Hypertension, or high blood pressure, affects over 1 billion people worldwide and 65 million Americans. It increases the risk of heart attack, stroke, heart disease, and kidney disease. The document defines hypertension as a systolic blood pressure of 140 mmHg or higher or a diastolic blood pressure of 90 mmHg or higher. Risk factors include age, family history, obesity, smoking, excessive alcohol, stress, and a diet high in salt. Preventing hypertension involves maintaining a healthy weight, exercising regularly, reducing salt intake, moderating alcohol, and regular blood pressure screenings.
What is hypertension, Definition of hypertension, Classification of hypertension, pathophysiology of hypertension, Signs and symptoms of hypertension, Risk factors of hypertension, Causes of hypertension, Differential diagnosis of hypertension, Medications of hypertension, Different class of medications for hypertension, Patient education for hypertension
Case history
Definition & incidence of Hypertension
Classification of Hypertension
Diagnosis/ Confirmation of Hypertension
Technique of Hypertension Measurement
White coat Hypertension
Type of Hypertension
Suspicion of secondary hypertension
Management of Hypertension(Stage 1& 2)
Why treatment is necessary
Life style modification
Drug treatment of Hypertension
Rationalae of combination
Hypertension management in special situation/ with complications
Hypertension, its causes, types and managementAbu Bakar
hypertention,it's causes, epidemiology, mechanism,primary and secondary hypertention, preeclampsia and eclampsia, disease related hypertention, classification, dietary plan, diagnosis, clinical presentation, drug related hypertention, treatment,
What is hypertension, Definition of hypertension, Classification of hypertension, pathophysiology of hypertension, Signs and symptoms of hypertension, Risk factors of hypertension, Causes of hypertension, Differential diagnosis of hypertension, Medications of hypertension, Different class of medications for hypertension, Patient education for hypertension
Case history
Definition & incidence of Hypertension
Classification of Hypertension
Diagnosis/ Confirmation of Hypertension
Technique of Hypertension Measurement
White coat Hypertension
Type of Hypertension
Suspicion of secondary hypertension
Management of Hypertension(Stage 1& 2)
Why treatment is necessary
Life style modification
Drug treatment of Hypertension
Rationalae of combination
Hypertension management in special situation/ with complications
Hypertension, its causes, types and managementAbu Bakar
hypertention,it's causes, epidemiology, mechanism,primary and secondary hypertention, preeclampsia and eclampsia, disease related hypertention, classification, dietary plan, diagnosis, clinical presentation, drug related hypertention, treatment,
Study material for Doctor of pharmacy and other medical students. Hypertension is a condition in which the force of the blood against the artery walls is too high. Approximately one billion adults or ~22% of the population of the world have hypertension. It is slightly more frequent in men, in those of low socioeconomic status, and prevalence increases with age. So it is more important to manage it as early, this includes Pharmacological as well as Non-pharmacological Management.
Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated.
this presentation have various hypertension management guidelines used in the Indian context, hypertension management algorithm, medication used and AYUSH interventions
Study material for Doctor of pharmacy and other medical students. Hypertension is a condition in which the force of the blood against the artery walls is too high. Approximately one billion adults or ~22% of the population of the world have hypertension. It is slightly more frequent in men, in those of low socioeconomic status, and prevalence increases with age. So it is more important to manage it as early, this includes Pharmacological as well as Non-pharmacological Management.
Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated.
this presentation have various hypertension management guidelines used in the Indian context, hypertension management algorithm, medication used and AYUSH interventions
High blood pressure or BP or hypertension has been termed as the ‘silent killer’. It is essential to know in detail about this silent killer and take measures not to fall prey to it. The pressure in your blood varies depending on the type of work you are doing.
After attending this presentation audience will be able to:
•Define Blood pressure, Normal BP and Hypertension
•Classify Hypertension
•Enlist Predisposing factors of Hypertension
•Describe the consequences of Hypertension
•Explain/plan that how to avoid Hypertension
A blood pressure measurement is always expressed in two numbers. The higher (systolic) number represents the pressure while the heart is beating, and the lower (diastolic) number represents the pressure when the heart is resting between beats.
Blood pressure is a fundamental indicator of your cardiovascular
health. It reflects the force of blood against your artery walls, and it
fluctuates naturally throughout the day. In this comprehensive guide,
we'll delve into the significance of blood pressure numbers, explore
the risks associated with high blood pressure (hypertension), and
discuss effective prevention and management strategies.
Hypertension is also known as high blood pressure. It is a long-term medical condition in which the blood pressure in the arteries is persistently elevated
To know more about hypertension click on the below link
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https://docmode.org/masked-hypertension-high-in-indians/
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Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
1. HYPERTENSION
ARE YOU AT RISK
FOR A HEART
ATTACK? STROKE?
OR HEART
DISEASE?
THESE ARE
COMLPLICATIONS OF
HYPERTENSION
LEARN WHAT
HYPERTENSION IS
AND HOW TO PREVENT
IT.
