Carol Mangione provides strategies for early career researchers to successfully transition from a K award to an R01 grant. She emphasizes building relationships at NIH, identifying the best fitting funding opportunities, and making the most of preliminary K award research. Researchers should publish findings, present at conferences, and collaborate with senior scientists. When preparing an R01 application, researchers should clearly outline the proposed project based on significant preliminary findings and check that the research aims have not already been funded.
How to Craft the "Significance” & "Innovation" Sections of a Grant Applicatio...UCLA CTSI
William Parks, PhD
Professor of Medicine at Cedars-Sinai Medical Center and UCLA
Associate Dean for Graduate Research Education
Scientific Director, Women’s Guild Lung Institute
A short presentation focus on introduce Zotero for Ph.D. in eLearning Methodology students, Graduate School of eLearning, Assumption University. The APA is a recommended format.
journal club, journal club presentation, public health, medicine, health care, epidemiology, health system, health policy, health management, health economics, critical appraisal, online journal club, article appraisal, bachelor of public health, nursing, allied health sciences
How to Craft the "Significance” & "Innovation" Sections of a Grant Applicatio...UCLA CTSI
William Parks, PhD
Professor of Medicine at Cedars-Sinai Medical Center and UCLA
Associate Dean for Graduate Research Education
Scientific Director, Women’s Guild Lung Institute
A short presentation focus on introduce Zotero for Ph.D. in eLearning Methodology students, Graduate School of eLearning, Assumption University. The APA is a recommended format.
journal club, journal club presentation, public health, medicine, health care, epidemiology, health system, health policy, health management, health economics, critical appraisal, online journal club, article appraisal, bachelor of public health, nursing, allied health sciences
This presentation was provided by David Kuliman of Elsevier, during the NISO event "Content Presentation: Diversity of Formats." The webinar was held on February 10, 2021.
ROBINS-I: A tool to appraise the risk of bias in non-randomized studies of interventions
The ROBINS-I tool can be used to appraise non-randomized studies comparing the health effects of two or more interventions. This includes a number of observational study designs such as cohort studies, quasi-randomized trials, and case-control and cross-sectional studies. Join us for a webinar to learn about the ROBINS-I!
This tool was developed by a team at the University of Bristol.
How can the ROBINS-I help you?
Many types of study designs that evaluate interventions in public health do not use randomization. The ROBINS-I provides a single process that can be used to appraise these different types of evidence. This supports the use of evidence to formulate recommendations and develop public health actions.
The ROBINS-I consists of a seven domain appraisal framework. The tool also offers a number of explanations for ratings, terms, definitions and theory.
This webinar includes an overview of the ROBINS-I by its developers, Jonathan Sterne and Julian Higgins, and a presentation by users Judy Brown and Duvaraga Sivajohanathan.
To see the summary statement of this tool developed by the National Collaborating Centre for Methods and Tools, click here: http://www.nccmt.ca/resources/search/281
The National Collaborating Centre for Methods and Tools is funded by the Public Health Agency of Canada and affiliated with McMaster University. The views expressed herein do not necessarily represent the views of the Public Health Agency of Canada.
NCCMT is one of six National Collaborating Centres (NCCs) for Public Health. The Centres promote and improve the use of scientific research and other knowledge to strengthen public health practices and policies in Canada.
How to Anticipate and Plan for an R Grant Application (2020)UCLA CTSI
Carol M. Mangione, MD, MSPH
Barbara A. Levey MD & Gerald S. Levey MD Endowed Chair
Chief, Division of General Internal Medicine and Health Services Research
Professor of Medicine and Public Health at UCLA
Associate Director, UCLA Clinical and Translational Science Institute
Leader, UCLA CTSI Workforce Development
How to Anticipate and Plan for an R Grant Application - 2023UCLA CTSI
CTSI R Workshop: How to Anticipate and Plan for an R Grant Application.
