Economies of synthesis
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This document discusses guidelines for efficient organic synthesis. It covers topics like atom economy, redox economy, cascade reactions, protecting groups, biomimetic synthesis, and lessons from natural products. The goal is to minimize waste and maximize the formation of carbon-carbon bonds in each step. Tactics include choosing reactions with 100% atom economy, reducing non-essential oxidation/reduction steps, exploiting the reactivity of functional groups, and incorporating tandem reactions to make multiple changes in one step.
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This document discusses various aspects of asymmetric synthesis, including stereochemical aspects, acyclic and cyclic stereoselection, and enantioselective synthesis. It defines terms like racemate, enantiopure, and enantiomer. It describes stereospecific and stereoselective reactions, and rules like Cram's rule and Prelog's rule that help explain stereoselection. It discusses strategies for stereoselective synthesis including additions to carbonyls and aldol reactions. It also covers topics like diastereoselective oxidations, catalytic hydrogenation, and enantioselective reductions using chiral reagents like (S)-PBMgCl and (R,R)-DIOP.
Sae 28.8.13
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Sandrogreco Lithium Diisopropylamide Solution Kinetics And
This document reviews the kinetics of reactions mediated by lithium diisopropylamide (LDA). It is organized into four sections. The first section provides an introduction and overview. The second section acts as a tutorial on solution kinetics, emphasizing how solvation and aggregation effects influence reaction rates. The third section summarizes substrate- and solvent-dependent reaction mechanisms, revealing principles of solvation and aggregation. The final section suggests how understanding mechanisms can be combined with empirical methods to optimize yields, rates, and selectivities of organolithium reactions.
Isome hoa pdf
The document studies the isomerization of desulfurized light Iraqi petroleum naphtha over two catalysts (Pt/HX and Pt/SrX) to produce high octane gasoline. It investigates the catalyst activity, selectivity, and deactivation rates. The key findings are:
1) The optimum isomerization temperature was found to be 270°C.
2) Pt/HX showed higher activity and selectivity than Pt/SrX. Both catalysts deactivated rapidly due to deposited carbon blocking pore mouths.
3) Only an average of 90% of carbon atoms in the naphtha feed were detected in the product stream due to coke deposits leading to catalyst deactivation.
MicelleFormation.pptx
The document discusses micelle formation from surfactants in water. Surfactants are amphiphilic molecules with both hydrophilic and hydrophobic parts that can self-assemble into micelles in aqueous solution above a critical concentration. The packing parameter concept predicts micelle shape based on the surfactant's geometry. Spherical, cylindrical, and bilayer structures are expected for different packing parameter ranges based on the surfactant head group size and tail volume. Micelle characteristics like size and critical concentration can be understood through thermodynamic models balancing hydrophobic effect, interfacial tension, and head group repulsion.
D07 abbrev arrhenius and catalysts_alg
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CHESC Methane Hydrate Poster
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Fragmentation rules mass spectroscopy
Thank you for the presentation on mass fragmentation and its rules. Mass spectrometry is a powerful analytical technique.
Novel composite electrodes:Preparation and application to the electroanalytic...
Novel composite electrodes:Preparation and application to the electroanalytic...Université de Dschang
M. Tchieno Melataguia Francis Merlin a soutenu une thèse de Doctorat/Phd en Chimie Inorganique ce 06 juin 2016 dans la salle des conférences de l'Université de Dschang. A l'issue de cette soutenance devant le jury présidé par le Prof. Emmanuel Ngameni lui a décerné la mention très honorable à l'unanimité de ses membres. Metathesis
This document discusses metathesis reactions and their applications in organic synthesis. It begins with definitions and examples of different types of metathesis reactions including alkene, alkyne, and enyne metathesis. It then covers the key catalysts used, such as Grubbs and Schrock catalysts, as well as the 2005 Nobel Prize awarded for the development of metathesis reactions. The document concludes by outlining several important applications of metathesis in synthesizing biologically active compounds and natural products.
