The fetal circulatory system differs from the adult system in that it facilitates an exchange of gases, nutrients, and waste between the fetus and mother via the placenta and umbilical cord. It includes three shunts - the ductus venosus, foramen ovale, and ductus arteriosus - that allow blood to bypass the liver and lungs and ensure oxygenated blood reaches the fetus. At birth, changes in pressure and the first breath cause the shunts to close as the circulatory system adapts to extrauterine life.
DEVELOPMENT OF PLACENTA,PLACENTA AT TERM , DECIDUA,PLACENTAL MEMBRANE , PLACENTAL CICULATION,PLACENTAL ENDOCRINE SYNTHESIS,ABNORMAL PLACENTA,FUNCTIONS.
Preparation for delivery of mother, baby and midwife and equipmentsDR MUKESH SAH
In addition to their delivery bags, midwives “carry” many other invaluable tools ... family planning, delivery preparation, postnatal counseling and breastfeeding. ... With this equipment, we can recover 80% of newborns. ... “Midwifery feels good when both the mother and baby come out of the labor ward alive.
DEVELOPMENT OF PLACENTA,PLACENTA AT TERM , DECIDUA,PLACENTAL MEMBRANE , PLACENTAL CICULATION,PLACENTAL ENDOCRINE SYNTHESIS,ABNORMAL PLACENTA,FUNCTIONS.
Preparation for delivery of mother, baby and midwife and equipmentsDR MUKESH SAH
In addition to their delivery bags, midwives “carry” many other invaluable tools ... family planning, delivery preparation, postnatal counseling and breastfeeding. ... With this equipment, we can recover 80% of newborns. ... “Midwifery feels good when both the mother and baby come out of the labor ward alive.
Describe the normal fetal circulation and mention the changes that occur in it is placental stage and after birth. Fetal circulation is composed of placenta, umbilical cord, heart and systemic blood vessels.
A major difference between the fetal circulation and postnatal circulation is that the lungs are not used during the fetal stage resulting in the presence of shunts to move oxygenated blood and nutrients from the placenta to the fetal tissue.
At birth, the start of breathing and the severance of the umbilical cord prompt various changes that quickly transform fetal circulation into postnatal circulation.
When the embryo develops into the fetus, it creates a functional cardiovascular system that cooperates with the mother's system.
During birth, there are functional physiological changes that transform the shared system into an individual one for the fetus.
In the fetus main filtration site for plasma nutrients and wastes in the placenta, which is outside of the body cavity.
In adults, the circulation occurs entirely inside the body.
The blood that flow to through the fetus is actually more complicated than after the baby is born (normal heart).
This is because the mother (the placenta) is doing the work that the baby's lungs will do after birth.
The placenta accepts the blood without oxygen from the fetus through blood vessels that leave the fetus through the umbilical cord (Umbilical arteries , there are two of them).
When blood goes through the placenta it pick up oxygwn.
The oxygen rich blood then returns to the fetus via the third vessels in the umbilical cord (Umbilical vein).
The oxygen rich blood that enters the fetus passes through the fetal liver and enters the right side of the heart.
The oxygen rich blood goes through one of the two extra connections in the fetal heart that will close after the baby is born.
The hole between the top two heart chmbers (right and left atrium) is called "Patent Foramen Ovale (PFO).
This hole allows the oxygen rich blood to go form the right atrium to left atrium and then to the left ventricle and out the aorta.
As a result the blood with the most oxygen gets to the brain.
Blood coming back from the fetus's body also enters the right atrium, but the fetus is able to send this oxygen poor blood from the right atrium to the right ventricle (the chamber that normally pumps blood to the lungs).
most of the blood that leaves the right ventricle in the fetus bypass the lungs through the second of the extra fetal connections known as the ductus arteriosus.
The ductus arteriosus sends the oxygen poor blood to the organs in the lower half of the fetal body. This also allows for the oxygen poor blood to leave the fetus through the umbilical arteries and get back to the placenta to pick up oxygen.
Since the patent foramen ovale and ductus arteriosus are normal findings in the fetus, it is impossible to predict whether or not these connections will close normally after birth in a normal fetal heart.
Fetal Circulation by Barkha Devi,Lecturer,Sikkim Manipal College of NursingBarkha Devi
This PowerPoint will provide you a short a sweet lecture about fetal circulation. Please give me your feed back .
