GP20 is a consulting division that helps pharmaceutical clients challenge the status quo. It provides portfolio optimization and strategy consulting, market entry planning and implementation support, and project management services. GP20's experienced team of professionals leverage their regulatory and technical expertise to help clients capitalize on opportunities across the generics/biosimilars industry.
ttopstart is a European science and business consulting company that specialises in leveraging the impact of your European project through providing professional management, dissemination and exploitation services. ttopstart focuses on projects in the field of life sciences,healthcare and medical technology.
Successful consortia have a sound scientific and non-scientific management framework. ttopstart provides professional non-scientific project management services as a full partner of your Horizon 2020 consortium. This allows you to focus on scientific management while ttopstart ensures that your project runs according to plan and fully in line with the EC grant agreement.
Find out more on ttopstart.com
ttopstart - Business development and strategic planningttopstart B.V.
ttopstart operates at the intersection of science and business. Because life sciences and medical markets are highly challenging, it takes more than a breakthrough technology to reach the finish line. Whether it is exploring markets, strategic decision making or business development, ttopstart is your partner to take the next step. We provide concrete guidance, spur venture funding and expedite commercial success.
ttopstart's vision on modern medicine Introducing innovations in the healthcare sector is particularly challenging due to the many stakeholders involved, fierce regulations, long time to market and enormous upfront investments. For this reason, the pharmaceutical, biotechnology and medical technology industry are characterised by an extremely high attrition rate. You have to implement more than a sound business strategy to succeed. Our vision is that in all phases of business development, it is crucial to gain detailed insight into market opportunities, competition, the regulatory environment and stakeholder interests. This allows the creation of tailored commercialisation strategies that leverage the value of your developments and straighten the route to market. Second, we believe it is vital to effectively balance dilutive and non-dilutive funding and make use of only those resources that enforce your business. Finally, efforts should be targeted at deal making.
The ultimate goal of ttopstart is to enable a business to reach its full economic, scientific and societal potential - supporting the market introduction of breakthrough medical products.
Leadership in science and business consulting
ttopstart is a European science and business consulting company that supports innovative companies and research organisations with the commercialisation of breakthrough innovations.
The ttopstart team collaborates with more than 150 academic and corporate clients across Europe in the fields of life sciences, health and medical technology. We add value to the development of innovative products such as blood-based biomarker diagnostics, targeted immunotherapies and medical devices. We do this through the design of tailored business models, funding plans and commercialisation strategies - all based on the latest scientific and sector information.
Our services are always tailored to your specific needs and venture maturity, and include the following activities:
- Market research providing strategic market insights and intelligence;
- Strategic planning of the optimal route-to-market;
- In-house support;
- Financing consultancy providing access to dilutive and
non-dilutive funding.
Technology commercialization strategy for a multidisciplinary R&D institutions such as GRO and CRO under new research and business development (R&BD) paradigm
Newlogic provides strategic consulting services to R&D organizations. We use technology and innovation to improve business, achieve market leadership, create IP assets and help our clients invest in the right products.
Newlogic's strategy and innovation expertise address critical new product opportunities and enhance the value of R&D efforts. We apply consumer insights, marketing, new technology, intellectual property and design processes to implement strategic management and create innovations that establish category leadership. We work throughout the supply chain and product life cycle to improve R&D outcomes. The result is more new products that succeed in the marketplace, defensible intellectual property and optimized organizational performance.
Newlogic is a trusted resource to leaders across many industries. We have achieved an extensive portfolio of market successes because our team is comprised of professionals with deep experience and industry insight. Newlogic has expertise in many industries including consumer and pharmaceutical packaging, medical products and disposables, chemical-based products and building supplies.
Based near Boston, Newlogic works globally, with clients throughout the Americas, China, Europe, India and Israel.
Resources from Business Victoria's workshop giving early stage innovators information on the steps you need to take to turn your new product into a commercial reality.
ttopstart is a European science and business consulting company that specialises in leveraging the impact of your European project through providing professional management, dissemination and exploitation services. ttopstart focuses on projects in the field of life sciences,healthcare and medical technology.
Successful consortia have a sound scientific and non-scientific management framework. ttopstart provides professional non-scientific project management services as a full partner of your Horizon 2020 consortium. This allows you to focus on scientific management while ttopstart ensures that your project runs according to plan and fully in line with the EC grant agreement.
