The document summarizes fetal circulation during pregnancy and at birth. During pregnancy, the placenta functions as the lungs and exchanges gases. The umbilical cord connects the fetus to the placenta, carrying oxygenated blood, nutrients to the fetus and deoxygenated blood, waste products back. In the fetus, blood circulation bypasses the nonfunctional lungs and liver through special openings called shunts. At birth, with the first breath the lungs inflate and the ductus arteriosus and foramen ovale close, establishing adult-like circulation.
The pelvis is the lower part of the trunk of the human body between the abdomen and the thighs.
Topographically it is made up of a bony and ligamentous framework which is lined internally and externally by soft tissue and it is closed inferior by a layer of muscle and fascia which constitute the pelvic floor.
The perineum lies below the pelvic floor.
The pelvis in its broadest sense is an anatomical region bounded behind by the sacrum and coccyx, on each side and anteriorly by the innominate bones which are the hip bones, or pelvic bones.
These bones form the skeletal base for the lower limb.
DEFINITION OR MEANING OF MENSTRUAL (REPRODUCTIVE) CYCLE:-
Menstruation (Greek word, men-month) is monthly uterine bleeding out flowing through vagina into vulva for 4-5 days every 28 days (24-35 days)during reproductive life of a woman from menarche to menopause.
The Menstrual cycle of 28 days starts on day of onset of menstruation and ends at day 28 on start of next mens.
The cycle consists of a series of changes taking place concurrently in the ovaries and uterine lining, stimulated by changes in blood concentration of hormones.
The pelvis is the lower part of the trunk of the human body between the abdomen and the thighs.
Topographically it is made up of a bony and ligamentous framework which is lined internally and externally by soft tissue and it is closed inferior by a layer of muscle and fascia which constitute the pelvic floor.
The perineum lies below the pelvic floor.
The pelvis in its broadest sense is an anatomical region bounded behind by the sacrum and coccyx, on each side and anteriorly by the innominate bones which are the hip bones, or pelvic bones.
These bones form the skeletal base for the lower limb.
DEFINITION OR MEANING OF MENSTRUAL (REPRODUCTIVE) CYCLE:-
Menstruation (Greek word, men-month) is monthly uterine bleeding out flowing through vagina into vulva for 4-5 days every 28 days (24-35 days)during reproductive life of a woman from menarche to menopause.
The Menstrual cycle of 28 days starts on day of onset of menstruation and ends at day 28 on start of next mens.
The cycle consists of a series of changes taking place concurrently in the ovaries and uterine lining, stimulated by changes in blood concentration of hormones.
Fetal Circulation by Barkha Devi,Lecturer,Sikkim Manipal College of NursingBarkha Devi
This PowerPoint will provide you a short a sweet lecture about fetal circulation. Please give me your feed back .
-Discuss anatomy and physiology of fetal circulation
-Compare and contrast fetal circulation to infant circulation
-Define specialized structures of fetal circulation
Describe the normal fetal circulation and mention the changes that occur in it is placental stage and after birth. Fetal circulation is composed of placenta, umbilical cord, heart and systemic blood vessels.
A major difference between the fetal circulation and postnatal circulation is that the lungs are not used during the fetal stage resulting in the presence of shunts to move oxygenated blood and nutrients from the placenta to the fetal tissue.
At birth, the start of breathing and the severance of the umbilical cord prompt various changes that quickly transform fetal circulation into postnatal circulation.
When the embryo develops into the fetus, it creates a functional cardiovascular system that cooperates with the mother's system.
During birth, there are functional physiological changes that transform the shared system into an individual one for the fetus.
In the fetus main filtration site for plasma nutrients and wastes in the placenta, which is outside of the body cavity.
In adults, the circulation occurs entirely inside the body.
The blood that flow to through the fetus is actually more complicated than after the baby is born (normal heart).
This is because the mother (the placenta) is doing the work that the baby's lungs will do after birth.
The placenta accepts the blood without oxygen from the fetus through blood vessels that leave the fetus through the umbilical cord (Umbilical arteries , there are two of them).
When blood goes through the placenta it pick up oxygwn.
The oxygen rich blood then returns to the fetus via the third vessels in the umbilical cord (Umbilical vein).
The oxygen rich blood that enters the fetus passes through the fetal liver and enters the right side of the heart.
The oxygen rich blood goes through one of the two extra connections in the fetal heart that will close after the baby is born.
The hole between the top two heart chmbers (right and left atrium) is called "Patent Foramen Ovale (PFO).
This hole allows the oxygen rich blood to go form the right atrium to left atrium and then to the left ventricle and out the aorta.
As a result the blood with the most oxygen gets to the brain.
Blood coming back from the fetus's body also enters the right atrium, but the fetus is able to send this oxygen poor blood from the right atrium to the right ventricle (the chamber that normally pumps blood to the lungs).
most of the blood that leaves the right ventricle in the fetus bypass the lungs through the second of the extra fetal connections known as the ductus arteriosus.
