A 58-year-old male with a history of end stage renal disease and hemodialysis for 15 years presented with generalized bone aches and persistent itching for one year. He was diagnosed with hyperparathyroidism. Medical treatment with calcium carbonate, cinacalcet, and sevelamer was unsuccessful in controlling his symptoms or lowering his elevated parathyroid hormone, calcium, and phosphate levels. Pre-operative evaluations found no abnormalities. The decision was made to proceed with parathyroidectomy after medical treatment failed to adequately manage his hyperparathyroidism.