This document discusses asking answerable clinical questions. It defines background questions, which seek general knowledge, and foreground questions, which seek specific information to inform patient care. Foreground questions are best formulated using the PICO framework - describing the patient population, intervention, comparison intervention, and outcome. Well-constructed PICO questions focus the search for evidence and help determine the appropriate study design to answer the clinical question. Formulating answerable clinical questions is an important part of evidence-based practice.