This document discusses chronic kidney disease (CKD) and strategies to retard its progression. It covers CKD epidemiology and risk factors like hypertension, diabetes, metabolic acidosis, sleep quality, uric acid levels, antibiotic use, gut microbiome, herbal remedies, nutrition, exercise, and weight management. Later sections discuss roles of primary care providers, predicting disease course, and virtual learning through the ESNT Virtual Academy. The overall goal is to review current knowledge on modifiable factors that impact CKD progression and identify opportunities for improved prevention and management of kidney disease.

1. Chronic Kidney Disease:
How to Retard Progression?
Hussein Sheashaa, MD, FACP
Professor of Nephrology, Urology and Nephrology Center and
Director of Medical E-Learning Unit, Mansoura University and
Executive Director of ESNT- Virtual Academy:
http://lms.mans.edu.eg/esnt/
Mansoura Medical Syndicate, 7 December 2018

5. CKD:
Epidemiology

6. CKD:
Mortality and Hospitalization

7. CKD:
Cost

8. European Heart Journal (2018) 00, 1–98, Published: 25 August 2018
Ten Year Cardiovascular Risk
Categories and CKD

9. Nephron Loss:
Contributing Factors

10. n 20.431
Chronic Kidney Disease:
Effect of Low Birth Weight
Am J Kidney Dis. 2018 Jan;71(1):20-26.

11. N Engl J Med 2018;378:428-38
Progression of CKD:
History of Childhood Kidney Disease
population-based, historical cohort study of 1,521,501

12. AKIKidney International (2018) 93, 460–469
n 657,840 Patients

13. Chronic Kidney Disease:
Aging
J Am Soc Nephrol 28: 407–420, Feb 2017

14. Kidney International (2018) 93, 278–283
Gender:
2018 WKD

16. J Am Soc Nephrol 30; 2019
3939 adults enrolled in the Chronic Renal Insufficiency Cohort study
ESRD Epidemiology:
Gender

17. Global Prevalence of
Hypertension
2017

18. Hypertension:
2018 European Treatment Guidelines
European Heart Journal (2018) 00, 1–98, Published: 25 August 2018

19. European Heart Journal (2018) 00, 1–98, Published: 25 August 2018
Hypertension:
2018 European Treatment Guidelines
CKD

20. Global Prevalence of
Diabetes
2017

21. PTDM:
An Overview

22. Diabetes Metab Res Rev. 2018;e3021.
Prevention of DKD:
Role of Glycemic Control
11,140 participants (RCT), 5 y

23. Antidiabetic Drugs:
MARE
Kidney Int Rep (September 2018) 3, 1030–1038

24. SGLT2 Inhibitors:
eGFR Slopes
J Am Soc Nephrol 2018; in press

25. Lancet. 2018, in press
SGLT2 Inhibitors
What is New?

26. Diabetes research and clinical practice 143 (September 2018) 88 – 100
Antidiabetic Drugs:
SGLT2-I or GLP1-RA

27. Holistic Approach

28. ADA:
Diabetes Risk Calculators

29. Curr Opin Nephrol Hypertens March 2018, 27:94–101
CKD Progression:
Impact of Metabolic Acidosis

30. CKD Progression:
Effects of Sleep Quality and Duration
J Am Soc Nephrol 28: 3708–3715, December 2017

31. CKD and Sleep Disorders

32. Uric Acid and CKD
Retrospective epidemiologic cohort study
lowering serum uric acid level (sUA) to
below 6 mg/dL (target)
Perm J 2018;22:17-142

33. AJKD Vol 72 | Iss 6 | December 2018
Uric Acid and CKD
467 patients with stage 3 CKD and asymptomatic hyperuricemia at
55 medical institutions in Japan.

34. Other Dimensions
Drugs

35. Gastroenterology 2017;153:702–710
Drugs

36. PPI
x
40 mg of intravenous pantoprazole (a proton-pump
inhibitor) or placebo daily during the ICU stay

37. Am J Kidney Dis. June 2014;63(6)

38. Antibiotic Use and Stones
J Am Soc Nephrol. 2018 Jun;29(6):1731-1740

39. Gut Microbiome and CKD

40. Herb Remedies
Clin J Am Soc Nephrol. 2018 Oct 8;13(10):1605-1611

41. Important Dimensions
Overweight, Obesity:
Nutrition and
Exercise

42. N Engl J Med. 2018 Apr 5;378(14):1302-1312
BW and DM
62,565 Danish men

43. 51,505 children
Risk of Sustained
Obesity

44. Metabolic Syndrome:
Risk of CKD
Int J Clin Pract. August 2018;72:e13201.

45. Progress in Cardiovascular Diseases 2018, in press
Adipo-Renal Axis

46. Obesity and Lifetime
Prevalence of CKD

47. Weight Management

48. Br J Surg. 2018 Feb;105(3):168-181
DKD:
Effects of Metabolic Surgery
The literature search yielded 1559 articles. Ten studies (3 RCTs, 7
controlled clinical trials) investigating 17 532 patients were included.

49. DKD:
Effects of Metabolic Surgery

51. Journal of Renal Nutrition 2018, 2018 Jul;28(4):251-258.
Renal Nutrition:
DAL

52. Renal Nutrition:
Vegetarian Diets and CKD
Nephrol Dial Transplant (2018) , in press

53. Nutrients 2018, 10, 544 Published: 27 April 2018
Renal Nutrition:
Protein Intake

54. Clin J Am Soc Nephrol 12: 79–86, 2017
CKD Progression:
Diet Soda

55. Nutrition, Volume 46, February 2018, Pages 26-32
Renal Nutrition:
Red Meat

56. Hypertension:
2018 European Treatment Guidelines
European Heart Journal (2018) 00, 1–98, Published: 25 August 2018

57. Role of Primary Care
Provider

58. Predicting The Future
Kidney International (June 2018) 93, 1442–1451

59. MDC

60. ESNT Virtual Academy
29388 Users

61. 16 September 2018

62. ‫المهد‬ ‫من‬ ‫العلم‬ ‫اطلبوا‬‫إلى‬‫اللحد‬