Enzymes are biological catalysts that speed up chemical reactions in living organisms. They are usually proteins that lower the activation energy of reactions and bring substrates together in the correct orientation. Enzymes work through specific active sites and are not consumed by reactions. They are affected by factors like temperature, pH, and substrate concentration. The lock and key and induced fit models describe how enzymes specifically interact with substrates. Enzymes have many uses in industries like food processing, brewing, paper production, and detergents.
Nucleophilic Substitution reaction (SN1 reaction)PRUTHVIRAJ K
Attack of nucleophile at a saturated carbon atom bearing substituent, known as leaving group results in Substitution reaction.
The group that is displaced (leaving group) carries its bonding electrons.
The new bond is formed between nucleophile and the carbon using the electrons supplied by the nucleophilic agent.
The compound on which substitution takes place is called “substrate.”
The substrate consists of two parts, alkyl group and leaving group.
Nucleophilic Substitution reaction (SN1 reaction)PRUTHVIRAJ K
Attack of nucleophile at a saturated carbon atom bearing substituent, known as leaving group results in Substitution reaction.
The group that is displaced (leaving group) carries its bonding electrons.
The new bond is formed between nucleophile and the carbon using the electrons supplied by the nucleophilic agent.
The compound on which substitution takes place is called “substrate.”
The substrate consists of two parts, alkyl group and leaving group.
intro of glycolysis there cycle and step - function-significance-defination-glucogenesis cycle-significance of gluconeogenesis-function of gluconeogenesis-conclusion
I hope You all like it. I hope It is very beneficial for you all. I really thought that you all get enough knowledge from this presentation. This presentation is about materials and their classifications. After you read this presentation you knowledge is not as before.
Introduction and defination
Classification
Reducing sugars
Non-reducing sugars
General properties
Common disaccharides
1) sucrose
Origin
Structure
Properties
Function
intro of glycolysis there cycle and step - function-significance-defination-glucogenesis cycle-significance of gluconeogenesis-function of gluconeogenesis-conclusion
I hope You all like it. I hope It is very beneficial for you all. I really thought that you all get enough knowledge from this presentation. This presentation is about materials and their classifications. After you read this presentation you knowledge is not as before.
Introduction and defination
Classification
Reducing sugars
Non-reducing sugars
General properties
Common disaccharides
1) sucrose
Origin
Structure
Properties
Function
International Conference on Infrastructure Needs For a Food Control System: Roadmap For Regional Harmonization” - organised by International Life Sciences Institute - India Chapter, 9 & 10 December, 2014 in Hotel Royal Plaza, New Delhi.
Food sanitation
Food sanitation
It included all practices involved in protecting food from risk of contamination, harmful bacteria, poisons and foreign bodies, preventing any bacteria from multiplying to an extent which would result in an illness of consumers; and destroying any harmful bacteria in the food by thorough cooking or processing.
The primary tenet of food-service sanitation is absolute cleanliness
It begins with personal hygiene, the safe handling of foods during preparation, and clean utensils, equipment, appliances, storage facilities, kitchen and dining room.
Definition of terms
Food – Any substance whether simple, mixed or compounded that is used as food, drink, confectionery or condiments.
Safety – is overall quality of food fit for consumption.
Sanitation – is a health of being clean and conducive to health.
Cleanliness – is the absence of visible soil or dirt and is not necessarily sanitized.
Microbiology - the branch of biology that deals with microorganisms and their effect on other microorganisms.
Microorganisms - organism of microscopic or submicroscopic
Food Infection - microbial infection resulting from ingestion of contaminated foods.
Food Intoxication - type of illness caused by toxins. Under favorable condition certain bacteria produce chemical compounds called toxins
Food Spoilage - means the original nutritional value, texture, flavor of the food are damaged, the food become harmful to people and unsuitable to eat.
Foodborne Illness – A disease carried or transmitted to people by food.
