2. ANATOMY OF PARATHYROID GLAND
Develop from endoderm of embryo.
Consist of four separate glands located on posterior
surface of lobes of thyroid gland.
They are two pairs oval in shape and each gland is pea
shape.
Each has mass about 40mg usually 1 superior and 1
inferior of parathyroid gland attached to each lateral
thyroid lobe.
3. FUNCTION OF PARATHYROID GLAND
Secrete PTH(parathyroid hormone) and secretion is regulated by blood calcium
level.
Main function of PTH is to increase blood calcium level when it is low.
PTH on kidney is to promote formation of hormone calcitriol, active form of
vitamin D.
Increases rate of calcium, phosphate and magnesium from GI tract into blood.
It helps in muscle contraction, nerve transmission, blood clotting.
5. INTRODUCTION
When calcium level is too low, body response increasing production of
pararthyroid hormone and calcium to be take from bone and more calcium to
be reabsorbed by intestines and kidney.
11. DIAGNOSTIC EVALUATION
History.
Physical Examination.
Blood test-serum calcium phosphorus.
Bone X-Ray.
Bone mineral denistry test.
Ultrasound.
12. MANAGEMENT
1. MEDICAL MANAGEMENT:
Diuretics are given to patient such as thiazide(hydrochloridethiazide).
Hormone replacement therapy- CINACALCET.
Calcimimetics terms action of PTH.
Bisphosphonates also provided.
16. DEFINITION
Hypoparathyroidism is a condition occurs when either insufficient level of
PTH or release by parathyroid gland in neck leads to low level of calcium and
high level of phosphorus in blood.
17. CAUSES
Recent neck surgery.
Family history.
Addison’s disease.
Magnesium deficiency due to alcoholism,
malnutrition.
Cancer or infectious disease.
Inadequate PTH secretion.
19. PATHOPHYSIOLOGY
Due to etiological factor such as inadequate PTH secretion
Decreased reabsorption of calcium from renal tubules
Decreased absorption of calcium in GI tract
Decreased reabsorption of calcium from bone
Blood calcium fails to low level
Muscular hyper-irritability, uncontrolled spasm, hypocalcemic tetany
HYPOPARATHYROIDISM
23. MANAGEMENT
Calcium chloride and calcium gluconate- 500mg to 1g.
Vitamin D supplement.
Low phosphorus diet.
Diuretics- Lasix given to patient.
To prevent tetany I.V calcium can be given.
25. CONCLUSION
When calcium level is too low, body response increasing production of
pararthyroid hormone and calcium to be take from bone and more calcium to be
reabsorbed by intestines and kidney.
Hypoparathyroidism is a condition occurs when either insufficient level of PTH
or release by parathyroid gland in neck leads to low level of calcium and high
level of phosphorus in blood.