Presented by Carol M. Mangione, MD, MSPH
Barbara A. Levey MD & Gerald S. Levey MD Endowed Chair
Chief, Division of General Internal Medicine and Health Services Research
Professor of Medicine and Public Health at UCLA
Leader, UCLA CTSI Workforce Development
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Carol Mangione, MD, MSPH “Navigating the NIH K Award Process”UCLA CTSI
Carol Mangione, MD, MSPH “Navigating the NIH K Award Process”
Barbara A. Levey MD & Gerald S. Levey MD Endowed Chair
Professor of Medicine and Public Health at UCLA
Associate Director, UCLA Clinical and Translational Science Institute
Program Leader, Research Education, Training and Career Development Program
UCLA CTSI K Workshop - February 4, 2016
Learn to navigate through the possible career development awards (CDAs) available to you and which you should target.
Carol M. Mangione, MD, MSPH
Barbara A. Levey MD & Gerald S. Levey MD Endowed Chair
Professor of Medicine and Public Health at UCLA
Associate Director, UCLA Clinical and Translational Science Institute
Leader, Research Education, Training and Career Development Program
How to Anticipate and Plan for an R Grant ApplicationUCLA CTSI
UCLA CTSI K-to_R Workshop, October 29, 2015
Presenter:
Carol M. Mangione, MD, MSPH
Barbara A. Levey MD & Gerald S. Levey MD Endowed Chair
Professor of Medicine and Public Health at UCLA
Associate Director, UCLA Clinical and Translational Science Institute
Program Leader, CTSI Research Education, Training and Career Development
Navigating the NIH K Award Process (2021)UCLA CTSI
Navigating the NIH K Award Process
Presented by Carol M. Mangione, MD, MSPH
Barbara A. Levey MD & Gerald S. Levey MD Endowed Chair
Professor of Medicine and Public Health at UCLA
Chief, Division of General Internal Medicine and Health Services Research
Associate Director, UCLA CTSI
Leader, UCLA CTSI Workforce Development
Navigating the NIH K Award Process (July 2015)UCLA CTSI
Carol M. Mangione, MD, MSPH
Barbara A. Levey MD & Gerald S. Levey MD Endowed Chair
Professor of Medicine and Public Health at UCLA
Associate Director, UCLA Clinical and Translational Science Institute
Program Leader, Research Education, Training and Career Development Program (CTSI-ED)
UCLA CTSI K Workshop
Learn to navigate through the possible career development awards (CDAs) available to you and which you should target.
Carol M. Mangione, MD, MSPH
Barbara A. Levey MD & Gerald S. Levey MD Endowed Chair
Professor of Medicine and Public Health at UCLA
Associate Director, UCLA Clinical and Translational Science Institute
Leader, UCLA CTSI Workforce Development
Presentation date: February 09, 2017
The Texas State SBDC presented this Spectrum program at the Austin Chamber of Commerce on January 15, 2015. Heath Naquin, Executive Director of the NSF I-Corps Node and Lisa Kurek, Managing Partner at BBC Entrepreneurial Training & Consulting were the main speakers. Additional information about the Spectrum technology commercialization program at Texas State SBDC is available at www.AustinSmallBusinessAnswers.com
This presentation was provided by David Kuliman of Elsevier, during the NISO event "Content Presentation: Diversity of Formats." The webinar was held on February 10, 2021.
ROBINS-I: A tool to appraise the risk of bias in non-randomized studies of interventions
The ROBINS-I tool can be used to appraise non-randomized studies comparing the health effects of two or more interventions. This includes a number of observational study designs such as cohort studies, quasi-randomized trials, and case-control and cross-sectional studies. Join us for a webinar to learn about the ROBINS-I!
This tool was developed by a team at the University of Bristol.
How can the ROBINS-I help you?
Many types of study designs that evaluate interventions in public health do not use randomization. The ROBINS-I provides a single process that can be used to appraise these different types of evidence. This supports the use of evidence to formulate recommendations and develop public health actions.
The ROBINS-I consists of a seven domain appraisal framework. The tool also offers a number of explanations for ratings, terms, definitions and theory.
This webinar includes an overview of the ROBINS-I by its developers, Jonathan Sterne and Julian Higgins, and a presentation by users Judy Brown and Duvaraga Sivajohanathan.
To see the summary statement of this tool developed by the National Collaborating Centre for Methods and Tools, click here: http://www.nccmt.ca/resources/search/281
The National Collaborating Centre for Methods and Tools is funded by the Public Health Agency of Canada and affiliated with McMaster University. The views expressed herein do not necessarily represent the views of the Public Health Agency of Canada.