Food Safety : A Top Priority
Food safety is the responsibility in every person who is involve in food service. Serving safe food is the top priority for every food service employee.
Dangers of food borne illness
Individual – Food borne illness are the greatest danger to food safety. It could result to illness or diseases to an individual that would affect their overall health, work and personal lives.
Loss of family income
Increased insurance
Medical expenses
Cost of special dietary needs
Loss of productivity, leisure and travel opportunities
Death or funeral expense
Establishment – Food borne illness outbreak can cost an establishment thousands of pesos, it can even be the reason an establishment is forced to closed.
Loss of customers and sales
Loss of prestige and reputation
Lawsuits
Increase insurance premiums
Lowered employee morale
Employee absenteeism
Increase employee turn over
Embarrassment
Types of Food Contaminants
Biological Contaminants
Physical Contaminants
Chemical Contaminant
Biological Contaminant – A microbial contaminant that may cause a food borne illness (bacteria, viruses, fungi, parasites, biological toxins)
Examples:
Sea food toxins
Mushroom toxins
Clostridium Botulinum
Salmonella bacteria
Preventing Bio
This presentation explains about the concept of food intoxication. The toxins produced by the microbes in food (fungal) and toxins present in the food stuff were provided. The information about the diseases caused by such toxins were disclosed.
GEN1301 S-A ASSIGNMENT 1 (20224316 MATOETOE MAMELLO).pptxMamelloMatoetoe1
This is grade 10 biology . Where i presented about enzymes.
definition of enzymes
examples of enzymes
classification of enzymes
structure of enzymes
factors affecting the enzyme activity
mechanism of enzymes
cofactors
the optimum conditions
active site and the substrate
Properties of Enzymes
Describes what they are, how they work
etc...
This presentation belongs to my Biology Teacher, I found this helpful and thought might help others..
so no copyright intended.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
2. ENZYMES
Enzymes are biological catalysts, mainly
proteins, generated by an organism to speed up
chemical reactions.
They can be described as any of several complex
proteins that are produced by cells and act as
catalysts in specific biochemical reactions.
Biological catalysts are those catalysts which are
found in living organisms and they speed up the
metabolic reactions occurring in them.
3. HISTORY OF ENZYMES
Around late 17th and early 18th centuries, the
digestion of meat by stomach secretions and the
conversion of starch to sugars by plant extracts and
saliva were known. However, the mechanism by which
this occurred had not been identified.
In 1833, French chemist Anselme Payen discovered
the first enzyme, diastase.
In 1877, German physiologist Wilhelm Kühne first
used the term enzyme, which is Greek for "in
leaven", to describe this process. It was later used to
refer to nonliving substances, such as pepsin.
5. CATALYSTS
A substance that lowers activation energy of a
reaction so the reaction occurs more quickly but, in
the end, is NOT used up by the reaction is called a
catalyst.
6. ACTIVATION ENERGY
To start any chemical reaction, energy is required.
The minimum amount of energy required to start a
reaction is known as it activation energy.
Activation Energy can be defined as the energy that
must be added to cause molecules to react with one
another.
7.
8. METABOLISM
Metabolism can be described as a set of biochemical
reactions on which the entire life of living organisms
depend.
METABOLISM= Anabolism + Catabolism
CATABOLISM: biochemical reactions in which
larger molecules are broken down.
ANABOLISM: biochemical reactions in which larger
molecules are synthesized.
9. This proves that biochemical reactions
are actually energy transfers.
Catabolism
Energy is
released
Energy is
gained
Anabolism
10. Importance of Metabolism:
Metabolism is very essential for carrying out all the life
processes as a disturbed metabolic system can result in
severe diseases and retardation.
11. EXTRACELLULAR AND INTRA
CELLULAR ENZYMES
Extracellular Enzymes:
Enzymes that are produced inside cells but work
outside them.
Intracellular Enzymes:
Enzymes that work inside the cells.
