This document provides an overview of searching PubMed, including:
I. PubMed searches the MEDLINE database and provides access to over 21 million records and abstracts indexed with Medical Subject Headings (MeSH).
II. MeSH terms standardize topics across articles and help retrieve related articles that use different terminology for the same concept.
III. Searching PubMed involves using keywords that are matched to MeSH terms, and filters can then focus results; searching for a term as a "MeSH Major Topic" limits to articles where it is a primary topic.
IV. Full text of articles can be accessed through setting preferences in a NCBI account, using the UST OneSearch database which includes Pub
Learn how to search on PubMed: basic module
- What is PubMed?
- Before starting your search
- Search operators
- What are MeSH descriptors?
- What is the methodology for an efficient search?
- Search strategy using MeSH
- Search results
- Sending results
- Using limiters (filters)
- Viewing articles
- Exercises
- Other tools
Learn how to search on PubMed: basic module
- What is PubMed?
- Before starting your search
- Search operators
- What are MeSH descriptors?
- What is the methodology for an efficient search?
- Search strategy using MeSH
- Search results
- Sending results
- Using limiters (filters)
- Viewing articles
- Exercises
- Other tools
How to do a Literature search for your research and scientific publication BhaskarBorgohain4
In the age of information boom it may be challenging task to find relevant information for your research work. its like finding a needle in a haystack. After initial readings from textbooks and library journals you may want to first search in Wikipedia, google, google scholar and then go to Pubmed, Medline, science direct , wileyonline, science.gov, cochrane library etc to formulate your keywords based on your research question. read a medical dictionary to find synonyms of the keywords and brainstorm with your supervisor, peers, friends etc to get more key words to search again and find the right search strategy. do not forget to look for Grey literature like unpublished Thesis works from reputed universities, proceedings of conferences of reputed professional associations as well. keep records using a software like end-note, Rayyan etc. References of authors must be recorded as you go along.
How to do a Literature search for your research and scientific publication BhaskarBorgohain4
In the age of information boom it may be challenging task to find relevant information for your research work. its like finding a needle in a haystack. After initial readings from textbooks and library journals you may want to first search in Wikipedia, google, google scholar and then go to Pubmed, Medline, science direct , wileyonline, science.gov, cochrane library etc to formulate your keywords based on your research question. read a medical dictionary to find synonyms of the keywords and brainstorm with your supervisor, peers, friends etc to get more key words to search again and find the right search strategy. do not forget to look for Grey literature like unpublished Thesis works from reputed universities, proceedings of conferences of reputed professional associations as well. keep records using a software like end-note, Rayyan etc. References of authors must be recorded as you go along.
The literature review usually precedes a research proposal and results section. Its goals are to situate the current study within the body of literature and to provide context for the particular reader. Literature reviews are important for research in nearly every academic field.
Evidence Based Medicine Master degree Course (Lecture 5) : How to search MEDL...Iman El Sayed
This lecture illustrates how to search PubMed using keywords, advanced search, clinical queries and MeSH terms. Also, different options are displayed to save, email, export to a citation manager and share hits.
Researchers could save search strategies either to a temporary storage (e.g. clipboard) or to a permanent storage (e.g. Collections and bibliography).
Finding scholarly nursing articles in databasesForsyth Library
This tutorial demonstrates how to find full-text, scholarly articles in a variety of nursing databases available to students, staff and faculty of Fort Hays State University.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
2. Goals
Through viewing this presentation, you will understand:
I. What PubMed searches
II. What MeSH is
III. The basics of searching PubMed
IV. Getting full text of articles
3. I. What is PubMed?
Searches MEDLINE, from U.S. National Library of
Medicine
Dates back to 1940s
Over 21 million bibliographic records and abstracts
Organized by MeSH, Medical Subject Headings
In addition to MEDLINE, PubMed searches ejournals,
ebooks, and more
Access in Databases list at library.stthom.edu
4. Goals
Through viewing this presentation and trying examples,
you will understand:
I. What PubMed searches
II. What MeSH is
III. The basics of searching PubMed
IV. Getting full text of articles
5. II. What is MeSH?
Medical Subject Headings
Lets you find MEDLINE articles on the same topic that
might use different words to describe that topic.
For example, the MeSH for heart attack is “myocardial
infarction.” Some articles on this topic use the phrase,
“heart attack,” but all articles on this topic in
MEDLINE have “myocardial infarction” as a MeSH
Subject Heading.
6. II. What is MeSH?
How do you use MeSH?
PubMed tries to automatically match your keywords
with the best MeSH terms
MeSH Major Topics are the most important topics
covered by a given article. In the article record, they
have an asterisk (*). You can search for any keyword as
a MeSH Major Topic using Advanced search.
Only MEDLINE articles have MeSH terms (i.e. not all
of PubMed)
7. Goals
Through viewing this presentation and trying examples,
you will understand:
I. What PubMed searches
II. What MeSH is
III. The basics of searching PubMed
IV. Getting full text of articles
8. III. How do I search PubMed?
This is the PubMed basic search page. As
a first step, click on the “Advanced”
search.
9. Enter terms into these “Builder” boxes on
the Advanced search page. The box above
shows your search string.
PubMed tries to match the terms you
enter with MeSH subject terms. Then
PubMed will search for both your term
and the MeSH subject term.
In this example, PubMed will search for
cholesterol AND either “heart attack” OR
the MeSH term, “myocardial infarction.”
10. This “Search details” box shows what key
terms PubMed actually used in its search.
In the results page, use the “Show
additional filters” and “more…” buttons
to show the full range of filters to help
focus your results.
11. Searching for “heart attack” as a “MeSH
Major Topic” means that all your results
will have “myocardial infarction” listed as
a major topic of the article, i.e. as what
the article is primarily about. “Myocardial
infarction” will have an asterisk next to it
in these article records’ subject lists.
Searching for a MeSH Major Topic limits
your results to articles already indexed by
MEDLINE.
12. III. How do I search PubMed?
In PubMed, you should keyword search just like other
databases, except:
PubMed matches your terms with MeSH.
Using quotation marks prevents MeSH matching (e.g.
“heart attack” will just search for “heart attack,” not
myocardial infarction.)
13. Goals
Through viewing this presentation and trying examples,
you will understand:
I. What PubMed searches
II. What MeSH is
III. The basics of searching PubMed
IV. Getting full text of articles
14. IV. How do I get full text of articles?
Here are three alternatives:
A. Go to askus.stthom.edu and type “pubmed” into
the question box. Use our tutorial to set up your
NCBI account preferences to connect you with our
full text.
B. Use UST OneSearch, on the library homepage. UST
OneSearch includes all PubMed content, showing
only our full-text resources by default. To access all
PubMed content, click “Search worldwide” on the
results page.
C. If these resources don’t work, use Interlibrary Loan.