This document provides a history of anesthesia from ancient times to the present day. It discusses early non-drug and drug methods used for pain management during surgeries. Key events included Morton's public demonstration of ether anesthesia in 1846 in Boston. Later developments included the introduction of chloroform and other inhaled anesthetic agents, as well as advances in equipment and monitoring. The document also describes the development of anesthesia services in Bangladesh, including the establishment of training programs and professional organizations.
Evolution of Boyle's Anaesthesia apparatusSelva Kumar
The machine which is used to give general anaesthesia is generally called as Boyle's machine even though there are many other names for that machine.This presentation tries to trace the development of the Boyles machine from 1846.
Evolution of Boyle's Anaesthesia apparatusSelva Kumar
The machine which is used to give general anaesthesia is generally called as Boyle's machine even though there are many other names for that machine.This presentation tries to trace the development of the Boyles machine from 1846.
Reflexions by the first president of SSAI - Looking back, ahead and around - ...scanFOAM
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The history of developments in the field of surgery since the dawn of civilization, leading to modernization of the field to the current scientific era.
When and where the history of volatile anesthesia started and what was the story ?
Whom was the triggering for discovering the effect of volatile anesthesia on human being ?
How the volatile anesthesia developed year by year till reach the best and the most safe volatile anesthetic ?
What were the complications of old volatile anesthetics ?
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
1. Prepared By: Dr. Tanjim Reza
DA Student, CMCH
ORGANISED BY
Bangladesh Society of anaesthesiologist
Chittagong branch
2. It is a pharmacologically induced and reversible state of
amnesia, analgesia, loss of responsiveness, loss of skeletal
muscle reflexes or decreased stress response, or all
simultaneously.
An alternative definition is a ‘’reversible lack of
awareness’’ including a total lack of awareness of a part of
the body such as spinal anesthetic.
The word Anaesthesia was coined by Oliver Wendell
Holmes Sr. in 1846
3. Triad of Anaesthesia
• Relive from painful surgery
• Need of unconsciousness
• Need of muscle relaxation
4. An understanding of our past, guiding our future
The history of surgery follows the history of
Anaesthesia
We are all part of it
5. Pre- 1846 – The foundation of Anaesthesia
1848-1900 – Establishment of Anaesthesia
20th century – Consolidation and growth
21st century – The future
8. Status of surgery:
• Barber shop surgery
Types of Surgery:
• Amputation and dental extractions
• No antisepsis
• Appalling Mortality
Indications:-
• Unbearable pain
• Crippling deformity
• Imminent death
9. 1665 _ 1st IV injection opiate through a quill
Late 1700 –
- Lots of new gases identified
- Treatment of existing diseases rather than novel use
10. Joseph Priestly – Produced N2O in 1772
Humphrey Davy – 1st Noted N2O’s analgesic properties
in 1800
11. Contd.
1834 – Colton Anesthetized 6 Indians by mistake
1844 – Horace Wells had his tooth pulled under N2O
1845 –Wells failed to demonstrate N2O at MGH
12. 1540 – Synthesized and named sweet oil of vitriol by
Valerius Cordus
* Forbenius renamed it to Ether
* 1744 – Methew Turner Published essay suggesting its
inhalation in certain types of pain
• Michael faraday Described narcotic effect of Ether
• 1842 First used as a clinical anesthetic in USA
• Clarke and Long used Ether for operations
15. • On 16th October 1846 first public demonstration of
Ether Anaesthesia took place in Boston
• William T G Morton
- Inventor and revealer of inhalation Anaesthesia:
- Before whom, in all time, surgery was agony by whom
pain in surgery was averted and annulled; since whom
science has control of pain.
16. Anesthetist: William Thomas
Green Morton
Agent: Diethyl Ether
Patient: Gilbert Abbott
Operation: Excision of tumor
under jaw
Surgeon: John Collins Warren
Comment: Gentleman this is
no humbug
18. Henry Hill
Hickman:
- 1821 semi asphyxiation due to air
starvation or by breathing CO2 gas
* After unconsciousness was induced
operated on them –
# Amputation
# Removal of ears
# Skin Incisions and observed
response to surgery
# Evidence of Pain
# Amount of bleeding to recovery
19. 1831 – Chloroform was synthesized
1847 – James Young Simpson used chloroform for
obstetric Anaesthesia
1847 – John Snows Regulating inhaler
1848 – Honnoh Greeners – First Anesthetic death
20. Dr. John Snow used Chloroform as anesthetic in 1853
Queen Victoria used it when she gave birth to her son Leopold, since it became
mainstream
21. - Intubation and Airway advances
- Anesthetic equipment
- Monitoring
- Drug Advance
- Local Anaesthesia
- Anaesthesia and intensive Care
- Pain Management
- Organization of Specialty
26. In the 1940s scientists discovered the active ingredient in
South american Amazon Indian arrow poison;It’s Curare.