2. Teaching Objectives
Explain the prevalence and affects of hypertension in
the U.S.
Define hypertension.
Describe the mechanisms involved in the regulation of
blood pressure.
Name the risks of Hypertension.
Describe the signs & symptoms and complications of
hypertension.
Define the classifications of hypertension.
Describe preventative measures for hypertension.
Explain how to monitor blood pressure at home using
manual and/or electronic devices.
3. Considerations
Hypertension is an important medical and public health issue.
It is estimated that 1 billion people Worldwide are affected
by hypertension.
At least 65 million American adults, or 1 in 3, have high Blood
pressure.
There is a direct relationship between hypertension and
Cardiovascular disease (CVD).
There is a proportional risk for heart attack, heart failure,
stroke, and renal disease with higher Blood pressure.
4. WHAT IS HYPERTENSION?
Blood pressure is expressed as two numbers, for example 120/80 mmHg
These numbers represent the pressure against the walls of your blood
vessels as the blood moves through them.
The top number (or first number) represents the systolic pressure, which
occurs when the heart contracts.
The bottom number (or second number) represents the diastolic pressure,
which occurs when the heart relaxes.
Normal blood pressure is less than 120 (systolic) over 80 (diastolic),
typically written as 120/80 mm Hg (read 120 over 80 millimeters of
mercury).
Hypertension, or High blood pressure is persistent
Systolic blood pressure SBP ≥140 mmHg, and
Diastolic blood pressure DBP ≥ 90 mmHg.
5. Lets take a step back and learn a
little about what happens in our
bodies……..
The organs and tissue in your
body need oxygen to survive.
Oxygen is bound to your
blood and is delivered( after
an exchange of carbon
dioxide for oxygen in your
lungs) to your body by blood
vessels.
When your heart beats, it
creates pressure that
pushes blood through your
arteries and veins, also
known as blood vessels and
capillaries.
Blood pressure is the force
of blood pushing against your
blood vessel walls.
Your blood pressure must be
within a normal range to
properly deliver this oxygen
rich blood to your organs and
tissues in order to survive.
6. Okay……so what does this mean?
When someone has high blood pressure , this increased force makes the heart work
harder to pump blood to the body.
The increased force puts a strain on both the heart and the blood vessels.
If the force of the blood flow is high for some time, eventually the tissue that
makes up the walls of the arteries gets stretched beyond its healthy limit.
This overstretching of the blood vessels makes them more prone to rupture.
Damages to the vessels results in the development of Atherosclerosis
( hardening of the arteries).
Uncontrolled high blood pressure increases your risk of serious health
problems, including heart attack and stroke.
7. Who is at risk for Hypertension?
Age- Blood pressure rises with increasing age.
Alcohol- Excessive alcohol intake is associated with Hypertension
Cigarette smoking- Smoking increases your risk for Cardiovascular disease. If you have hypertension &
smoke and/or take Oral contraceptives you have a greater risk for Cardiovascular disease and blood
clots.
Diabetes Mellitus- Hypertension is more common in Diabetics
Elevated Cholesterol & Triglycerides- High levels of cholesterol & triglycerides are primary risk
factors for atherosclerosis (plaque build up in your blood vessels).
Too much salt in your diet- High sodium intake contributes to high blood pressure and causes water
retention.
Gender- Hypertension is more common in young adulthood men & middle aged men (<55 yr of age). After
the age off 55 Hypertension is more common in women.
Family history- Having a close blood relative ( parents or sibling) with hypertension increases your risk
of developing hypertension.
Obesity- Weight gain is highly associated with increased frequency of hypertension, especially with
central abdominal obesity.
Ethnicity- The incidence of hypertension is twice as high in African Americans as they are in whites.
Sedentary lifestyle- Inactivity and weight gain are associated with high blood pressure & increases
the risk for heart disease.
Stress- People exposed to repeated stress may develop hypertension more
frequently than others.
8. Signs & Symptoms Of Hypertension
Hypertension is often called the “Silent killer” because it is frequently asymptomatic- meaning “without
symptoms” until it has become severe and damage to organs have occurred.
A person with severe hypertension may have symptoms caused by the effects on the blood vessels
which my be:
Fatigue
Reduced activity tolerance
Dizziness
Palpitations
Angina (chest pain)
And difficulty breathing
• According to the American Heart Association There's a common misconception that people with high
blood pressure will experience symptoms such as nervousness, sweating, difficulty sleeping or facial
flushing. The truth is that HBP (high blood pressure) is largely a symptomless condition. If you ignore
your blood pressure because you think symptoms will alert you to the problem, you are taking a
dangerous chance with your life. Everybody needs to know their blood pressure numbers, and everyone
needs to prevent high blood pressure from developing.