Find out more on ttopstart.com
ttopstart - Business development and strategic planningttopstart B.V.
ttopstart operates at the intersection of science and business. Because life sciences and medical markets are highly challenging, it takes more than a breakthrough technology to reach the finish line. Whether it is exploring markets, strategic decision making or business development, ttopstart is your partner to take the next step. We provide concrete guidance, spur venture funding and expedite commercial success.
ttopstart's vision on modern medicine Introducing innovations in the healthcare sector is particularly challenging due to the many stakeholders involved, fierce regulations, long time to market and enormous upfront investments. For this reason, the pharmaceutical, biotechnology and medical technology industry are characterised by an extremely high attrition rate. You have to implement more than a sound business strategy to succeed. Our vision is that in all phases of business development, it is crucial to gain detailed insight into market opportunities, competition, the regulatory environment and stakeholder interests. This allows the creation of tailored commercialisation strategies that leverage the value of your developments and straighten the route to market. Second, we believe it is vital to effectively balance dilutive and non-dilutive funding and make use of only those resources that enforce your business. Finally, efforts should be targeted at deal making.
The ultimate goal of ttopstart is to enable a business to reach its full economic, scientific and societal potential - supporting the market introduction of breakthrough medical products.
Leadership in science and business consulting
ttopstart is a European science and business consulting company that supports innovative companies and research organisations with the commercialisation of breakthrough innovations.
The ttopstart team collaborates with more than 150 academic and corporate clients across Europe in the fields of life sciences, health and medical technology. We add value to the development of innovative products such as blood-based biomarker diagnostics, targeted immunotherapies and medical devices. We do this through the design of tailored business models, funding plans and commercialisation strategies - all based on the latest scientific and sector information.
Our services are always tailored to your specific needs and venture maturity, and include the following activities:
- Market research providing strategic market insights and intelligence;
- Strategic planning of the optimal route-to-market;
- In-house support;
- Financing consultancy providing access to dilutive and
non-dilutive funding.
Technology commercialization strategy for a multidisciplinary R&D institutions such as GRO and CRO under new research and business development (R&BD) paradigm
Newlogic provides strategic consulting services to R&D organizations. We use technology and innovation to improve business, achieve market leadership, create IP assets and help our clients invest in the right products.
Newlogic's strategy and innovation expertise address critical new product opportunities and enhance the value of R&D efforts. We apply consumer insights, marketing, new technology, intellectual property and design processes to implement strategic management and create innovations that establish category leadership. We work throughout the supply chain and product life cycle to improve R&D outcomes. The result is more new products that succeed in the marketplace, defensible intellectual property and optimized organizational performance.
Newlogic is a trusted resource to leaders across many industries. We have achieved an extensive portfolio of market successes because our team is comprised of professionals with deep experience and industry insight. Newlogic has expertise in many industries including consumer and pharmaceutical packaging, medical products and disposables, chemical-based products and building supplies.
Based near Boston, Newlogic works globally, with clients throughout the Americas, China, Europe, India and Israel.
Resources from Business Victoria's workshop giving early stage innovators information on the steps you need to take to turn your new product into a commercial reality.
Pivotal Scientific Limited is a dynamic experienced consultancy working specifically with research reagent manufacturers - manufacturers of antibodies, proteins, ELISA/Assay kits and tools for molecular biology
HiValue - New product, service and process developmentHiSeedTech
HiValue is a hands-on training program designed for cross-functional teams that provides a comprehensive coverage of major topics in new product, service and process development (NPSPD) and allows participating teams to undertake a business project of strategic importance to the company.
The Innovation Commercialization Process:A Case StudyCheryl Tulkoff
When people think of innovation, they frequently think of the “big idea” or product while overlooking the fact that innovation is really a process.
They think of innovation solely in the creative sense rather than considering the importance or even existence of an innovation methodology.
Countless examples exist of good inventions that never succeeded in the marketplace or failed to live up to expectations while lesser ones thrived.
Many of these failures could have been eliminated through use of an innovation commercialization process.
This presentation describes the process and demonstrates its application through a case study.
