Enzymes are globular proteins that regulate and speed up metabolic reactions in cells. They lower the activation energy needed for reactions to occur at normal body temperatures. Enzymes have an active site that binds specifically to substrates, catalyzing their conversion to products. The substrate fits into the active site like a key in a lock (lock-and-key model), though the induced fit model suggests the active site changes shape to better accommodate the substrate. The rate of enzyme-catalyzed reactions depends on factors like temperature, pH, enzyme and substrate concentrations - each enzyme works best within a specific range of conditions.
Enzymes are biological catalysts. They play some of the most important roles in the processes of life sustenance. They are presence even at the tiniest level of metabolism - acting as the lubricant for life to progress smoothly. Without enzymes, complex life would not be possible.
activation energy of biological systemKAUSHAL SAHU
SOME GENERAL TERM
FREE ENERGY
ENDERGONIC REACTION
EXERGONIC REACTION
ACTIVATION ENERGY
DEFINITION
TRANSITION STATE
WHERE DOES ACTIVATION ENERGY COME FROM?
DETERMINING THE ACTIVATION ENERGY THROUGH ARREHINIUS EQUATION
EFFECTS OF TEMPERATURE ON ACTIVATION ENERGY
NEGATIVE ACTIVATION ENERGY
EFFECTS OF ENZYMES ON ACTIVATION ENERGY
CONCLUSION
REFERENCES
Enzymes are biological catalysts. They play some of the most important roles in the processes of life sustenance. They are presence even at the tiniest level of metabolism - acting as the lubricant for life to progress smoothly. Without enzymes, complex life would not be possible.
activation energy of biological systemKAUSHAL SAHU
SOME GENERAL TERM
FREE ENERGY
ENDERGONIC REACTION
EXERGONIC REACTION
ACTIVATION ENERGY
DEFINITION
TRANSITION STATE
WHERE DOES ACTIVATION ENERGY COME FROM?
DETERMINING THE ACTIVATION ENERGY THROUGH ARREHINIUS EQUATION
EFFECTS OF TEMPERATURE ON ACTIVATION ENERGY
NEGATIVE ACTIVATION ENERGY
EFFECTS OF ENZYMES ON ACTIVATION ENERGY
CONCLUSION
REFERENCES
Normally the immune system plays an important role in protecting the body from microorganisms and other foreign substances. If the activity of the immune system is excessive or overreactive, a hypersensitivity reaction develops. The consequences of a hypersensitivity reaction may be injury to the body or death.
Immunity is defined as the capacity of the body to resist pathogenic agents.
It is the ability of body to resist the entry of different types of foreign bodies like bacteria, virus, toxic substances, etc.
Normally the immune system plays an important role in protecting the body from microorganisms and other foreign substances. If the activity of the immune system is excessive or overreactive, a hypersensitivity reaction develops. The consequences of a hypersensitivity reaction may be injury to the body or death.
Immunity is defined as the capacity of the body to resist pathogenic agents.
It is the ability of body to resist the entry of different types of foreign bodies like bacteria, virus, toxic substances, etc.
Enzymes are dynamic proteins that accelerate biochemical reactions.
Each enzyme acts on a specific reactant, the substrate.
Enzymes are characterized by greater activity, specificity and susceptibility to the influence of pH, temperature and other environmental changes.
Enzymes act in the presence of non-peptide cofactors or coenzymes.
An enzyme lacking its cofactor is called apoenzyme and the active enzyme with its co-factor, the holoenzyme.
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
Safalta Digital marketing institute in Noida, provide complete applications that encompass a huge range of virtual advertising and marketing additives, which includes search engine optimization, virtual communication advertising, pay-per-click on marketing, content material advertising, internet analytics, and greater. These university courses are designed for students who possess a comprehensive understanding of virtual marketing strategies and attributes.Safalta Digital Marketing Institute in Noida is a first choice for young individuals or students who are looking to start their careers in the field of digital advertising. The institute gives specialized courses designed and certification.
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Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...Dr. Vinod Kumar Kanvaria
Exploiting Artificial Intelligence for Empowering Researchers and Faculty,
International FDP on Fundamentals of Research in Social Sciences
at Integral University, Lucknow, 06.06.2024
By Dr. Vinod Kumar Kanvaria
2. What are Enzymes?
The chemical reactions that take place inside an organism, i.e. its’
metabolism, must be controlled. The rate of these metabolic
reactions is controlled by enzymes.
