Unlock the mysteries of Partial Differential Equations (PDEs) with this comprehensive presentation. Dive into the realm of 1st and 2nd order PDEs, exploring their classification into linear and non-linear forms.
In this enlightening slideshow, we delve into the intricacies of both linear and non-linear PDEs, shedding light on their significance in diverse fields such as physics, engineering, and mathematics. Discover the fundamental principles governing these equations and their varied applications.
One of the focal points of this presentation is the exploration of solution methods for 2nd order linear PDEs. Delve into techniques such as direct integration and variation of parameters, unraveling the step-by-step processes that lead to finding solutions to these complex equations.
Whether you're a seasoned mathematician, an aspiring physicist, or a curious learner, this slideshow is designed to demystify PDEs and equip you with the knowledge needed to tackle them confidently. Join us on this journey through the realm of Partial Differential Equations, where understanding meets application.
HIGHWAY AND TRANSPORT ENGINERING EXAM AND ANSWER-2HIGHWAY AND TRANSPORT ENGINERING EXAM AND ANSWER-2HIGHWAY AND TRANSPORT ENGINERING EXAM AND ANSWER-2HIGHWAY AND TRANSPORT ENGINERING EXAM AND ANSWER-2HIGHWAY AND TRANSPORT ENGINERING EXAM AND ANSWER-2HIGHWAY AND TRANSPORT ENGINERING EXAM AND ANSWER-2HIGHWAY AND TRANSPORT ENGINERING EXAM AND ANSWER-2
formulation of first order linear and nonlinear 2nd order differential equationMahaswari Jogia
• Equations which are composed of an unknown function and its derivatives are called differential equations.
• Differential equations play a fundamental role in engineering because many physical phenomena are best formulated mathematically in terms of their rate of change.
• When a function involves one dependent variable, the equation is called an ordinary differential equation (ODE).
• A partial differential equation (PDE) involves two or more independent variables.
Figure 1: CHARACTERIZATION OF DIFFERENTIAL EQUATION
FIRST ORDER DIFFERENTIAL EQUATION:
FIRST ORDER LINEAR AND NON LINEAR EQUATION:
A first order equation includes a first derivative as its highest derivative.
- Linear 1st order ODE:
Where P and Q are functions of x.
TYPES OF LINEAR DIFFERENTIAL EQUATION:
1. Separable Variable
2. Homogeneous Equation
3. Exact Equation
4. Linear Equation
i. SEPARABLE VARIABLE:
The first-order differential equation:
Is called separable provided that f(x,y) can be written as the product of a function of x and a function of y.
Suppose we can write the above equation as
We then say we have “separated” the variables. By taking h(y) to the LHS, the equation becomes:
Integrating, we get the solution as:
Where c is an arbitrary constant.
EXAMPLE 1.
Consider the DE :
Separating the variables, we get
Integrating we get the solution as:
HIGHWAY AND TRANSPORT ENGINERING EXAM AND ANSWER-2HIGHWAY AND TRANSPORT ENGINERING EXAM AND ANSWER-2HIGHWAY AND TRANSPORT ENGINERING EXAM AND ANSWER-2HIGHWAY AND TRANSPORT ENGINERING EXAM AND ANSWER-2HIGHWAY AND TRANSPORT ENGINERING EXAM AND ANSWER-2HIGHWAY AND TRANSPORT ENGINERING EXAM AND ANSWER-2HIGHWAY AND TRANSPORT ENGINERING EXAM AND ANSWER-2
formulation of first order linear and nonlinear 2nd order differential equationMahaswari Jogia
• Equations which are composed of an unknown function and its derivatives are called differential equations.
• Differential equations play a fundamental role in engineering because many physical phenomena are best formulated mathematically in terms of their rate of change.
• When a function involves one dependent variable, the equation is called an ordinary differential equation (ODE).
• A partial differential equation (PDE) involves two or more independent variables.
Figure 1: CHARACTERIZATION OF DIFFERENTIAL EQUATION
FIRST ORDER DIFFERENTIAL EQUATION:
FIRST ORDER LINEAR AND NON LINEAR EQUATION:
A first order equation includes a first derivative as its highest derivative.