Gartner Supply Chain Executive Conference 2013
Sponsored by Gartner Learn details about Gartner's upcoming Supply Chain Executive Conference in September and how it offers the objective guidance and expertise today's supply chain proficiency demands.
ref >> www.techtarget.com
SDSU Mgt747 FA13 summary - Technology Commercialization Ricardo dos Santos
Summary of SDSU's MBA class, MGT 747: Seminar in Technology Commercialization
Overview of major frameworks covered in class including disruptive innovation, customer development, business model generation and strategic choice canvas
Independently responsible for managing multiple innovation projects currently from ideation through to commercialization, Innovations awarded Novelty "A" and recognized by NHS and Indian Government
Presented by Dr. Tom Corr, CEO – Waterloo Research and Technology Park Accelerator Centre & Associate Vice President, Commercialization – University of Waterloo
Part of the Ontario Post Doctoral Fellowship Networking Event, October 6, 2008
TOPICS
Research Funding
Who Owns the Intellectual Property?
Commercialization Options
Dealing with VCs
Outcomes of Commercialization Efforts
Pivotal Scientific Limited is a dynamic experienced consultancy working specifically with research reagent manufacturers - manufacturers of antibodies, proteins, ELISA/Assay kits and tools for molecular biology
HiValue - New product, service and process developmentHiSeedTech
HiValue is a hands-on training program designed for cross-functional teams that provides a comprehensive coverage of major topics in new product, service and process development (NPSPD) and allows participating teams to undertake a business project of strategic importance to the company.
The Innovation Commercialization Process:A Case StudyCheryl Tulkoff
When people think of innovation, they frequently think of the “big idea” or product while overlooking the fact that innovation is really a process.
They think of innovation solely in the creative sense rather than considering the importance or even existence of an innovation methodology.
Countless examples exist of good inventions that never succeeded in the marketplace or failed to live up to expectations while lesser ones thrived.
Many of these failures could have been eliminated through use of an innovation commercialization process.
This presentation describes the process and demonstrates its application through a case study.
Gartner Supply Chain Executive Conference 2013
Sponsored by Gartner Learn details about Gartner's upcoming Supply Chain Executive Conference in September and how it offers the objective guidance and expertise today's supply chain proficiency demands.
ref >> www.techtarget.com
SDSU Mgt747 FA13 summary - Technology Commercialization Ricardo dos Santos
Summary of SDSU's MBA class, MGT 747: Seminar in Technology Commercialization
Overview of major frameworks covered in class including disruptive innovation, customer development, business model generation and strategic choice canvas
Independently responsible for managing multiple innovation projects currently from ideation through to commercialization, Innovations awarded Novelty "A" and recognized by NHS and Indian Government
Presented by Dr. Tom Corr, CEO – Waterloo Research and Technology Park Accelerator Centre & Associate Vice President, Commercialization – University of Waterloo
Part of the Ontario Post Doctoral Fellowship Networking Event, October 6, 2008
TOPICS
Research Funding
Who Owns the Intellectual Property?
Commercialization Options
Dealing with VCs
Outcomes of Commercialization Efforts
Panel - Digital Disruption in Healthcare - Where is the Google of Healthcare ...NOAH Advisors
Digital Disruption in Healthcare - Where is the Google of Healthcare and Why Haven’t We Seen One Yet? - Panel with Ulli Jendrik Koop, XLHEALTH - Daniel Nathrath, medx - Juliane Zielonka, LARA companion - Frank Neumann, Advisors in Healthcare - moderated by Roman Rittweger, Advisors in Healthcare at the NOAH 2015 Conference in Berlin, Tempodrom on the 9th of June 2015.
A complete, end-to-end process for coming up with your next big idea. In this video I explain in detail how to leverage market, technology and industry trends to come up with your next big idea.
Global Generic Pharmaceutical Market - Qualitative and Quantitative AnalysisAiswariya Chidambaram
This report was presented at the Pharma Tech 2013 Conference - India A Game Changer in the Pharma Industry at Ahmedabad, India in December 2013. The presentation highlights the overview of the global generic pharmaceuticals market, with particular focus on the key market trends and challenges by therapeutic areas and geographies including the U.S, EU and India. List of key blockbuster drugs scheduled to lose patent protection between 2010 and 2020 have been included. Additionally impact of regulation on generic drugs by region and strategic recommendations for the success of market participants are also covered in this report.
Pre-Launch Planning: Priming Your Pharma Brand For Profit And Success (mini)Eularis
In today’s environment, Pharmaceutical companies find themselves in a bind. Until recently, if drugs made over $500 Million in annual revenue within 3 to 5 years of launch, they were considered hugely successful. They were a support to an extensive company portfolio and a component of greater company profit.
However, things have changed. The standards for a successful drug have become much higher and much more dangerous. With so many revenue-producing drugs going off patent, companies are facing large holes in their balance sheets and sales that are increasingly slow.