NCCMT is one of six National Collaborating Centres (NCCs) for Public Health. The Centres promote and improve the use of scientific research and other knowledge to strengthen public health practices and policies in Canada.
How to Anticipate and Plan for an R Grant Application (2020)UCLA CTSI
Carol M. Mangione, MD, MSPH
Barbara A. Levey MD & Gerald S. Levey MD Endowed Chair
Chief, Division of General Internal Medicine and Health Services Research
Professor of Medicine and Public Health at UCLA
Associate Director, UCLA Clinical and Translational Science Institute
Leader, UCLA CTSI Workforce Development
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Presented by Carol M. Mangione, MD, MSPH
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Professor of Medicine and Public Health at UCLA
Leader, UCLA CTSI Workforce Development
Ask an NIH Program Officer: Tips and Tools for New & Early-Stage ResearchersNorbert Tavares, Ph.D.
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Carol Mangione, MD, MSPH “Navigating the NIH K Award Process”UCLA CTSI
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Associate Director, UCLA Clinical and Translational Science Institute
Program Leader, Research Education, Training and Career Development Program
UCLA CTSI K Workshop - February 4, 2016
Learn to navigate through the possible career development awards (CDAs) available to you and which you should target.
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Professor of Medicine and Public Health at UCLA
Associate Director, UCLA Clinical and Translational Science Institute
Leader, Research Education, Training and Career Development Program
How to Anticipate and Plan for an R Grant ApplicationUCLA CTSI
UCLA CTSI K-to_R Workshop, October 29, 2015
Presenter:
Carol M. Mangione, MD, MSPH
Barbara A. Levey MD & Gerald S. Levey MD Endowed Chair
Professor of Medicine and Public Health at UCLA
Associate Director, UCLA Clinical and Translational Science Institute
Program Leader, CTSI Research Education, Training and Career Development
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Barbara A. Levey MD & Gerald S. Levey MD Endowed Chair
Professor of Medicine and Public Health at UCLA
Chief, Division of General Internal Medicine and Health Services Research
Associate Director, UCLA CTSI
Leader, UCLA CTSI Workforce Development
Navigating the NIH K Award Process (July 2015)UCLA CTSI
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Professor of Medicine and Public Health at UCLA
Associate Director, UCLA Clinical and Translational Science Institute
Program Leader, Research Education, Training and Career Development Program (CTSI-ED)
UCLA CTSI K Workshop
Learn to navigate through the possible career development awards (CDAs) available to you and which you should target.
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Barbara A. Levey MD & Gerald S. Levey MD Endowed Chair
Professor of Medicine and Public Health at UCLA
Associate Director, UCLA Clinical and Translational Science Institute
Leader, UCLA CTSI Workforce Development
Presentation date: February 09, 2017
The Texas State SBDC presented this Spectrum program at the Austin Chamber of Commerce on January 15, 2015. Heath Naquin, Executive Director of the NSF I-Corps Node and Lisa Kurek, Managing Partner at BBC Entrepreneurial Training & Consulting were the main speakers. Additional information about the Spectrum technology commercialization program at Texas State SBDC is available at www.AustinSmallBusinessAnswers.com
Navigating the NIH K Award Process and Choosing Your Mentorship Team (2023)UCLA CTSI
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Navigating the NIH K Award Process (July 25, 2013)UCLA CTSI
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NIH Loan Repayment Program (LRP) Info Session - 9/26/23UCLA CTSI
The UCLA CTSI and DGSOM Office of Physician Scientist Career Development held this webinar to provide information on the NIH Loan Repayment Program (LRP). This funding is designed to recruit and retain highly qualified health professionals into biomedical or biobehavioral research careers. The LRPs counteract financial pressure by repaying up to $50,000 annually of a researcher's qualified educational debt in return for a commitment to engage in NIH mission-relevant research.
Thinking about applying for a K award? Wondering how to put together the most competitive application?
NIH Research Career Development Awards (K awards) promote career development and provide support for senior postdoctoral fellows or faculty-level candidates. In this presentation, Dr. Sheila Lukehart leverages her many years of chairing K-award review committees at the NIH to provide practical tips and advice.
