In this webinar we introduce you to the workflows supported by Embase, describe the benefits of Embase content and coverage and show you how you may utilize deep drug indexing to pinpoint and track biomedical information.
NATIONAL WORKSHOP ON RESEARCH METHODOLOGY, STATISTICAL
ANALYSIS AND STRESS MANAGEMENT
Organized by: - Panjab University Campus Students Council (PUCSC) in Collaboration With
Centre for Public Health, Panjab University, Chandigarh
Scopus is Elsevier’s abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences, and health sciences
Learn how to search on PubMed: basic module
- What is PubMed?
- Before starting your search
- Search operators
- What are MeSH descriptors?
- What is the methodology for an efficient search?
- Search strategy using MeSH
- Search results
- Sending results
- Using limiters (filters)
- Viewing articles
- Exercises
- Other tools
Web of Science and Scopus: Understanding the indexing systemDr. Sharad Chand
In this article, Ii is explained about the Web of Science and Scopus indexing databases and their quality measures. This provides a basic insight into the selection of a good quality journal for publications.
Embase: Tips and tricks for trainers - 27 Feb 2013Ann-Marie Roche
In this webinar, Ann-Marie reviewed the following:
- How to demonstrate value in Embase
- How to scope out and build searches
- Where to find tools and materials for training.
Embase - Answers to your biomedical answers webinar - 27 Sept 2012Ann-Marie Roche
Our webinar was aimed at all biomedical researchers with a need to search biomedical literature and we focused on how content, indexing and specific search tools help you to find relevant answers.
NATIONAL WORKSHOP ON RESEARCH METHODOLOGY, STATISTICAL
ANALYSIS AND STRESS MANAGEMENT
Organized by: - Panjab University Campus Students Council (PUCSC) in Collaboration With
Centre for Public Health, Panjab University, Chandigarh
Scopus is Elsevier’s abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences, and health sciences
Learn how to search on PubMed: basic module
- What is PubMed?
- Before starting your search
- Search operators
- What are MeSH descriptors?
- What is the methodology for an efficient search?
- Search strategy using MeSH
- Search results
- Sending results
- Using limiters (filters)
- Viewing articles
- Exercises
- Other tools
Web of Science and Scopus: Understanding the indexing systemDr. Sharad Chand
In this article, Ii is explained about the Web of Science and Scopus indexing databases and their quality measures. This provides a basic insight into the selection of a good quality journal for publications.
Embase: Tips and tricks for trainers - 27 Feb 2013Ann-Marie Roche
In this webinar, Ann-Marie reviewed the following:
- How to demonstrate value in Embase
- How to scope out and build searches
- Where to find tools and materials for training.
Embase - Answers to your biomedical answers webinar - 27 Sept 2012Ann-Marie Roche
Our webinar was aimed at all biomedical researchers with a need to search biomedical literature and we focused on how content, indexing and specific search tools help you to find relevant answers.
Embase is an online biomedical information source and our free 45-min Embase webinar introduces:
• The basics of searching in Embase, including the different content sources, indexing and retrieval tools.
• Setting up email alerts and saving your searches.
Embase webinar: An introduction - 20 June 2012Ann-Marie Roche
During our 45-min webinar (including time for questions), our Embase expert, Ann-Marie Roche introduced:
• The basics of searching in Embase, including the different content sources, indexing and retrieval tools.
• Setting up email alerts and saving your searches.
In this webinar we introduce you to the workflows supported by Embase, describe the benefits of Embase content and coverage and show you how you may utilize deep drug indexing to pinpoint and track biomedical information.
Learn how to use Embase for all your biomedical searches
• Which workflows are supported by Embase and why
• An overview of content and indexing compared to Medline
• A demo in Embase of some introductory searches
• Answers to the most frequently asked questions by new users
• Where to find materials to support trainers
Embase – Building search strategies 21 March 2012Ann-Marie Roche
This free 45-min webinar (including time for questions) was presented by our Embase expert, Ann-Marie Roche and covered how to:
- Best utilise the Emtree thesaurus to investigate and find the best terms for your search.
- Search in specific fields and use filters for precise retrieval
- Use wildcards and operators when free-text searching.
