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Pediatric cardiovascular problems in emergency setting 1 (5 feb- 2011)
1. Emergency Cardiovascular
Problems in Pediatrics
Jarupim Soongswang, M.D.
Professor in Pediatric Cardiology
Dept of Pediatrics, Faculty of Medicine
Siriraj Hospital, Mahidol University
Annual Meeting in Emergency Medicine
Feb 5, 2011
3. LOGO
Case 1
A seven-year-old boy presents with dyspnea,
tachypnea for 1 day. He has had upper
respiratory tract infection for 2-3 days with
rhinorrhea, low grade fever.
PE: T 36.5oC, RR 40/min, HR 140/min, BP 80/60,
dyspnea, capillary refilled 5 second,
restlessness
Lung: fine crepitation,
CVS: Normal S1,S2, S3 gallop, soft SM grade 2/6
at apex
Liver: 3 cm below RCM, rubbery consistency
6. LOGO
Cardiogenic shock
Definition: Inadequate CO and O2
transport to vital organs and functions.
Continuing process of CHF.
Life threatening condition.
Requires aggressive and prompt
treatment.
7. LOGO
Cardiogenic shock
Physiology :
CO = HR X SV
SV = EDV X (EDV-ESV)
EDV
CO = HR X EDV X EF
Oxygen delivery = CO x Hb X SaO2 x 13.9
CO: cardiac output, HR: heart rate, SV: stroke volume,
EDV: end diastolic volume, ESV: end systolic volume, EF:
ejection fraction, HB: hemoglobin, SaO2: oxygen
saturation
21. LOGO
Management of cardiogenic shock
Monitoring: Intensive care
Invasive arterial blood pressure:
Central venous pressure:
Pulmonary artery wedge pressure:
Urine output:
Arterial blood gas, venous gas
Serum lactate
Blood chemistry: liver function, kidney
function, sugar, electrolytes
Non-invasive monitoring : ECG, O2 sat, RR, T
22. LOGO
Case 2
A one-year-old boy with history of cyanotic
heart disease presents with deep cyanosis
after crying for 15 min.
He develops dyspnea and unconscious
PE: RR 30/min, PR 120/min, BP 80/65, deep
cyanosis, O2 sat 40-50%,
Heart: normal S1, S2, SM grade 1/6 LUSB
Lung: clear
23. LOGO
Hypoxic spell
Definition: Sudden and transient
uncompensated hypoxia in cyanotic heart
diseases (Rt to Lt shunt)
TOF is the prototype
Majority is self limited in 15-20 mins.
Depend on balance between pulmonary and
systemic pressure and resistance
Precipitating factors: crying, defecation etc.
26. LOGO
Hypoxic spell
Signs and symptoms: Increase in
cyanosis, hyperpnea, conscious
change, decrease intensity of SEM,
syncope, +/- convulsion
Management:
Knee chest position
O2
Sedate
NaHCO3
27. LOGO
Hypoxic spell
Continue management
Propanolol IV: 0.1 mg/kg/dose dilute IV slowly
(monitor HR)
Correct hypoglycemia: 25% glucose 1-2
cc/kg/dose IV push
Keep normal systemic BP
Correct Hct: PRC infusion (anemia), blood
letting (polycythemia; Hct >65%)
Paralyze and ventilate
Emergency shunt surgery
Closed FU. blood gas, correct acidosis etc.
28. LOGO
Case 3
Ten-year-old girl presents with
palpitation, and chest pain for 10
hours.
PE: BP 100/70, HR 200 /min, RR 18/min,
capillary refill 2 sec, no dyspnea
Lung: clear
Heart: no murmur
Liver: 3 cm rubbery consistency.
30. LOGO
Cardiac Dysrrhythmia
Tachyarrhythmia: Abnormally fast HR and rhythm
HR>220 in infants,
HR>180/min in children < 8 yo.
HR>160/min in children > 8 yo.
1. SVT: tachyarrhythmia which originates
from or involve pathways mostly above bifurcation
of His
2. VT: tachyarrhymia which originates from
myocyte or Purkinje fiber below bifurcation of His.