The ductus arteriosus sends the oxygen poor blood to the organs in the lower half of the fetal body. This also allows for the oxygen poor blood to leave the fetus through the umbilical arteries and get back to the placenta to pick up oxygen.
Since the patent foramen ovale and ductus arteriosus are normal findings in the fetus, it is impossible to predict whether or not these connections will close normally after birth in a normal fetal heart.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
2. INTRODUCTION
•During pregnancy, the fetus depends on its mother
for nutrition and oxygen.
•The fetus doesn’t breathe air
•The placenta is the air exchange place instead of lungs
3. INTRODUCTION
•The fetus is connected to the placenta by the umbilical
cord.
•All the necessary nutrition from the mother’s to the baby
through umbilical cord.
4. INTRODUCTION
• Waste products and carbon dioxide from the baby are sent back
through the umbilical cord to the mother's.
• Umbilical cord contains two artery and one vein
5. INTRODUCTION
• While the baby is still in the uterus, his or her lungs are not
being used.
• The baby’s liver is not fully developed.
• Circulating blood bypasses the lungs and liver by special
openings called shunts.
7. ADULT CIRCULATION
• Superior vena cava carries the deoxygenated blood from upper
parts of the body and Inferior vena cava carries the deoxygenated
blood from lower parts of the body and pour into right atrium
• Through atrial contraction deoxygenated blood moves into right
ventricle via tricuspid valve
• By ventricular contraction deoxygenated blood pumped into lungs
via Pulmonary artery
• At lungs exchange of air takes place
8. ADULT CIRCULATION
• Oxygenated blood moves to left atrium via pulmonary veins
• Through atrial contraction Oxygenated blood transfer to Left
ventricle via mitral valve
• By ventricular contraction Oxygenated blood pumped into all
parts of the body through Aorta
9. FETAL CIRCULATION
AT UTERUS
From the Placenta, oxygenated blood and nutrients are carried
through the Umbilical Vein to the liver.
There, in the Ductus venosus, this blood mixes with some
deoxygenated blood from the portal vein (draining the gut) and then
exits via the Inferior Vena Cava.
10.
11. FETAL CIRCULATION
In the Inferior vena cava the blood mixes with more deoxygenated
blood returning from the legs and trunk and is carried to the
right atrium.
In the right atrium the partially oxygenated blood (62-67%) is mostly
shunted through the foramen ovale to the left atrium where it mixes
with a very small amount of deoxygenated blood from the lungs.
12. FETAL CIRCULATION
From the left atrium, the blood flows into the left ventricle and is
pumped out the ascending aorta, delivering partially oxygenated
blood to the head and arms and to the descending aorta.
13. FETAL CIRCULATION
Deoxygenated blood returning to the right atrium from the superior
vena cava (draining head and arms) flows mostly into the right
ventricle and is pumped out the Pulmonary trunk.
14. FETAL CIRCULATION
The ductus arteriosus shunts much of this blood from the
pulmonary trunk to the descending aorta where it mixes with the
blood that did not enter the arteries to the head and arms.
15. FETAL CIRCULATION
The descending aorta carries semi-oxygenated blood (57%) to the
gut and lower extremities, with a branch to the umbilical arteries
that deliver the poorly oxygenated blood to the placenta for
oxygenation.
16. FETAL CIRCULATION
• AT BIRTH
• When child breath the alveoli fill with air, the pulmonary vessels
dilate and decrease the pressure in the pulmonary system.
• Decreased pressure in the pulmonary arteries prevents blood
from being shunted through the ductus arteriosus, and the duct
usually closes within 10 to 15 hours of birth.
17. FETAL CIRCULATION
• Blood flowing back into the left atrium from the lungs increases the
pressure in that chamber and presses the septum and closing the
foramen ovale.
• At the same time, spontaneous constriction of the umbilical vessels
(or clamping) cuts off the exchange of blood with the placenta.
18. S.NO
Fetal Structure Function
Nonfunctional
Adult Structure
1 Umbilical vein Brings oxygen and nutrients to the fetus from the
placenta
Ligamentum teres hepatis
2 Ductus venosus shunts most of this blood through the liver, because it has
already been processed by the mother’s liver
Ligamentum venosum
3 Foramen ovale shunts blood from the right atrium directly to the left atrium,
bypassing nonfunctional lungs
Fossa ovalis
4 Ductus
arteriosus
shunts right ventricular blood from the pulmonary trunk to the
aorta, bypassing nonfunctional lungs
Ligamentum arteriosum
5 Umbilical
arteries
returns poorly oxygenated blood and metabolic waste to the
placenta
Medial umbilical ligaments
19. CLOSURE OF SHUNT AFTER BIRTH
Shunt Functional Closure Anatomical Closure
Foramen Ovale Within Several Minutes After Birth OneYear After Birth
DuctusVenosus Within Several Minutes After Birth 3 – 7 Days After Birth
Ductus Arteriosus 10 – 96 Hours After Birth 2 – 3 Weeks After Birth