Plus, with the stakes high and available funds low, pipelines are drying up. Add to this the closer scrutiny of safety issues, the rise of Generics, slower physician acceptance and adoption of new therapies, and the Pharma Industry is in trouble.
More and more, companies are expecting marketers to be instrumental at the key moment of launch, and marketers are under extreme pressure. To deliver on the high hopes of Pharmaceutical brand launch, companies must engage in comprehensive pre-launch planning.
In this report we analyze why launch is increasingly important, the issues involved in pre-launch planning, including key organizational strategies, marketing tactics, regulatory considerations, global issues, and methods for ensuring the most effective plans.
6. International Marketing, Market Selection, Modes of Entry in International...Charu Rastogi
This presentation defines international marketing, international marketing decisions, challenges of international marketing, and driving and restraining forces of international marketing. It goes on to discuss the process of market selection, firm related, market related and other factors effecting market selection. It also reflects on various modes of entry into foreign markets such as exporting (commercial strategy, commercial mode), foreign direct investment (industrial strategy, integrated modes) and associated or contractual modes (contractual strategy, competitive alliances). The presentation closes with a case study on the experience of Proctor and Gamble (P&G) in various international markets like Japan, China and India.
Crafting a Winning Product Innovation Strategy | Eninracseoeninrac
Elevate Your Product Innovation Strategy. We specialize in systematically identifying unmet customer needs and targeting growth opportunities in your market.
Helping our clients boost their CSR & communication strategies, restore and portray the right brand image, engage with their clients effectively and to explore new markets.
This was a proposal for a business plan for a company that I had once worked with that wanted to develop a long term business plan. I had worked with this company on TQM back in the 90's and they asked me to submit a proposal to help develop a business plan.
International team of experts, each with a long track record of responsibility for industrial innovation projects.
We support companies in discovery of real customer needs, we help them deploy those into new generation products and services that are fully aligned with organisational strategy.
Founded in 2009 and headquartered in Dublin, Firm Thinking is a Business Consulting and Coaching practice and developers of The Order® model performance coaching. With extensive experience in working with CEO and senior managements teams, in strategy design and implementation across a variety of sectors, Firm Thinking is uniquely positioned to deliver business advisory and coaching services to organisations seeking change, development and growth.
SSCG Consulting Practice support clients to navigate the complex issues and challenges impacting their businesses and the rapidly evolving industries and markets they operate in. We bring a sharp perspectives, diverse experience working in different global markets and insights.
Access 2-healthcare Company Introduction- English - Apr 2017Access-2-Healthcare
Introducing Access-2-Healthacare, providing consulting and education for small / medium sized medical technology companies for market entry to various countries, business due diligence, quality, regulatory, trade
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
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Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
2. about usThought leaders and experienced
professionals combine to help clients
challenge the status quo in the
pharmaceutical industry.
1|
3. a little bit of backgroundWe started out in 2008 as a spin
out of the renowned regulatory
and technical services provider
in the UK, ICE Pharma Group,
founded in the mid 90s. Since
2008 we have launched several
on-line platforms, which have
opened a rich dialogue with
an international community of
C-level executives and decision
makers around the globe.
Our first platform,
Genericlicensing.com was
the industry’s first searchable
database of dossiers – with
8,000+ products, reaching
hundreds of product developers
and licensing teams. GP20 also
launched NewPharmaThinkers,
a digital magazine that today
inspires key thought leaders in
our industry.
These innovative
communication and data
platforms have helped create an
unparalleled industry network;
supporting an unique channel
for new opportunities and ideas.
Together with a solid industry
background of over 15 years,
GP20 is ideally positioned to
bring you specialised consulting
services.
2|
4. management team
Asa Cox
Asa has been involved in the generic
pharmaceutical industry for
15 years; his work experience
covers both technical and
commercial aspects of the
industry. Sourcing, finished dose
contract manufacturing, regulatory
approvals and formulation development. He also
has extensive experience in negotiating global
licensing deals with all the major players.
Asa has worked on projects for Merck & Co,
Sanofi, Teva, Apotex, Reckitt Benckiser, Sandoz &
many more.
Miguel Coronado
Miguel has over 8 years international
experience both in technical and
commercial roles within the pharma
industry. He has provided strategic
consulting to pharmaceutical
companies in Europe, LATAM
and MENA regions with specialized
expertise in Strategy, Market Entry and Portfolio
Management in generics.
Miguel holds a Master degree in Pharmacy and is a
fellow member of RPSGB.