43. LOGO
Polymorphic VT
Torsades de Points in Long QT syndrome
44. LOGO
Management of VT
Mechanical: resuscitation
Electrical treatment: DC shock or
synchronized mode 2-4 J/kg
Medical:
Lidocaine:1 mg/kg IV bolus, follow by IV
infusion
Amiodarone: 5 mg/kg IV in 20-60 min , follow
by IV infusion
Procainamide 15 mg/kg IV drip in 30-60 mins
MgSO4: 25-50 mg/kg IV, max 2 gm
Correct hypoMg, hypoCa, hypo&hyperkalemia
45. LOGO
Cardiac dysrrhythmia
Bradyarrhythmia: abnormally slow heart and rhythm
complete heart block: congenital, acquired (post
operative CHD)
49. LOGO
Case 4
A 3-day-old boy was brought to the ER
due to develop cyanosis 1 hour ago.
PE: RR 65/min, PR 150/min, BP 58/30
O2 sat 60%, active, no dyspnea,
cyanosis,
no dysmorphic features
CVS: normal S1, S2 single, no murmur
Abd: liver just palpable
50. LOGO
Differential Diagnosis
Cyanotic heart diseases with decrease
pulmonary blood flow eg.
VSD with pulmonary atresia supply by
PDA (closing)
Complex heart diseases with pulmonary
atresia
51. LOGO
Cyanotic heart disease with parallel
circuit eg.
D-transposition of great arteries with
inadequate mixing
52. LOGO
Obstructed total anomalous pulmonary
venous connection
65. LOGO
Case 4
A 1-year-old boy with atrioventricular septal
defect and severe pulmonary hypertension,
underwent total repaired.
4 hours PO. he develops hypotension,
PE: On ventilator, BP 60/40, CVP 13 mmHg,
PA pressure 80/55, HR 150/min
O2 sat 98%
66. LOGO
Pulmonary hypertensive crisis
Def: Decrease pulmonary blood flow from
sudden increase in pulmonary vascular
resistant with result in inadequate cardiac
output.
Clinical manifestations:
Low cardiac output: hypotension, tachycardia,
decrease urine output
Increase CVP
Decrease LA pressure
Metabolic acidosis
67. LOGO
Management of PHT crisis
Sedate, paralyze with ventilatory support
Keep serum alkalosis
Pulmonary vasodilator:
Milinone
NO
Iloprost: inhale, IV
Sildenafil
Keep dry:
Decrease pulmonary vasoconstrictor:
adrenaline, high dose dopamine
Correct metabolic disturbance
68. LOGO
Pathways of anti-pulmonary hypertensive drug
70. LOGO
แสดงขนาดและกลไกการออกฤทธิ์ของ Vasodilator แต่ละชนิด
Medication Route Dosage Site action
Captopril PO 0.1-2.0 mg/kg/dose arteriolar and Competitive inhibition of
ทุก 6-8 ชม. venous Angiotensin-converting
Maximum 6 mg/kg/day enzyme
Enalapril PO 0.1-0.2 mg/kg/day arteriolar and Competitive inhibition of
ทุก 12 or 24 ชม. venous Angiotensin-converting
enzyme
Hydralazine IV 0.1-0.5 mg/kg/day arteriolar Direct vasodilation by unknown
PO ทุก 6-8 ชม. mechanism
0.25-1.0 mg/kg/day
ทุก 6-8 ชม.
Maximum 7 mg/kg/day
Prazosin PO 0.01-0.05 mg/kg/day arteriolar and Competitive blockade of
ทุก 6-8 ชม. venous alpha-1 adrenergic receptors
Maximum 0.1 mg/kg/dose
Nitroprusside IV 0.5-6.0 µg/kg/min arteriolar and Direct vasodilation mediated
Maximum 10 µg/kg/min venous by changes in intracellular
cGMP
Nitroglycerin IV 1-20 arteriolar and Direct vasodilation
venous
71. LOGO
Tachyarrhythmia
Atrial flutter: reentry circuit in atrium
- Congenital atrial flutter