- Linear 1st order ODE:
Where P and Q are functions of x.
TYPES OF LINEAR DIFFERENTIAL EQUATION:
1. Separable Variable
2. Homogeneous Equation
3. Exact Equation
4. Linear Equation
i. SEPARABLE VARIABLE:
The first-order differential equation:
Is called separable provided that f(x,y) can be written as the product of a function of x and a function of y.
Suppose we can write the above equation as
We then say we have “separated” the variables. By taking h(y) to the LHS, the equation becomes:
Integrating, we get the solution as:
Where c is an arbitrary constant.
EXAMPLE 1.
Consider the DE :
Separating the variables, we get
Integrating we get the solution as:
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
FAIRSpectra - Towards a common data file format for SIMS imagesAlex Henderson
Presentation from the 101st IUVSTA Workshop on High performance SIMS instrumentation and machine learning / artificial intelligence methods for complex data.
This presentation describes the issues relating to storing and sharing data from Secondary Ion Mass Spectrometry experiments, and some potential solutions.
Gliese 12 b: A Temperate Earth-sized Planet at 12 pc Ideal for Atmospheric Tr...Sérgio Sacani
Recent discoveries of Earth-sized planets transiting nearby M dwarfs have made it possible to characterize the
atmospheres of terrestrial planets via follow-up spectroscopic observations. However, the number of such planets
receiving low insolation is still small, limiting our ability to understand the diversity of the atmospheric
composition and climates of temperate terrestrial planets. We report the discovery of an Earth-sized planet
transiting the nearby (12 pc) inactive M3.0 dwarf Gliese 12 (TOI-6251) with an orbital period (Porb) of 12.76 days.
The planet, Gliese 12 b, was initially identified as a candidate with an ambiguous Porb from TESS data. We
confirmed the transit signal and Porb using ground-based photometry with MuSCAT2 and MuSCAT3, and
validated the planetary nature of the signal using high-resolution images from Gemini/NIRI and Keck/NIRC2 as
well as radial velocity (RV) measurements from the InfraRed Doppler instrument on the Subaru 8.2 m telescope
and from CARMENES on the CAHA 3.5 m telescope. X-ray observations with XMM-Newton showed the host
star is inactive, with an X-ray-to-bolometric luminosity ratio of log 5.7 L L X bol » - . Joint analysis of the light
curves and RV measurements revealed that Gliese 12 b has a radius of 0.96 ± 0.05 R⊕,a3σ mass upper limit of
3.9 M⊕, and an equilibrium temperature of 315 ± 6 K assuming zero albedo. The transmission spectroscopy metric
(TSM) value of Gliese 12 b is close to the TSM values of the TRAPPIST-1 planets, adding Gliese 12 b to the small
list of potentially terrestrial, temperate planets amenable to atmospheric characterization with JWST.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
2. 1. Differential Equation
• Let x be independent variable. Derivatives of any function
(say z1), depend upon x is the rate of change z1 as x
changes slightly.
• The equation that contains one or more unknown functions
of single independent variable and their derivatives is
differential equation.
• When no. of independent variable is 2 or more(say x,y)
such that z(x,y) is function of x and y, then partial
derivative of dependent variable with any one independent
variable keeping other independent variable as constant.
• Ordinary Differential Equations (ODEs) deal with
functions of one independent variable, while Partial
Differential Equations (PDEs) deal with functions of
multiple independent variables.
•
dz1
dx
•
d2z1
dx2 +
dz1
dx
+ z1=2
•
𝜕𝑧
𝜕𝑥
,
𝜕𝑧
𝜕𝑦
(zx , zy)
•
𝜕𝑧
𝜕𝑥
+
𝜕𝑧
𝜕𝑦
+ z2 = xy
3. Taking z(x,y), as a dependent and x,y as an independent variable,
we will adopt the following notations through out the presentation.
