New adverse reactions have been reported by the FDA and EMA regarding fluoroquinolone antibiotics. These include potential risk of hypoglycemic coma from blood sugar disturbances and mental health issues like attention disturbances. There is also an increased risk of heart valve problems, aortic aneurysms, and cervical artery dissections. This risk is higher in those with pre-existing heart conditions, connective tissue disorders, rheumatoid arthritis, or who are elderly or have renal failure. Patients should report any shortness of breath, palpitations, or edema to their provider and stop using fluoroquinolones.

1. ‫الدوائي‬ ‫الرصد‬ ‫وحدة‬
Fluoroquinolone’s Updates
New Adverse reactions reportedby FDA/EMA
Blood sugar disturbances (potential risk of hypoglycaemic coma)
Mental health S.E (attention disturbances, disorientation, agitation,
nervousness, memory impairments & delirium)
Risk of heart valve regurgitation, aortic dissection & aneurysm, and cervical
artery dissection
Risk is increasedin previous history of &/pt. with
Congenital or pre-existing heart valve disease, hypertension & infective
endocarditis
Connective tissue disorders as Marfan/ Ehlers-Danlos syndrome
Rheumatoid arthritis, Behçet disease & Turner syndrome
Elderly
Renal failure
Organ transplant
PLEASE TEL YOUR PT. TO REPORT THESE ADVERSE EFFECT IN
ORDER TO STOP USING FLUOROQUINOLONE & DOCUMENT YOUR
CASES WITH INDIVIDUAL CASE SAFETYREPORTS:
Shortness of breath, palpitation & oedema
Ref. ( ‫المرقم‬ ‫الدوائي‬ ‫الرصد‬ ‫وحدة‬ /‫الصيدلة‬ ‫قسم‬ ‫اعمام‬36‫بتاريخ‬8/1/9112 )
( ‫المرقم‬ ‫الدوائي‬ ‫الرصد‬ ‫وحدة‬ /‫الصيدلة‬ ‫قسم‬ ‫اعمام‬8228‫بتاريخ‬8/19/9191 )