Venous thromboembolism (VTE) includes deep vein thrombosis (DVT) and pulmonary embolism (PE), which can cause death or disability. Post-thrombotic syndrome damages venous valves and causes leg swelling and pain. Inflammation and platelet activation via neutrophil extracellular traps promote thrombosis. Genetic mutations like factor V Leiden increase thrombotic risk. Symptoms are often nonspecific, while d-dimer and imaging tests aid diagnosis. Anticoagulation prevents further clots, while thrombolysis treats active clots. Outcomes depend on risk stratification of right heart strain and biomarker levels.
Deep vein thrombosis (DVT), is the formation of a blood clot in a deep vein, most commonly the legs.[2][a] Symptoms may include pain, swelling, redness, or warmth of the affected area. About half of cases have no symptoms. Complications may include pulmonary embolism, as a result of detachment of a clot which travels to the lungs, and post-thrombotic syndrome.[2][3]
Risk factors include recent surgery, cancer, trauma, lack of movement, obesity, smoking, hormonal birth control, pregnancy and the period following birth, antiphospholipid syndrome, and certain genetic conditions. Genetic factors include deficiencies of antithrombin, protein C, and protein S, and factor V Leiden mutation. The underlying mechanism typically involves some combination of decreased blood flow rate, increased tendency to clot, and injury to the blood vessel wall.
Deep vein thrombosis (DVT), is the formation of a blood clot in a deep vein, most commonly the legs.[2][a] Symptoms may include pain, swelling, redness, or warmth of the affected area. About half of cases have no symptoms. Complications may include pulmonary embolism, as a result of detachment of a clot which travels to the lungs, and post-thrombotic syndrome.[2][3]
Risk factors include recent surgery, cancer, trauma, lack of movement, obesity, smoking, hormonal birth control, pregnancy and the period following birth, antiphospholipid syndrome, and certain genetic conditions. Genetic factors include deficiencies of antithrombin, protein C, and protein S, and factor V Leiden mutation. The underlying mechanism typically involves some combination of decreased blood flow rate, increased tendency to clot, and injury to the blood vessel wall.
to down load this presentation from this link
https://mohmmed-ink.blogspot.com/2020/11/deep-vein-thrombosis-dvt.html
deep vein thrombosis, diagnosis and managment.
Deep vein thrombosis (DVT) and Pulmonary embolism (PE)Aminul Haque
Deep vein thrombosis (DVT) and pulmonary embolism (PE), collectively referred to as venous thromboembolism (VTE), constitute a major global burden of disease.
Its a elaborate presentation on deep vein thrombosis by surgery resident.
Inform me if any thing needed to be correction.
thank you.
Dr Syed Aftub Uddin, MBBS,CCCD, MS ( Resident)
email: aftub_16@yahoo.com
to down load this presentation from this link
https://mohmmed-ink.blogspot.com/2020/11/deep-vein-thrombosis-dvt.html
deep vein thrombosis, diagnosis and managment.
Deep vein thrombosis (DVT) and Pulmonary embolism (PE)Aminul Haque
Deep vein thrombosis (DVT) and pulmonary embolism (PE), collectively referred to as venous thromboembolism (VTE), constitute a major global burden of disease.
Its a elaborate presentation on deep vein thrombosis by surgery resident.
Inform me if any thing needed to be correction.
thank you.
Dr Syed Aftub Uddin, MBBS,CCCD, MS ( Resident)
email: aftub_16@yahoo.com
In this playlist I have discussed some important Venous diseases like Varicose veins, deep vein thrombosis and Pulmonary embolism. If you watch all these videos together, you will become confident in managing these venous pathologies.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
2. Venous thromboembolism (VTE) encompasses
deep venous thrombosis
(DVT) and pulmonary embolism (PE) and causes
cardiovascular
death and disability. Postthrombotic syndrome
(also known as chronic venous insufficiency)
damages the venous valves
of the leg and causes ankle or calf swelling and leg
aching, especially
after prolonged standing. In its most severe form,
postthrombotic
syndrome causes skin ulceration
3.
4. Inflammation and Platelet ActivationVirchow’s triad of
inflammation,
hypercoagulability, and endothelial injury leads to
recruitment of
activated platelets, which release microparticles. These
microparticles
contain proinflammatory mediators that bind
neutrophils, stimulating
them to release their nuclear material and form web-
like extracellular
networks called neutrophil extracellular traps. These
prothrombotic
networks contain histones that stimulate platelet
aggregation and
promote platelet-dependent thrombin generation.
5. Prothrombotic StatesThe two most common autosomal dominant
genetic mutations are factor V Leiden, which causes resistance to
theendogenous anticoagulant, activated protein C (which
inactivates clotting
factors V and VIII), and the prothrombin gene mutation, which
increases the plasma prothrombin concentrationAntithrombin, protein
C, and protein S are naturally occurring coagulation
inhibitors. Deficiencies of these inhibitors are associated with VTE
but are rare. Antiphospholipid antibody syndrome is the most
common
acquired cause of thrombophilia and is associated with venous or
arterial
thrombosis. Other common predisposing factors include cancer,
obesity, cigarette smoking, systemic arterial hypertension, chronic
obstructive pulmonary disease, chronic kidney disease, blood
transfusion,
long-haul air travel, air pollution, oral contraceptives, pregnancy,
postmenopausal hormone replacement, surgery, and trauma.