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How to Anticipate and Plan for an R Grant Application. (2022)
1. Carol M. Mangione, MD, MSPH
Barbara A. Levy and Gerald S. Levey Distinguished Professor of Medicine and Public Health
Director, UCLA CTSI Workforce Development Program
David Geffen School of Medicine at UCLA, UCLA Fielding School of Public Health
How to anticipate and plan for an R grant
application
2. Outline
• Strategies for making the most of the research you
conduct during the K award
• The importance of relationship building at the NIH
• Keep an eye out for the FOAs and RFAs that are the
best fit for your work
• Next Generation Researchers Initiative
• Getting Organized:
– Your results
– Your team
– Your timeline
3. Making the most of the K research
• Early on, try to identify at least one research
question and testable hypothesis that is
important regardless of the direction or
significance of your findings.
• If you can link the K research to the first R grant
this will help you have strong preliminary studies
and it will be easier to defend why the work
proposed in the R is the most important and
logical next step and why you are the best PI to
do this work
4. Making the most of the K research
• Get out front with your research findings so that
you start to develop a name and identity in your
field
– Present your work at the most important meetings
– Take advantage of opportunities to participate in NIH
conferences and other symposia in your field
– Get to know the most prominent scientists in your
field so that you can get their input on your work
– Publish… try not to get scooped!
– Time is your most precious commodity, don’t waste it
on low yield activities – If you are not sure which ones
fall in this category, talk to your mentor
5. Be aware of who else is working in
your area of research!
• Literature search
- Pubmed: what has been published
- Google scholar (may pick up abstracts
presented at meetings)
• NIH reporter (grants that have been funded
already)
- http://projectreporter.nih.gov/reporter.cfm
6. Making the most of the K research
• Look for opportunities to be independent of your
mentor
– In some fields this is accomplished by working and
publishing with more than one senior researcher
– Or, you may have the opportunity to “PI” a smaller
foundation grant in your field that is related to or is an
extension of your main work
– Early on, talk to your mentor about what you should
do now or in the next couple of years so that when
the first R goes in with you as PI there will not be
questions about your independence.
7. Relationship Building at the NIH
• Establish relationships with the program officers
at the institute(s) in your research area
• Know the institute’s priority areas in your field
• Each Institute handles grants in slightly different
ways
• 2 parts:
– Program- Includes the Institutes that set the research
priorities – get to know your institute’s priorities!
– Review - CSR or Center for Scientific Review
• Evaluates the scientific merits of the proposals
• http://www.csr.nih.gov
8. Sign up for the NIH GUIDE ListServe
http://grants1.nih.gov/grants/guide/listserv.htm
once a week receive a Table of
Contents with ‘links’ to PAs,
Notices, FOAs and RFAs
The best way to know your institute
Follow your Institute’s Blogs!
9. Resources
• NIH Guide for Grants and Contracts
• Institute web pages/blogs
• Grants Net (http://www.grantsnet.org)
• Mentors and colleagues
• NIH staff
10. NIH Program staff
Program
Director/Administrator
or ‘Project Officer’
Works for an Institute or
Center
Handles pre-application
questions
Manages grant
portfolios
Develops RFAs and PAs
Observers at study
section meetings
Handles post-review
issues
Sends out summary
statements
Initiates funding plans
Reviews yearly progress
reports
11. Governmental Alphabet Soup
• NIH - National Institutes of Health
• AHRQ - Agency for Healthcare Research and
Quality
• PCORI – Patient Centered Outcomes Research
Institute
• CDC – Centers for Disease Control
• RFA - Request for application
• RFP - Request for proposals
• PA - Program announcement
• FOA – Funding opportunity announcement
12. Funding the transition from K to R
• Look for funding announcements, preferably RFAs
or FOAs that have specific dollars allocated to
your area
• What if there aren’t any or what if the pay lines
are unrealistically low?
– Consider foundations, professional organizations,
industry, or institutional grants to tide you over
– Awards from these sources can keep you working,
publishing, and staying active in the field and can
strengthen your portfolio while you try to identify the
best opportunity at NIH
13. % Effort and Support for K Awardees
• Commit minimum 75% full-time professional
effort.
• Remaining effort (up to 25%) for additional
research, teaching, clinical work, or other efforts
complementary to career development of the K
awardee.
