This document discusses how Web 2.0 technologies are enabling new forms of collaborative research known as Science 2.0 or Open Science. It analyzes several examples including GeoVue, a virtual globe for overlaying data; JOVE, a journal publishing platform; science blogging; and The Pynchon Wiki, a collaborative online annotation of a novel. These tools lower barriers to participation and encourage contributions from outside academia. However, challenges include a lack of recognition for contributions and ensuring quality amid more open and diffuse forms of online research.