This document summarizes a study on the epidemiology of cancer in patients seeking palliative care at Nairobi Hospice in Kenya. The study found that the most common cancers seen were breast, prostate, cervical, esophageal and Kaposi's sarcoma. A majority of patients were female (64.7%) and the median age was 54 years. The top five cancers accounted for over 60% of cases. Late diagnosis was also indicated by a median survival time of only 7 months from diagnosis. The study concludes there is a need for increased cancer care facilities, education and research to address the growing burden of cancer in Kenya.
Prevention and early detection of Prostate Cancer: a global view Vitaly Smelov, International Agency for Research on Cancer (IARC), World Health Organisation (WHO)
Prevention and early detection of Prostate Cancer: a global view Vitaly Smelov, International Agency for Research on Cancer (IARC), World Health Organisation (WHO)
The presentation begins with a brief history of how cancer epidemiology evolved, and what is the status at present. After describing the burden of the disease of cancer globally and in India, the presentation includes a brief description of Cancer causes and prevention including screening activities. It also talks about the national Cancer Registry Program, NPCDCS and NCCP.
Epidemiology of oral cancer, cancer registry in India,Global Initiatives,Tobacco,Tobacco cessation centre,WHO framework,National Tobacco Control Programme,Squamous cell carcinoma,Leukoplakia, Benign,Malignant,Epidemiology,World
The presentation begins with a brief history of how cancer epidemiology evolved, and what is the status at present. After describing the burden of the disease of cancer globally and in India, the presentation includes a brief description of Cancer causes and prevention including screening activities. It also talks about the national Cancer Registry Program, NPCDCS and NCCP.
Epidemiology of oral cancer, cancer registry in India,Global Initiatives,Tobacco,Tobacco cessation centre,WHO framework,National Tobacco Control Programme,Squamous cell carcinoma,Leukoplakia, Benign,Malignant,Epidemiology,World
Sharad Ghamande, MD, FACOG
Professor and Director of Gynecologic Oncology
Augusta University Cancer Center
Presentation to the Georgia Senate Women's Adequate Healthcare Study Committee
www.gacommissiononwomen.org
National Cancer Registry 2014-2018 - UAEAnjalaNizam
Presented on 07/10/2019 by Anjala Nizam & Arshiya Adhnon,
An insightful presentation on the UAE National Cancer Registry 2014-2018 with emphasis on Breast Cancer.
Background: The incidence of cancers is increasing worldwide, particularly in the developing countries as shown by recent cancer stastics from the WHO. It is even anticipated that with the increase in life expentancy, consequent upon inproved standard of living and globalization, the burden of cancers will increase within this millenium. With respective to cancer of the prostate, it is the most common type of cancer in urology. In developing countries, diagnostic is done at a late stage of evolution. In Cameroon, data on prostate cancer are scanty whereas the incidence of this disease is increasing. Objective: This article is designed to describe the epidemiological features of prostate cancer at the General Hospital of Yaoundé. Patients and methods: A 4-year retrospective study of patients seen with the diagnosis of cancer at the Medical Oncology unit of the Yaoundé General Hospital between January 2012 and December 2015. The demographic pattern (age of patients, socio professional activity, marital status), clinical features (cancer diagnosis), treatment modalities and outcome were studied. Main results: Of the 7 775 patients enrolled in the Medical Oncology Service over the study period, 1.4% (n = 108) cases of prostate cancer were seen. The prevalence over the study period was 1.38% and a relatively large annual growth of cases with an annual average of 27 cases was noted. The average age of patients was 67.82 years with a range of 34-83 years. The commonest presenting symptoms were the urinary frequency (54.63%) whereas the least common were fatigue (05.5%) and straining (03.70%). PSA was obtained in 49 patients, representing about 45.4% of all patients. Only 14 (01.26%) had biopsy reports. Conclusion: Prostate cancer is a major problem facing the aging male, and inadequate facilities make early detection difficult. Therefore, treatment is mainly palliative because of late diagnosis.
Cervical cancer global burden and where do we stand todayNiranjan Chavan
Cervical cancer is the 4th most common cancer in women worldwide but most common cause of cancer related death in India.
All over the world, including India, there is decreasing trend of cervical cancer.
