This document provides instructions for searching the PubMed database. It begins by explaining what PubMed is and how it is developed by the National Library of Medicine. It then discusses important concepts for an effective search like search operators, MeSH descriptors, and methodology. Specific steps are outlined for constructing searches using MeSH terms and filters. Examples are provided to demonstrate searches on topics like nursing care in stroke, psychological aspects of obesity, and sinusitis treatment with amoxicillin.