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Essential Hypertension
Prof. Samir S. al- msalha
Definition
Persistent elevation of BP
( ≥ 140/90 mmHg)
Classification of BP According to
JNC – 7 report
Normal ≤ 120 mmHg systolic and ≤ 80
mmHg diastolic
 Prehypertention 120 -139 mm Hg systolic
and 80-90mm Hg diastolic
 Stage -1 Hypertension 140-159 mmHg
systolic and 90- 99 mmHg diastolic
 Ssage -2 Hypertention ≥ 160 mmHg
systolic and ≥ 100 mmHg diastolic

BP
classification

Life style
Without compelling
modification indication

With
compelling
indication

Normal

encourage

Prehypertension

yes

No anti-HTN drugs

Drug(s) for the
compelling
indication

Stage 1 HTN

yes

Thiazide-diuretics for
most; may consider
ACE,ARB,
B-blockers,CCB,or
combination

Drug(s)for the
compelling
indicatios
( thiazides,
ACEI,CCB,ARB,
B-blocker)

Stage 2 HTN

yes

2-drug combination
for most
(thiazide,ACEI or ARB
or B-blocker or CCB)

Drug(s) for the
compelling
indications
( thiazides,
ACEI, ARB, Bblocker, CCB)
as indicated
CAUSES
Essential Hypertention (95 %)
 Secondary ( 5%)
1. DRUGS( steroids , Contraceptive
pills,NSAIDS,carbenoxolone,Liquorice,
sympathomimetics)
2. Cardiovascular (Coarctation of the aorta)
3. Renal (Renovascular i.e RAS and renal
artery occlusion or Parenchymal i.e ch.
Pyelonephritis,acute and
ch.glomeronephritis,obstructive
uropathy,polycystic kidney disease and
hypernephromas.

CAUSES
4.Endocrine: ( pheochromocytoma,
1 aldosteronism, cushing’s,acromegaly,
hyperparathyroidism and hypothyroidism).

5.Others
(brain tumors with increased intracranial
pressure,bulbar poliomyelitis,connective tissue
disorders i.e SLE and polyarteriti nodosa,DM
nephropathy,Polycythemia rubra vera)
INITIAL or PRIMARY INVESTIGATIONS
in HYPERTENSION










Urinalysis
Renal profile
ECG
Chest x-ray
Plain U-T x-ray or renal ultrasound
Urine culture
HB, PCV
FBS,s.lipids,s.urate
Echocardiography
When to investigate for a
secondary cause of hypertension
1.
2.

3.
4.

Clues from the history
Clues from physical examination
Clues from initial investigations
Malignant stage hypertension
Complications of hypertension
Cardiovascular(angina,MI,LVH,HF,dissecting
aortic aneurysm)
 Cerebrovascular(TIA,Thrombotic
infarction,intracerebral
hemorrhge,encephalopathy)




Peripheral vascular

disease(atherosclorosis,intermittent
claudication, gangrene)
 Retinopathy(Grades1,2,3,4)
 Nephropathy(nephrosclerosis,fibrinoid necrosis)
 Malignant hypertension
Treatment of hypertension
1st. Non-pharmacological measures:
1. Diet
2. Weight reduction
3. Stopping smoking and excess alcohol
consumption
4. Regular exercise ( behavioral,
biofeedback therapy)
5. Treatment of other associated risk
factors
B. Antihypertensive medications:
1. Diuretics
Thiazide, loop, K+ sparing
2. B-Blockers
Non-cardioselective
Cardioselective
Drugs with ISA
Alpha and Beta-blockers(labetolol)
3. Alpha-blockers ( prazosin)
4. Central acting drugs (reserpine,
methyldopa,clonidine)
5. vasodilators:
1st. Direct relaxation of arteriolar smooth
muscle:
-Hydralazine
-Minoxidil
-Diazoxide
-Na-nitroprusside
2nd. Calcium-channel blockers:
- Verapamil
- Nifedipine
- Amlodipine
3rd. ACE inhibitors :
- Captopril
- Enalapril
- Lysinopril
- Quinapril
6. ARBs
- Losartan
- Candesartan
- Irbisartan
- Valsartan
Hypertensive Crisis:
Severe hypertension with one of the
following:
1. Heart failure
2. MI
3. Renal failure
4. Encephalopathy
5. Dissecting aneurysm
6. Intracerebral hemorrhage
7. Accelerated or malignant hypertension
Parentral Drugs Used In
Hypertensive Emergencies:
Na-nitroprusside infusion
2. Diazoxide i.v
3. Hydralazine iv
4. Furosemide i.v
5. Phentolamine i.v
6. Nifedipine s/L
7. Labetolol i.v
( N.B: B.P shouldn’t be reduced to below
diastolic of 100 mmHg )
1.

