~593~pid~59108.aspx Mayer, M., & Erickson, S. (2011, June 23). Heritage.org. Retrieved December 8, 2014, from http://www.heritage.org/research/reports/2011/06/changing-todays-law-enforcement- culture-to-face-21st-century-threats Meselson, M. (1994). The Sverdlovsk Anthrax Outbreak of 1979. Science, 266, 1202-1208. Mission, Role and Pledge. (2014, April 14). Retrieved October 21, 2014, from http://www.cdc.gov/about/organization/mission.htm Osterholm, M. (1999). The Medical Impact of a Bioterrorist Attack: Is It All Media Hype or Clearly a Potential Nightmare. Postgraduate Medicine, 106(2), 121-130.
  • 59. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 59 Peskin, N. (1999). Do US Emergency Medicine Residency Programs Provide Adequate Training For Bioterrorism? Annals of Emergency Medicine, 34(2), 173-176. Quinn, M. (2014, November 3). BioShield: Obama Diverted Its Funds From Fighting Ebola. Retrieved November 23, 2014, from http://dailysignal.com/2014/11/03/bioshield-obama- diverted-funds-from-its-fight-against-ebola-other- threats/?utm_source=heritagefoundation&utm_medium=email&utm_campaign=mornin gbell&mkt_tok=3RkMMJWWfF9wsRokuKTBZKXonjHpfsX56+QtWqC0lMI/0ER3fO vrPUfGjI4CSM Richards, C. (1999). Emergency Physicians and Biological Terrorism. Annals of Emergency Medicine, 34(2), 183-190. SMI1EM SHEL LAB Economy Laboratory Incubator with Digital Controller, 1 Cu. Ft. (28 L). (2014, November 17). Retrieved November 17, 2014, from http://www.shellab.com/store/SMI1EM-Lab-Laboratory-general-purpose-economy- incubator-120V-also-model-E1500M.html Science Department / Chemistry Safety Guidelines. (2011, November 8). Retrieved October 23, 2014, from http://www.portnet.k12.ny.us/Page/5592 Seto, Y. (2001, June 1). The Sarin Gas Attack in Japan and the Related Forensic Investigation. Retrieved October 21, 2014, from http://www.opcw.org/news/article/the-sarin-gas- attack-in-japan-and-the-related-forensic-investigation/ Siegrist, D. (1999, August 1). The Threat of Biological Attack: Why Concern Now? - Volume 5, Number 4-August 1999 - Emerging Infectious Disease journal - CDC. Retrieved October 22, 2014, from http://wwwnc.cdc.gov/eid/article/5/4/99-0407_article
  • 60. FIRST RESPONDERS IN A BIOTHREAT ENVIRONMENT 60 Tauberger, J., & Morens, D. (2006, January 1). 1918 Influenza: The Mother of All Pandemics - Volume 12, Number 1-January 2006 - Emerging Infectious Disease journal - CDC. Retrieved October 21, 2014, from http://wwwnc.cdc.gov/eid/article/12/1/05-0979_article Torok, T. (1997). A Large Community Outbreak of Salmonellosis Caused by Intentional Contamination of Restaurant Salad Bars. JAMA, 278, 389-395. Typhoid Fever. (2013, May 14). Retrieved October 22, 2014, from http://www.cdc.gov/nczved/divisions/dfbmd/diseases/typhoid_fever/ Unknown. (2012). Indicators and Warning of Improvised Chemical and Biological Agent Production. Arlington: Technical Support Working Group. Wendell, W. (2012). Chemical Biological Advanced Warfighter Training. Dugway Proving Grounds: Special Programs Division.