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Sandrogreco Lithium Diisopropylamide Solution Kinetics And
Sandrogreco Lithium Diisopropylamide Solution Kinetics And
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Recently uploaded
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
Context. With a mass exceeding several 104 M⊙ and a rich and dense population of massive stars, supermassive young star clusters
represent the most massive star-forming environment that is dominated by the feedback from massive stars and gravitational interactions
among stars.
Aims. In this paper we present the Extended Westerlund 1 and 2 Open Clusters Survey (EWOCS) project, which aims to investigate
the influence of the starburst environment on the formation of stars and planets, and on the evolution of both low and high mass stars.
The primary targets of this project are Westerlund 1 and 2, the closest supermassive star clusters to the Sun.
Methods. The project is based primarily on recent observations conducted with the Chandra and JWST observatories. Specifically,
the Chandra survey of Westerlund 1 consists of 36 new ACIS-I observations, nearly co-pointed, for a total exposure time of 1 Msec.
Additionally, we included 8 archival Chandra/ACIS-S observations. This paper presents the resulting catalog of X-ray sources within
and around Westerlund 1. Sources were detected by combining various existing methods, and photon extraction and source validation
were carried out using the ACIS-Extract software.
Results. The EWOCS X-ray catalog comprises 5963 validated sources out of the 9420 initially provided to ACIS-Extract, reaching a
photon flux threshold of approximately 2 × 10−8 photons cm−2
s
−1
. The X-ray sources exhibit a highly concentrated spatial distribution,
with 1075 sources located within the central 1 arcmin. We have successfully detected X-ray emissions from 126 out of the 166 known
massive stars of the cluster, and we have collected over 71 000 photons from the magnetar CXO J164710.20-455217.
waterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
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Cytokines and their role in immune regulation.pptx
This presentation covers the content and information on "Cytokines " and their role in immune regulation .
在线办理(salfor毕业证书)索尔福德大学毕业证毕业完成信一模一样
学校原件一模一样【微信：741003700 】《(salfor毕业证书)索尔福德大学毕业证》【微信：741003700 】学位证，留信认证（真实可查，永久存档）原件一模一样纸张工艺/offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。
本公司拥有海外各大学样板无数，能完美还原。
1:1完美还原海外各大学毕业材料上的工艺：水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠。文字图案浮雕、激光镭射、紫外荧光、温感、复印防伪等防伪工艺。材料咨询办理、认证咨询办理请加学历顾问Q/微741003700
【主营项目】
一.毕业证【q微741003700】成绩单、使馆认证、教育部认证、雅思托福成绩单、学生卡等！
二.真实使馆公证(即留学回国人员证明,不成功不收费)
三.真实教育部学历学位认证（教育部存档！教育部留服网站永久可查）
四.办理各国各大学文凭(一对一专业服务,可全程监控跟踪进度)
如果您处于以下几种情况：
◇在校期间，因各种原因未能顺利毕业……拿不到官方毕业证【q/微741003700】
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◇回国时间很长，忘记办理；
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◇需要报考公务员、购买免税车、落转户口
◇申请留学生创业基金
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
bordetella pertussis.................................ppt
Bordettela is a gram negative cocobacilli spread by air born drop let
Authoring a personal GPT for your research and practice: How we created the Q...