The only problem with using this stuff is that person was so
relaxed that be can’t breathe or swallow –but he was fully
awake .This opened the “age of Anaesthesia.”
29. 1932-Assosiation of anesthetist GB & I
1935-Diploma in Anaesthesia
1948-Faculty of anesthetist of RCS
1953-FRCA
30. New and better drugs
New equipments
Increased demand for anaesthetic services
Questioning roles inside theatre
Stuffing and workload issues
31. In 2000 BC , Sushratha used to perform plastic surgery
of cut nose with use of opium,Indian hemp and wine
to keep the patient sedated.
In the Buddhist Era ,in BC 247 ,laparotomy was
described using alcohol to obtund pain.
In 1843 Esdale reported surgical operation under
mesmeric anaesthesia in Hoogly Hospital In West
Bengal.
Ether anaesthesia was used in India only six months its
official demonostration on october 16,1846 in
MGH,USA.
32. For operative procedures,Local anaesthesia and
regional blocks were in use and practiced by the
Surgeons themselves at DMC.
General anaesthesia was used under supervision of the
surgeons and used to be administered by the house
surgeons of the respective departments.
33. Dr.Beni Madhab Basak a house surgeon was mostly
responsible to administer general anaesthesia till
December ,1948.
Dr.S.M Mukhlesur Rahman ,MB was the first
physiacian appointed as an Anaesthetist,DMCH.
Upto sixties most of the hospital have no recognized
anaesthetist to deliver anaesthesia and sometimes it
was given by nondoctors under the supervision of
surgeon.
34. The first post-graduate anaesthetist is Dr.k.A.S.M.A
Quader ,DA (London).
1951 Dr.Abdul Quader ,MB,DA (London) has been in
charge,Dep’t of Anaesthesia of the Medical College
Hospital ,Dhaka.
35. Infiltration analgesia,field blocks,regional blocks were
popular amongst the surgeons in those days.
Procaine was the drug used for local analgesia.
Heavy Cinchocaine(Nupercaine)was in use for spinal
analgesia.
Chloroform,ether and ethyl chloride were the volatile
anaesthetics used for general anaesthesia.
36. Gradually,modern anaesthetic machines replaced in
most centre’s and in all of the educational institutes.
The first machine was the Boyle’s apparatus available
since 1949 at DMCH.
37. Ether continued to be in use in opendrop method and in Boyle’s
Machines.
Halothane was introduced in late fifties,in course of time
Halothane replaced other volatile agents.
Suxamethonium was introduced in early sixties.
Pancuronium Bromide was introduced in mid –eightes.
Atracurium was introduced in late eighties.
Vacuronium was introduced in early nineties.
Pipecuronium was introduced in late nineties.
Spinal anaesthesia was re –introduced and very popularly used in
most of the hospitals.
Piped Medical gases & Vacuum was introduced in DMCH on 19th
February 1985 and are extended in many hospitals.
38. Anaesthesia service was recorded with a very short of
trained manpower in Chittagong Medical college &
Hospital in 1956.
Department extended in all govt.medical college
hospitals or institutes,private medical college
hospitals,
District hospitals and upto Upazila health complexes
still with a a very short of trained manpower.
39. Prof.S N Samad Chowdhury DA
(London).FCPS.FFARCS who was the long time
president of BSA and has great contribution for
anaesthetic expansion in Bangladesh.
40. In 1947 there is no recognized trained
anaesthesiologist.
In 1948 two self trained and one in 1951 ,total three
with one recognized .
1981 gradually increased interest in this field due to
national demand with improved some dignity but still
slow.
41. DA : First two were Dr.Fakhrun Nissa and Dr.Dilip
Kumar Das.
MCPS :First Bangladesh MCPS is Dr M Khalilur
Rahman in 1976.
FCPS : The First fellow was Dr.Selim M Jahangir who
was awarded fellowship in 1983.
MD : The first MD was Dr. Md.Abdul Hai ,Chairman
of BSMMU .
42. Bangladesh Society of Anaesthesiologists (BSA) was
formed in 1974 with Pro.K.A.S.M. Quader and
Dr.Md.Shafiqur Rasul as its President and Secretary
respectively .
43. Peri –operative anesthetic management .
Intensive Care
Pain clinic
Palliative care .
Intensive care unit was started in DMCH in September
1985 with a six bed only.
44. The First Journal of BSA was published in 1987 Dr.K.M
Iqbal as its Editor.Two issues of Journals per year are
published regularly.
46. Now a days complicated surgical procedures like cardiac
surgery ,neuro surgery,thoracic surgery,kidney transplant
,pain management and intensive care patients have been
possible due to improvement of Anaesthesiology.
Still we are lacking of some basic infrastructural problems
like -
-proper placement and distribution of manpower.
-Availabilty of equipments,
-Standard monitors and Drugs at all levels of health
care .
However we are very mutch hopefull awaiting a golden
future.