Cartilage: Cartilage is a specialized type of dense collective tissue designed to give support , bear weight and withstand tension , torsion , and bending. General Features : • Cartilage supports regions of body that requires flexibility. • Non nervous structure • Avascular • Very poor regeneration power • Usually surrounded by pericondrium (dense irregular connective tissue surrounding cartilage) except fibro cartilage. Classification:  Hyaline cartilage  Elastic cartilage  Fibro cartilage Fibro Cartilage : White colored, tough cartilage containing dense connective tissue and collagen fibers often known as intervertebral discs is called fibro cartilage. Structure :  Fibro cartilage consists of chondrocytes dispersed among bundles of type 1 collagen fibers.  Chondrocytes are present in lacunae (cavity).  The arrangement of cells is different from all other type of cartilages.  Chondrocytes are arranged in parallel rows of 2, 4 or 6 cells.  These rows of cells are called isogenous cell groups. Chemical Compounds Present : Proteoglycans rich in sulphated glucosaminoglycans especially  Chondroiton sulphate  Dermatan sulphate Stain :  Due to the abundance of collagen type 1 fibers , the matrix of fibrocartilage stains intensely acidophilic/eosinophilic. (since collagen is basic in nature)  Stained by EOSIN which is pink in color.  Chondrocytes are stained in purple usually by HEMATOXYLIN and looks purple in color due to acidic nature of large centeral nucleus present. Occurrence in body :  Intervertebral disc  Disc of pubic symphysis  Menisci of knee joint  Sternoclavicular joint  Temporomandibular joint  Ligamentum tere  Labrum glenoidale  Labrum acetabulare  Fibrocartilage is also found at places where tendons and ligaments attach to bones. Disorders:  Degeneration of fibrocartilage is seen in degenerative disc disease.  A fibrocartilaginous embolism (FCE) is an unusual cause of spinal cord and cerebral ischemia (insufficient bloodsupply). Symptoms may include sudden, severe pain in the neck and/or back; progressive weakening reduced sensation and paralysis. It may be caused by the blocking of an artery interrupting vascular supply.  A herniated disk is a disk that ruptures. This allows the jelly-like center of the disk to leak, irritating the nearby nerves. This can cause sciatica or back pain. References:  http://www.nlm.nih.gov/medlineplus/herniateddisk.html  http://www.ncbi.nlm.nih.gov/pubmed/3289246  histology by laiq hussaain

1. FIBRO
CARTILAGE
Presented to:
Dr. Rabail
Presented by:
Hussan Ara

2. Contents
 Cartilage
 General features of cartilage
 Classification
 Fibro cartilage
 Structure
 Chemical compounds present
 Staining
 Occurrence in body
 Disorders

3. Cartilage
Cartilage is a specialized type
of dense collective tissue
designed to give support ,
bear weight and withstand
tension , torsion , and
bending.

4. General Features
 Cartilage supports regions of body
that requires flexibility.
 Non nervous structure
 Avascular
 Very poor regeneration power
 Usually surrounded by pericondrium
(dense irregular connective tissue
surrounding cartilage)except fibro
cartilage.

5. Classification
Hyaline cartilage
Elastic cartilage
Fibro cartilage

6. Fibro Cartilage
White colored , tough
cartilage containing
dense connective
tissue and collagen
fibers often known
as intervertebral
discs is called fibro cartilage.

7. Structure
 Fibro cartilage consists of
chondrocytes dispersed
among bundles of type 1
collagen fibers.
 Chondrocytes are
present in lacunae
(cavity).

8. Continued…
 The arrangement of
cells is different from all
other type of cartilages.
 Chondrocytes are
arranged in parallel rows
of 2, 4 or 6 cells.
 These rows of cells
are called isogenous
cell groups.

9. Chemical Compounds
Present
 Proteoglycans rich in sulphated
glucosaminoglycans especially
Chondroiton sulphate
Dermatan sulphate

10. Stain
 Due to the abundance of collagen type
1 fibers , the matrix of fibrocartilage
stains intensely
acidophilic/eosinophilic. (since
collagen is basic in nature)
 Stained by EOSIN which is pink in
color.
 Chondrocytes are stained in purple
usually by HEMATOXYLIN and looks
purple in color due to acidic nature of

12. Occurrence in body
Intervertebral disc
Disc of pubic symphysis
Menisci of knee
joint

13. Occurrence
Sternoclavicular joint
Temporomandibular joint
Ligamentum teres

14. Occurrence
Labrum glenoidale
Labrum acetabulare
Fibrocartilage is also found at places
where tendons and ligaments attach
to bones.

15. Disorders
 Degeneration of
fibrocartilage is
seen in degenerative
disc disease.

16. Continued…
 A fibrocartilaginous embolism (FCE)
is an unusual cause of spinal cord and
cerebral ischemia (insufficient bloodsup
ply). Symptoms may include sudden
, severe pain in the neck and/or back;
progressive
weakening reduced sensation; and par
alysis. It may be caused by the blocking
of an artery interrupting vascular
supply.

17. Continued…
 A herniated disk is a disk that
ruptures. This allows the jelly-like
center of the disk to leak, irritating the
nearby nerves. This can
cause sciatica or back pain.