Thematic analysis in qualitative research is a time-consuming and systematic task, typically done using teams. Team members must ground their activities on common understandings of the major concepts underlying the thematic analysis, and define criteria for its development. However, conceptual misunderstandings, equivocations, and lack of adherence to criteria are challenges to the quality and speed of this process. Given the distributed and uncertain nature of this process, we wondered if the tasks in thematic analysis could be supported by readily available artificial intelligence chatbots. Our early efforts point to potential benefits: not just saving time in the coding process but better adherence to criteria and grounding, by increasing triangulation between humans and artificial intelligence. This tutorial will provide a description and demonstration of the process we followed, as two academic researchers, to develop a custom ChatGPT to assist with qualitative coding in the thematic data analysis process of immersive learning accounts in a survey of the academic literature: QUAL-E Immersive Learning Thematic Analysis Helper. In the hands-on time, participants will try out QUAL-E and develop their ideas for their own qualitative coding ChatGPT. Participants that have the paid ChatGPT Plus subscription can create a draft of their assistants. The organizers will provide course materials and slide deck that participants will be able to utilize to continue development of their custom GPT. The paid subscription to ChatGPT Plus is not required to participate in this workshop, just for trying out personal GPTs during it.
Equivariant neural networks and representation theory
Or: Beyond linear.
Abstract: Equivariant neural networks are neural networks that incorporate symmetries. The nonlinear activation functions in these networks result in interesting nonlinear equivariant maps between simple representations, and motivate the key player of this talk: piecewise linear representation theory.
Disclaimer: No one is perfect, so please mind that there might be mistakes and typos.
dtubbenhauer@gmail.com
Corrected slides: dtubbenhauer.com/talks.html
如何办理(uvic毕业证书)维多利亚大学毕业证本科学位证书原版一模一样
原版纸张【微信：741003700 】【(uvic毕业证书)维多利亚大学毕业证】【微信：741003700 】学位证，留信认证（真实可查，永久存档）offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。
本公司拥有海外各大学样板无数，能完美还原海外各大学 Bachelor Diploma degree, Master Degree Diploma
1:1完美还原海外各大学毕业材料上的工艺：水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠。文字图案浮雕、激光镭射、紫外荧光、温感、复印防伪等防伪工艺。材料咨询办理、认证咨询办理请加学历顾问Q/微741003700
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
Bob Reedy - Nitrate in Texas Groundwater.pdf
Presented at June 6-7 Texas Alliance of Groundwater Districts Business Meeting
Deep Software Variability and Frictionless Reproducibility
Deep Software Variability and Frictionless ReproducibilityUniversity of Rennes, INSA Rennes, Inria/IRISA, CNRS
The ability to recreate computational results with minimal effort and actionable metrics provides a solid foundation for scientific research and software development. When people can replicate an analysis at the touch of a button using open-source software, open data, and methods to assess and compare proposals, it significantly eases verification of results, engagement with a diverse range of contributors, and progress. However, we have yet to fully achieve this; there are still many sociotechnical frictions.
Inspired by David Donoho's vision, this talk aims to revisit the three crucial pillars of frictionless reproducibility (data sharing, code sharing, and competitive challenges) with the perspective of deep software variability.
Our observation is that multiple layers — hardware, operating systems, third-party libraries, software versions, input data, compile-time options, and parameters — are subject to variability that exacerbates frictions but is also essential for achieving robust, generalizable results and fostering innovation. I will first review the literature, providing evidence of how the complex variability interactions across these layers affect qualitative and quantitative software properties, thereby complicating the reproduction and replication of scientific studies in various fields.
I will then present some software engineering and AI techniques that can support the strategic exploration of variability spaces. These include the use of abstractions and models (e.g., feature models), sampling strategies (e.g., uniform, random), cost-effective measurements (e.g., incremental build of software configurations), and dimensionality reduction methods (e.g., transfer learning, feature selection, software debloating).
I will finally argue that deep variability is both the problem and solution of frictionless reproducibility, calling the software science community to develop new methods and tools to manage variability and foster reproducibility in software systems.