• Institutions normally supplement the salary of K
award PIs up to a level that is consistent with the
institution’s salary scale.
https://nexus.od.nih.gov/all/2017/10/11/clarifying-percent-effort-and-support-for-career-
development-k-awardees/
14. Salary Supplementation (NOT-OD-17-094)
• Effort directly committed to the K award - must be
from non-Federal sources (including institutional
sources) and not require extra duties that would
interfere with the goals of the K award.
• Effort not directly committed to the K award,
recipients may devote effort, with compensation,
on Federal or non-Federal sources as PD/PI or in
another role (e.g., co-I), as long the specific aims
of the other supporting grant(s) differ from those
of the K award.
https://nexus.od.nih.gov/all/2017/10/11/clarifying-percent-effort-and-support-for-career-
development-k-awardees/
16. K to R % Effort (NOT-OD-08-065, NOT-OD-18-157)
During the last two years of a mentored career development
award (K01, K07, K08, K22, K23, K25, K12/KL2), NIH will permit
you to receive concurrent salary support from any peer-
reviewed grant from any FEDERAL agency and NON-FEDERAL
SOURCES (NOT-OD-18-157), if you meet the following criteria:
– You are the PI on a competing research project grant, or
director of a sub-project on a multi-component grant of at least
$100,000 in direct costs.
– Your K award is active when the R, P or U grant is submitted.
– If awarding entity allows such an arrangement.
– Under those circumstances, you may reduce your K award's
time and effort to 50%.
– NIH will adjust salary for reduced effort but will provide full
research development support costs.
18. Common R Grant Types
R01 NIH Research Project Grant Program
• Parent FOAs: PA-18-484 (No Clinical Trial) and PA-18-345 (Clinical Trial)
• Used to support a discrete, specified, circumscribed research project
• NIH's most commonly used grant program
• No specific dollar limit unless specified in FOA
• Advance permission required for $500K or more (direct costs) in any year
• Generally awarded for 3 -5 years
• Utilized by all ICs
R03 NIH Small Grant Program (parent FOA: PA-18-488)
• Provides limited funding for a short period of time to support a variety of types of projects,
including: pilot or feasibility studies, collection of preliminary data, secondary analysis of existing
data, small, self-contained research projects, development of new research technology, etc.
• Limited to two years of funding
• Direct costs generally up to $50,000 per year for two years of funding
• Not renewable
• Utilized by more than half of the NIH ICs
R21 NIH Exploratory/Developmental Research Grant Award
• Parent FOAs: PA-18-489 (No Clinical Trial) and PA-18-344 (Clinical Trial)
• Encourages new, exploratory and developmental research projects by providing support for the
early stages of project development. Sometimes used for pilot and feasibility studies.
• Limited to up to two years of funding
• Combined budget for direct costs for the two year project period usually may not exceed
$275,000.
• No preliminary data is generally required
• Most ICs utilize
Other R grants: http://grants.nih.gov/grants/funding/funding_program.htm#RSeries
19. New Investigators (NI)
Definition: A PD/PI is identified as a New
Investigator if he/she has not previously
competed successfully for an NIH-
supported research project other than early
stage or small research grants (R03, R21) or for
training, infrastructure, and career awards (F, T,
K).
20. Early Stage Investigators (ESI)
• ESIs are New Investigators who are:
– Within 10 years of completing terminal research degree.
– Within 10 years of completing residency (or equivalent.
