This document discusses the need for rigorous evaluation of e-health and mhealth technologies. It notes that while such technologies are widely used, their actual impacts on productivity and health outcomes are unclear. Evaluations of healthcare IT have found unintended consequences like increased clinician workload and new types of medical errors. The document calls for investment in e-health to be based on evidence from well-designed trials and evaluations. It identifies key questions around measuring impacts, designing technologies to improve health, and supporting organizational changes. Finally, it presents guidelines for good evaluation practices in health informatics.