3|
5. GP20 divisions
Business
Development
Agency
Management
Consulting Marketing Digital
Platforms
• GENERICS & BIOSIMILARS
• OVER THE COUNTER
• MEDICAL DEVICES
• PORTFOLIO STRATEGY
• MARKET ENTRY
• PROJECT MANAGEMENT
• ON-LINE MARKETING
• WEB & PRINT DESIGN
• LEAD GENERATION
• GENERIC LICENSING
• NEW PHARMA THINKERS
• GENERIC PHARMA INDUSTRY
4|
6. Whether you require optimisation your
current portfolio or plan your next market
entry move, GP20 can definitely assist.
our consulting division
7. DEDICATION
We help companies capitalize on
opportunities across the value
chain for generics, branded
generics and biosimilars, forging
connections among industry
stakeholders.
EXPERTISE
Our work has covered a wide
range of topics, including portfolio
optimization, market entry,
operations, corporate strategy,
regulatory affairs and due diligence.
PASSION
Our people bring new ideas, inspiration, and
dedication to help you succeed in the pharmaceutical
field. We are passionate about the possibilities ahead
for those that challenge the status quo today and are
pleased to work with all participants in the generics
industry, API manufacturers, specialty pharmaceutical,
and private-equity players.
6|
what can we do for you?
8. our consulting division
We offer broad experience and deep expertise in three key areas:
7|
PORTFOLIO OPTIMIZATION
& STRATEGY
Experience in industry best
practice to help you integrate and
implement portfolio strategy across
the organisation. Implementing
best practice in portfolio strategy
requires more than market data and
profit & loss analysis. We believe that
without an integrated vision across
the organisation successful portfolio
strategy is extremely challenging.
MARKET ENTRY PLANNING AND
IMPLEMENTATION
We apply our understanding of
the pharmaceutical industry on
international and regional markets
to develop long-term perspectives
that help clients achieve sustained
competitive advantage in target
regions.
PROJECT MANAGEMENT
GP20’s project management
expertise is applied to maximize
of shareholder value, as well as to
opportunities in M&A due diligence
and licensing. We work with clients to
transform their companies, improve
effectiveness, increase productivity,
and build new capabilities. Our
experience in technical and
commercial project management
means you can focus on your core
activities.
9. portfolio optimization
and strategy
We believe that planning and decision making must be aligned and
integrated with all divisions involved in portfolio development. At GP20
we can help you create a living framework that enables stakeholders
communicate efficiently at all stages of portfolio processing.
OUR PROPRIETARY FRAMEWORK
HELPS YOUR ORGANIZATION ON:
• Portfolio planning process globally
• Data capture
• Communication approach between
stakeholders
• Portfolio optimisation tools
• Risk management
• Guidance and training material
ARE INNOVATION AND CONTINUOUS
IMPROVEMENT INGRAINED AT THE CORE
OF YOUR COMPANY?
Whether you are planning the development
of high quality generics, biosimilars or
new molecular entities into new markets,
achieving operational excellence is a key
factor to succeed in the long run. Here
are a few hints that will help you avoiding
portfolio disaster across a single or multi-
country market approach.
• The company strategy must drive the
portfolio
• Horizontal integration in relation to the
portfolio presents interesting upsides
• Consider the implementation of a
dedicated cross-functional portfolio team
• Establish an integrated platform
that monitors all divisions in your
organisation closely.
10. market entry planning
and implementation
At GP20 we share our experience for mitigating the risks inherent in
entering any new market, helping achieve desired outcomes in the most
cost effective way possible.
OUR PROPRIETARY FRAMEWORK HELPS YOUR
ORGANIZATION ON:
• Analysis: identifying the entry option and validating
target market
• Planning: assembling a coherent market entry strategy
and implementation plan
• Implementation: pilot project
• Operations: business set up, marketing launch, recruitment
• Communication approach between stakeholders
• Risk management
HAVE YOU PERFORMED
A PROPER MARKET
VALIDATION TO VERIFY
YOUR PLAN WILL
WORK?
We would like to share
with you a few points
when considering market
validation.
• Assess the resources and capabilities
required for different scenarios
• Validate your market entry portfolio from
a cross-functional point of view
• Validate your pricing strategy
• Evaluate the ability to completely address
the need, making sure your portfolio
and associated procedures will satisfy
customers and stakeholders
11. project management
The right mix of planning, monitoring, and controlling can make the
difference in completing a project on time, on budget, and with high
quality results.
