This document discusses estrogen and progestin, female sex hormones. It defines estrogen as substances that can induce estrus in spayed animals. The three major natural estrogens are estradiol, estrone, and estriol, which vary throughout the menstrual cycle. Estradiol is the predominant estrogen during reproductive years. Synthetic estrogens like ethinyl estradiol and mestranol are orally active. Progesterone is the major natural progestin, secreted from the corpus luteum during the menstrual cycle and maintained in early pregnancy. Synthetic progestins like medroxyprogesterone acetate and desogestrel are highly active orally. Estrogens and progestins act through
These slides contain the information about Estrogen, its basic pharmacology, its synthesis in human body, Functions of estrogen, role in female puberty, Agonists of estrogen and antagonists of estrogen, also contain detail of the receptors associated with the estrogen functioning.
These slides contain the information about Estrogen, its basic pharmacology, its synthesis in human body, Functions of estrogen, role in female puberty, Agonists of estrogen and antagonists of estrogen, also contain detail of the receptors associated with the estrogen functioning.
sex-hormones belong to the steroid class of compounds and are produced in the gonads, i.e., testes in the male and ovaries in the female. In fact, their activity seems to be controlled and monitored by the hormones that are produced in the interior.
The two main sex hormones — estrogen and testosterone — have wide-ranging effects in the body. Produced primarily by the ovaries (estrogen) and testes (testosterone), these hormones affect not just your sexual function but also your bones, brain, and blood vessels.
Here is another topic named as sex hormones of both male and female. you get all the info from this presentation about this topic. Hope you will like it and get beneficial for you.
the presentation includes a definition of oral contraceptives, type of oral contraceptives, detail description of both types with its mode of action and potential beneficial and unwanted effects also include pharmacokinetics of oral contraceptives and knowledge of emergency contraceptives
sex-hormones belong to the steroid class of compounds and are produced in the gonads, i.e., testes in the male and ovaries in the female. In fact, their activity seems to be controlled and monitored by the hormones that are produced in the interior.
The two main sex hormones — estrogen and testosterone — have wide-ranging effects in the body. Produced primarily by the ovaries (estrogen) and testes (testosterone), these hormones affect not just your sexual function but also your bones, brain, and blood vessels.
Here is another topic named as sex hormones of both male and female. you get all the info from this presentation about this topic. Hope you will like it and get beneficial for you.
the presentation includes a definition of oral contraceptives, type of oral contraceptives, detail description of both types with its mode of action and potential beneficial and unwanted effects also include pharmacokinetics of oral contraceptives and knowledge of emergency contraceptives
This presentation explains in detail the Physiology of female reproductive system. For more Physiology subscribe: https://www.youtube.com/channel/UC1QhJfPiWnmk2WpKVH1fzrQ
in this slide physiological, psychological and social aspects of menopause, Hormonal replacement therapy, surgical menopause , guidance and counselling / role of midwifery nurse practitioner in menopause.
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
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ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
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- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
3. ESTROGENS
Female sex hormones.
ESTROGEN IS THE SUBSTANCE WHICH CAN INDUCE
ESTRUS IN SPAYED ANIMAL
Natural estrogens are steroid hormones, while some
synthetic ones are non-steroidal.
ESTROGEN =Greek
Oistros - Sexual desire, gen - "producer of".
Like all steroid hormones, estrogens readily diffuse
across the cell membrane. Goes inside the cell, they
bind & activate estrogen receptors which in turn
modulate the expression of many genes.
Estrogen levels vary through the menstrual cycle with
levels highest near the end of the follicular phase just
before ovulation.
4. NATURAL ESTROGENS:
Estradiol is the major estrogen secreted by the
ovary.
It is synthesized in the graffian follicle, corpus
luteum & placenta from cholesterol,
Estrediol is the most potent estrogen.
ESTREDIOL
↓ Oxidized in liver
ESTRONE
↓
ESTRIOL
Estrone (E1), Estradiol (E2) & Estriol (E3) all 3 are
found in blood
5. ESTRADIOL:
It is the predominant estrogen during reproductive
years,
It is the strongest with a potency of approximately
80 times than estriol.
It is the most important estrogen in non-pregnant
females who are between the menarche (first
menstrual cycle) and menopause stages of life.
ESTRONE
It is the predominant estrogen during menopause,
ESTRIOL
It is the predominant estrogen during pregnancy.
It is the most plentiful of the three estrogens
It is also the weakest,
6. REGULATION OF SECRETION:
Amount of secretion of estrogen depending on
the phase of the cycle.
Secretion starts from GRAFIAN FOLICLE, under the
influence of FSH.
Blood level raises during follicular phase after
ovulation, Corpus luteum continues to secrete
estrogen till about 2 days before menstruation.