Exposé invité Journées Nationales du GDR GPL 2024
The debris of the ‘last major merger’ is dynamically young
The Milky Way’s (MW) inner stellar halo contains an [Fe/H]-rich component with highly eccentric orbits, often referred to as the
‘last major merger.’ Hypotheses for the origin of this component include Gaia-Sausage/Enceladus (GSE), where the progenitor
collided with the MW proto-disc 8–11 Gyr ago, and the Virgo Radial Merger (VRM), where the progenitor collided with the
MW disc within the last 3 Gyr. These two scenarios make different predictions about observable structure in local phase space,
because the morphology of debris depends on how long it has had to phase mix. The recently identified phase-space folds in Gaia
DR3 have positive caustic velocities, making them fundamentally different than the phase-mixed chevrons found in simulations
at late times. Roughly 20 per cent of the stars in the prograde local stellar halo are associated with the observed caustics. Based
on a simple phase-mixing model, the observed number of caustics are consistent with a merger that occurred 1–2 Gyr ago.
We also compare the observed phase-space distribution to FIRE-2 Latte simulations of GSE-like mergers, using a quantitative
measurement of phase mixing (2D causticality). The observed local phase-space distribution best matches the simulated data
1–2 Gyr after collision, and certainly not later than 3 Gyr. This is further evidence that the progenitor of the ‘last major merger’
did not collide with the MW proto-disc at early times, as is thought for the GSE, but instead collided with the MW disc within
the last few Gyr, consistent with the body of work surrounding the VRM.
Compexometric titration/Chelatorphy titration/chelating titration
Classification
Metal ion ion indicators
Masking and demasking reagents
Estimation of Magnisium sulphate
Calcium gluconate
Complexometric Titration/ chelatometry titration/chelating titration, introduction, Types-
1.Direct Titration
2.Back Titration
3.Replacement Titration
4.Indirect Titration
Masking agent, Demasking agents
formation of complex
comparition between masking and demasking agents,
Indicators/Metal ion indicators/ Metallochromic indicators/pM indicators,
Visual Technique,PM indicators (metallochromic), Indicators of pH, Redox Indicators
Instrumental Techniques-Photometry
Potentiometry
Miscellaneous methods.
Complex titration with EDTA.
Micronuclei test.M.sc.zoology.fisheries.
Current Ms word generated power point presentation covers major details about the micronuclei test. It's significance and assays to conduct it. It is used to detect the micronuclei formation inside the cells of nearly every multicellular organism. It's formation takes place during chromosomal sepration at metaphase.
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...University of Maribor
Slides from talk:
Aleš Zamuda: Remote Sensing and Computational, Evolutionary, Supercomputing, and Intelligent Systems.
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Inter-Society Networking Panel GRSS/MTT-S/CIS Panel Session: Promoting Connection and Cooperation
https://www.etran.rs/2024/en/home-english/Unlocking the mysteries of reproduction: Exploring fecundity and gonadosomati...
The pygmy halfbeak Dermogenys colletei, is known for its viviparous nature, this presents an intriguing case of relatively low fecundity, raising questions about potential compensatory reproductive strategies employed by this species. Our study delves into the examination of fecundity and the Gonadosomatic Index (GSI) in the Pygmy Halfbeak, D. colletei (Meisner, 2001), an intriguing viviparous fish indigenous to Sarawak, Borneo. We hypothesize that the Pygmy halfbeak, D. colletei, may exhibit unique reproductive adaptations to offset its low fecundity, thus enhancing its survival and fitness. To address this, we conducted a comprehensive study utilizing 28 mature female specimens of D. colletei, carefully measuring fecundity and GSI to shed light on the reproductive adaptations of this species. Our findings reveal that D. colletei indeed exhibits low fecundity, with a mean of 16.76 ± 2.01, and a mean GSI of 12.83 ± 1.27, providing crucial insights into the reproductive mechanisms at play in this species. These results underscore the existence of unique reproductive strategies in D. colletei, enabling its adaptation and persistence in Borneo's diverse aquatic ecosystems, and call for further ecological research to elucidate these mechanisms. This study lends to a better understanding of viviparous fish in Borneo and contributes to the broader field of aquatic ecology, enhancing our knowledge of species adaptations to unique ecological challenges.
