The document discusses gene-environment interactions related to obesity. It provides the example of the Pima Indians, noting that the Pimas in Arizona have experienced an obesity epidemic in recent decades due to lifestyle changes including a higher fat diet and more sedentary lifestyle compared to their genetic relatives in Mexico who maintain a traditional diet and active lifestyle and have lower obesity rates. While genetics play a role in obesity susceptibility, the rapid increase in obesity cannot be explained by genetics alone and is likely due to environmental factors, with certain genetic profiles making individuals more vulnerable to weight gain in obesogenic environments.
Allelic and Non-allelic interactions : Complete dominance; Incomplete dominance-in Four O'clock plant, Mirabilis jalapa and Snapdragon, Antirrhinum majus ; Co-dominance- MN blood group, AB blood group, Roan coat colour in shorthorn breed of cattle; Inheritance of Comb pattern in Poultry; Epistasis -Dominant - Fruit colour in Summer squash, Recessive - Coat colour in mice; Complementary gene interaction -Purple flower colour in Sweet pea (Lathyrus odoratus)
Cell cell hybridization or somatic cell hybridizationSubhradeep sarkar
What is Cell-Cell Hybridization?
History
More about Somatic cell Hybridization
Mapping of genes by somatic cell Hybridization
Hybridoma technology
Other Applications of Somatic Cell Hybridization
What is Genome,Genome mapping,types of Genome mapping,linkage or genetic mapping,Physical mapping,Somatic cell hybridization
Radiation hybridization ,Fish( =fluorescence in - situ hybridization),Types of probes for FISH,applications,Molecular markers,Rflp(= Restriction fragment length polymorphism),RFLPs may have the following Applications;Advantages of rflp,disAdvantages of rflp, Rapd(=Random amplification of polymorphic DNA),Process of rapd, Difference between rflp &rapd
This PPT consists of 15 slides only explaining Pleiotropy. This is a phenomenon when one gene controls more than one trait , the traits may be related .Generally one gene's product acts for many reactions and so can affect more than one trait. Examples can be seen in pea Coloured flower and pigmentation in leaf axil, frizzle trait in chicken, fur colour and deafness in cats,Human pleiotropic traits are PKU,Sickle cell Anaemia. HOsyndrome , p53 gene etc
Allelic and Non-allelic interactions : Complete dominance; Incomplete dominance-in Four O'clock plant, Mirabilis jalapa and Snapdragon, Antirrhinum majus ; Co-dominance- MN blood group, AB blood group, Roan coat colour in shorthorn breed of cattle; Inheritance of Comb pattern in Poultry; Epistasis -Dominant - Fruit colour in Summer squash, Recessive - Coat colour in mice; Complementary gene interaction -Purple flower colour in Sweet pea (Lathyrus odoratus)
Cell cell hybridization or somatic cell hybridizationSubhradeep sarkar
What is Cell-Cell Hybridization?
History
More about Somatic cell Hybridization
Mapping of genes by somatic cell Hybridization
Hybridoma technology
Other Applications of Somatic Cell Hybridization
What is Genome,Genome mapping,types of Genome mapping,linkage or genetic mapping,Physical mapping,Somatic cell hybridization
Radiation hybridization ,Fish( =fluorescence in - situ hybridization),Types of probes for FISH,applications,Molecular markers,Rflp(= Restriction fragment length polymorphism),RFLPs may have the following Applications;Advantages of rflp,disAdvantages of rflp, Rapd(=Random amplification of polymorphic DNA),Process of rapd, Difference between rflp &rapd
This PPT consists of 15 slides only explaining Pleiotropy. This is a phenomenon when one gene controls more than one trait , the traits may be related .Generally one gene's product acts for many reactions and so can affect more than one trait. Examples can be seen in pea Coloured flower and pigmentation in leaf axil, frizzle trait in chicken, fur colour and deafness in cats,Human pleiotropic traits are PKU,Sickle cell Anaemia. HOsyndrome , p53 gene etc
Austin Journal of Nutrition & Metabolism is an international scholarly peer reviewed Open Access journal, aims to promote the research in the field of Nutrition and Metabolism.
Austin Journal of Nutrition & Metabolism is a comprehensive Open Access peer reviewed scientific Journal that covers multidisciplinary fields. We provide limitless access towards accessing our literature hub with colossal range of articles. The journal aims to publish high quality varied article types such as Research, Review, Case Reports, Short Communications, Perspectives (Editorials), Clinical Images.
Austin Journal of Nutrition & Metabolism support the scientific modernization and enrichment in Nutrition and Metabolism research community by magnifying access to peer reviewed scientific literary works. Austin also brings universally peer reviewed member journals under one roof thereby promoting knowledge sharing, collaborative and promotion of multidisciplinary science.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
2. Genes
To date, genome-wide association studies
have identified more than 30 candidate
genes on 12 chromosomes that are
associated with body mass index.
