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NEPHROSIS
When urine outflow is obstructed, a large fluctuating collection
or mass of urine forms in the kidney. This mass subsides as
retained urine finally passes into the ureters and bladder.
Stagnation of urine in the kidney leads to infection.
 Hydronephrosis is distension of the kidney with urine that leads
to progressive atrophy and eventual destruction of the kidney.
The kidney ends up looking like a thin walled shell filled with
fluid.
CAUSES
Structural abnormalities cause backward pressure on the kidney when
urine flow is obstructed. Such as
 Birth defects
 BPH
 Scarring of ureters
 Cancer
 Rectal impaction
 Pregnancy
Kidney or ureter stone obstructs the ureters causing urine to back flow into
the kidney
PATHOPHYSIOLOGY
Ureter calculi or BPH
Obstruction of urinary flow
Urinary retention
Collection of urine in kidney
Severe pain in retroperitoneal region
Chronic retention leads palpable mass in kidney
CLINICAL MANIFESTATION
 Acute: Extreme flank pain on affect side; pain may radiate to groin
 Chronic: Mild discomfort over affected side due to blockage of the
urethra or ureters
 Urinary tract infection
 Nausea, vomiting, abdominal pain
 Palpable mass over flank area seen only in extreme cases; due to
enlargement of obstructed area related to the collection of urine
COMPLICATION
 End stage renal disease/ Chronic kidney disease
 Infection
DIAGNOSTIC EVALUATION
 Physical examination : distended kidney is palpable
 Bladder catheterization : detects site of the obstruction
 Urinalysis : increased white blood cells and presence of
red bloodcells
 Ultrasound : detects cause of obstruction
 Intravenous urography : detects flow of urine through the
kidneys
MEDICAL MANAGEMENT
 Immediate drainage of urine via needle directly into
the kidney through the skin
 Hormone therapy for prostate cancer
 Antibiotic to treat infection
SURGICAL MANAGEMENT
 Remove obstruction
 Urethral stent : bypass obstruction

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NEPHROSIS Nephrosis Nephrosis Nephr.pptx

  • 2. When urine outflow is obstructed, a large fluctuating collection or mass of urine forms in the kidney. This mass subsides as retained urine finally passes into the ureters and bladder. Stagnation of urine in the kidney leads to infection.  Hydronephrosis is distension of the kidney with urine that leads to progressive atrophy and eventual destruction of the kidney. The kidney ends up looking like a thin walled shell filled with fluid.
  • 3. CAUSES Structural abnormalities cause backward pressure on the kidney when urine flow is obstructed. Such as  Birth defects  BPH  Scarring of ureters  Cancer  Rectal impaction  Pregnancy Kidney or ureter stone obstructs the ureters causing urine to back flow into the kidney
  • 4. PATHOPHYSIOLOGY Ureter calculi or BPH Obstruction of urinary flow Urinary retention Collection of urine in kidney Severe pain in retroperitoneal region Chronic retention leads palpable mass in kidney
  • 5. CLINICAL MANIFESTATION  Acute: Extreme flank pain on affect side; pain may radiate to groin  Chronic: Mild discomfort over affected side due to blockage of the urethra or ureters  Urinary tract infection  Nausea, vomiting, abdominal pain  Palpable mass over flank area seen only in extreme cases; due to enlargement of obstructed area related to the collection of urine
  • 6. COMPLICATION  End stage renal disease/ Chronic kidney disease  Infection
  • 7. DIAGNOSTIC EVALUATION  Physical examination : distended kidney is palpable  Bladder catheterization : detects site of the obstruction  Urinalysis : increased white blood cells and presence of red bloodcells  Ultrasound : detects cause of obstruction  Intravenous urography : detects flow of urine through the kidneys
  • 8. MEDICAL MANAGEMENT  Immediate drainage of urine via needle directly into the kidney through the skin  Hormone therapy for prostate cancer  Antibiotic to treat infection
  • 9. SURGICAL MANAGEMENT  Remove obstruction  Urethral stent : bypass obstruction