Recently uploaded (20)
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
waterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
waterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
Cytokines and their role in immune regulation.pptx
Cytokines and their role in immune regulation.pptx
bordetella pertussis.................................ppt
bordetella pertussis.................................ppt
Authoring a personal GPT for your research and practice: How we created the Q...
Authoring a personal GPT for your research and practice: How we created the Q...
Equivariant neural networks and representation theory
Equivariant neural networks and representation theory
Deep Software Variability and Frictionless Reproducibility
Deep Software Variability and Frictionless Reproducibility
The debris of the ‘last major merger’ is dynamically young
The debris of the ‘last major merger’ is dynamically young
aziz sancar nobel prize winner: from mardin to nobel
aziz sancar nobel prize winner: from mardin to nobel
mô tả các thí nghiệm về đánh giá tác động dòng khí hóa sau đốt
mô tả các thí nghiệm về đánh giá tác động dòng khí hóa sau đốt
Compexometric titration/Chelatorphy titration/chelating titration
Compexometric titration/Chelatorphy titration/chelating titration
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...
Unlocking the mysteries of reproduction: Exploring fecundity and gonadosomati...
Unlocking the mysteries of reproduction: Exploring fecundity and gonadosomati...
Economies of synthesis
- 3. INTROduCTIO N CHEMICAL GENOME CHEMIST IN MOLECULAR REVOLUTION INTERPRETING CHEMICAL GENOME LESSONS FROM NATURAL PRODUCTS REVERSE MOLECULAR ENGINEERING STRUCTURE, FUNCTION, DESIGN & SYNTHESIS
- 5. HISTORY OF ORGANIC SYNTHESIS
- 7. PALYTOXIN 128 carbon atoms 64 Stereocentres 7 Geometrical
- 8. HENdRICSON’S CONCEPT “ The ideal synthesis creates a complex skeleton…. in a sequence of successive construction reactions involving no intermediate refunctionalizations and leading directly the structure of the target not only it’s skeleton but also its correctely placed functionality” J. Am. Chem Soc.,1975, 97, 5784
- 9. STEP ECONOMY Nature, 460, 2009, 197
- 10. GuIdELINES A. SINGLE OPERATION, MULTISTEPPROCESS (Cascade, tandem, domino, chain, regenerative)
- 11. Pericyclic, electroPlilic, NucleoPhilic, radical, Metal based
- 14. B. DESIGN & DISCOVERY OF NEW REACTIONS WITHHIGHTRC TRC: TARGETRRELEVANT COMPLEXITY TAXOL ANTICANCERANTIRETROVIRAL PROSTRATI N MLn
- 15. 0 10 20 30 40 50 60 1 2 3 4 5 6 7 8 9 10 11 NO OF STEPS COMPLEXITY
- 16. C. PROTECTIVE GROUPFREE Masks one functional group Solves selectivity problems X Y Y X Z Z PG PG
- 17. GuideliNes 1. In situ protection & deprotection O O PG O PG HO MgBr O HO O O LiHMDS OLi O MgBr OLi HO O HO 2. Biogenesis oriented synthesis 3. TM catalysed skeleton formation 4. Order of introduction of functional group
- 18. • Target-oriented • Protecting groups (PG) needed • Reactivity is ‘caged’ • Target-oriented • No protecting groups • No enzymes • Natural reactivity of functional groups is used constructively • Function-oriented • No protecting groups • Enzymes needed to promote/control reactivity AMBIGUINE
- 19. Nature, 2007, 446, 404-408
