This document discusses eicosanoids and their role in skin inflammation. Eicosanoids are lipid-derived autacoids primarily derived from arachidonic acid. In skin, prostaglandins like PGE2 and PGD2 are produced and regulate processes like wound healing and inflammation. Lipoxygenases produce compounds like 12-HETE that are pro-inflammatory. Eicosanoids are involved in inflammatory skin diseases like psoriasis, atopic dermatitis, and sunburn responses. Omega-3 fatty acids can reduce inflammation by altering eicosanoid production through competing as substrates.