It’s important to keep in mind that even
the most promising of these candidate
genes, FTO, accounts for only a small
fraction of the gene-related susceptibility
to obesity.
http://www.hsph.harvard.edu/obesity-prevention-source/obesity-causes/genes-and-obesity/
3. The increased global prevalence of obesity
could not be driven by genes alone
Substantial changes in the gene pool takes thousands of
years to accumulate and affect the phenotype of a
population
Obesity epidemic is occurring on genetic backgrounds that
have not changed
Genetic factors likely confer susceptibility in a permissive
environment
“susceptibility” genes that underlie the propensity to develop
obesity
Genes that regulate distribution of body fat, metabolic
rate, response to exercise and diet, and control feeding
and food preferences
AHA Scientific Statement Circulation 2006;113:898-918
4. Gene Environment Interactions
Obesity results from a complex interplay of many genetic
factors and environmental factors. In epidemiology,
interaction is defined by estimating whether the degree
of risk attributable to the joint effects of a genotype and
an environmental factor on an outcome is greater or less
than would be expected if these joint effects were
additive.
Alternatively, GEI exists where the risk conveyed by
specific genotype depends on one or more
environmental exposure levels. This definition is quite
helpful in the context of intervention studies where the
environmental exposures can be intervened upon, such
as diet and physical activity, to offset genetic risk.
http://bmcmedgenomics.biomedcentral.com/articles/10.1186/1755-8794-8-S1-S2
5. Nutrigenomics and
Nutrigenetics
Nutrigenomics explores the effects of nutrients or other dietary
factors on the gene expression, DNA methylation, proteome and
metabolome, while nutrigenetics is aimed to elucidate whether
genetic variations modify the relationships between dietary factors
and risk of diseases.
Nutrigenetics is a special area of GEI research, where the
environmental exposure is consumption of specific foods or
nutrients.
Nutrigenetics has the potential to provide scientific evidence for
personalized dietary recommendations based on the individual’s
genetic makeup for weight control. Looking from a different
perspective, nutrigenetic studies also assess whether genetic factors
modify the effects of specific dietary factors on diseases or related
traits.
http://bmcmedgenomics.biomedcentral.com/articles/10.1186/1755-8794-8-S1-S2
6. Gene-environment interaction
in the pathogenesis of obesity
Although genetics is an important factor in the pathogenesis of obesity, the
recent increase in obesity cannot be attributed to genetics alone and must be a
result of alterations in environmental influences.
However, people with certain genetic backgrounds are particularly predisposed
to weight gain and obesity-related diseases, especially when they are exposed to
a precipitating lifestyle. A striking example of this is given by the Pima Indians of
Arizona. Lifestyle changes have resulted in an epidemic of obesity and diabetes
within this population during the last 50 years [1].
Today, the Pimas of Arizona consume a high-fat diet (50% of energy as fat)
provided by government surplus commodities rather than their traditional low-fat
diet (15% of energy as fat), and they are much more sedentary than when they
were farmers.
In contrast, Pima Indians who live in the Sierra Madre mountains of Northern
Mexico, and consequently who have been isolated from Western influences, eat
a traditional Pima diet and are physically active as farmers and sawmill workers.
The Pimas of Mexico have a much lower incidence of obesity and diabetes than
their genetic kindred in Arizona.
8. Gene-environment interaction in the
pathogenesis of obesity
People with certain genetic backgrounds are particularly predisposed to
weight gain and obesity-related diseases, especially when they are
exposed to a precipitating lifestyle.
A striking example of this is given by the Pima Indians of Arizona.
Lifestyle changes have resulted in an epidemic of obesity and diabetes
within this population during the last 50 years [1]. Today, the Pimas of
Arizona consume a high-fat diet (50% of energy as fat) provided by
government surplus commodities rather than their traditional low-fat diet
(15% of energy as fat), and they are much more sedentary than when
they were farmers.
In contrast, Pima Indians who live in the Sierra Madre mountains of
Northern Mexico, and consequently who have been isolated from
Western influences, eat a traditional Pima diet and are physically active
as farmers and sawmill workers. The Pimas of Mexico have a much lower
incidence of obesity and diabetes than their genetic kindred in Arizona.
1. Pratley RE. Gene-environment interactions in the pathogenesis of type 2 diabetes mellitus: lessons learned from the Pima
Indians. Proc Nutr Soc. 1998;57:175-181.
2. Ravussin E et al. Effects of a traditional lifestyle on obesity in Pima Indians. Diabetes Care 1994; 17:1067-1074