Embase: Systematic searching in 10 mins at MLA 2012Ann-Marie Roche
It is a daunting task to try and explain the value of Embase and all its features in only 10 minutes, but our Product Manager, Daan De Jong, rose to the challenge and in case you missed any of his sessions, we’d like to share them with you. This one focuses on carrying out systematic searches in Embase.
Learn how to use Embase for all your biomedical searches.
- Which workflows are supported by Embase and why
- An overview of content and indexing compared to Medline
- A demo in Embase of some introductory searches
- Answers to the most frequently asked questions by new users
- Where to find materials to support trainers
Embase - Supporting Evidence Based Medicine - Webinar 24 Oct 2012Ann-Marie Roche
During this webinar, Ian Crowlesmith, our Embase expert:
- Outlined recent changes in Embase which you can use to identify medical evidence that is difficult to find elsewhere.
- Demonstrated Embase tools which help to search with greater precision, and support the preparation of Systematic Reviews.
- Evidence in therapy, diagnosis, prognosis and prevention were also covered
Embase is an online information source, combining Embase and MEDLINE, of published biomedical literature. Its unique and comprehensive journal and conference coverage and deep drug indexing, supports comprehensive biomedical searches. These slides are part of a webinar program: http://trainingdesk.elsevier.com/events/calendar.
How predictive models help Medicinal Chemists design better drugs_webinarAnn-Marie Roche
All scientific disciplines, including medicinal chemistry, are experiencing a revolution in unprecedented rates of data being generated and the subsequent analysis and exploitation of this data is increasingly fundamental to innovation. Using data to design better compounds is a challenge for Medicinal and Computational chemists.
The design of small-molecule drug candidates, encompassing characteristics such as potency, selectivity and ADMET (absorption, distribution, metabolism, excretion and toxicity) is a key factor in the success of clinical trials and computer-aided drug discovery/design methods have played a major role in the development of therapeutically important small molecules for over three decades. These methods are broadly classified as either structure-based or ligand-based.
In this webinar our expert Dr. Olivier Barberan will discuss ligand-based methods and he will cover the following:
How to use only ligand information to predict activity depending on its similarity/dissimilarity to previously known active ligands.
- Discuss ligand-based pharmacophores, molecular descriptors, and quantitative structure-activity relationships and important tools such as target/ligand databases necessary for successful implementation of various computer-aided drug discovery/design methods in a drug discovery campaign.
Webinar: New RMC - Your lead_optimization Solution June082017Ann-Marie Roche
The drug discovery landscape is rapidly changing and drives the need to generate leads with lower attrition rates.
In this webinar, our expert Dr. Olivier Barberan discussed how NEW Reaxys Medicinal chemistry in NEW Reaxys allows better discovery and exploration of structure activity relationship and also supports a more efficient property-based drug design approach. He covered the following:
• How has RMC being transformed into a more accessible tool for all users, allowing complex searches and workflows to be easily carried out.
• A demonstration of how more than ever RMC is the only lead-optimization solution you will need.
Oil&Gas Thought Leader Webinar - New Plays for Old Ideas - Dr.Gabor TariAnn-Marie Roche
In our April 2017 webinar, three industry experts shared their research and demonstrated the importance of focusing on fundamental geologic and geophysical research approaches that integrate variety of data, information and concepts from disparate sources and related disciplines.
This back-to-fundamentals research can both inspire and accelerate exploration teams’ thinking about petroleum systems and lead to a path to success.
Dr Gabor Tari is currently the Group Chief Geologist at OMV. He has over 20 years’ experience working in upstream oil & gas and has worked for Amoco, BP, and Vanco, before joining OMV in 2007. Gabor has worked on exploration projects in basins around the globe, including Romania, Angola, North Africa, and the Middle East. He has authored over 50 scientific publications, presented papers at dozens of conferences, and most recently co-authored the book Permo-Triassic Salt Provinces of Europe, North Africa and the Atlantic Margins, with Dr Joan Flinch (Repsol) and Juan Soto, Professor of Geodynamics in the Granada University and in the Instituto Andaluz de Ciencias de la Tierra, Spain, which is currently available from Elsevier for pre-order online.
Gabor discussed and shared some examples of how new plays can be built on a solid foundation of petroleum system development and research, and how new ideas can be garnered from building on published research of oil & gas companies, academia, service providers and consultants.
