How to Craft the "Significance” & "Innovation" Sections of a Grant Application by Scott Filler, PhD

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Scott Filler, PhD speaks on the topic of "How to Craft the "Significance” & "Innovation" Sections of a Grant Application (Basic Science)" at the R Award Workshop on November 08, 2018 at UCLA.

Education

Significance
and Innovation
(Basic Science)
Scott G. Filler, M.D.
Los Angeles Biomedical Research Institute
at Harbor-UCLA Medical Center

Review Criteria
• Does the application address a problem
of high importance in the field?
• Will the results of the work have a broad,
sustained impact?
• Is their a strong scientific foundation
(premise) for the proposed work?
o Is the prior research that serves as the key
support for the proposed project rigorous?

Goals of Significance Section
• Emphasize importance of the research
and gaps in current knowledge
o How your proposed research will fill these gaps
o How knowledge gained can be applied to other
systems
• Provide essential background information
for an uninformed reader
o Must support the premise
• Get reviewer interested

Key Points
• Don’t assume the reviewer will read every
word
• Reviewer may or may not have expertise
in your area of research
• Try to describe broad overall impact
• This is the sale pitch for your grant

Innovation
• One paragraph
• Some use bullet points
• Avoid prolonged rehash of the
proposed research

Innovation
• Two types of innovation:
o Innovative technology—applying new tools to
an old question
o Innovative hypothesis—applying standard
tools to a new question
• Optimal to have new tools and
innovative hypothesis

Mistakes to Avoid
• Using standard tools to answer old
questions:
o Which of the 3 known signaling pathways are active
under these conditions?
• Overly broad or narrow focus:
o Survey grants
o Identifying specific key amino acids in your
favorite protein

This document provides guidance on crafting the Approach section of an R grant application. It discusses key elements to include for the preliminary data, study design, sample size and power analysis, and statistical methods subsections. For preliminary data, strong relevant data is needed to demonstrate expertise and support for hypotheses. The study design must match objectives and have clearly defined populations and measures. Sample size must be powered for primary endpoints and account for variability and dropouts. Statistical methods should be appropriate for the study design and endpoints. Writing strategies include using graphical displays and avoiding long blocks of text.

The document provides guidance on writing the Specific Aims section of a grant application. It recommends structuring the Specific Aims section in 3 paragraphs that: 1) establish the significance of the research area and overall goal, 2) describe the team's preliminary work leading to the project, and 3) state the specific aims of the project and expected impact. Each specific aim should be a single sentence stating an experimentally feasible and time-bound goal. The section should convince reviewers of the project's importance and addressance of funding criteria in 1 page without detail.

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How to Craft the "Significance” & "Innovation" Sections of a Grant Application by Scott Filler, PhD

1. Significance and Innovation (Basic Science) Scott G. Filler, M.D. Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center

2. Review Criteria • Does the application address a problem of high importance in the field? • Will the results of the work have a broad, sustained impact? • Is their a strong scientific foundation (premise) for the proposed work? o Is the prior research that serves as the key support for the proposed project rigorous?

3. Goals of Significance Section • Emphasize importance of the research and gaps in current knowledge o How your proposed research will fill these gaps o How knowledge gained can be applied to other systems • Provide essential background information for an uninformed reader o Must support the premise • Get reviewer interested

4. Key Points • Don’t assume the reviewer will read every word • Reviewer may or may not have expertise in your area of research • Try to describe broad overall impact • This is the sale pitch for your grant

5. Strategic Points • Do not directly criticize previous work BAD: Previous microarray studies were flawed by their inability to detect low abundance transcripts. GOOD: While microarray studies have provided valuable insight into the transcriptional profile of ..., the frequency of low abundance transcripts remains unknown. • Consider citing the work of potential reviewers and influential researchers in the field

6. Innovation • One paragraph • Some use bullet points • Avoid prolonged rehash of the proposed research

7. Innovation • Two types of innovation: o Innovative technology—applying new tools to an old question o Innovative hypothesis—applying standard tools to a new question • Optimal to have new tools and innovative hypothesis

8. Mistakes to Avoid • Using standard tools to answer old questions: o Which of the 3 known signaling pathways are active under these conditions? • Overly broad or narrow focus: o Survey grants o Identifying specific key amino acids in your favorite protein

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