There are also myths of headaches/nosebleeds believed to be related to HBP. According to the AHA
studies have shown that people with higher systolic (top number) blood pressure were up to 40% less
likely to have headaches ( except in the cases of Hypertensive crisis SBP ≥180mmHg and DSP
≥110mmHg)
It is important to know that nosebleeds can be associated with other factors,. Most common reasons
for nosebleeds are dry air especially in hot climates like the desert Southwest (Arizona). Other causes
may be allergies, sinusitis or anticoagulants such as Warfarin or aspirin.
9. Cardiovascular disease
Atherosclerosis – “ Hardening of the
arteries”
Coronary Artery Disease- damage to the
heart & coronary arteries
Cerebrovascular Disease
Peripheral Vascular Disease
Stroke or Heart Attack
Angina- Chest pain
Kidney damage
Vision loss
Heart failure- Over time as
the heart works harder to push
the blood throughout the body,
the heart (which is a muscle)
enlarges.
Just like any other muscle in
your body enlarges when you
work it out.
This enlargement causes
stretching of the heart muscle
and eventually not enough blood
is pumped out of the heart to
the body to meet the body’s
requirements of oxygen as
discussed earlier.
Complications of Hypertension
10. Classifications of Blood Pressure
Normal BP ‘
SBP <120 mmHg & DBP < 80 mmHg
Prehypertension
SBP 120-139 mmHg or DBP 80-89
Stage 1 Hypertension
SBP 140-159 mmHg or DBP 90-99
Stage 2 Hypertension
SBP ≥ 160 mmHg or DBP ≥ 100 mmHg
11. Prevention Of Hypertension
Maintain a healthy weight- A weight loss of
even 10 pounds can decrease your SBP ( top
number of your blood pressure)by 5-20mmHg .
Exercise- at least 30 minutes of aerobic
physical activity (brisk walking, jogging, swimming)
most days of the week.
Reduce salt and sodium intake- Foods that have
a lot of salt are processed foods ( frozen
dinners, canned foods) and Lunch meats.
Increase level of physical activity.
Limit alcohol consumption to moderate levels-
Men should limit their alcohol intake to no more
than 2 drinks per day and women to no more than
one drink per day.
1 drink = 1.5 oz. alcohol or 12 0z. Beer, 5 oz. of
wine, 1.5 oz 80 proof whiskey.
Monitor Blood pressure and know if it is high,
low, normal, or borderline for hypertension.
Regular check ups with your Primary care
Physician.
How can I prevent Hypertension ?
12. Prevention: Numbers to Remember
Lifestyle
Maintain a healthy
weight
BMI < 25%
Waist circumference
Men: 40 in. or less
Women: 35 in. or l less
Diet
5 or more servings of
fruits & veggies a day
1 tsp or less of salt per
day
Exercise
Jogging, walking,
swimming
30 minutes a day most
days of the week
Quit smoking
Limit Alcohol
consumption to 1 0z per
day
Regular Health Check
ups
LDL Cholesterol < 130
mg/dl
HDL Cholesterol 50
mg/dl or higher
13. Monitoring your Blood pressure
Your blood pressure should be taken during your regular health
check ups.
Your doctor may recommend checking your blood pressure at home
if you have risk factors of hypertension or if you have been
diagnosed with pre-hypertension (systolic -top number between 120
and 139 mm Hg OR diastolic -bottom number between 80 and 89
mm Hg).
A record of readings taken over time can provide you and your
healthcare provider a clearer picture of your blood pressure.
AHA Recommendation:
The American Heart Association recommends an automatic, cuff-
style, bicep (upper-arm) monitor. Wrist and finger monitors are not
recommended because they yield less reliable readings.
14. Monitoring your blood pressure cont.
How to monitor your blood pressure
Use a bicep (upper-arm) monitor for more accurate readings as recommended
by the AHA.
electronic or automatic versions at work or in your local pharmacy/shopping
center may be used but can give inaccurate readings.
A manual blood pressure cuff can also be used if you have someone that knows
how to accurately use it.
Make sure the cuff fits
Be still
Sit correctly with your back straight & supported (using a dining chair instead
of a sofa is recommended), feet flat (don’t cross your legs), and upper arm
supported at heart level.
Make sure the middle of the cuff is directly over the brachial artery.
Record all your readings & understand the readings (optimal BP is < 120/80
mmHg).
The average of three readings, at least one minute apart, should be used as the
BP reading.
Consult your health care provider if you get several high recordings.
16. Prevention is Key
According to the U.S. Health and Human Services a combination
of increased physical activity, moderation in alcohol intake, and
consumption of an eating plan that is lower in sodium content and
higher in fruits, vegetables and low-fat dairy products than the
average American diet represents the best approach for
preventing high blood pressure in the general population and in high
risk groups.
17. References
Lewis, S.L., & Heitkemper, M.M., & Dirksen, S. R., &
O’Brien, P. G., & Bucher, L. (2007). Medical Surgical
Nursing. Philadelphia, PA: Mosby Elsevier.
Primary prevention of hypertension. (2002). National
Institutes of Health , 14.
What is high blood pressure. (2010).
Retrieved October 20th, 2010, from
http://www.heart.org.