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Essential hypertension lecture

  • 2. Definition Persistent elevation of BP ( ≥ 140/90 mmHg)
  • 3. Classification of BP According to JNC – 7 report Normal ≤ 120 mmHg systolic and ≤ 80 mmHg diastolic  Prehypertention 120 -139 mm Hg systolic and 80-90mm Hg diastolic  Stage -1 Hypertension 140-159 mmHg systolic and 90- 99 mmHg diastolic  Ssage -2 Hypertention ≥ 160 mmHg systolic and ≥ 100 mmHg diastolic 
  • 4. BP classification Life style Without compelling modification indication With compelling indication Normal encourage Prehypertension yes No anti-HTN drugs Drug(s) for the compelling indication Stage 1 HTN yes Thiazide-diuretics for most; may consider ACE,ARB, B-blockers,CCB,or combination Drug(s)for the compelling indicatios ( thiazides, ACEI,CCB,ARB, B-blocker) Stage 2 HTN yes 2-drug combination for most (thiazide,ACEI or ARB or B-blocker or CCB) Drug(s) for the compelling indications ( thiazides, ACEI, ARB, Bblocker, CCB) as indicated
  • 5. CAUSES Essential Hypertention (95 %)  Secondary ( 5%) 1. DRUGS( steroids , Contraceptive pills,NSAIDS,carbenoxolone,Liquorice, sympathomimetics) 2. Cardiovascular (Coarctation of the aorta) 3. Renal (Renovascular i.e RAS and renal artery occlusion or Parenchymal i.e ch. Pyelonephritis,acute and ch.glomeronephritis,obstructive uropathy,polycystic kidney disease and hypernephromas. 
  • 6. CAUSES 4.Endocrine: ( pheochromocytoma, 1 aldosteronism, cushing’s,acromegaly, hyperparathyroidism and hypothyroidism). 5.Others (brain tumors with increased intracranial pressure,bulbar poliomyelitis,connective tissue disorders i.e SLE and polyarteriti nodosa,DM nephropathy,Polycythemia rubra vera)
  • 7. INITIAL or PRIMARY INVESTIGATIONS in HYPERTENSION          Urinalysis Renal profile ECG Chest x-ray Plain U-T x-ray or renal ultrasound Urine culture HB, PCV FBS,s.lipids,s.urate Echocardiography
  • 8. When to investigate for a secondary cause of hypertension 1. 2. 3. 4. Clues from the history Clues from physical examination Clues from initial investigations Malignant stage hypertension
  • 9. Complications of hypertension Cardiovascular(angina,MI,LVH,HF,dissecting aortic aneurysm)  Cerebrovascular(TIA,Thrombotic infarction,intracerebral hemorrhge,encephalopathy)   Peripheral vascular disease(atherosclorosis,intermittent claudication, gangrene)  Retinopathy(Grades1,2,3,4)  Nephropathy(nephrosclerosis,fibrinoid necrosis)  Malignant hypertension
  • 10. Treatment of hypertension 1st. Non-pharmacological measures: 1. Diet 2. Weight reduction 3. Stopping smoking and excess alcohol consumption 4. Regular exercise ( behavioral, biofeedback therapy) 5. Treatment of other associated risk factors
  • 11. B. Antihypertensive medications: 1. Diuretics Thiazide, loop, K+ sparing 2. B-Blockers Non-cardioselective Cardioselective Drugs with ISA Alpha and Beta-blockers(labetolol)
  • 12. 3. Alpha-blockers ( prazosin) 4. Central acting drugs (reserpine, methyldopa,clonidine) 5. vasodilators: 1st. Direct relaxation of arteriolar smooth muscle: -Hydralazine -Minoxidil -Diazoxide -Na-nitroprusside
  • 13. 2nd. Calcium-channel blockers: - Verapamil - Nifedipine - Amlodipine 3rd. ACE inhibitors : - Captopril - Enalapril - Lysinopril - Quinapril
  • 14. 6. ARBs - Losartan - Candesartan - Irbisartan - Valsartan
  • 15. Hypertensive Crisis: Severe hypertension with one of the following: 1. Heart failure 2. MI 3. Renal failure 4. Encephalopathy 5. Dissecting aneurysm 6. Intracerebral hemorrhage 7. Accelerated or malignant hypertension
  • 16. Parentral Drugs Used In Hypertensive Emergencies: Na-nitroprusside infusion 2. Diazoxide i.v 3. Hydralazine iv 4. Furosemide i.v 5. Phentolamine i.v 6. Nifedipine s/L 7. Labetolol i.v ( N.B: B.P shouldn’t be reduced to below diastolic of 100 mmHg ) 1.