Enzymes are globular proteins (3-D spherical shape). They are usually
named by adding the suffix –ase to the name of the substrate it
helps metabolise.
E.g. Maltase – helps break down the disaccharide maltose
Lactase – helps break down the disaccharide lactose
Amylase – helps break down the polysaccharide starch (amylose)
• Enzymes regulate the metabolic processes that occur in cells
• They are catalysts, they speed up reactions and are not used
up themselves in the reaction
• The energy needed to start a reaction is the ACTIVATION
ENERGY
• Enzymes lower the activation energy, so reactions can take
place at acceptable temperatures in living organisms
3. Activation Energy
Activation energy is the amount of energy required to
start off a chemical reaction, where the reactant(s)
are turned into product(s).
The reaction will not occur unless ‘extra energy’ is
given temporarily to the molecules:
WITH ENZYME – when a WITHOUT ENZYME –
substrate binds to an to change into a product the
Potential Energy
Potential Energy
enzyme, the ActivationActivation
(of molecules)
energy of the substrate must
(of molecules)
Energy Activation
Energy is lowered because be briefly raised by an
Energy
they split the reaction into amount Substrate(s)as the
known
Substrate
Substrate(s) Substrate
smaller stages Activation Energy
Product(s) Product(s)
Time Time
http://www.sumanasinc.com/webcontent/animation
5. How Enzymes Work
Enzymes are globular proteins, coiled into a precise 3-D shape,
with hydrophilic side chains on the outer parts of the molecule
(making them soluble).
Enzymes have a special feature called an active site, where a
substrate molecule(s) bind to, forming an ‘enzyme-substrate
complex’. The substrate is then converted to product(s).
Substrate (has
complimentary Product
shape)
Enzyme
Active
Site
Here side-chains of
amino acids in the active
site temporarily bind with
the substrate
Enzyme-substrate
Enzyme + Substrate Enzyme + Product(s)
Complex
6. Hypotheses
This leaves the active site unchanged and ready to bind
with another substrate molecule.
This was traditionally called the ‘Lock and Key’
hypothesis because the substrate fits into a rigid
active site like a key into a lock.
This explains why enzymes are very specific (the
substrate must fit the active site exactly to be
catalysed).
However this theory has since been developed into the
‘Induced Fit’ hypothesis. Here the active site is
believed to change shape slightly so that the enzyme
moulds itself around the substrate. (See fig 3, p.43)
Now answer Qu.2 from p.43 in your book)
http://www.sumanasinc.com/webcontent/animations/content/enzymes/enzymes.html
10. What factors affect enzymes?
The rate of an enzyme-controlled reaction is affected by
several factors:
temperature
pH
enzyme concentration
(you must know in detail!)
substrate concentration.
Each enzyme works best within a
range of conditions, and this range is
different for each enzyme.
Enzymes are also affected by the
presence of inhibitors.
Boardworks AS Biology Enzymes Teacher notes This reaction involves the breakdown of a single substrate molecule into two product molecules, so it is an example of a catabolic reaction.
Boardworks AS Biology Enzymes Teacher notes As the enzyme and substrate bind, it is possible that bonds in the substrate become stretched or strained, stabilizing the transition state of the substrate, which lowers the activation energy and enables bonds to be broken more easily. This reaction involves the breakdown of a single substrate molecule into two product molecules, so it is an example of a catabolic reaction.
Boardworks AS Biology Enzymes
Boardworks AS Biology Enzymes Photo credit: New Brunswick Scientific A BioFlo ™ Pro fermentor from New Brunswick Scientific, Edison NJ, USA. www.nbsc.com Teacher notes A fermentor, such as the one in the image, is a vital piece of equipment in the industrial use of enzymes as it makes it relatively easy to monitor and maintain optimum conditions.
Boardworks AS Biology Enzymes
Boardworks AS Biology Enzymes
Boardworks AS Biology Enzymes Teacher notes Students could be asked if they can deduce the equation for calculating the Q 10 of this reaction based on the data from this graph. Q 10 = rate of reaction at x + 10 ° C / rate of reaction at x ° C