DURING PREGNENCY – placenta secrete large
quantities of estrogen 30mg /day, which reduced
after delivery.
IN POST MENOPUSAL WOMEN: very low amount
secretes.
7. SYNTHETIC ESTROGENS:
All are Synthetic estrogens
Natural estrogens are inactive, because of first pass
metabolism in liver therefore, synthetic estrogens are
prepared.
STEROIDAL:
ETHNYLESTRADIOL
MESTRANOL
TIBOLONE
NON-STEROIDAL:
DIETHYLSTILBESTEROL
HEXESTROL
DIENESTROL
All preparations have similar action.
Potencies differ from others due to the type of first
pass metabolism.
8. ACTIONS:
PUBERTAL CHANGES IN FEMALE
Growth of uterus, fallopian tube and vagina.
Vaginal epithelium gets thickened, stratified and
cornified.
Proliferation of endometrium in the pre ovulatory
phase, Progesterone brings secretory changes.
Increase rhythmic contraction of fallopian tubes and
uterus; induce watery alkaline secretion from the
cervix.
SECONDERY SEX CHARECTERS:
Growth of breasts.
Pubic and axillery hair.
Feminine body contours (STRUCTURE), behavior.
Acne
10. PHARMACOKINETICS:
Well absorbed orally & transdermally
Natural estrogens are inactive orally,
Natural estrogens are largely bound to protein
Estradiol, estriol, estrone are metabolized in liver
Excreted in urine & bile
ADR:
Suppression of libido
Gynaecomastia
Feminization
Irregular bleeding
Breast cancer
Gall stones
11. PROGESTINS
PROGESTIN = FAVPURING PREGNENCY
“THESE ARE THE SUBSTANCE WHICH CONVERT
THE ESTROGEN PRIMED ENDOMETRIUM TO
SECRETORY & MAINTAIN PREGNANCY IN
ANIMAL SPAYED AFTER CONCEPTION”
• Identified in 1929, but full therapeutic potential
find out after 1950
• After that large number of orally active
synthetic progestin's were developed.
12. NATURAL PROGESTIN:
It is a 21 carbon steroid, Derived from cholesterol
It is secreted from corpus luteum (10-20mg/day) during
the menstrual cycle by LH
Synthesis Declines few days before the next menstrual
cycle
If ovum gets fertilized and implants blastocytes
producing CHRONIC GONADOTROPIN, which sustains
corpus luteum in early pregnancy
In second trimester placenta secretes lot of estrogens
and progesterone
SYNTHETIC PROGESTINS:
It is highly active orally
Various synthetic progestin's are available nowadays
PROGESTERONEDERIVATIVES (contain 21 carbon)
19-NORTESTOSTERONE DERIVATIVES (contain 18
carbon)
14. ACTIONS:
• Mainly progesterone prepare the uterus for nidation
(implantation) & maintenance of pregnancy
UTERUS:
• Secretory changes in the estrogen primed
endometrium,
• Hyperemia (increase of blood flow)& tortuocity
(twist) of glands occurs and increases the secretion
• During pregnancy causes decidual changes
(characteristic of the endometrium of the pregnant
uterus) in endometrium, enlargement of stroma it
become spongy
• Decreases the sensitivity of myometrium to oxytocin
16. BREAST:
• Proliferation of acini in the mammary gland
• Prepares breast for lactation
• After child birth withdrawal of progestin
release of prolactin from pituitary Milk secretion
CNS:
• During pregnancy High concentration of
progesterone induce sedation
BODY TEMPERATURE:
• Cause slight raise in temp (0.5oc)
RESPIRATION:
• At high dose – stimulate respiration during
pregnancy
17. MECHANISM OF ACTION:
Only limited progestin receptor present in the body
Mostly present in females, in Genital tract, Breast, CNS, Pituitary.
Located in the nucleus of the target cell
PROGESTERONE
BINDS TO PROGESTIRONE RECEPTOR PRESENT ON THE
TARGET CELL
DIMERIZATION OF RECEPTOR
DIFFUSE IN TO NUCLEUS
BINDS TO PROGESTERONE RESPONSE ELEMENT OF TARGET
GENE
REGULATION OF TRANSCRIPTION
SPECIFIC PROTEIN SYNTHESIS
BIOLOGICAL ACTION
18. PHARMACOKINETICS:
It is inactive orally
But the synthetic progesterone are orally active
Mostly injected (i.m) in oily solution
Has short half life 5-7 minutes
Metabolized in liver
Excreted in urine
Microionized formulation of progesterone administered in the form
of soft gelatin capsule
ADR:
Breast enlargement
Head ache
Rise in body temperature
Edema
Acne
Irregular bleeding