6. EmbolizationWhen deep venous thrombidetach
from
their site of formation, they embolize to the vena
cava, right atrium,
and right ventricle, and lodge in the pulmonary
arterial circulation,
thereby causing acute PE. Paradoxically, these
thrombi occasionally
embolize to the arterial circulation through a
patent foramen ovale or
atrial septal defect. Many patients with PE have no
evidence of DVT
because the clot has already embolized to the
lungs.
7. Pulmonary Hypertension, Right Ventricular (RV) Dysfunction, and RV
MicroinfarctionPulmonary artery obstruction causes a rise in
pulmonaryartery pressure and in pulmonary vascular resistance.
When RV wall
tension rises, RV dilation and dysfunction ensue, with release of the
cardiac biomarker, brain natriuretic peptide. The interventricular
septum bulges into and compresses an intrinsically normal left
ventricle
(LV). Diastolic LV dysfunction reduces LV distensibility and
impairs LV filling. Increased RV wall tension also compresses the
right
coronary artery, limits myocardial oxygen supply, and precipitates
right coronary artery ischemia and RV microinfarction, with release
of cardiac biomarkers such as troponin. Underfilling of the LV may
lead to a fall in LV cardiac output and systemic arterial pressure,
with
consequent circulatory collapse and death.
8. Pulmonary EmbolismMassive PE accounts for 5–10% of cases, and
is characterized by extensive thrombosis affecting at least half of
the
pulmonary vasculature. Dyspnea, syncope, hypotension, and
cyanosis
are hallmarks of massive PE. Patients with massive PE may present
in cardiogenic shock and can die from multisystem organ failure.
Submassive PE accounts for 20–25% of patients, and is
characterized
by RV dysfunction despite normal systemic arterial pressure. The
combination of right heart failure and release of cardiac
biomarkers
indicates an increased likelihood of clinical deterioration. Low-risk
PE constitutes about 70–75% of cases. These patients have an
excellent
prognosis.
9. Deep Venous ThrombosisLower extremity DVT usually begins
in the
calf and propagates proximally to the popliteal vein, femoral
vein,
and iliac veins. Leg DVT is about 10 times more common than
upper
extremity DVT, which is often precipitated by placement of
pacemakers,
internal cardiac defibrillators, or indwelling central venous
catheters. The likelihood of upper extremity DVT increases as
the
catheter diameter and number of lumens increase. Superficial
venous
thrombosis usually presents with erythema, tenderness, and a
“palpable
cord.” Patients are at risk for extension of the thrombosis to
the
deep venous system.
10. Clinical EvaluationPE is known as “the Great Masquerader.” Diagnosis
is difficult because symptoms and signs are nonspecific. The most
common symptom is unexplained breathlessness. When occult PE
occurs concomitantly with overt congestive heart failure or
pneumonia,
clinical improvement often fails to occur despite standard medical
treatment of the concomitant illness. This scenario presents a clinical
clue to the possible coexistence of PE. With DVT, the most common
symptom is a cramp or “charley
horse” in the lower calf that persists and intensifies over several days.
Point score criteria help estimate the clinical likelihood of DVT and
PEPatients with a low-to-moderate likelihood of DVT or
PE should undergo initial diagnostic evaluation with d-dimer testing
alone (see “Blood Tests”) without obligatory imaging testsHowever,
patients with a high clinical likelihood of VTE should skip
d-dimer testing and undergo imaging as the next step in the
diagnostic
algorithm.
11. Clinical Pearls Not all leg pain is due to DVT, and not all dyspnea is
due to PESudden, severe calf discomfort suggests a
ruptured Baker’s cyst. Fever and chills usually herald cellulitis rather
than DVT. Physical findings, if present, may consist only of mild
palpation discomfort in the lower calf. However, massive DVT often
presents with marked thigh swelling, tenderness, and erythema. If the
leg is diffusely edematous, DVT is unlikely. More probable is an acute
exacerbation of venous insufficiency due to postthrombotic
syndrome. Upper extremity venous thrombosis may present with
asymmetry in
the supraclavicular fossa or in the circumference of the upper arms.
Intravenous drug users
may inject themselves with a wide array of substances that can
embolize
such as hair, talc, and cotton. Amniotic fluid embolism occurs when
fetal
membranes leak or tear at the placental margin.
12. Clinical Variable DVT
score
Active cancer
Paralysis, paresis, or recent
cast Bedridden for >3 days; major surgery <12 weeks
Tenderness along distribution of deep veins
Entire leg swelling
Unilateral calf swelling >3 cm
Pitting edema
Collateral superficial nonvaricose veins
Alternative diagnosis at least as likely as DVT
1
1
1
1
1
1
1
1
2
13. Clinical Variable PE Score
Signs and symptoms of DVT 3.0
Alternative diagnosis less likely than PE 1.5
Heart rate >100/min 1.5
Immobilization >3 days; surgery within 4 weeks 1.5
Prior PE or DVT 1.5
Hemoptysis 1.0
Cancer 1.0
14. Nonimaging Diagnostic Modalities. BLOOD TESTSThe quantitative
plasma d-dimer enzyme-linked immunosorbent assay (ELISA) rises
in
the presence of DVT or PE because of the breakdown of fibrin by
plasmin.
