"Etiology & Molecular Genetics of MALT Lymphoma" Presentation. Master of Molecular Genetics, Semester 2.

1. Etiology & Molecular Genetics of
MALT Lymphoma
Present by: Parisa Nj; Master: Dr. Khatami; March 2018; Yazd University

2. a) The Peyer’s patch is a representative of the extensive MALT system
b) b) A stained tissue cross-section of Peyer’s patch lymphoid nodules in the intestinal submucosa
c) The intestinal lamina propria contains loose clusters of lymphoid cells and diff use follicles
What’s MALT?
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3. The topology and function of intestinal MALT is shown.
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4. B Cell Ontogeny & Lymphomagenesis
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6. MALT Lymphoma Etiology
• Microbial Pathogens
• Molecular genetics of MALT Lymphoma (NF kappa B Signaling Pathway)
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7. Microbial Pathogens
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8. Helicobacter Pylori Infection
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9. • Chromosomal Translocations
i. T(1;2) (p22;p12)
ii. T(1;14) (p21;q32) CNN3
iii. T (1;14) (p22;q32) BCL10
iv. T(3;14) (p14;q32) FOXP1
v. T(5;14) (q34;q32) ODZ2
vi. T(9;14) (p24;q32) JMJD2C
vii. T(x;14) (p11;q32) GPR34
viii. T (11;18) (q21;q21) BIRC2/MALT1
ix. T (14;18) (q32;q21) MALT1
Molecular Genetics  TSG
 Oncogene
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10. • Numeric Chromosomal Aberration
i. Trisomy 3, 12 & 18 (FOXP1 & BCL6)
ii. Deletion TNFAIP3
• Somatic Mutations
i. Missense at PIM1 & Cmyc
ii. Frameshift & Missense at myd88; P16, 53,57
• Epigenetic Alternations
i. Hyper Methylation at P16,57,73; Hmlh1; DAPK; MINT1,2,31;A20
ii. Somatic Hyper Mutation at RhoH/TTF; Pax5; PIM1
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11. Genetic alterations in MALT lymphomas
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12. Incidence of Chromosomal Translation
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13. NF-κB Signaling Pathway
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14. BCR Signaling Pathway
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15. TCR Signaling Pathway
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16. Right: Normal Peyer Patch
Left: Early stage lesion of MALT lymphoma
Right: High Grade of MALT Lymphoma
Left: Low Grade of MALT Lymphoma
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17. Staging of gastric MALT lymphoma: comparison of different systems
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