Oil&Gas Thought-Leader Webinar - New Plays for Old Ideas - Dr. Rob ForknerAnn-Marie Roche
In our April 2017 webinar, three industry experts shared their research and demonstrated the importance of focusing on fundamental geologic and geophysical research approaches that integrate variety of data, information and concepts from disparate sources and related disciplines. This back-to-fundamentals research can both inspire and accelerate exploration teams’ thinking about petroleum systems and lead to a path to success.
Dr Rob Forkner is a carbonate geologist at Statoil, working in the carbonate plays and reservoirs research group in Austin, Texas, focusing on carbonate play prediction in Atlantic margin systems. Prior to Statoil, Rob worked at Maersk and Shell in onshore and offshore in well planning, geosteering, high-resolution sequence stratigraphy and facies prediction, carbonate sedimentology in unconventional assets, evaporite classification and prediction, rock typing, and more recently, carbonate system suppression and recovery during Oceanic Anoxic Events.
Oil&Gas Thought-Leader Webinar - New Plays for Old Ideas - Dr. Sander HoubenAnn-Marie Roche
In our April 2017 webinar, three industry experts shared their research and demonstrated the importance of focusing on fundamental geologic and geophysical research approaches that integrate variety of data, information and concepts from disparate sources and related disciplines.
This back-to-fundamentals research can both inspire and accelerate exploration teams’ thinking about petroleum systems and lead to a path to success.
Dr. Sander Houben is a biostratrapher and researcher within the Basin Analysis team at TNO, Netherlands Organisation for Applied Scientific Research, and the leading research institute for applied sciences in the Netherlands. As part of the Basin Analysis Team, Sander provides scientific and technical expertise regarding stratigraphic and paleo-environmental constraints for multidisciplinary projects. In addition to conducting research, he leads TNO’s biostratigraphic consultancy research programs.
Embase for pharmacovigilance: Search and validation March 22 2017Ann-Marie Roche
Scientific literature plays a critical role in Pharmacovigilance and Drug Safety workflows. Monitoring literature for mentions of adverse drug reactions (ADRs) is mandated by regulatory bodies, and marketing authorization holders (MAHs) that do not properly report ADRs can be subject to heavy fines. With an increasing volume of unstructured content to cover, along with rising labor costs, MAHs are looking for ways to make their literature monitoring more effective and efficient.
Abstract and indexing (A&I) databases play an important role in Literature Monitoring – due to the vast amount of scientific literature published daily – in order for MAH’s to locate specific articles or conference presentations that may be relevant for their products (for both benefit/risk analysis and ADR detection). Rather than reading all the literature, MAH’s create search strategies that identify the relevant records in A&I databases and execute the searches regularly. GVP module VI mandates that searches are done at least weekly, but many companies maintain a daily monitoring and review cycle.
In this webinar, Senior Product Development Manager Embase, Dr. Ivan Krstic discussed best practices for saving time, staying current, validating search strategies and mitigating risk in the face of these increasingly complex processes in literature monitoring
Literature Management for Pharmacovigilance: Outsource or in-house solution? ...Ann-Marie Roche
Pharmaceutical companies are required to screen scientific literature on a regular basis and this comes with many challenges, such as handling large amounts of data, building search strings and integrating EMA MLM results. Out-sourcing literature screening to service providers reduces the workload for the PV-team, but how does it impact the literature management process overall? Maybe it results in decreased oversight and additional activities like audits and reconciliation? And what about building the search strategy?
During this webinar our PV expert, Dr. Joyce De Langen spoke about the following:
• The importance of literature management in Pharmacovigilance and the challenges.
• An evaluation of the benefits and risks of outsourcing literature management versus alternative solutions.
About the speaker:
Joyce de Langen, Ph.D has more than 10 years of experience in the domain of pharmacovigilance and drug safety. Through her work in the pharmaceutical industry, academia and regulatory authorities, Joyce has developed a broad perspective and knowledge in pharmacovigilance and drug safety.
The All-New 2016 Engineering Academic Challenge - developed by students for students
The Engineering Academic Challenge (formerly as the Knovel Academic Challenge) is an immersive, 5-week interactive problem-set competition, featuring weekly thematic engineering challenges built around five transdisciplinary themes inspired by the National Academy of Engineering Grand Challenges.