-Discuss anatomy and physiology of fetal circulation
-Compare and contrast fetal circulation to infant circulation
-Define specialized structures of fetal circulation
Embark on a captivating exploration of #FetalCirculation in this presentation. Delve into the intricacies of the developing cardiovascular system, understanding how the fetus receives oxygen and nutrients for optimal growth within the womb. Uncover the role of critical structures such as the ductus venosus and foramen ovale in facilitating unique circulatory patterns. Gain insights into the transition from fetal to neonatal circulation and its crucial significance for newborns. This presentation provides a comprehensive overview of the physiological marvel that sustains life before the first breath.
This is a presentation I had made for giving a seminar on Fetal Circulation in the first year of my MBBS course in Maharashtra.
Please share it with your juniors and colleagues.Thank You
Presentation By Tashif Jilani
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Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
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Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
2. definition
• The Fetal Circulation is defined as- The
blood circulation in the fetus or in other
words it is the circulatory system of
a fetus.
• The term usually encompasses the entire
feto-placental circulation, which
includes the umbilical cord and the
blood vessels within the placenta that
carry fetal blood.
3. CHARACTERTICS
• The fetal circulation system is distinctly different
from adult circulation,
• It facilitates the exchange of materials between
fetus and mother.
• It allows the fetus to receive oxygenated blood and
nutrients from maternal blood circulation and
elimination of CO2 & waste through the placenta,
• There are three bypasses or shunts in this
circulation which is specific to this circulation.
4.
5. ANATOMY & PHYSIOLOGY
• Placenta - Site where exchange of
gases, nutrients and waste take places
with maternal circulation.
7. Bypasses -
• Ductus Venosus – carries oxygenated
blood from umbilical vein to inferior venacava
bypassing fetal liver
• Foramen Ovale – connects the right and
left. It pushes blood from right atrium to the
left atrium bypassing the pulmonary
circulation.
• Ductus Arteriosus - carries oxygenated
blood from pulmonary artery to aorta
bypassing fetal lung.
10. AT BIRTH -
• As the baby is born, the cardiovascular system
undergoes a quick, drastic change.
• With its first breath, the baby's pulmonary
vascular resistance substantially drops, which is
in response to the oxygen now present in the
lungs and the physical act of breathing.
• With the clamping of the umbilical cord after
birth, the systemic vascular resistance
increases helping the blood flow towards the
lungs.
11. AT BIRTH -
• The ductus arteriosus has a left-to-right flow
within 10 minutes. The smooth muscle in the
ductus arteriosus responds to the oxygen by
increasing calcium channel activity causing
constriction and ultimately closure of the shunt.
• The increased systemic resistance also raises
the pressure in the left atrium to be higher than
the right atrium, and this causes the foramen
ovale to close.
12. AT BIRTH -
• The ductus arteriosus becomes the
ligamentum arteriosum,
• The foramen ovale becomes the fossa
ovalis,
• The umbilical vein becomes the ligamentum
teres (round ligament).
13. SUMMARY
• The fetal circulatory system provides the fetus
with nutrients and oxygen, while also removing
waste products and carbon dioxide from fetal
circulation.
• The umbilical cord develops from the placenta
and is attached to the fetus. Oxygenated blood
from the mother in the placenta flows through
the umbilical vein and into the inferior vena
cava (IVC), bypassing the liver via the ductus
14. SUMMARY– (conti.)
• From the IVC, oxygenated blood travels to
the right atrium of the heart. There is greater
pressure in the right atrium compared to the
left atrium in fetal circulation; therefore most
of the blood is shunted from the right atrium
to the left atrium through an opening called
the foramen ovale.
• Once in the left atrium, blood travels through
the left ventricle into the aorta and the
systemic circulation.
15. SUMMARY– (conti.)
• The deoxygenated blood travels back to the
placenta via the umbilical arteries to be
oxygenated by the mother.
• Additionally, some oxygenated blood in the
right atrium can also enter the right ventricle
and then the pulmonary artery.
16. SUMMARY– (conti.)
• Because there is high resistance to blood flow
in the lungs, the blood is shunted from the
pulmonary artery into the aorta via the ductus
arteriosus, hence bypassing the lungs.
• Blood then enters the systemic circulation, and
the deoxygenated blood is recycled back to the
mother via the umbilical arteries.