REMEMBER
zx=
𝜕𝑧
𝜕𝑥
zy =
𝜕𝑧
𝜕𝑦
zxx =
𝜕2
𝑧
𝜕𝑥.𝜕𝑥
zxy=
𝜕2
𝑧
𝜕𝑥.𝜕𝑦
zyy=
𝜕2
𝑧
𝜕𝑦.𝜕𝑦
4. Introduction To PDE
• A partial differential equation (PDE) is a mathematical equation that contains
an unknown function (z) of two or more independent variables(x,y), as well as
the partial derivatives of that unknown function(zx, zy, zxx) with respect to those
variables.
• That unknown Function (z) is called dependent variables.
• PDEs can be classified into various types based on their order, linearity, and
coefficients.
6. Degree of PDE is degree of highest order partial derivative involved in that PDE
(1st degree) (2nd degree)
(1st degree) (1st degree)
Order of PDE is order of highest order partial derivative involved in that PDE
(1st order) (3rd order)
(1st order) (2nd order)
The concept of degree cannot be attributed to all PDE. For example, the given PDE doesnot have any degree.
sin zx + e^(zy) = 1
7. Non-Linear:
• zx
2+zy
2=0
• z.zx+z.zy=z
• zx+zy+zxx+zxy+zyy=z2
Linearity: Linear and Non Linear PDE:
• LINEAR :- If the dependent variable (z) and its partial derivatives (zx, zy, zxx, zxy, zyy)
occurs in the first power only and are not multiplied.
• NON LINEAR :- Else
EXAMPLES
Linear:
• zx +zy =0
• x.zx+y.zy=z
• zx+zy+zxx+zxy+zyy=z
9. • The general form of first order PDE is of type f(x,y,z,p,q)=0
• It can also be written as:
A.zx+B.zy+C.z = D or A
𝝏𝒛
𝝏𝒙
+B.
𝝏𝒛
𝝏𝒚
+C.z = D
where D is the function of independent variables and constants
• If D=0, the PDE above becomes Homogeneous.
10. Origin Of First Order Partial Differential Equation
By the elimination of the arbitrary
constants from a relation between x, y
and z.
By the elimination of arbitrary
functions of these variables.
g(x,y,z,a,b)=0
Differentiating g wrt. x and y partially, and
from f, fx, and fy
We get equation of the form
f(x,y,z,p,q)=0
is required PDE
f(u, v) = 0,
where u and v are function of x,y,z
Differentiating f wrt. x and y, taking z as dependent
variable
We get equation of the form
pP + qQ = R
is required PDE
Where P,Q,R are Lagrange’s linear equation.
x2+y2 = (z-c)2 tan2α Algebric
xq-yp=0 PDE
z = xy + f(x2+y2) Algebric
py-y2 = qx-x2 PDE
11. Solution: Linear PDE of the First Order
• The PDE of the type pP + qQ =
R, where P, Q, R are functions of
(x, y, z), is called a linear PDE of
the first order or Lagrange’s
linear equation.
• Its solution is in the form of F(u,
v) = 0, where F is arbitrary
function and u(x, y, z) = c1 and
v(x, y, z) = c2
Rules for solving pP + qQ = R
• Put the given PDE in the standard form pP + qQ = R.
• Write down Lagrange’s auxiliary equations
𝒅𝒙
𝑷
=
𝒅𝒚
𝑸
=
𝒅𝒛
𝑹
• Solve these equations
• Let u(x, y, z) = c1 and v(x, y, z) = c2 are two independent
solutions.
• 4. The general solution is then written one of the equivalent
form F(u, v) = 0
• PDE : y2p − xyq = x(z-2y)
• Step1: P= y2, Q= xy, R= x(z-2y)
• Step2: x2+y2 = c1, zy−y2 = c2
• Step3: F(c1,c2) = F(x2+y2, zy−y2)=0
13. A second order PDE involves second-order partial derivatives of an unknown
function(z) with respect to one or more independent variables.
General Second order Linear PDE (with 1D/2I variable) is:
Azxx + Bzxy + Czyy + Dzx + Ezy + Fz = G ------(i)
when, G=0, equation (i) is homogeneous.
Depending on the coefficients, second-
order PDEs can be classified as:
Parabolic if B2-4AC = 0
Elliptic if B2-4AC < 0
Hyperbolic if B2-4AC > 0
Solutions (BCs and ICs): Second-order PDEs often require
boundary conditions for elliptic and hyperbolic equations,
while parabolic equations typically require initial conditions
along with boundary conditions.