3. Need to know
• Webinar control panel:
o‘chat’ or ‘ask a question’ for questions
and comments
o Option for full screen view
• Q&A at the end
4. Our value story
With over 24 million indexed records and more than 7,600 currently indexed peer-
reviewed journals, Embase is a highly versatile, multipurpose and up-to-date database
covering the most important international biomedical literature from 1947 to the present
day.
Core strengths of Embase include coverage and in-depth indexing of the drug-related
and clinical literature, with a particular focus on comprehensive indexing of adverse
drug reactions; emphasis on Evidence Based Medicine (EBM) indexing including
systematic reviews, and coverage and indexing of journals and articles relevant to the
development and use of medical devices.
If you are searching for answers to your questions or simply need reliable, peer-
reviewed information on topics such as drug development or use, toxicology, drug
safety / adverse drug reactions, clinical trials, evidence based medicine, medical
devices, pharmacoeconomics, preclinical reports, basic biomedical science or
regulatory affairs, then Embase is the solution you are looking for.
5. How Embase delivers value…
...by including literature and information Conference Scientific In Press We make sure you don’t
resources in a timely manner proceedings Journals (unpublished) miss any
biomedical literature
...by reading full-text to identify
drugs, diseases, adverse
Deep indexing using own They only close
alternative is reading
affects, clinical trials, drug trade
names etc. taxonomy all the articles
...by enabling advanced search filters to
drill down a comprehensive search to a
relevant and manageable record set
Very powerful Good precision and
recall balance
Search
Environment
...by allowing users to automate searching Automation and
and result management documentation
E-mail Alerting API Interoperability
5
6. How Embase delivers value…
Information overload Currency & Completeness Dispersed Information
With a growing universe of scientific Information that can have impact on the future Information resources are dispersed across
information, consumers have a hard time of a research project, development pipeline or different platforms, thus requiring multiple
keeping up with the latest information and existing business is of high value. Getting that searches to be executed and build in multiple
determining the value and reliability of that information complete and in time is critical. query languages. The more platforms, the
information. Evidence Based Medicine is Pharma/ Device (co)vigilance is driven by more cumbersome to maintain and support.
driven by the need to cope with information the need to have timely insight into potential Tools that help consolidate and search
overload. adverse effects or new applications of a drug comprehensive files are in demand.
or device
How do we find the most valuable How do you make sure we capture How do you capture all the
information? the most current information? information effectively?
Research community Business community & regulators Information professionals
By doing systematic By setting up structural By trying to
reviews to searches and alerts to consolidate
identify, appraise, select monitor for drug or searching and
and synthesize all scientific device mentions storing on as few
information systems as possible
10. Content Overview
Emtree: Biomedical thesaurus, over 60k terms
1947 1950 1974 2009
Including
Embase: Fully indexed: Over 7,700 journals (including MEDLINE), 1950-
5.5M not
found in
MEDLINE: 2,500 journals unique to Embase, mapped to Embase MEDLINE
indexing, 1950- (including MEDLINE Classic)
Embase Classic: AIP and In Process:
Digitally scanned and Indexing added, from 2009
re-indexed, 1947-1973
Conference Abstracts:
Indexing added, from 2009
12. Deep indexing - Emtree
60K terms (>260,000 synonyms) and all MeSH
terms
29K drug and chemical terms
Updated 3 times a year (back-posting each time)
All drug generic names described by FDA
and EMA, all International Non-
Proprietary Names (INNs) described by
WHO from 2000.
What is mapping? Mapping means you retrieve the same results regardless of
which term you use e.g. Type II diabetes or non insulin dependant diabetes
mellitus.
13. Deep indexing - Emtree
14 study types, including NEW Diagnostic Test
Accuracy Study
78 drug and disease subheadings
15. Start searching…
Find the best terms for your search and
include synonyms automatically with
autocomplete in Quick Search
16. Click on Disease Filter for example, to see
which diseases are referenced with
Januvia, either as a therapeutic area or side
effect.
17. Conference Abstracts
• Coverage began in 2009.
• http://embase.com/info/wh
at-is-embase/coverage for
the up to date list of
conferences and number
of abstracts covered.