OUR PROPRIETARY FRAMEWORK HELPS YOUR
ORGANIZATION ON:
• Identify strategic options: GP20 brings clarity to the
project goals, aligned to a detailed understanding of
your business needs
• Project definition and planning: we design a rigorous
programme, including team roles and responsibilities,
identifying risk and saving opportunities
• Project execution: we act quickly, operating from
within the organisation and working harmoniously
with your company culture
• Project closure: we aim to deliver to the satisfaction
of all stakeholders, demonstrating real value in both
quantitative and qualitative terms
Our project management experts offer a flexible and highly bespoke
service based on a strong focus on delivery. Working alongside our clients,
GP20 adopts a value-driven approach to defining project objectives.
Regardless the scale or complexity of a project, we refine our systems and
processes to provide control, governance and transparency from inception
to completion. At the point of every decision, we challenge the status
quo and work diligently to find the smartest, most efficient and most cost
effective solution.
GP20 provides a full spectrum of project management services
along all functions of the value chain in pharmaceuticals, including
manufacturing, supply chain, regulatory affairs, quality compliance,
and commercial operations.
12. We are delighted to share some examples of
our work and what clients say about us.
examples of our work
13. Assessing a hospital portfolio
for Central Europe
CASE STUDY / PORTFOLIO STRATEGY
Challenge
A leading generics manufacturer wanted to leverage
one of their injectable facilities to build a hospital
portfolio targeting simultaneously several countries
in Central Europe. The company was facing certain
complexities to align their internal resources and
capabilities with a commercially attractive portfolio on
a multi-country level.
Outcome
The final portfolio proposed by the GP20 team was agreed and accepted by the executive management and core
divisions. The client now has an optimal portfolio and associated guideline for introduction, which allows full
visibility across market entry implementation processes.
Solution
GP20 assessed the portfolio opportunities in the hospital sector and the
entry requirements for the targeted regions. GP20 conducted extensive
research that answered essential questions regarding the portfolio
options and what approach would truly succeed as a value proposition.
Our consultants and Subject Matter Experts worked with the client to
define several approaches and associated risks/benefits for the portfolio
across the targeted regions and facilitated a set of recommendations.
14. Helping a regional player
obtaining EU GMP standards
CASE STUDY / PROJECT MANAGEMENT
Challenge
A pharmaceutical distribution company with operations
in MENA engaged GP20 to handle all its technical and
regulatory processes in Europe, including the production
of a Quality Management System suitable for obtaining
EU GMP certificate. At the time the client had no
consistent QMS framework in place and ownership of
SOPs and other process documents was unclear.
Outcome
The client is now able to demonstrate a coherent quality and compliance infrastructure to its clients and other
stakeholders in MENA region. The integrated project management service supported the production of a coherent
QMS framework and helped the organization focus on their core activities.
Solution
The GP20 team provided a fully integrated project management and
planning support handling all aspects of quality assurance and regulatory
affairs. We helped designing a set of SOPs that supported the new Quality
Management System of the organization and provided liaison with
regulatory agencies in Europe for obtaining GMPc.
15. a selecton of our clients
We are proud to have worked with fantastic companies in the last decade
Medical Brands
Maikel Hendriks, CEO
We have been working with the
GP20 team for many successful
years. The company has grown
fourfold in this time, with Asa and his
colleagues contributing significantly
in all aspects of the business. We
have secured major clients purely
because of the good relationships
GP20 has developed with them.
“ “ “
Marz Sprays
Brandon Marz, CEO
We have been very happy with
Generic Pharma 2.0’s work. They’re
professional, efficient and get
done what they say they will get
done. They’ve helped us set up our
CRM and Business Development
processes/templates. They’ve
helped guide us through the
process of International Sales
making it a lot easier! They’ve also
provided us access to decision
makers while orchestrating a
follow-up system for our leads.
Resolute Oncology
David Guy, CEO
Generic Pharma 2.0 have been an
extremely valuable partner with the
building of our business, the team’s
experience in the generic business
and his wealth of connections have
helped us at every step.
16. Let’s Talk
We look very much forward to hearing
from you soon.
Asa Cox
asa.cox@genericpharma20.com
Miguel Coronado
miguel.coronado@genericpharma20.com
Offices
UK 96 Kensington High Street
London
W8 4SG
CANADA 12 Dunlop Street
Barrie, Ontario
L4M 1A3
You can also find us at:
www.genericpharma20.com