Cell is the basic structural and functional unit of living organisms. All known living things are made up of one or more cells, and all cells arise from pre-existing cells through cell division. Important discoveries in cell theory included Hooke discovering cells in 1665, van Leeuwenhoek observing living cells in 1674, and Virchow proposing that all cells come from pre-existing cells in 1855. Cells vary greatly in size, from the smallest bacterial cell at 0.1 micrometers to the largest animal cell, the ostrich egg, at 18 centimeters. Cells also exhibit different shapes depending on their function, such as circular red blood cells for passing through capillaries or branched nerve cells for conducting impulses.