The document discusses bone marrow failure syndromes, which occur when there is a decrease or damage to hematopoietic stem cells and their microenvironment resulting in hypoplastic or aplastic bone marrow. Some examples of bone marrow failure syndromes discussed include aplastic anemia, myelodysplastic syndromes, paroxysmal nocturnal hemoglobinuria, and various constitutional bone marrow failure syndromes such as Fanconi anemia, dyskeratosis congenita, and Diamond-Blackfan anemia. The causes, signs, diagnostic evaluation, and treatment approaches for different bone marrow failure syndromes are described.

2. Bone Marrow Failure Syndromes Ahmed Elshebiny University of Menoufyia

3. Blood is continuously renewed

4. The Bone Marrow is the blood Factory May be exposed to damage or failure

5. Bone Marrow Failure Syndromes Bone Marrow Failure Syndromes AA PNH MDS Acquired Constitutional Autoimmune Fanconi DC Diamond-Blackfan others Toxic, Irradiation, Infection Pure Red Cell Aplasia Agranulocytosis

7. Venn Diagram AML APLASTIC ANEMIA MDS PNH

8. Bone Marrow Failure Syndromes

11. Aplastic Anemias Aplastic Anemias Acquired Conistituitional Single line Agranulocytosis Pure Red Cell Aplasia Multilineage

14. Aplastic Anemia

24. Bone marrow aspiration and biopsy Hypocellular but there may be pockets of cellularity ( hot spots)

36. Copyright ©2010 Ferrata Storti Foundation Dokal, I. et al. Haematologica 2010;95:1236-1240 Table 1. Characteristics of the inherited bone marrow failure syndromes

40. P.N.H

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