Pattern of Head and Neck Cancer in a Tertiary Institution in Lagos Nigeriaiosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Cancer Magnitude in Elderly Indian Women, an Experience from Regional Cancer ...Crimsonpublishers-IGRWH
Cancer Magnitude in Elderly Indian Women, an Experience from Regional Cancer Centre, India by Ravi Kiran Pothamsetty in Open access journal of Gynecology
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Epidemiology of cancer in patients seeking palliative care by l.w. cushny
1. EPIDEMIOLOGY OF CANCER IN
PATIENTS SEEKING PALLIATIVE CARE
AT NAIROBI HOSPICE – NAIROBI,
KENYA.
DR. L. W. CUSHNY,
SCHOOL OF MEDICINE,
UNIVERSITY OF NAIROBI.
2. INTRODUCTION:
• Cancer is among the leading causes of
morbidity and mortality worldwide.
• GLOBOCAN estimates from 2008 showed 12.7
million cases and 7.6 million deaths from
cancer (13% of the worlds deaths)
• Of these, 56% of the cases and 64% of the
deaths are from the economically developing
world.
3. Cont..
• The overall burden of cancer in the world is
projected to continue rising, particularly in
developing countries.
• It is projected that by 2030, the number of
new cancer cases and deaths will increase by
69% and 72% to 21.4 million and 13.2 million
respectively
• The estimated Incidence and mortality rates
for Eastern Africa are 123 and 100 per
100,000 respectively.
4. JUSTIFICATION
• Comprehensive data on the burden and
trends of cancer in most of Sub-Saharan Africa
is scarce.
• In Kenya, cancer ranks third as a cause of
death after infectious and cardiovascular
diseases but data on the same is scarce and
inconsistent with the magnitude of the
problem.
• There are few population based cancer
registries and no cancer surveillance system.
• No similar studies have been published.
5. MATERIALS AND METHODS 1/2
• Study site: Nairobi Hospice located at KNH.
• It was the first Hospice facility in Kenya
established in 1990.
• It is an outpatient site that provides pain and
relief treatment to cancer patients along with
social and psychological support.
• Study Design: This was a retrospective
descriptive study
– I reviewed 290 records from the patient files and
registers of the patients enrolled by the hospice
between 1st Nov 2012 and 30th Oct 2013.
6. MATERIALS AND METHODS 2/2
• Study Period: 4th Nov 2013 – 8th Nov 2013
• Study population: Cancer patients attending
hospice for palliative care
• Case definition: A cancer patient of any age
presenting to Nairobi hospice for palliative care
between Nov 2012 and Oct 2013.
• Specific objectives
– To determine the various types of cancers in
patients attending Nairobi hospice.
– To characterize the cases in time place and
person.
7. DATA COLLECTION AND
MANAGEMENT
• Socio-demographic and cancer data on cancer
cases and deaths was abstracted using a
standardized form.
• Data from Nov 2012 to Oct 2013 was abstracted.
• Data entry
– SPSS 17.0 software and Ms Excel 2007 used
• Data analysis
– Means , proportions and frequencies were calculated
for categorical and continuous variables
9. Results…
• Median age of the patients: 54 (range:18-
93)years
• Mortality rate during the twelve month period
in those attending the hospice for care - 21.5%
(62)
• Median duration from diagnosis to first visit
to the hospice – 7 months (range =0-231
months)
• Median duration from diagnosis to death-7
months (range= 0- 85 months)
• 60.4 % of the patients had NHIF
16. Distribution of Forms of Treatment
received:
YES NO
RADIOTHERAPY 32.9% (95) 66.4 % (192)
CHEMOTHERAPY 37.0 % (107) 62.3% (180)
SURGERY 37.4% (108) 61.9% (179)
19. DISCUSSION:
• In Kenya there is an estimated 28,000 new cases
each year and 22,000 deaths due to cancer.
• The most common cancers among women are
breast, cervical and Oesophagus while the most
common in men are Prostrate, Head and Neck
and Hepatocellular carcinoma.
• This is somewhat similar to the KEMRI estimates.
• According to this study, 80% of cancers occur in
those aged between 30 and 70. This is a
reflection of the KEMRI estimate that in the
Kenyan population over 60% of those affected
are under the age of 70.
• The median survival time is 7 months which is an
indication of late diagnosis.
20. CONCLUSION AND
RECCOMENDATIONS:
• There is need for setup of cancer care facilities
countrywide in order to increase the rates of
early diagnosis and subsequent treatment.
• A majority of the population remains unaware
of the disease and IEC materials should be
tailored to address the masses in a clear and
concise way.
• There is also a need to support research in the
field of cancer.