- 20. D. FUNCION ORIENTEDSYNTHESIS (FOS) Nature, 460, 2009, 197
- 21. PHORBOL ESTER DESIGNED MAINTAINS ACTIVITY PHORBOL ESTERS (AcTivE TumOR PROmOTER)
- 22. >70 STEPS, 1.4 nM 29 STEPS, 0.3 nM BRYOSTATiN (REvERSE muLTidRug RESiSTANcE, ANTicANcER, mEmORY ENHANcER (ALzHEimER)) NATURE SUPPLY: 0.00014%
- 23. FOS : STABLE ANALOguE dESigN (LAuLimidE) ANTICANCER(TAXOL RESISTANT) J. Org. Chem. 1988, 53, 3642–3644. NATURE SUPPLY: 0.00016%
- 25. CONTRIBUTION FROMDRDE N OH NH O NH S PSCl3/Et3N/H2O Chem. Commun., 2009, 5409–5411
- 26. REdOX EcONOmY Angew. Chem. Int. Ed. 2009, 48, 2854 – 2867 Redox economy refers to the endeavours to reduce the number of nonstrategic (those that do not set stereochemistry or are not skeleton-building) or corrective oxidation and reduction steps
- 27. redox economy in a synthesis achieved by properchoice of reactions C A S E S T U D Y
- 30. LiNEAR iNcREASE/dEcREASE iN OXidATiON LEvEL BiOmimETic APPROAcH
- 31. J. Am. Chem. Soc. 1995, 117,11106 – 11112. 1. Pd2(dba)3, HCO2H 1. NaBH4, CeCl3 1.AD-mix β NaIO42. NaBH4 3. TIPSCl 3.Bu3SnH AIBN HO 2.OSO4, , NaIO4 2.Raney Ni 1.NaBH4 1.HF 2. DMP 3.NaCl02
- 32. J. Am. Chem. Soc. 2005, 127, 15712 – 15713.
- 33. GUIDELINES Redox economy should be applied tactically by examining slight changes in the starting materials. Choreography must be scrutinized in orderto optimally introduce functionality and avoid chemo-unselective reactions Whetherreagents exist that could make the redox step unnecessary. The most drastic maximization of redox economy( most difficult) can occurthrough examining connectivity and choosing challenging retrosynthetic disconnections
- 34. ATOM ECONOMY Nature, 1991, 254, 1471-1477 HOw MUCH Of rEACTANTS END Up IN THE prODUCT? MASS EffICIENCY BENEfITS : EffECTIvE USE Of rAw MATErIALS DECrEASED EMISSIONS & wASTE DISpOSAL HIGHEST DEGrEE Of ATOM ECONOMY: COMBINE TwO Or MOrE BUILDING BLOCkS wITH ANY OTHEr rEACTANT/rEAGENT NEEDED CATALYTICALLY
- 35. CYCLOADDITION/ELECTrOCYCLIC rEACTIONS 100% Atom Economic Stereochemistry Only aromatic Transition State (4n+2) electron Fails for Unactivated Dienes UNCATALYSED TM CATALYSED Co-Oligomerisation Regioselectivity (Tethering) Both 4n & 4n+2 systems 2+2, 4+2, 4+4, 3+4, 5+3, 5+2, 6+2, 6+4, 2+2+2, 2+2+2+2 etc…… MLn MLn X X C Y N X Y
- 37. CONCLUSION minimizing nonstrategic redox operation & maximizing c-c bond forming reaction Disconnections should be made to maximize convergency The overall oxidation level of intermediates should linearly escalate during assembly of the molecularframework(except in cases where there is strategic benefit such as an asymmetric reduction) cascade (tandem) reactions should be designed and incorporated to elicit maximum structural change perstep The innate reactivity of functional groups should be exploited so as to reduce the numberof (orperhaps even eliminate) protecting groups Effort should be spent on the invention of new methodology to facilitate the aforementioned criteria and to uncovernew aspects of chemical reactivity If the target molecule is of natural origin, biomimetic pathways (either known orproposed) should be incorporated
- 38. prOf SHEEHAN prOf COrEY prOf NICHOLAU prOf BArAN prOf TrOST prOf wENDEr prOf HOffMAN prOf HENDrICkSON
- 39. THANkS