To set up a Twitter account, go to Twitter.com and enter your name, email, and desired password on the home screen. Select a username under 15 characters that uniquely identifies you. Click "Create Account" and confirm your email. Once logged in, go to the gear menu and select "Edit Profile" to upload a profile photo, add a header image, and write a 160-character bio. Select "Save Changes" to complete your profile. You can now start exploring Twitter with your new account.