17
18. Registering in Embase
•Setting up email alerts
•Saving your searches
18 •Staying up to date
20. Case study
•A clinician is working on a systematic review for publication.
She needs to adhere to certain guidelines to ensure she has
conducted a through search of the literature.
http://www.youtube.com/watch?v=QzZbYMS1tQ4
Question
•Are there any risks associated with the administration of
antibiotics together with digoxin in a patient with congestive
heart failure who has contracted pneumonia?
24. 2 sets of results…Why are
the results so different and
does it matter…?
25. 23 synonyms as well as ‘antibacterial agent’ are
searched simultaneously as well as over 38 narrower
terms (including moxifloxacin).
No simultaneous searching of synonyms
or narrower terms= Only ‘antibacterial
agent’ is searched and this does not find
all the vital information
26. Found in your Embase results, not in your
non-indexed supported search...
27. 2 thesaurus assisted searches
but different results? Embase
has unique content ,such as
conference abstracts.
28. Found in your Embase search,
not in your MEDLINE search...
We are looking for digoxin AND ‘antibacterial agent’
but Medline does NOT index digoxin in this article.
30. Let’s take a look at Embase...
…by going to www.embase.com
31. Building and combining searches
• Use single quotes to capture a phrase ‘diabetes mellitus’
for example (not with Autocomplete in Quick Search)
• Break up your search into individual searches, such as a
drug search (in Drug Search form) and a disease search
(in Disease Search form) and combine your results in
Session Results
• Run your cursor over your search to Edit or copy to a
Search Form for guided editing.
• Truncation and operators, AND, OR, NOT, NEXT, NEAR
Refer to http://info.embase.com/helpfiles for more guidance
and links to materials such as the Quick User Guide.
32. Refining your search
• Quick and Advanced Limits on Advanced, Drug and
Disease Search forms
• Major Focus on all advanced forms – major drugs and
diseases retrieved
• Field limits under Advanced Search box to search in
specific fields such as article title, abstract, conference
name, drug name etc
• Drug and Disease Subheadings to limit to specific
concepts such as Adverse Drug Reaction, Drug
Comparison and Side Effect.
• Filters on Session Results page for specific diseases or
study types for example
Check out our training videos at
www.trainingdesk.elsevier.com/embase for more guidance.
33.
34. Thank you and see you next time
• Q&A will be sent to you by email and for more
information and questions please contact
bdtraining@elsevier.com
• Embase webinars occur on the 04th Wednesday
of every month and our next webinar Train the
trainer is aimed at trainers.
• Go to www.trainingdesk.elsevier.com/embase for
all training related materials
Please fill out the survey that
appears on your screen after
leaving the webinar.
Editor's Notes
MEDLINE you probably know and MEDLINE data is included in Embase, as well as unique Embase content, not found in MEDLINE. Will this additional content make a difference and most importantly lead you with more confidence to an answer? We will come back to this when in Embase later in the webinar.What about having the most up to date content when you carry out your search or including in regular email alerts? AiP/In Process and conference abstracts give you access to the most up to date research and we will show you how to integrate in your searches and email alerts later in the webinar. We now cover over 2.5K conferences with over 800K conference abstracts.
If your research is around Diabetes type II or non-insulin dependant Diabetes Mellitus as it is also known for example, then you need to include all published research but what if an author uses a different term to the one you used in your search? Emtree, our biomedical thesaurus automatically supports your search and will map your search terms so all synonyms are included in your search. Here you can see the enormous selection of terms available, over 60K with 29K being drug and chemical terms.Maybe not all synonyms are there yet? Emtree is updated 3 times a year so the chance of missing a term is considerably lower compared to databases which are updated once a year with new terms. Content is updated daily by the way, here we are talking about updating the thesaurus with new terms.
Here we see that studies directly related to levels of evidence used in evidence based medicine practice are included in Emtree, which means you can search for all RCTs indexed by our indexers, not just where they are mentioned or have to think of a sufficient search string to retrieve them. It is also possible to search for drugs and diseases within a specific context, such as drug combination, pharmacoeconomics, pharmaceutics, endogenous compound, disease management and epidemiology. Routes of drug administration may also be specifically searched for.