14. Solution method for second order L. PDE
(Direct Integration)
• Direct integration (PDEs) is a method where both sides of a PDE are integrated with
respect to one of the independent variables to eliminate one derivative from the
equation. And the process continues till all Partial derivatives are removed.
• Example:
where f(t) and g(t) are unknown function
using ICs,
Final Sol.n
15. Why Separation of Variable?
• Reduction to ODEs: Separate solution into functions of single variables, simplifying
PDE into manageable ODEs.
• Homogeneous Boundary Conditions: Effective for PDEs with homogeneous
boundary conditions, facilitating solution combination.
• Orthogonality of Solutions: Solutions may form orthogonal sets, easing coefficient
determination for boundary value problems.
• Versatility: Applicable to various linear second-order PDEs, including heat, wave, and
Laplace's equations.
• Physical Interpretation: Provides clear physical interpretations, aiding understanding
in fields like mathematical physics and engineering.
When the equation is more complex or doesn't lend itself well to direct
integration. In such cases, separation of variables becomes a valuable alternative.
16. Solution method for second order L. PDE
(Separation of Variable)
• If we have a second order PDE
ut=αuxx -------------(i)
(where u is dependent variable depend upon x and t)
• To get solution we assume product 2 different function X(x) and T(t) of x and t
respectively, be the solution of PDE above. ie’.
u(x,t)=X(x).T(t) -----(ii)
• Solving (i) and (ii), we get
𝑋"
𝑋
=
1
α
𝑇’
𝑇
= k (Separation Constant)
• According to the value of k (k <,=,> 0) we can found 3 pair of distinct solution for X
and T and final Solution will be u(x,t)=X(x).T(t), where, 3 different solutions can be
found.
• Finally, using initial and boundary condition, we can found one out of 3 as a non
trivial solution.
17. Example:
PDE: ut=3.uxx , 0<x<2, t>0
BCs: u(0,t)=0, u(2,t)=0, t>0
IC: u(x,0)=x
We get the non-trivial solution from 2nd solution
u(x,t)= 𝑖=1
∞ 4. −1 𝑛
+
1
𝑛π
sin
𝑛π𝑥
2
. exp{
−3𝑛2
𝜋2
𝑡
4
}
Example 2:
PDE: ut=a.uxx , 0<x<L, t>0
BCs: u(0,t)=0, ux(L,t)=0, t>0
IC: u(x,0)=x
We get the non-trivial solution from 2nd solution
u(x,t)= 𝑖=1
∞ 4. −1 𝑛
+
1
𝑛π
sin
𝑛π𝑥
2
. exp{
−3𝑛2
𝜋2
𝑡
4
}
Three Different solution for above equation(ut=αuxx ) is found as:
1. u(x,t)=(A.eλ𝑥+B.e
−λ𝑥)eαλ^2.t , when k=λ2 for λ >0
2. u(x,t)=(C.cosλ𝑥+B.sinλ𝑥)e-αλ^2.t , when k=-λ2 for λ >0
3. u(x,t)= E.x+F , when k=0
18. Other Solution Methods:
• Fourier and Laplace Transforms: Transforming the PDE into a different
domain (frequency or Laplace space) can simplify the problem, allowing for
easier solution.
• Numerical Methods: When analytical solutions are not feasible, numerical
methods such as finite difference, finite element, or spectral methods are
employed to approximate solutions.
19. One Dimension Heat Equation:
• We need to find the temperature distribution 𝑢(𝑥,𝑡)
along the medium over time. This involves
determining how the temperature varies with both
position 𝑥 along the medium and time 𝑡.
• It is a classic example of a parabolic PDE and is used
to model heat conduction processes.
1. Homogeneous Medium (ρ,s:const)
2. Heat flows in direction of decreasing Temperature
3. Heat flow rate (Q) across an area (A) is proportional to A
and temperature gradient. (ρ as proportionality Constant)
4. Quantity of heat gained and lost by body is proportional
to mass of body ‘m’ and change in temperature ‘dT’ ((‘s’
as proportionality Constant)
ASSUMPTIONS