This document discusses the rapidly changing landscape of e-publishing for global health. It provides an overview of e-book formats, channels for distribution, tools for conversion and considerations for determining what content to publish digitally. Key points include that tablets are projected to outpace PC sales, ePub and Mobi are common formats, and intermediaries will likely play a role in the complex process of direct digital distribution. Global health organizations should consider creating interactive e-books for medical schools in developing areas as an alternative to printing textbooks.