And now you have access to the biomedical literature and a huge selection of relevant index terms, how DO you find your answers?Quick Search allows easy and quick access to the best terms for your search...
And from the session results page, you can use the filters on the left of your results to further refine. Here you see the disease filter and we can see which diseases are referenced in our result set for Januvia, either as a therapeutic area or side effect.
Searching for specific types of content is also possible but using the field limits as seen here to search for conference name, conference date and conference location.You may also select conferences from the Publication Type limit or AiP. You will also notice AiP/In Process in Quick limits for even easier accessibility.
Don’t loose those important searches, register in Embase so you may save your searches or set up email alerts. Registering also means you receive all up to date information such as upcoming webinars.
ME: May I introduce Pierre. Pierre is a clinical liaison librarian, in the Information Services Biomedical Library, Center for Evidence-Based Research. They work with 3 main hospitals.Pierre, can you tell us more about your role and your main points of concern?PIERRE: It is many, for example, I instruct users in the use of library resources and management of information and I assist with literature searches on evidence-based practice issues, consulting with staff conducting systematic reviews with regards to search strategies. I serve as the primary library contact for many of the resources used by clinicians.My users are mainly involved in finding information from relevant and reliable sources regarding the effects of different forms of healthcare and they must be through when conducting this research and when publishing.ME: Are your users preparing articles for publication, particularly Systematic Review Articles. PIERRE: Yes and we hear more and more that journal editors and referees now stipulate that Embase searches are needed and authors publishing in the field of EBM, who need to follow Cochrane guidelines MUST conduct Embase searches. How can we best incorporate this into their workflow? Some users are still convinced that Medline is enough and some have even asked about Scopus. ME: Let’s have a look at the unique value Embase offers and also how easy it is to search with confidence!
We can now refer to the full text for more details, having already checked the relevance of the article to our clinical query , in Embase.
One of the major steps in conducting a systematic review is a comprehensive literature search. With Embase, all users, regardless of experience may enter the best term or terms to search, even on the Quick Search page. Entering the drug in a non-indexed database is possible but if you do not enter the generic name, there are no prompts in Scopus, used here as an example. A clinician trying to carry out a literature search alone, may know to use some of the commonly known terms for his search but maybe not all. Embase will help him/her select the term which automatically includes all the synonyms for that term.In Scopus, they are carrying out a free text search for januvia. I would like to point out that Scopus is an excellent all-science database with strengths in citation and author analysis for example but here we are looking at finding the best biomedical results and how indexing impacts your results.
Pubmed (MEDLINE) does allow thesaurus assistedsearching but here also we notice a difference in the number of results retrieved. Pubmed finds 132 results compared to 8,000 in Embase. We know there is unique content in Embase, the conference abstracts shown here for example,but there is also a difference in indexing focus and so Embase indexes more drugs, more deeply.
In Medline, this article although present in Medline is not indexed with digoxin and therefore our search for digoxin and antibacterial agents did not find this article. As we know already, it is found in Embase.
Antibiotic and digoxin with drug combinationANDCongestive heart failure with drug therapyAND PneumoniaSave this search – remove drug therapy from disease and rerun main searchNow in session results, remove drug comparison from drug sub-searches and note asterix (indicates which searches have been effected by a change to a related search)– now click on result number to update your search strategy.Compare the effectiveness of sitagliptin and saxagliptin in the treatment of type II diabetes mellitus (show this in Emtree)Go to Drug Search and type in sitagliptin and saxagliptin with drug comparison. Go to Emtree and show diabetes mellitus and then go to ‘type 2 diabetes mellitus’. Take this to Disease Search and combine with disease subheading ‘drug therapy’. Combine both searches.Show editing options. NOT [review]/limAdvanced combine on the Session Results: Last search above NOT saxagliptin search, for example #2 NOT #1.Quickly show Emtree to find suitable terms/subject headings and then using Drug Search to add subheadings.
Find disease management studies for Type II diabetesGo to Emtree and type in diabetes. Once you see the tree, select non-insulin dependant diabetes mellitus. Click on ‘take this to Disease search’. Point out ‘major focus’ option if users would like to limit their search to only records where the disease is of major importance and show on Disease Search form. Show quick and advanced limits.You can then add the subheading ‘disease management’. Check filters for drugs and study types.