BMK Glycidic Acid (sodium salt) CAS 5449-12-7 Pharmaceutical intermediates
Hydronephrosis.pptx
1.
2. Definition
It is a aseptic dilatation of pelvicalcyeal system due to partial or intermittent
obstruction to the outflow of urine.
M:F= 2:1
Right kidney is more commonly affected
3. Aetiology
UNILATERAL
a) Extramural
:Retroperitoneal fibrosis,
aberrant renal
vessels,tumour
b) Intramural :
Strictures,renal pelvis
tumour, ureterocoele,
c) Intraluminal : Stone ,
sloughed papillae
BILATERAL
a) Congenital :
Posterior urethral valve
, phimosis
b) Acquired :
BPH,urethral stricture ,
phimosis, carcinoma of
prostate
5. Pathophysiology
Due to eitological factors
Obstruction of the urine flow
Fluid backs up into the kidney
Causing dilatation of renal pelvis
Results in pressure trauma
Higher pressure causes irreversible destruction of nephron
Hypertrophy of the kidney as a consequence of increased work load
Hydronephrosis
Renal failure
6. Clinical Features
Unilateral cases
Dull aching loin pain
Mass in the loin
Dullness in renal angle
Dietl’s crisis : pain and
swelling disappears when
patient passes large
amount of urine
Bilateral cases
Loin pain
Frequency
Hesitancy
Poor stream
Mass in loin
Oliguria
Edema
7. Investigations
USG (IOC) : dilated pelvic calyces system , thinning of cortex , soap bubble
appearance
Intravenous urogram : normal calycx is cup shaped, it gets flattened and later club
shaped which eventually becomes broadened
CT scan
Blood urea and creatinine
Urine for microscopy
Whitaker test