– Extension: injury, parental leave (NOT-OD-09-034)
• Breaks for ESIs
– Separate payline 5-10 points higher
– Fund all years requested
– Expedited review for revision if within 5-10% of payline
(NOT-OD-06-013)
– First competitive renewal: 5 points higher
• Applies to R01 applications only
21. NIH Next Generation Researchers Initiative
The NIH will:
• Commit substantial funds from NIH’s base budget, beginning in 2017 with
about $210 million, and ramping to approximately $1.1 billion per year
after five years (pending availability of funds) to support additional
meritorious early-stage investigators and mid-career investigators
• Create a central inventory and track the impact of NIH institute and
center funding decisions for early- and mid-career investigators with
fundable scores to ensure this new strategy is effectively implemented in
all areas of research
• Place greater emphasis on current NIH funding mechanisms aimed at
early- and mid-career investigators
• Aim to fund most early-career investigators with R01 equivalent
applications that score in the top 25th percentile
• Encourage multiple approaches to develop and test metrics that can be
used to evaluate the effectiveness of our research portfolio, and assess
the impact of NIH grant support on scientific progress, to ensure the best
return on investment
See this website for more information: https://grants.nih.gov/ngri.htm
22. NIH Next Generation Researchers Initiative
Applications will receive special consideration if you are:
• an early-stage investigator (within 10 years of completing your
terminal research degree or medical residency and have not
previously received a substantial independent NIH research
award) and receive a score in the top 25th percentile (or an
impact score of 35 if the application is not percentiled)
• a mid-career investigator (within 10 years of receiving your first
NIH R01 equivalent award) who scores in the 25th percentile,
and either:
– are at risk of losing all support, or,
– are a particularly promising investigator currently supported
by a single ongoing award (i.e, NIH will prioritize funding an
additional concurrent research project grant award)
See this website for more information: https://grants.nih.gov/ngri.htm
23. Stephen I. Katz Early Stage Investigator
Research Grant Program
PAR-21-038 & PAR-21-039
• The new Katz R01 award program will build on the
successful Next Generation Researchers Initiative.
• ESIs may apply for this new opportunity to support their
innovative ideas if they are proposing research that is a
change in direction from their past work and experience,
and for which they have no preliminary data.
• ESIs who have preliminary data for research projects or
those who want to continue on with their current research
direction, NIH’s Parent R01 funding opportunities are still
available.
• The first due date for applications was January 26, 2021.
https://grants.nih.gov/funding/katz-esi-r01.htm
24. New Investigator R01 Resubmission Policy
NOT-OD-19-053
The special New Investigator (NI) deadline for next round resubmission of A1
R01 applications will be eliminated.
Starting with R01 applications submitted for due dates on or after January 25,
2019:
• New Investigator (NI) R01 applications will be reviewed on the same timeline
as other applications submitted to the same FOA.
• NI R01 applications will be clustered together for review within a meeting.
• Summary statements for all NI R01 applications will be prioritized: to the
extent possible, they will be released before summary statements for other
applications reviewed in the same meeting.
• In general, summary statements will be available no later than 30 days
before council.
• A1 resubmission of NI R01 applications will be accepted on the resubmission
due date of any Program Announcement (PA, PAR, or PAS), both standard
and special due dates, that accepts resubmission applications. See the NIH
Resubmission Policy for requirements and instructions.
https://grants.nih.gov/grants/guide/notice-files/NOT-OD-19-053.html
https://grants.nih.gov/grants/guide/notice-files/NOT-OD-18-197.html
25. First steps in R proposal preparation
• Take a hard look at what you have published and try
to build the R around your most significant research
findings – this may or may not be your K funded
research
• Decide where the grant will go and/or who your
audience is
• Check NIH Reporter to make sure that the study isn’t
already underway
• Requires several months of reading, organizing,
writing, and revising
26. Review and Award Cycles
Cycle I Cycle II Cycle III
Scientific
Merit
Review
June – July October –
November
February -
March
Advisory
Council
Round
August or
October *
January May
Earliest Start
Date
September or
December *
April July
* Advisory Council Round for Cycle I applications may be August or October, and
their earliest project start date may be September or December respectively.
27. First steps in proposal preparation
• EARLY ON talk to the scientific administrator!
• Follow the written guidelines from the funder carefully
– Outline of the structure
– Page limits
– Font sizes
– Funding limits
– Elements that must be included
– Priority areas
28. Get Organized
• Work from an outline
• Establish a timeline for completing the proposal - make
time to work on this
• Have the project team meet periodically
• Give assignments with deadlines
• Make deadlines for yourself
• Find a model proposal
– recently funded by the same agency
– look over the reviews if you can get a hold of them
• REVIEW, PRETEST, REVISE RETEATABLY
29. Are You On the Fence About Whether to Resubmit?
30. Summary
• Things won’t go as smoothly as this talk
sounds
• Be flexible, take advantage of unexpected
opportunities when they come your way
• Be very protective of your time
• Be strategic, keep doing the research you love
and you will be in the strongest position to
compete when the time is right to submit an R