12. WHAT DO ENZYMES DO?
Some of the ways in which enzymes react are:
Lowering the activation energy by creating suitable
environment.
Bringing substrates together in the correct
orientation to react.
It forms ES complex for a while during the reactions.
13.
14. CHARACTERISTICS OF ENZYMES
1. Structure
Enzymes are globular complex protein structures
made up of long linear chains of amino acid ranging
from just 62 amino acid residues in size to over
2,500 residues.
Most enzymes are much larger than the substrates
they act on.
15. 2. Reactions
Unlike most catalysts enzymes are NOT consumed by the
reactions they catalyze.
During reactions only a small area is directly involved.
This area is called active site.
• It is the region where the substrate is recognized and then bound for
the reaction.
Active Site
• An enzyme substrate is the material upon which an enzyme acts.
Substrate
• A product is something "manufactured" by an enzyme from its
substrate.
Product
16. 3. Cofactors
There are some enzymes that need additional non
protein molecules/ions called cofactors. Cofactors
can be considered "helper molecules" that assist in
biochemical transformations.
Cofactor
Organic
Prosthetic Group:
tightly packed
Coenzyme: loosely
attached
Inorganic
18. 4. Metabolic Pathways
When enzymes work together metabolic pathways
are formed. In metabolic pathways a chain or path of
reactions is formed.
19. 5. Inhibitors
Inhibitors are molecules that decrease enzyme activity.
Many drugs and poisons are enzyme inhibitors.
20. Some types of inhibitors are given here:
Competitive :Substrate and inhibitor compete for
the enzyme.
Uncompetitive :The inhibitor cannot bind to the free
enzyme, only to the ES-complex.
Non-competitive : can bind to the enzyme at the
binding site at the same time as the substrate, but not
to the active site.
22. WHAT FACTORS AFFECT ENZYMES?
Enzymes are specific about the working conditions
they are provided.
Changes in the working conditions can change the type
of enzyme, its active site or its speed.
Some of the factors affecting enzyme activity are
discussed here:
1. Temperature
2. pH
3. Substrate Concentration
23. 1. Temperature
Every enzyme works at its best when given a specific
temperature. This temperature is called the
optimum temperature of that enzyme.
The optimum temperature of human enzyme is
37°C.
Reactions are accelerated when the temperature
rises to a certain limit .But when this limit is crossed
denaturation of enzymes takes place.
24. 2. pH
Optimum pH is the range of pH at which enzymes
work best.
A slight change in this optimum pH causes:
i).retardation in enzyme activity.
ii).blockage of enzymes.
iii).ionization of amino acids at the active sites.
25. 3. Substrate Concentration
If enzyme molecules are available in a
reaction, increase in substrate concentration causes
increase in the rate of reaction.
If the ratio of enzymes is less than the ratio of
substrates then the enzymes enter a state called
saturation of active sites.
26. HOW ENZYMES REACT?
Lock and Key Model:
The enzyme and substrate are specific to each other.
The active site of an enzyme fits together with a
substrate like a lock and key. The key is the substrate
and the lock is the enzyme.
27. Induced Fit Model:
The enzyme is induced to undergo a slight alteration
in order to fit with the substrate perfectly.
28. USES OF ENZYMES IN DAILY LIFE
Enzymes are produced in living organisms by cells but
the enzymes used for commercial purposes are
synthetic and made in industries.
Enzymes are used in:
1. Bread production.
2. Fermentation.
3. Paper production.
4. Production of cleaning products (detergent etc.)
29. Some Enzymes And Their Applications
APPLICATION ENZYMES USED
Food processing Amylase,Protease
Baby food Trypsin
Brewing industry Amylase,Protease
Fruit juices Cellulase,Pectinases
Dairy industry Lipases,Lactases
Paper industry Amylase,Ligninase,
Xylanases,Cellulases
Biological detergent Amylase,Lipase,Cellulases
Rubber industry Catalase
Photographic industry Protease