Elevation of d-dimer indicates endogenous although often clinically
ineffective thrombolysis. The sensitivity of the d-dimer is >80%
for DVT (including isolated calf DVT) and >95% for PE. The d-dimer
is less sensitive for DVT than for PE because the DVT thrombus
size
is smaller. A normal d-dimer is a useful “rule out” test. However,
the
d-dimer assay is not specific. Levels increase in patients with
myocardial
infarction, pneumonia, sepsis, cancer, and the postoperative state
and those in the second or third trimester of pregnancy. Therefore,
d-dimer rarely has a useful role among hospitalized patients,
because
levels are frequently elevated due to systemic illness.
15. ELEVATED CARDIAC BIOMARKERSSerum troponin and
plasma heart-type
fatty acid–binding protein levels increase because of RV
microinfarction.
Myocardial stretch causes release of brain natriuretic
peptide or
NT-pro-brain natriuretic peptide.
This finding is relatively specific but insensitive. RV
strain and
ischemia cause the most common abnormality, T-wave
inversion in
leads V1 to V4. The most frequently cited abnormality,
in addition
to sinus tachycardia, is the S1Q3T3 sign: an S wave in
lead I, a
Q wave in lead III, and an inverted T wave in lead III
18. PRIMARY THERAPY
Primary therapy consists of clot dissolution with
pharmacomechanical
therapy that usually includes low-dose catheter-
directed
thrombolysis. This approach is reserved for patients
with extensive
femoral, iliofemoral, or upper extremity DVT. The
open vein hypothesis
postulates that patients who receive primary therapy
will
sustain less long-term damage to venous valves,
with consequent
lower rates of postthrombotic syndrome.
19. SECONDARY PREVENTION
Anticoagulation or placement of an inferior
vena caval filter constitutes
secondary prevention of VTE. To lessen the
severity of postthrombotic
syndrome of the legs, below-knee graduated
compression
stockings may be prescribed, 30–40 mmHg, for
2 years after the
DVT episode. They should be replaced every 3
months because they
lose their elasticity
20. SECONDARY PREVENTION
Anticoagulation or placement of an inferior vena
caval filter constitutes
secondary prevention of VTE. To lessen the
severity of postthrombotic
syndrome of the legs, below-knee graduated
compression
stockings may be prescribed, 30–40 mmHg, for 2
years after the
DVT episode. They should be replaced every 3
months because they
lose their elasticity
21. RISK STRATIFICATIONHemodynamic instability, RV dysfunction
on echocardiography,
RV enlargement on chest CT, or elevation of the troponin
leveldue to RV microinfarction portend a high risk of an
adverse clinical
outcome. When RV function remains normal in a
hemodynamically
stable patient, a good clinical outcome is highly likely with
anticoagulation
Alone
ANTICOAGULATION
Effective anticoagulation is the foundation for successful
treatment
of DVT and PE. There are three options: (1) the conventional
strategyused for monitoring, becomes elevated more
rapidly. If warfarin
is initiated as monotherapy during an acute thrombotic illness,
a paradoxical exacerbation of hypercoagulability increases the
likelihood of thrombosis.
22. Warfarin Dosing In an average-size adult, warfarin
is often initiated
in a dose of 5 mg. The prothrombin time is
standardized by calculating
the international normalized ratio (INR), which
assesses the
anticoagulant effect of warfarin The target INR is
usually
2.5, with a range of 2.0–3.0. The warfarin dose is
usually titrated empirically to achieve
the target INR. Proper dosing is difficult because
hundreds of
drug-drug and drug-food interactions affect
warfarin metabolism
23. MANAGEMENT OF MASSIVE PE
For patients with massive PE and hypotension, replete volume
with
500 mL of normal saline. Additional fluid should be infused with
extreme caution because excessive fluid administration
exacerbates
RV wall stress, causes more profound RV ischemia, and worsens
LV
compliance and filling by causing further interventricular septal
shift
toward the LV. Dopamine and dobutamine are first-line
inotropic
agents for treatment of PE-related shock. Maintain a low
threshold
for initiating these pressors. Often, a “trial-and-error” approach
works
best; other agents that may be effective include norepinephrine,
vasopressin, or phenylephrine.
24. FIBRINOLYSIS
Successful fibrinolytic therapy rapidly reverses right
heart failure
and may result in a lower rate of death and
recurrent PE by
(1) dissolving much of the anatomically obstructing
pulmonary arterial
thrombus, (2) preventing the continued release of
serotonin and
other neurohumoral factors that exacerbate
pulmonary hypertension,
and (3) lysing much of the source of the thrombus
in the pelvic
or deep leg veins, thereby decreasing the likelihood
of recurrent PE.